FREE ENERGY LANDSCAPE MODELING WITH PARALLEL PATHS

    公开(公告)号:US20220148685A1

    公开(公告)日:2022-05-12

    申请号:US17092910

    申请日:2020-11-09

    Inventor: Frank Russo

    Abstract: Embodiments include simulating the behavior of enzymatic reactions involving multiple substrates binding with an enzyme. Some embodiments may allow for modeling the reactions without requiring known values for kinetic rate constants for microsteps of the reaction. Embodiments may include computer-implemented methods. Methods may include initializing an initial free energy profile for a reaction. The initial free energy profile may include a plurality of initial waypoints. The methods may include generating a plurality of rate equations, each rate equation representing a component step of the plurality of component steps. Methods may include simulating an in silico behavior of the reaction. Simulating may include generating concentrations of the substrates using the plurality of rate equations. Simulating may include updating the plurality of initial waypoints to reduce a difference between the in silico behavior of the reaction and an expected behavior of the reaction, forming a new free energy profile comprising a plurality of updated waypoints.

    IN SILICO ENZYMOLOGY
    182.
    发明申请

    公开(公告)号:US20220148684A1

    公开(公告)日:2022-05-12

    申请号:US17093057

    申请日:2020-11-09

    Inventor: Frank Russo

    Abstract: Embodiments include simulating the behavior of enzymatic reactions in silico in place of or in addition to running in vitro experiments. The in silico simulations may involve varying the initial concentrations of the reactant while setting the rate of change of concentration each form of an enzyme to be at steady state, which may aid in realistically representing the kinetics of the reaction. Some embodiments may allow for modeling enzymatic reactions so as to obtain mathematical relationships between the reaction rate and initial concentration of a reactant. Some embodiments may determine rate constants for microscopic steps within the enzymatic reactions. In addition, some embodiments may include optimizing for a plurality of initial reactant concentrations simultaneously rather than optimizing for one initial reactant concentration at a time, in order to generate a velocity versus concentration curve and to determine the catalytic rate constant kcat and Michaelis constant Km.

    Action prediction networks for robotic grasping

    公开(公告)号:US11325252B2

    公开(公告)日:2022-05-10

    申请号:US16570522

    申请日:2019-09-13

    Abstract: Deep machine learning methods and apparatus related to the manipulation of an object by an end effector of a robot are described herein. Some implementations relate to training an action prediction network to predict a probability density which can include candidate actions of successful grasps by the end effector given an input image. Some implementations are directed to utilization of an action prediction network to visually servo a grasping end effector of a robot to achieve a successful grasp of an object by the grasping end effector.

    Grounded SEA actuator
    184.
    发明授权

    公开(公告)号:US11325246B2

    公开(公告)日:2022-05-10

    申请号:US17119353

    申请日:2020-12-11

    Abstract: A device is provided. The device includes a worm drive comprising a worm and a worm gear. The device also includes an actuator comprising a motor, a shaft, and the worm, wherein the shaft is configured to rotate about a shaft axis, and the actuator is configured to (i) drive the worm drive, and (ii) move linearly along the shaft axis. The device also includes a first spring and a second spring, wherein the second ends are fixed, and wherein the first and second springs are configured to resist movement of the actuator along the shaft axis in opposite directions as a result of forces transmitted through the worm drive. The device further includes a linear position encoder configured to determine a position of the actuator along the shaft axis.

    Crop type classification in images
    185.
    发明授权

    公开(公告)号:US11321943B2

    公开(公告)日:2022-05-03

    申请号:US17162806

    申请日:2021-01-29

    Abstract: In embodiments, obtaining a plurality of image sets associated with a geographical region and a time period, wherein each image set of the plurality of image sets comprises multi-spectral and time series images that depict a respective particular portion of the geographical region during the time period, and predicting one or more crop types growing in each of particular locations within the particular portion of the geographical region associated with an image set of the plurality of image sets. Determining a crop type classification for each of the particular locations based on the predicted one or more crop types for the respective particular locations, and generating a crop indicative image comprising at least one image of the multi-spectral and time series images of the image set overlaid with indications of the crop type classification determined for the respective particular locations.

    Visual Detection of Haloclines
    187.
    发明申请

    公开(公告)号:US20220130061A1

    公开(公告)日:2022-04-28

    申请号:US17078490

    申请日:2020-10-23

    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for visually detecting a halocline. In some implementations, a method includes moving a camera through different depths of water within a fish enclosure, capturing, at the different depths, images of fish, determining that changes in focus in the images correspond to changes in depth that the images were captured, and based on determining that the changes in focus in the images correspond to the changes in depths that the images were captured, detecting a halocline at a particular depth.

    Modeling the chemical composition of a biological cell wall

    公开(公告)号:US11309058B2

    公开(公告)日:2022-04-19

    申请号:US15942339

    申请日:2018-03-30

    Abstract: Techniques are described for determining the strain on a cell wall using two models: 1) a short timescale model, describing the relationship between physical properties assumed to be fixed and 2) a long timescale model, describing the dynamic chemical composition of a cell wall. Short term modeling of the physical properties in a cell wall is used to properly understand how physical factors such as osmotic pressure affects the strain on the cell wall, which is in turn used to identify conditions under which a cell wall will cease to function properly or lyse entirely. Although temporally the physical properties which cause cell walls to underperform/lyse can be evaluated under a short time frame, the chemical properties that lead to the physical properties which cause that behavior themselves change over much longer timescales, in a relative sense.

    MICROWAVE ENHANCED 3D CONCRETE PRINTING

    公开(公告)号:US20220112732A1

    公开(公告)日:2022-04-14

    申请号:US17069163

    申请日:2020-10-13

    Abstract: Methods, systems, and apparatus, for performing additive manufacturing with concrete. One example is an additive manufacturing print head. The print head includes a body defining an internal flow path, a print nozzle at an outlet of the internal flow path, an auger disposed within the internal flow path, a first microwave emitter, and a second microwave emitter. The auger is operable to convey a concrete mixture towards the print nozzle. The first microwave emitter is operable to alter a viscosity of the concrete moisture within the flow path by directing first microwave energy towards the internal flow path. The second microwave emitter is arranged to direct second microwave energy towards the concrete mixture when it exits the print nozzle.

Patent Agency Ranking