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公开(公告)号：US10363245B2
公开(公告)日：2019-07-30
申请号：US15902316
申请日：2018-02-22
Inventor： Jerry S. Wolinsky , John A. Lincoln , Leorah A. Freeman , Ponnada A. Narayana
IPC: A61K45/06 , A61P25/00 , A61K31/433
Abstract: Provided herein are methods for repairing central nervous system, particularly brain, lesions in a subject comprising orally administering a carbonic anhydrase inhibitor.
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152.发明申请公开(公告)号：US20190192537A1
公开(公告)日：2019-06-27
申请号：US16221094
申请日：2018-12-14
Inventor： Thomas J. SLAGA , Jacob Junco , Huiyun Liang , Sara Reyna
Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
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153.发明授权公开(公告)号：US10319994B2
公开(公告)日：2019-06-11
申请号：US15237892
申请日：2016-08-16
Inventor： Mataz Alcoutlabi , Victor Anafo Agubra
Abstract: Tin-containing carbon fibers may be produced by centrifugal spinning of a precursor composition that includes a base polymer and a tin-containing compound. The produced fibers are heated at a temperature sufficient to convert at least a portion of the base polymer in the collected fibers into carbon fibers comprising tin.
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公开(公告)号：US10316073B2
公开(公告)日：2019-06-11
申请号：US14580771
申请日：2014-12-23
Inventor： Peter Ulrichts , Christophe Blanchetot , Torsten Dreier , Johannes de Haard , E. Sally Ward Ober , Nicolas G. H. Ongenae
Abstract: Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
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公开(公告)号：US10307088B2
公开(公告)日：2019-06-04
申请号：US14794022
申请日：2015-07-08
Inventor： Rinat Esenaliev , Donald S. Prough , Yuriy Petrov , Irene Petrov , George Saade , Gayle L. Olson
IPC: A61B5/1455 , A61B5/145 , A61B5/00 , A61B5/1464 , A61B5/1459
Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
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Patent Agency Ranking
公开(公告)号：US20190152892A1
公开(公告)日：2019-05-23
申请号：US16316692
申请日：2017-07-11
Inventor： John R. FALCK , Mahesh P. PAUDYAL , László KÜRTI
IPC: C07C209/02 , C07D203/10 , C07C213/02 , C07J41/00 , C07C227/06 , C07D489/02 , C07D215/06 , C07D215/20 , C07D215/18 , C07D215/12 , C07D265/36 , C07D209/08 , C07D223/16 , C07D207/06 , C07D209/58 , C07D211/02
Abstract: In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.
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157.发明申请公开(公告)号：US20190151296A1
公开(公告)日：2019-05-23
申请号：US16097405
申请日：2017-04-28
Inventor： Maithili P DALVI , Elisabeth D MARTINEZ , John D MINNA , Juan BAYO-FINA , Amit DAS
IPC: A61K31/444 , A61K31/55 , A61K31/337 , A61K45/06 , A61P35/00 , A61N5/10 , A61K31/282 , A61K33/243
Abstract: Disclosed are methods for the use of Jumonji C demethylase inhibitors for the radiosensitization of cancers cells and the treatment and prevention of chemotherapy resistance in cancer.
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公开(公告)号：US20190142977A1
公开(公告)日：2019-05-16
申请号：US16246890
申请日：2019-01-14
Inventor： Christian PREIHS , Jing YU , Veronica Clavijo JORDAN , Yunkou WU , Khaled NASR , A. Dean SHERRY , Sara CHIRAYIL
IPC: A61K49/10 , C07D213/38 , A61B5/055
Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
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公开(公告)号：US10280369B2
公开(公告)日：2019-05-07
申请号：US14395720
申请日：2013-04-22
Inventor： Charles J. Neef , John Lee Massingill, Jr. , Clois E. Powell
Abstract: Thermal barrier mixtures and method of making the thermal barrier mixtures are described herein. The thermal barrier mixtures may be used to make thermal barrier coatings. Thermal barrier mixture may include halloysite and one or more silicon compounds.
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公开(公告)号：US10266765B2
公开(公告)日：2019-04-23
申请号：US15034124
申请日：2014-11-06
IPC: C09K11/77
Abstract: This invention relates to new phosphor materials exhibiting luminescence and methods for their production. More particularly, the invention relates to new europium-doped zinc sulfide-manganese (ZnS:Mn,Eu) phosphors and use thereof for radiation detection.
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