公开(公告)号：US10746736B2

公开(公告)日：2020-08-18

申请号：US15560018

申请日：2016-03-28

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor Sendra ,  Badrinath Roysam

IPC: G01N33/00 ,  G01N33/569 ,  C12Q1/68 ,  G01N33/50 ,  C12Q1/6869

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

公开(公告)号：US20200246278A1

公开(公告)日：2020-08-06

申请号：US16636478

申请日：2018-08-06

Applicant: University of Houston System ,  Board Of Regents Of The University Of Texas System

Inventor： Diana S-L Chow ,  Tanay S. Samant ,  Shi-Ming Tu

IPC: A61K31/05 ,  A61K9/16 ,  A61K9/00 ,  A61P35/00

Abstract: Embodiments of the present disclosure pertain to formulations for cancer treatment that include a particle loaded with diethylstilbestrol (DES) and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier may also be loaded into the particle. The formulations may also include a stabilizer that is also loaded into the particle. The particles may be dispersed in an aqueous solution to form a nanosuspension that is adapted for subcutaneous administration and sustained release of DES. Additional embodiments pertain to methods of treating cancer in a subject by administering to the subject a formulation of the present disclosure. The subject may be a human suffering from prostate cancer. The administration of the formulations to the subject may bypass or minimize first pass metabolism. The administration may also minimize hepatic exposure of DES. Additional embodiments pertain to methods of making the formulations of the present disclosure by loading a particle with DES.

公开(公告)号：US10722129B2

公开(公告)日：2020-07-28

申请号：US16104750

申请日：2018-08-17

Applicant: UNIVERSITY OF HOUSTON SYSTEM ,  THE METHODIST HOSPITAL

Inventor： Luca Pollonini ,  Scott E. Parazynski ,  Kiefer Forseth

IPC: A61B5/1455 ,  A61B5/026 ,  A61B5/00

Abstract: Embodiments described herein generally relate to devices, methods and systems for determining blood oxygenation. By applying near infrared radiation of an appropriate wavelength to the tissue and determining the absorbance at a plurality of points where the distance between the source of the near infrared radiation and the detector are known, the oxygenation state of the hemoglobin can be determined based on position in a three dimensional space.

公开(公告)号：US10707397B2

公开(公告)日：2020-07-07

申请号：US14657247

申请日：2015-03-13

Applicant: University of Houston System

Inventor： Zhifeng Ren ,  Machhindra Koirala

IPC: H01L35/20 ,  C22C1/04 ,  C22C28/00 ,  H01L35/34 ,  H01L35/14 ,  C22C9/00 ,  B22F1/00 ,  B22F3/02 ,  C22C30/02

Abstract: Materials and systems and methods of manufacture thereof that function as thermoelectric materials both in and near a cryogenic temperature range. In particular, the synthesis of heavy fermion materials that exhibit higher ZTs than previously achieved at cryogenic and near-cryogenic temperatures.

公开(公告)号：US10690586B2

公开(公告)日：2020-06-23

申请号：US15745596

申请日：2016-07-18

Applicant: University of Houston System

Inventor： Cumaraswamy Vipulanandan

IPC: G01N17/04 ,  G01N17/02 ,  G01N27/20 ,  G01N27/24

Abstract: Systems and methods for real-time detecting and quantification of surface and bulk corrosion and erosion in materials involve measuring and characterizing the electrical resistances, capacitances, and/or inductances of the materials and their interfaces, preferably by using an impedance analyzer precision LCR meter. The materials may be metals, non-metals (such as plastics, polymers, cements, concrete, ceramics, rocks and soils) and composite materials with various types of material constituents (such as metals, plastics, polymers, and cements).

公开(公告)号：US10662070B2

公开(公告)日：2020-05-26

申请号：US16183862

申请日：2018-11-08

Applicant: University of Houston System

Inventor： Jeffrey D. Rimer ,  Manjesh Kumar

IPC: C01B39/04 ,  B01J29/70 ,  C01B39/48 ,  B01J29/85 ,  C01B39/54 ,  B01J47/00 ,  C30B7/14 ,  C30B29/14 ,  C30B29/34 ,  C30B29/60 ,  B01J29/06 ,  B01J35/00 ,  B01J35/02 ,  B01J29/035

Abstract: Embodiments of the invention generally provide compositions of crystalline zeolite materials with tailored crystal habits and the methods for forming such crystalline zeolite materials. The methods for forming the crystalline zeolite materials include binding one or more zeolite growth modifiers (ZGMs) to the surface of a zeolite crystal, which results in the modification of crystal growth rates along different crystallographic directions, leading to the formation of zeolites having a tailored crystal habit. The improved properties enabled by the tailored crystal habit include a minimized crystal thickness, a shortened internal diffusion pathlength, and a greater step density as compared to a zeolite having the native crystal habit prepared by traditional processes. The tailored crystal habit provides the crystalline zeolite materials with an aspect ratio of about 4 or greater and crystal surfaces having a step density of about 25 steps/μm2 or greater.

公开(公告)号：US10547076B2

公开(公告)日：2020-01-28

申请号：US15547641

申请日：2016-01-29

Applicant: University of Houston System ,  Rabi Ebrahim ,  Mukhtar Yeleuov ,  Alex Ignatiev

Inventor： Rabi Ebrahim ,  Mukhtar Yeleuov ,  Alex Ignatiev

IPC: H01M8/124 ,  H01M4/86 ,  H01M4/90

Abstract: Electrochemical devices including solid oxide fuel cells (SOFCs) or thin film solid oxide fuel cells (TFSOFCs) having a porous metallic anode with nanoporous surface structure enabling the deposition of a dense, impermeable thin film electrolyte layer on the porous anode. Fabricating methods include forming a mixture of nanopowder metallic agents and nanopowder proppant that are sintered, smoothed and etched to form the nanoporous surface structure.

公开(公告)号：US10533777B2

公开(公告)日：2020-01-14

申请号：US15580271

申请日：2016-06-17

Applicant: University of Houston System ,  Massachusetts Institute of Technology

Inventor： Zhifeng Ren ,  Feng Cao ,  Daniel Kraemer ,  Gang Chen

IPC: B32B17/06 ,  B32B15/04 ,  F24S70/20 ,  G02B1/115 ,  G02B19/00 ,  F24S70/30

Abstract: Systems and methods disclosed herein are directed towards the fabrication of a solar absorber comprising an IR reflector layer deposited on a substrate; a first cermet layer deposited in contact with the IR reflector layer; a second cermet layer deposited in contact with the first cermet layer; a first anti-reflection coating layer deposited in contact with the second cermet layer; a second anti-reflection coating layer deposited in contact with the first anti-reflection coating layer. A sputtering process may be used to deposit some or all of the layers, and the YSZ layers in each cermet layer may be deposited with a tuned partial oxygen pressure in order to form a layer that is oxygen-deficient.

公开(公告)号：US10513521B2

公开(公告)日：2019-12-24

申请号：US15326262

申请日：2015-07-14

Applicant: The Brigham and Women's Hospital, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services, National Institutes of Health ,  University of Houston System

Inventor： Arthur Lee ,  John C. McKew ,  Paresma R. Patel ,  Paul B. Yu ,  Agustin H. Mohedas ,  Philip E. Sanderson ,  Gregory D. Cuny ,  Wei Zheng ,  Xiuli Huang

IPC: C07D487/04 ,  C07D519/00

Abstract: The present invention provides bicyclic heteroaryl inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. Exemplary compounds include those of Formula I: These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

公开(公告)号：US10476234B2

公开(公告)日：2019-11-12

申请号：US15562462

申请日：2016-04-08

Applicant: University of Houston System

Inventor： Jae-Hyun Ryou ,  Shahab Shervin ,  Seung Hwan Kim

IPC: H01L29/84 ,  H01S5/32 ,  H01L29/778 ,  H01L29/06 ,  H01L21/8238 ,  H01L29/49 ,  H01L29/78 ,  H01S5/323 ,  H01S5/34 ,  H01L29/10 ,  H01L29/20 ,  H01L29/22 ,  H01L33/02 ,  H01L33/48

Abstract: Externally-strained devices such as LED and FET structures as discussed herein may have strain applied before or during their being coupled to a housing or packaging substrate. The packaging substrate may also be strained prior to receiving the structure. The strain on the devices enables modulation of light intensity, color, and electrical currents in some embodiments, and in alternate embodiments, enables a fixed strain to be induced and maintained in the structures.