公开(公告)号：US10765776B1

公开(公告)日：2020-09-08

申请号：US15791720

申请日：2017-10-24

Applicant: South Dakota Board of Regents (SDBOR)

Inventor： Gudiseva Chandrasekher ,  Somshuvra Bhattacharya

IPC: A61L27/36 ,  A61L27/38 ,  A61K35/30

Abstract: The present disclosure relates to a composition and methods for preparing a tissue-derived, dissolved extracellular matrix. In implementations, the extracellular matrix composition includes components native to the cornea including liquefied corneal tissue. The extracellular matrix composition can be prepared by dissolving extracted corneas in an aqueous solution of inorganic base. The resulting solution is then dialyzed to achieve a physiological pH. In some implementations, the extracellular matrix composition can be seeded and/or chemically cross-linked to form a gel matrix. The extracellular matrix and/or the gel matrix can be seeded with a desired cell type (e.g., endothelial cells, epithelial cells, stromal keratocytes, etc.) to stimulate cell proliferation and regeneration.

公开(公告)号：US20200260753A1

公开(公告)日：2020-08-20

申请号：US16793818

申请日：2020-02-18

Applicant: South Dakota Board of Regents

Inventor： Lloyd E. Metzger ,  Ahmed Hammam

IPC: A23C19/08

Abstract: A process cheese produced by a combination of an acid curd and a concentrated milk protein at specific ratios is disclosed. The process cheese is produced without an emulsifying salt. A method of producing the process cheese is disclosed. The method includes preparing a volume of concentrated milk protein and a volume of acid curd. The method further includes producing a volume of process cheese product by combining the volume of the concentrated milk protein and the volume of acid curd. The ratio of protein in the acid curd to the protein in the concentrated milk protein ranges from 1.35:1 to 3.35:1.

公开(公告)号：US10675598B2

公开(公告)日：2020-06-09

申请号：US15561503

申请日：2016-03-23

Applicant: South Dakota Board of Regents

Inventor： Ilchgerel Dash ,  Robb M. Winter

IPC: B01F7/00 ,  B01F15/06 ,  B82Y40/00 ,  B01F3/14 ,  C08J3/20 ,  C08J5/00

Abstract: An improved a device and method for dispersion and simultaneous orientation of nanoparticles within a matrix is provided. A mixer having a shaft and a stator is provided. The shaft may have a rupture region and erosion region. Further, an orienter having an angled stationary plate and a moving plate are provided. The nanoparticles and the matrix are fed into the mixer. A rotational force is applied to the shaft to produce shearing forces. The shearing forces disperse and exfoliate the nanoparticles within the matrix. The dispersed mixture is outputted onto the moving plate. The moving plate is forced across the angled stationary plate to produce fully developed laminar shear flow. The fully developed laminar shear flow or the two-dimensional extensional drag flow orients the dispersed nanoparticles-matrix mixture.

公开(公告)号：US10468674B2

公开(公告)日：2019-11-05

申请号：US16249330

申请日：2019-01-16

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： David R. Salem ,  Chunhui Chen ,  Abdulmenan Hussein

IPC: H01M4/36 ,  H01M4/38 ,  H01M4/587 ,  H01M4/02

Abstract: This application relates to anode compositions and methods of making and using the same. In particular, the anode compositions are preferably layered. Preferably, the methods of making the anode compositions comprise a surfactant mediated assembly of layers. The anode compositions have improved structural integrity and capacity while reducing capacity fade due to cycling.

公开(公告)号：US10383943B2

公开(公告)日：2019-08-20

申请号：US15441191

申请日：2017-02-23

Applicant: South Dakota Board of Regents

Inventor： Hemachand Tummala ,  Pratik Muley

IPC: A61K45/06 ,  A61K31/555 ,  A61K47/54

Abstract: Compositions and methods for the use thereof for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising an anticancer composition comprising a antineoplastic compound and a conjugated targeting moiety with or without a chemical linker. In certain aspects the antineoplastic compound is a platin and the conjugated targeting moiety is an amino acid.

公开(公告)号：US10316010B2

公开(公告)日：2019-06-11

申请号：US15383935

申请日：2016-12-19

Applicant: South Dakota Board of Regents

Inventor： Grigoriy Sereda ,  Joseph Keppen

IPC: C08K3/04 ,  C07D307/52 ,  C07C225/06 ,  C07C227/14 ,  C07D207/448 ,  C07D405/14 ,  C07F9/38 ,  C08J3/24 ,  C08K3/22 ,  C08K7/06 ,  C08K9/04

Abstract: Disclosed is a non-destructive universal method of functionalization of graphitic carbonaceous materials that enables their alignment, cross-linking, and effective integration into composite materials.

公开(公告)号：US20190078315A1

公开(公告)日：2019-03-14

申请号：US16131863

申请日：2018-09-14

Applicant: South Dakota Board of Regents

Inventor： Mostafa Tazarv ,  Abdullah Boudaqa

IPC: E04B1/21 ,  E04H9/02

Abstract: The disclosed apparatus, systems and methods relate to reinforced concrete moment-resisting buildings with precast beams, precast columns, and replaceable buckling restrained reinforcements. Modular channels and pins or boxes are provided that allow for the replacement and repair of the precast moment-resisting beams and columns. Replaceable buckling restrained reinforcements are used to attach the beams and columns via embedded reinforcements and couplers.

公开(公告)号：US20180343880A1

公开(公告)日：2018-12-06

申请号：US15775762

申请日：2016-11-18

Applicant: South Dakota Board of Regents

Inventor： Lloyd Metzger

IPC: A23C9/142 ,  A23C9/152 ,  A23J3/10

CPC classification number: A23J3/10 ,  A23C9/1422 ,  A23C9/1524

Abstract: A method for forming a modified micellar casein concentrate includes providing a volume of skim milk. The method further includes performing a first filtration process on the volume of skim milk to form a micellar casein concentrate. The method includes mixing carbon dioxide with at least a portion of the micellar casein concentrate to solubilize one or more components of the micellar casein concentrate. The method includes performing an additional filtration process on the mixture of carbon dioxide and micellar casein concentrate to remove at least a portion of the one or more solubilized components of the micellar casein concentrate to form a modified micellar casein concentrate.

公开(公告)号：US20180171086A1

公开(公告)日：2018-06-21

申请号：US15843828

申请日：2017-12-15

Applicant: South Dakota Board of Regents

Inventor： Haoran Sun

IPC: C08J5/18 ,  C08G12/08

CPC classification number: C08J5/18 ,  C08G12/08 ,  C08J2361/22

Abstract: Synthesis and growth of large area free-standing ultra-thin two-dimensional (2D) polymeric films including 2D covalent organic frameworks (COF) are achieved by utilizing fluorocarbon-soluble fluorinated aldehyde derivatives and hydrocarbon-soluble amine derivatives at a liquid-liquid interface of respective fluorocarbon and hydrocarbon solvents.

公开(公告)号：US09925181B2

公开(公告)日：2018-03-27

申请号：US15682218

申请日：2017-08-21

Applicant: South Dakota Board of Regents

Inventor： Ying Deng ,  Bo Yang

IPC: A61K31/4745 ,  A61K31/155

CPC classification number: A61K31/4745 ,  A61K31/155

Abstract: A method of producing a drug-loaded Poly (Glycerol Sebacate) (PGS) comprising providing PGS; dissolving at least one drug in a solvent; incubating the PGS in the solvent; and evaporating the solvent.