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公开(公告)号：US11622731B2
公开(公告)日：2023-04-11
申请号：US16342072
申请日：2017-10-16
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Isha Gupta , Alexantrou Serb , Themistoklis Prodromakis
Abstract: The present invention provides a method and system for processing data from an event, such as a neurological event. When a neurological event occurs, a spike in a neural waveform is generated. The spike can be detected and used to determine information about the neurological event. The method uses data values from a resistive switching component capable of undergoing a resistive state change when a voltage is applied to it. The data values represent a sequence of resistive state changes of the resistive switching component which correspond to the neurological event. The method further comprises processing the received data values to identify a resistive state change corresponding to the neurological event and to obtain information about the neurological event. Thus, a method and system for processing neural spikes is provided.
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公开(公告)号：US20230093989A1
公开(公告)日：2023-03-30
申请号：US17800093
申请日：2021-02-16
Applicant: University of Southampton
Inventor： Sumeet MAHAJAN , Niall HANRAHAN , Konstaninos BOURDAKOS , Simon Lane
Abstract: A method for obtaining chemical and/or material specific information of a sample based on scattered light. The method comprises receiving detection data comprising at least two images. Each image is indicative of the intensity of scattered light i) for incident light of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state. The scattered light comprises an elastic scattering component that is due to Rayleigh scattering of the incident light in at least a portion of the sample. Alternatively, each image is indicative of the intensity of scattered light i) of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state, wherein the scattered light comprises an inelastic scattering component that is due to Raman scattering of the incident light in at least a portion of the sample. The method further comprises determining the chemical and/or material specific information of the sample based on the change in intensity of the elastic scattering component in dependence on the change in wavelength and/or the change in polarization state of the incident and/or scattered light.
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173.发明授权公开(公告)号：US11596364B2
公开(公告)日：2023-03-07
申请号：US16349107
申请日：2017-10-16
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Isha Gupta , Alexantrou Serb , Themistoklis Prodromakis
Abstract: The present invention provides a method for detecting events in an input signal. The method uses a volatile resistive switching component to detect the events in the input signal. The method comprising identifying the events based on sampling an output from the resistive switching component.
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公开(公告)号：US11569568B2
公开(公告)日：2023-01-31
申请号：US16635410
申请日：2018-08-01
Applicant: University of Southampton
Inventor： Hywel Morgan , Shilong Lu , Ying Cheong
Abstract: A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.
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公开(公告)号：US11504054B2
公开(公告)日：2022-11-22
申请号：US16489219
申请日：2017-03-07
Applicant: University of Southampton
Inventor： Hywel Morgan , Ying Cheong , Nick Macklon , Shilong Lu
Abstract: An intra-uterine monitoring system is described. The system comprises an implantable sensor device, shaped and dimensioned for implantation in a uterus for measuring conditions within the uterus to generate sensor data, and a wearable receiver device, for wirelessly receiving the sensor data generated by the implantable sensor device. In this way, real-time, in-vivo monitoring of the intra-uterine environment can be performed. The implantable sensor device can be kept small and simple, requiring only the mechanical and electronic structures necessary to take sensor measurements and transmit those to the receiver device. By making the receiver device wearable, it can be kept in relatively close proximity to the implantable sensor device on a long-term basis, making regular monitoring viable.
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Patent Agency Ranking
公开(公告)号：US20220365091A1
公开(公告)日：2022-11-17
申请号：US17625226
申请日：2020-07-11
Inventor： Pandurangan Vijayanand , Christian Ottensmeier , Simon Eschweiler
IPC: G01N33/574 , C12Q1/6886
Abstract: The present invention includes methods of detecting follicular regulatory T cells (TFR) comprising: obtaining a biological sample from a subject and detecting whether TFR are increased in the tumor sample by contacting the biological sample with antibodies that detect CD3+CD4+ FOXP3+BCL6+ T cells CD3+CD4+CXCR5+GITR+ T cells, or both, when compared to a healthy subject, and detecting the increase of TFR in the tumor sample. The present invention also includes combination therapy that depletes follicular regulatory T cells (TFR) with minimal effect on regulatory T cells (TREGS) to prevent or reduce immune related adverse effects (irAEs).
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公开(公告)号：US20220299840A1
公开(公告)日：2022-09-22
申请号：US17619355
申请日：2020-06-17
Applicant: University of Southampton
Inventor： Lewis Glynn CARPENTER , Sam Adam BERRY , Corin Barry Edmund GAWITH , Peter George Robin SMITH
Abstract: A method for fabricating an optical waveguide comprises: providing a sample of lithium niobate doped with magnesium oxide and having at least one grating of periodic domain inversion defined therein; applying a layer of metallic zinc to a surface of the sample over the at least one grating using sputter deposition; heating the sample in an atmosphere of pure oxygen to cause the zinc to indiffuse into the lithium niobate to form a waveguiding layer of increased refractive index under the surface of the sample; and using a dicing blade to cut two substantially parallel channels along a length direction of the at least one grating, to define a ridge waveguide between the two channels.
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公开(公告)号：US20220268983A1
公开(公告)日：2022-08-25
申请号：US17628998
申请日：2020-08-27
Applicant: University of Southampton
Inventor： Masaaki SAKAKURA , Lei WANG , Peter KAZANSKY , Yanhao YU , Yuhao LEI
IPC: G02B5/30 , C03C23/00 , G11B7/0045
Abstract: A method of fabricating an optical element comprises: providing a substrate (1, 50) of a transparent material in which is to be formed a plurality of birefringent nanostructures spaced apart in plane substantially parallel to a surface of the substrate in a first direction (2) by a distance X and in a second direction (3) by a distance Y; generating from the output of a source (20) of femtosecond laser pulses a laser beam group comprising a plurality of focused seeding beams (44) having a circular polarisation and spaced apart along a line by the distance X and a focused writing beam (26) having a non-circular polarisation and spaced apart from one of the seeding beams by the distance Y or the distance X; directing the laser beam group onto the surface of the substrate at a first position and applying one or more femtosecond laser pulses from each beam to corresponding volumes in the substrate; repeatedly translating the laser beam group relative to the substrate parallel to the line of seeding beams and along the first direction by the distance X to a next position and applying one or more femtosecond laser pulses from each beam, in order to deliver a plurality of femtosecond laser pulses from the seeding beams to each corresponding volume to create substantially optically isotropic nanostructures in the corresponding volumes; translating the laser beam group relative to the substrate along the second direction by the distance Y and repeating the repeated translation and application of the femtosecond laser pulses along the first direction; wherein the relative translation of the laser beam group and the substrate aligns the writing beam with successive corresponding volumes in which substantially optically isotropic nanostructures have been created, so that the one or more femtosecond laser pulses applied from the writing beam transform the optically isotropic nanostructure in each corresponding volume into an optically isotropic nanostructure with optical birefringence.
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公开(公告)号：US20220244580A1
公开(公告)日：2022-08-04
申请号：US17587679
申请日：2022-01-28
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Weiwei ZHANG , Graham REED , David THOMSON , Martin EBERT , Shinichi SAITO
IPC: G02F1/025
Abstract: A resonator modulator for modulating light in a photonic circuit, the modulator comprising: a capacitor formed of a ring-shaped insulating region sandwiched between an outer conductive region and an inner conductive region, wherein at least one of the outer conductive regions or the inner conductive regions is a polycrystalline semiconductor material.
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公开(公告)号：US20220222517A1
公开(公告)日：2022-07-14
申请号：US17613979
申请日：2020-05-26
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Alexander SERB , Jiaqi WANG , Ivan KOBYZEV
Abstract: A computer-implemented method for creating encoded data for use in a cognitive computing system. The method comprises the steps of receiving a plurality of hypervectors, each representing a respective semantic object; element-wise modular addition of two or more of the plurality of hypervectors, thereby binding the corresponding semantic objects; and vector concatenation of two or more of the plurality of hypervectors, thereby superposing the corresponding semantic objects. The method may be carried out by a cognitive processing unit that may be part of a cognitive computing system.
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