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公开(公告)号：US20220096591A1
公开(公告)日：2022-03-31
申请号：US17548662
申请日：2021-12-13
Applicant: Ministry of Health, State of Israel , Sami Shamoon College of Engineering (R.A) , Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventor： Israel NISSAN , Noa Lea TEJMAN-YARDEN , Chaim RUBINOVITZ , Yakov DAVIDOV , Galia RAHAV , Ari ROBINSON , Yoram SHOTLAND
IPC: A61K38/08 , A61P31/04 , A61K33/242 , C12N1/20 , C12P21/02
Abstract: Cultures of Delftia bacteria are disclosed. Antimicrobial agents derived therefrom are also disclosed.
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公开(公告)号：US20210353456A1
公开(公告)日：2021-11-18
申请号：US17391227
申请日：2021-08-02
Inventor： Ygal Rotenstreich
Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.
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公开(公告)号：US20210170048A1
公开(公告)日：2021-06-10
申请号：US16071168
申请日：2017-01-19
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Talia SHEKHTER ZEHAVI , Ehud GAZIT , Mor HERMAN-ORON , Genady KOSTENICH , Arie ORENSTEIN
Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.
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公开(公告)号：US20210113298A1
公开(公告)日：2021-04-22
申请号：US16972601
申请日：2019-06-06
Applicant: THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Amihay SHINFELD , Yoav PAZ , Emanuel MENDES , Joseph FELDMAN
Abstract: An endotracheal tube cleaning device, including a rod, and a cleaning head coupled to a distal end of the rod, including a low friction-generating surface; and a high friction-generating surface, wherein the low friction-generating surface contacts an inner surface of the endotracheal tube when moved along the tube in a first direction and the high friction-generating surface contacts the inner surface of the endotracheal tube when moved in a second, opposite direction.
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公开(公告)号：US10975354B2
公开(公告)日：2021-04-13
申请号：US16676481
申请日：2019-11-07
Inventor： Sarah Ferber
IPC: C12N5/071 , G01N33/543
Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic β-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic β-cell phenotype and function.
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Patent Agency Ranking
公开(公告)号：US10970594B2
公开(公告)日：2021-04-06
申请号：US16280089
申请日：2019-02-20
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Leor Zach , David Guez , David Last , Dianne Daniels Elmakias , Yael Mardor , Shirley Sharabi , Noam Nissan , Miriam Sklair-Levy
Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
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公开(公告)号：US10947509B2
公开(公告)日：2021-03-16
申请号：US15961907
申请日：2018-04-25
Inventor： Sarah Ferber
IPC: C12N5/071 , G01N33/50 , A61K38/17 , A61K35/407 , A61K35/38
Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
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公开(公告)号：US10905392B2
公开(公告)日：2021-02-02
申请号：US16699660
申请日：2019-12-01
Inventor： Miriam Sklair-Levy , Arnaldo Mayer , Shmuel Yitzhak Pfeffer
IPC: A61B6/00 , G06T7/00 , G06T7/40 , G06K9/50 , G06K9/48 , G06K9/46 , G06T7/11 , G06T7/13 , A61B6/04 , G06T7/44 , A61B6/12
Abstract: Apparatus for diagnosing breast cancer, the apparatus comprising a controller having a set of instructions executable to: acquire a contrast enhanced region of interest (CE-ROI) in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; determine a texture neighborhood for each of a plurality of X-ray pixels in the CE-ROI, the texture neighborhood for a given X-ray pixel of the plurality of X-ray pixels extending to a bounding pixel radius of BPR pixels from the given pixel; generate a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI that are located within the texture neighborhood; and use a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.
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公开(公告)号：US20200330229A1
公开(公告)日：2020-10-22
申请号：US16764012
申请日：2018-11-14
Inventor： Alain Elie SERRAF , Mila Shai Raziel TEJMAN-YARDEN , Roey SHAFRIR
IPC: A61F2/24 , A61B17/00 , A61B17/064 , A61B17/072
Abstract: Apparatus for supporting a leaflet of a cardiac valve having an annulus and a plurality of leaflets extending from the annulus, the apparatus comprising: at least one support brace mountable to the cardiac valve and having: first and second ends each configured to be mounted to the cardiac valve in a region near a commissure of the cardiac valve associated with a leaflet of the plurality of leaflets; and a body configured to be attached to the leaflet and extend between the first and second ends along a lip of the leaflet.
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公开(公告)号：US20200222233A1
公开(公告)日：2020-07-16
申请号：US16830784
申请日：2020-03-26
Inventor： Ygal ROTENSTREICH
Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.
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