公开(公告)号：US20210252058A1

公开(公告)日：2021-08-19

申请号：US17056181

申请日：2019-05-17

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  BAYLOR COLLEGE OF MEDICINE

Inventor： Stephen GOTTSCHALK ,  Brooke PRINZING ,  Giedre KRENCIUTE

IPC: A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  A61P35/00 ,  C07K16/28

Abstract: The application relates to a chimeric antigen receptor that targets Eph receptors and allows activation of co-stimulatory pathways. The application also relates to polynucleotides that encode the chimeric antigen receptor, vectors, and host cells comprising the chimeric antigen receptor. The application also relates to methods for preparing host cells comprising a chimeric antigen receptor in order to improve the in vivo effector function of the chimeric antigen receptor host cells.

公开(公告)号：US11083725B2

公开(公告)日：2021-08-10

申请号：US15520756

申请日：2015-10-16

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Heather S. Smallwood ,  Marie Morfouace ,  Martine F. Roussel ,  Paul G. Thomas

IPC: A61K31/4745 ,  A61K31/415 ,  A61K31/427 ,  A61K31/433 ,  A61K31/505 ,  A61K31/519 ,  A61K31/34 ,  A61K31/4164 ,  A61K31/454 ,  A61K31/277 ,  A61K31/352 ,  A61K31/365 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4439 ,  A61K31/555 ,  A61K31/7004 ,  A61K45/06

Abstract: The invention generally relates to methods of treating viral infections using known drugs and pharmaceutical compositions comprising same. More specifically, the disclosed methods are useful for the treatment of viral infections that are enveloped viruses. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11028051B2

公开(公告)日：2021-06-08

申请号：US16468657

申请日：2017-12-12

Applicant: St. Jude Children's Research Hospital

Inventor： R. Kip Guy ,  P. Jake Slavish ,  William Robert Shadrick ,  Brandon M. Young ,  Vincent A. Boyd ,  Nagakumar Bharatham ,  Jeanine E. Price ,  Anang Shelat

IPC: C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12

Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210115404A1

公开(公告)日：2021-04-22

申请号：US17067016

申请日：2020-10-09

Applicant: St. Jude Children's Research Hospital, Inc. ,  National University of Singapore

Inventor： Dario CAMPANA ,  Yu-Hsiang Chang

IPC: C12N5/0783 ,  A61K38/00 ,  C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  C12N5/00

Abstract: The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompansses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases.

公开(公告)号：US20210023081A1

公开(公告)日：2021-01-28

申请号：US16957996

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne JACKOWSKI ,  Charles O. ROCK ,  Richard E. LEE ,  Lalit Kumar SHARMA ,  Mi Kyung YUN ,  Chitra SUBRAMANIAN ,  Rajendra P. TANGALLAPALLY ,  Anne V. EDWARDS ,  Robert ZAMBONI ,  T. Jagadeeswar REDDY ,  Jiuyu LIU

IPC: A61K31/501 ,  A61K31/205 ,  A61K31/197 ,  A61P3/00

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US10829737B2

公开(公告)日：2020-11-10

申请号：US15857268

申请日：2017-12-28

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Dario Campana ,  Yu-Hsiang Chang

IPC: C12N5/0783 ,  A61K38/00 ,  C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  C12N5/00

Abstract: The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompasses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases.

公开(公告)号：US20200031872A1

公开(公告)日：2020-01-30

申请号：US16588738

申请日：2019-09-30

Applicant: St. Jude Children's Research Hospital

Inventor： Richard E. Lee ,  Ying Zhao ,  Liu Jiuyu

IPC: C07K11/02 ,  A61K38/12 ,  A61K31/407 ,  A61K38/14 ,  A61K45/06 ,  C07D498/14 ,  C07D498/22 ,  C07K7/06 ,  A61K9/00 ,  A61K47/02 ,  A61K9/20 ,  A61K38/15

Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20200016189A1

公开(公告)日：2020-01-16

申请号：US16584338

申请日：2019-09-26

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Stanislav S. ZAKHARENKO

IPC: A61K31/713 ,  C12N15/113 ,  C12Q1/6883 ,  A61K9/00

Abstract: The invention is directed to a method for treating the 22q11 deletion syndrome (22q11 DS) and schizophrenia (SCZ) by replenishment of decreased levels of miR-338-3p in thalamic neurons.

公开(公告)号：US20190376037A1

公开(公告)日：2019-12-12

申请号：US16550548

申请日：2019-08-26

Applicant: National University of Singapore ,  St. Jude Children's Research Hospital, Inc.

Inventor： Dario Campana ,  David Shook ,  Masaru Imamura

IPC: C12N5/0783 ,  A61K35/17 ,  A61K38/20 ,  C07K14/54 ,  C07K14/705

Abstract: The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

公开(公告)号：US20190316154A1

公开(公告)日：2019-10-17

申请号：US16309289

申请日：2017-07-05

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Byoung Ryu ,  Matthew M. Wielgosz ,  Francesca Ferrara

IPC: C12N15/86 ,  C07K14/47

Abstract: A DNA construct containing an erythroid lineage-specific promoter operably linked to a nucleotide coding sequence of interest and a method of using the same in the prevention or treatment of a hematopoietic disorder such as a hemoglobinopathy are described. Further disclosed are erythroid-specific promoters and erythroid-specific enhancers that can be used in the DNA construct.