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187 条记录 (耗时 0.028 秒)

    Shipping/display container
    162.
    发明授权
    Shipping/display container 失效
    运输/展示容器

    公开(公告)号：US6029820A

    公开(公告)日：2000-02-29

    申请号：US75453

    申请日：1998-05-09

    申请人： David L. Brown ,  Donnalee S. Brown

    发明人： David L. Brown ,  Donnalee S. Brown

    IPC分类号： B65D21/02 ,  B65D21/00

    CPC分类号： B65D21/022

    摘要： A combination shipping/display container that has gripping surfaces in two planes associated with the end walls of the container such that lifting of the container is facilitated for placing the containers on their bottom walls for shipping and for placing the containers on their side walls for display purposes.

    摘要翻译： 在与容器的端壁相关联的两个平面中具有抓握表面的组合运输/展示容器，使得容器的提升便于将容器放置在其底壁上用于运输和将容器放置在其侧壁上用于展示 目的

    Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
    163.
    发明授权
    Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents 失效
    作为抗感染剂的N-肉豆蔻酰基转移酶的丝氨酰赖氨酰基肽和肽模拟抑制剂

    公开(公告)号：US5942600A

    公开(公告)日：1999-08-24

    申请号：US823101

    申请日：1997-03-24

    申请人： James A. Sikorski ,  Balekudru Devadas ,  Daniel P. Getman ,  David L. Brown ,  Srinivasan Nagarajan ,  Mark E. Zupec ,  Jeffrey I. Gordon

    发明人： James A. Sikorski ,  Balekudru Devadas ,  Daniel P. Getman ,  David L. Brown ,  Srinivasan Nagarajan ,  Mark E. Zupec ,  Jeffrey I. Gordon

    IPC分类号： A61K38/00 ,  C07K5/06 ,  C07K5/083 ,  A61K38/06

    CPC分类号： C07K5/06191 ,  C07K5/0606 ,  C07K5/081 ,  A61K38/00

    摘要： Seryl-lysyl-based peptide and peptidomimetic compounds are described as inhibitors of the enzyme N-myristoyl transferase to provide selective control of the fungal organism Candida albicans. Peptidomimetic compounds of particular interest are those of the formula: ##STR1## wherein R.sup.1 is selected form aminoalkyl, p-aminoalkylphenylalkyl, imidazolylalkylphenylalkyl, 2-alkylimidazolylalkylphenylalkyl, benzimidazolylalkylphenylalkyl and 2-alkylbenzimidazolylalkylphenylalkyl; wherein R.sup.2 is selected from hydrido, alkyl, cycloalkyl, akenyl, alkynyl, haloalkyl, benzyl, alkylphenylalkyl, alkoxyphenylalkyl, halophenylalkyl, phenethyl, cycloalkylalkyl, halocycloalkylalkyl, alkylcycloalkylalkyl, alkoxycycloalkylalkyl and naphthylalkyl; wherein Y is selected from carboxylic acid, hydroxamic acid, phosphonic acid and tetrazolyl; or a pharmaceutically-acceptable salt, amide or ester thereof. Compounds of the formula are species-specific inhibitors of C. albicans with little effect on human NMT enzyme and thus would be useful in treating C. albicans fungal infections in humans.

    摘要翻译： 基于丝氨酰赖氨酰的肽和拟肽化合物被描述为N-肉豆蔻酰转移酶的抑制剂，以提供真菌生物体白色念珠菌的选择性控制。 特别感兴趣的拟肽化合物是下式的化合物：其中R1选自氨基烷基，对氨基烷基苯基烷基，咪唑基烷基苯基烷基，2-烷基咪唑基烷基苯基烷基，苯并咪唑基烷基苯基烷基和2-烷基苯并咪唑基烷基苯基烷基; 烷基，环烷基，烯基，炔基，卤代烷基，苄基，烷基苯基烷基，烷氧基苯基烷基，卤代苯基烷基，苯乙基，环烷基烷基，卤代环烷基烷基，烷基环烷基烷基，烷氧基环烷基烷基和萘基烷基。 其中Y选自羧酸，异羟肟酸，膦酸和四唑基; 或其药学上可接受的盐，酰胺或酯。 式的化合物是白色念珠菌的物种特异性抑制剂，对人NMT酶几乎没有影响，因此可用于治疗人类白色念珠菌真菌感染。

    Endoscopic surgical method
    170.
    发明授权
    Endoscopic surgical method 失效
    内窥镜手术方法

    公开(公告)号：US5611780A

    公开(公告)日：1997-03-18

    申请号：US241167

    申请日：1994-05-10

    申请人： Andre P. Decarie ,  David L. Brown ,  Stanley J. Malinowski ,  Douglas M. Dunklee

    发明人： Andre P. Decarie ,  David L. Brown ,  Stanley J. Malinowski ,  Douglas M. Dunklee

    IPC分类号： A61B1/00 ,  A61B19/02 ,  A61M5/178

    CPC分类号： A61B1/00144 ,  A61B50/33 ,  A61B17/3417 ,  A61B2017/00362

    摘要： The present disclosure relates to a method of performing endoscopic or laparoscopic surgical procedures, including the steps of providing an endoscopic kit including an obturator for penetrating body tissue and at least two sleeve members adapted for use with the obturator. The method further includes the steps of inserting the obturator into a first sleeve member, penetrating a body wall of a patient with the obturator and the first sleeve member, and removing the obturator from the first sleeve member such that the first sleeve member remains in the body wall. The method further includes the steps of inserting the obturator into a second sleeve member, penetrating the body wall with the obturator and the second sleeve member, and removing the obturator from the second sleeve member such that the second sleeve member remains in the body wall.

    摘要翻译： 本公开内容涉及执行内窥镜或腹腔镜外科手术的方法，包括提供包括用于穿透身体组织的闭孔器和适于与闭孔器一起使用的至少两个套筒构件的内窥镜套件的步骤。 该方法还包括以下步骤：将闭塞器插入到第一套筒构件中，用闭塞器和第一套筒构件穿透患者的身体壁，以及从第一套筒构件移除闭塞器，使得第一套筒构件保持在 体壁。 该方法还包括以下步骤：将闭塞器插入第二套筒构件中，用闭塞器和第二套筒构件穿透体壁，以及从第二套筒构件移除闭塞器，使得第二套筒构件保留在体壁中。