公开(公告)号：US08304234B2

公开(公告)日：2012-11-06

申请号：US11317548

申请日：2005-12-23

Applicant: David B. Weiner ,  William V. Williams ,  Bin Wang

Inventor： David B. Weiner ,  William V. Williams ,  Bin Wang

IPC: A61K31/167 ,  C12N15/63 ,  C12N15/87 ,  C07H21/04

CPC classification number: A61K38/193 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/0225 ,  A61K39/12 ,  A61K39/205 ,  A61K39/21 ,  A61K39/29 ,  A61K39/292 ,  A61K48/0008 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55566 ,  C07K14/005 ,  C12N15/87 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/13022 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2760/20122 ,  C12N2760/20134 ,  C12N2770/24222 ,  C12N2770/24234 ,  Y02A50/464 ,  Y02A90/26

Abstract: Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV am disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.

Abstract translation: 公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。 所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。 核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位， 涉及缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。 公开了预防和治疗个体免受HIV的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。

公开(公告)号：US08299021B2

公开(公告)日：2012-10-30

申请号：US13450885

申请日：2012-04-19

Applicant: Lawrence M Blatt ,  Scott D Seiwert ,  Steven W Andrews ,  Pierre Martin ,  Andreas Schumacher ,  Bradley Barnett ,  C. Todd Eary ,  Robert Kaus ,  Timothy Kercher ,  Weidong Liu ,  Michael Lyon ,  Paul Nichols ,  Bin Wang ,  Tarek Sammakia ,  April Kennedy ,  Yutong Jiang

Inventor： Lawrence M Blatt ,  Scott D Seiwert ,  Steven W Andrews ,  Pierre Martin ,  Andreas Schumacher ,  Bradley Barnett ,  C. Todd Eary ,  Robert Kaus ,  Timothy Kercher ,  Weidong Liu ,  Michael Lyon ,  Paul Nichols ,  Bin Wang ,  Tarek Sammakia ,  April Kennedy ,  Yutong Jiang

IPC: A61K38/00

CPC classification number: C07K5/0806 ,  A61K38/00 ,  A61K38/1793 ,  A61K38/212 ,  A61K38/217 ,  A61K38/2292 ,  A61K38/55 ,  C07D471/04 ,  C07D487/04 ,  C07K5/0804 ,  A61K2300/00

Abstract: The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：US20120263890A1

公开(公告)日：2012-10-18

申请号：US13409747

申请日：2012-03-01

Applicant: Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

Inventor： Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

IPC: C09K19/02 ,  C08B3/16

CPC classification number: C08B3/16 ,  B32B2457/202 ,  C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  C08J5/18 ,  C08J2301/14 ,  C08L1/14 ,  G02B1/04 ,  G02F1/13363 ,  G02F2001/133631 ,  Y10T428/10 ,  Y10T428/1036 ,  Y10T428/105

Abstract: Regioselectively substituted cellulose esters having a plurality of aryl-acyl substituents and a plurality of alkyl-acyl substituents are disclosed along with methods for making the same. Such cellulose esters may be suitable for use in optical films, such as optical films having certain Nz values, −A optical films, and/or +C optical films. Optical films prepared employing such cellulose esters have a variety of commercial applications, such as, for example, as compensation films in liquid crystal displays and/or waveplates in creating circular polarized light used in 3-D technology.

Abstract translation: 公开了具有多个芳基酰基取代基和多个烷基 - 酰基取代基的区域选择性取代的纤维素酯及其制备方法。 这种纤维素酯可以适用于光学膜，例如具有一定Nz值的光学膜，-A光学膜和/或+ C光学膜。 使用这种纤维素酯制备的光学薄膜具有各种商业应用，例如作为在3D技术中使用的产生圆偏振光的液晶显示器和/或波片中的补偿膜。

公开(公告)号：US20120263889A1

公开(公告)日：2012-10-18

申请号：US13409743

申请日：2012-03-01

Applicant: Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

Inventor： Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

IPC: C09K19/02 ,  C08B3/16

CPC classification number: C08B3/16 ,  B32B2457/202 ,  C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  C08J5/18 ,  C08J2301/14 ,  C08L1/14 ,  G02B1/04 ,  G02F1/13363 ,  G02F2001/133631 ,  Y10T428/10 ,  Y10T428/1036 ,  Y10T428/105

Abstract: Regioselectively substituted cellulose esters having a plurality of aryl-acyl substituents and a plurality of alkyl-acyl substituents are disclosed along with methods for making the same. Such cellulose esters may be suitable for use in optical films, such as optical films having certain Nz values, −A optical films, and/or +C optical films. Optical films prepared employing such cellulose esters have a variety of commercial applications, such as, for example, as compensation films in liquid crystal displays and/or waveplates in creating circular polarized light used in 3-D technology.

公开(公告)号：US20120208995A1

公开(公告)日：2012-08-16

申请号：US13450885

申请日：2012-04-19

Applicant: Lawrence M. Blatt ,  Scott D. Seiwert ,  Steven W. Andrews ,  Pierre Martin ,  Andreas Schumacher ,  Bradley Barnett ,  C. Todd Eary ,  Robert Kaus ,  Timothy Kercher ,  Weidong Liu ,  Michael Lyon ,  Paul Nichols ,  Bin Wang ,  Tarek Sammakia ,  April Kennedy ,  Yutong Jiang

Inventor： Lawrence M. Blatt ,  Scott D. Seiwert ,  Steven W. Andrews ,  Pierre Martin ,  Andreas Schumacher ,  Bradley Barnett ,  C. Todd Eary ,  Robert Kaus ,  Timothy Kercher ,  Weidong Liu ,  Michael Lyon ,  Paul Nichols ,  Bin Wang ,  Tarek Sammakia ,  April Kennedy ,  Yutong Jiang

IPC: C07D498/18

CPC classification number: C07K5/0806 ,  A61K38/00 ,  A61K38/1793 ,  A61K38/212 ,  A61K38/217 ,  A61K38/2292 ,  A61K38/55 ,  C07D471/04 ,  C07D487/04 ,  C07K5/0804 ,  A61K2300/00

Abstract: The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：US08231112B2

公开(公告)日：2012-07-31

申请号：US12565706

申请日：2009-09-23

Applicant: Xinhui Hua Cao ,  Stephane Joseph Pierre Beland ,  Bin Wang ,  Jason Ableitner ,  Brad Terlson ,  Evelyne Tremblay ,  Vincent Boutin

Inventor： Xinhui Hua Cao ,  Stephane Joseph Pierre Beland ,  Bin Wang ,  Jason Ableitner ,  Brad Terlson ,  Evelyne Tremblay ,  Vincent Boutin

IPC: B01F3/04

CPC classification number: F24F6/043 ,  F24F11/0008 ,  F24F11/30 ,  F24F2110/20 ,  Y10S261/15

Abstract: A humidifier for adding humidity to an air stream of an HVAC system includes a housing configured to be mounted to a surface of an HVAC duct. A back side of the housing may be positioned adjacent to an opening in the surface of the HVAC duct, and the housing may be configured to hold a humidifier pad in an operating position. The housing may define a first air flow path from a first side of the humidifier pad to the opening in the surface of the HVAC duct when the housing is mounted to the surface of the HVAC duct. The housing may further define a second air flow path from a second side of the humidifier pad to a bypass aperture. At least part of the second air flow path may be defined by a bypass duct member. The bypass duct member may be field-reconfigurable between at least a first position resulting in the bypass aperture being located at a first location, and a second position resulting in the bypass aperture being located at a second location. In some cases, the first and second locations are on the left and right sides, respectively, of the humidifier housing.

Abstract translation: 用于向HVAC系统的空气流添加湿度的加湿器包括构造成安装到HVAC管道的表面的壳体。 壳体的后侧可以邻近于HVAC管道的表面中的开口定位，并且壳体可以被配置为将加湿器垫保持在操作位置。 当壳体安装到HVAC管道的表面时，壳体可以限定从加湿器衬垫的第一侧到HVAC管道的表面中的开口的第一空气流动路径。 壳体还可以限定从加湿器垫的第二侧到旁路孔的第二空气流动路径。 第二气流路径的至少一部分可以由旁路管道构件限定。 旁路管道构件可以在导致旁路孔位于第一位置的至少第一位置和导致旁路孔位于第二位置的第二位置之间进行现场重构。 在一些情况下，第一和第二位置分别位于加湿器壳体的左侧和右侧。

公开(公告)号：USD663843S1

公开(公告)日：2012-07-17

申请号：US29353552

申请日：2010-01-11

Applicant: Bin Wang

Designer： Bin Wang

公开(公告)号：USD663033S1

公开(公告)日：2012-07-03

申请号：US29353557

申请日：2010-01-11

Applicant: Bin Wang

Designer： Bin Wang

公开(公告)号：US20120165352A1

公开(公告)日：2012-06-28

申请号：US13395892

申请日：2010-08-26

Applicant: Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

Inventor： Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

IPC: A61K31/517 ,  C07D403/12 ,  C07F9/6512 ,  A61P35/00 ,  C12N9/99 ,  C07F9/60 ,  C07D401/14 ,  A61K31/4709

CPC classification number: A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07F9/60 ,  C07F9/65128

Abstract: 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Abstract translation: 公开了6-氨基喹唑啉或3-氰基喹啉衍生物，其制备方法和药物用途。 具体地，本公开公开了通式（I）所示的新的6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变异构体，对映异构体，非对映异构体，外消旋体或其药学上可接受的盐或其代谢前体或前药， 用作特别是作为蛋白激酶抑制剂的治疗剂，其中通式（I）的每个取代基如本说明书中所定义。

公开(公告)号：US20120155246A1

公开(公告)日：2012-06-21

申请号：US13392948

申请日：2009-12-24

Applicant: Bin Wang ,  Shaoyong Wu

Inventor： Bin Wang ,  Shaoyong Wu

IPC: H04L12/26

CPC classification number: H04L12/437 ,  H04L41/06 ,  H04L45/02 ,  H04L69/40

Abstract: The present invention provides a method for blocking a protocol message at a Sub-ring control channel without a virtual channel, for avoiding the problem that the Sub-ring is in a continuous refresh state all the time caused by the existing solution of the Sub-ring control channel without the virtual channel, and the method includes: blocking forwarding of relevant messages when a forced switch is initiated or a failure is detected.

Abstract translation: 本发明提供了一种在没有虚拟信道的子环控制信道上阻塞协议消息的方法，用于避免子环处于由Sub-Ring的现有解决方案引起的连续刷新状态的问题， 环路控制信道，无虚拟信道，该方法包括：当发起强制交换或检测到故障时，阻塞相关消息的转发。