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公开(公告)号：US12072274B2
公开(公告)日：2024-08-27
申请号：US17276717
申请日：2019-09-16
IPC分类号： G01N15/12 , C12Q1/18 , G01N15/02 , G01N15/0227 , G01N15/10 , G01N15/1031
CPC分类号： G01N15/12 , C12Q1/18 , G01N15/0227 , G01N15/1023 , G01N15/1031 , G01N2015/0294 , G01N2015/1006 , G01N2015/1029 , G01N2015/103
摘要： A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.
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公开(公告)号：US20210098865A1
公开(公告)日：2021-04-01
申请号：US16635410
申请日：2018-08-01
发明人： Hywel Morgan , Shilong Lu , Ying Cheong
摘要： A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.
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公开(公告)号：US20200060607A1
公开(公告)日：2020-02-27
申请号：US16489219
申请日：2017-03-07
发明人： Hywel Morgan , Ying Cheong , Nick Macklon , Shilong Lu
摘要： An intra-uterine monitoring system is described. The system comprises an implantable sensor device, shaped and dimensioned for implantation in a uterus for measuring conditions within the uterus to generate sensor data, and a wearable receiver device, for wirelessly receiving the sensor data generated by the implantable sensor device. In this way, real-time, in-vivo monitoring of the intra-uterine environment can be performed. The implantable sensor device can be kept small and simple, requiring only the mechanical and electronic structures necessary to take sensor measurements and transmit those to the receiver device. By making the receiver device wearable, it can be kept in relatively close proximity to the implantable sensor device on a long-term basis, making regular monitoring viable.
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公开(公告)号：US10359351B2
公开(公告)日：2019-07-23
申请号：US14392103
申请日：2014-04-15
摘要： A method of electrically measuring the electrical properties of individual particles flowing in a liquid, which method comprises: (i) providing apparatus (3) which is for electrically measuring the individual particles and which has: (a) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (b) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); and (c) at least one other electrode arrangement (9) having at least one measurement electrode (18) and at least one signal electrode (13); (ii) providing a flow of the liquid (6) through the fluidic channel (5); (iii) applying a first electrical signal through the liquid (6) and along a first conduction path between the measurement electrode (16) and the signal electrode (11) of the first electrode arrangement (8); (iv) applying an electrical signal through the liquid (6) and along at least one other conduction path; (v) comparing the electrical signal between the first and the other conduction paths to generate a comparison signal; (vi) detecting an individual particle passing through the apparatus (3) by detecting a feature of the comparison signal of the individual particle, and obtaining at least one output waveform; (vii) measuring a height-related feature of the output waveform of the individual particle, and generating a first order assessment of the electrical properties of the individual particle; and (viii) assessing the shape of the output waveform to perform a second order adjustment to the first order assessment of the electrical properties of the individual particle, with the second order adjustment utilising data on a perceived degree of error in the first order assessment based on information on a known relationship between the waveform shape and the error in the first order assessment.
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公开(公告)号：US10267720B2
公开(公告)日：2019-04-23
申请号：US14392104
申请日：2014-04-15
摘要： Apparatus (3) for electrically measuring individual particles (4) flowing in a liquid (6), which apparatus (3) comprises: (i) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (ii) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); (iii) at least one other electrode arrangement (9) having at least one measurement electrode and at least one signal electrode (13); (iv) at least one signal conditioning electrode (10, 12, 14, 15, 17, 19) positioned adjacent to at least one of the measurement electrodes (16, 18) or at least one of the signal electrode (9); and (v) measuring means (20, 21) for measuring electrical signal changes; and the apparatus (3) being such that: (vi) the first and the other electrode arrangements (8, 9) are connected to the measuring means (20, 21) whereby individual particles passing between the first and other electrode arrangements (8, 9) cause a change in electrical signal which is measured; and (vii) the electrical potential of the signal conditioning electrode (10, 12, 14, 15, 17, 19) is controlled to substantially prevent current flow between the first electrode arrangement (8) and the other electrode arrangement (9).
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公开(公告)号：US09448200B2
公开(公告)日：2016-09-20
申请号：US14392031
申请日：2013-09-19
IPC分类号： G01N27/327 , G01N27/416 , G01N27/49 , G01N33/18
CPC分类号： G01N27/4163 , G01N27/49 , G01N33/18
摘要： Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) a dissolved oxygen sensor (4) for sensing dissolved oxygen in the water; and which apparatus (2) is such that: (ii) the dissolved oxygen sensor (4) has a working electrode and a reference electrode; and (iii) a voltage signal is applied between the working electrode and the reference electrode, and the voltage signal provides a conditioning waveform, then a wait time, and then a measurement function.
摘要翻译： 用于感测水中的至少一个参数的装置（2），所述装置（2）包括：（i）用于感测水中的溶解氧的溶解氧传感器（4） 以及（ii）溶解氧传感器（4）具有工作电极和参考电极的装置（2） 和（iii）在工作电极和参考电极之间施加电压信号，并且电压信号提供调理波形，然后是等待时间，然后进行测量功能。
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公开(公告)号：US20150192535A1
公开(公告)日：2015-07-09
申请号：US14392030
申请日：2013-09-19
发明人： Hywel Morgan , Matthew Charles Mowlen , Xi Huang
CPC分类号： G01N27/06 , G01F23/00 , G01K13/00 , G01N33/18 , G01N33/1806
摘要： Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) a conductivity sensor (6) for sensing conductivity in water; (ii) the conductivity sensor (6) is an electrode-based conductivity sensor having bare electrodes (12) which contact the water; (iii) there are at least four of the electrodes (12); (iv) the conductivity sensor (6) is fabricated on a substrate (14) using photolithography and etching; (v) the conductivity sensor (6) is an open cell sensor having a physically unconstrained electric field; (vi) the conductivity sensor (6) is of a dot construction comprising a dot and a surrounding formation; (vii) the conductivity sensor (6) has two electrodes which are for current stimulation and which geometrically bound and enclose another two electrodes which are for voltage sensing; and (viii) the conductivity sensor (6) is a laminar construction on the substrate (14).
摘要翻译： 用于感测水中的至少一个参数的装置（2），所述装置（2）包括：（i）用于感测水中的电导率的电导率传感器（6） （ii）电导率传感器（6）是具有与水接触的裸露电极（12）的基于电极的电导率传感器; （iii）至少有四个电极（12）; （iv）使用光刻和蚀刻在基板（14）上制造电导率传感器（6）; （v）电导率传感器（6）是具有物理无约束电场的开放式电池传感器; （vi）电导率传感器（6）是点状结构，其包括点和周围地层; （vii）电导率传感器（6）具有两个用于电流刺激的电极，并且几何结合并且包围用于电压感测的另外两个电极; 和（viii）电导率传感器（6）是衬底（14）上的层状结构。
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公开(公告)号：US20150192534A1
公开(公告)日：2015-07-09
申请号：US14392029
申请日：2013-09-19
发明人： Hywel Morgan , Matthew Charles Mowlem , Xi Huang
摘要： Apparatus (2) for sensing at least one parameter in water, which apparatus comprises: (i) a conductivity sensor (6) for sensing conductivity in the water; (ii) a dissolved oxygen sensor (4) for sensing dissolved oxygen in the water; (iii) a glass substrate (14); and (iv) the conductivity sensor (6) and the dissolved oxygen sensor (4) are fabricated on the glass substrate (14) using photolithography and etching.
摘要翻译： 用于感测水中的至少一个参数的装置（2），所述装置包括：（i）用于感测水中的电导率的电导率传感器（6） （ii）用于感测水中溶解氧的溶解氧传感器（4）; （iii）玻璃基板（14）; 和（iv）使用光刻和蚀刻在玻璃基板（14）上制造电导率传感器（6）和溶解氧传感器（4）。
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公开(公告)号：US12025547B2
公开(公告)日：2024-07-02
申请号：US17276697
申请日：2019-09-16
发明人： Hywel Morgan , Daniel Spencer
IPC分类号： G01N15/1031 , B01L3/00 , G01N15/10 , G01N15/1434
CPC分类号： G01N15/1031 , B01L3/502715 , B01L3/502761 , G01N15/1436 , B01L2300/0645 , G01N2015/1006
摘要： Impedance flow cytometry apparatus comprises: a flow channel for carrying a flow of fluid comprising particles suspended in an electrolyte from an inlet to an outlet; a first electrode group and a second electrode group, each electrode group providing first and second current paths through fluid flowing in the flow channel; wherein each electrode group comprises: a first signal electrode to provide to the first current path a first electrical signal of frequency, magnitude and phase; a second signal electrode to provide to the second current path a second electrical signal of substantially equal frequency and magnitude as the first electrical signal and of opposite phase to the first electrical signal; and one or more measurement electrodes to detect current flow in the first current path and the second current path and produce a summed signal representing the sum of the current flow in the first current path and the current flow in the second current path; wherein the first electrode group produces a first summed signal and the second electrode group produces a second summed signal; and circuitry to determine a differential signal representing the difference between the first summed signal and the second summed signal.
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公开(公告)号：US11569568B2
公开(公告)日：2023-01-31
申请号：US16635410
申请日：2018-08-01
发明人： Hywel Morgan , Shilong Lu , Ying Cheong
摘要： A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.
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