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公开(公告)号：US5700897A
公开(公告)日：1997-12-23
申请号：US453442
申请日：1995-05-30
CPC分类号： C09K11/06 , G01N21/6428 , G01N21/7703 , G01N33/552 , G01N2021/6432 , G01N2021/6484 , G01N2021/772 , G01N21/81 , Y10T428/31645 , Y10T428/31855
摘要： A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chromophores and lumophores, the photoactive moieties spaced apart so as to minimize chemical or physical interaction therebetween while optimizing the density of photoactive moieties. In one embodiment, a polymer chain is covalently bound to photoactive moieties through functional groups such as esters, amides, or the like. In a second embodiment, a polymer chain is inherently fluorescent and is formed from at least one monomeric unit. These devices are particularly useful as pH and oxygen sensors.
摘要翻译： 提供了一种用于测量体液或组织的化学或生理参数的光纤感测装置。 纤维的一端连接聚合物，该聚合物包括选自发色团和间隙基团的多个光活性部分，间隔开的光活性部分，以使其间的化学或物理相互作用最小化，同时优化光活性部分的密度。 在一个实施方案中，聚合物链通过官能团如酯，酰胺等与光活性部分共价结合。 在第二个实施方案中，聚合物链固有地是荧光的并且由至少一个单体单元形成。 这些装置特别适用于pH和氧传感器。
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公开(公告)号：US20080183059A1
公开(公告)日：2008-07-31
申请号：US12021938
申请日：2008-01-29
IPC分类号： A61B5/00
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/0261 , A61B5/0295 , A61B5/14539 , A61B5/14542 , A61B5/445 , A61B5/6828 , A61B8/06
摘要： A device for assessing capillary vitality comprises an inflatable cuff, a blood flow sensor and a pressure sensor in communication with the cuff, a pressure instrument in fluid communication with the cuff for inflation and deflation thereof, a microprocessor coupled to the pressure instrument for controlling airflow, at least one metabolic sensor for measuring a metabolic condition, and a computer program executable by the microprocessor. The pressure instrument includes a source of pressurized air and a conduit connecting the source of pressurized air to the cuff. The microprocessor is arranged to receive inputs from the blood flow, pressure and metabolic sensors. When executed by the microprocessor, the computer program causes the microprocessor to initiate an automatic inflation sequence resulting in a no flow condition, initiate an automatic deflation sequence, automatically qualify a perfusion measurement as an SPP value upon one or more conditions being met during the deflation sequence, and initiate the measurement of at least one metabolic factor.
摘要翻译： 一种用于评估毛细血管活力的装置，包括与袖带连通的可充气袖带，血流传感器和压力传感器，与袖带流体连通以使其膨胀和收缩的压力仪器，耦合到压力仪器以控制气流的微处理器 ，用于测量代谢状况的至少一种代谢传感器和由微处理器执行的计算机程序。 压力仪器包括加压空气源和将压缩空气源连接到袖带的导管。 微处理器布置成从血流，压力和代谢传感器接收输入。 当由微处理器执行时，计算机程序使得微处理器启动自动充气序列，导致无流动状况，启动自动放气序列，在通气期间满足一个或多个条件时，自动限定灌注测量值作为SPP值 序列，并开始测量至少一种代谢因子。
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公开(公告)号：US06879850B2
公开(公告)日：2005-04-12
申请号：US10222616
申请日：2002-08-16
申请人： Victor E. Kimball
发明人： Victor E. Kimball
IPC分类号： A61B5/145 , A61B5/00 , A61B5/053 , A61B5/11 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/14552 , A61B5/053 , A61B5/14551 , A61B5/7207 , A61B5/721 , A61B2562/0233 , A61B2562/043
摘要： There is a need for a technique to compensate for, or eliminate, motion-induced artifacts in patient-attached critical care monitoring instruments. Consequently, the invention is directed to improving pulse-oximetry by incorporating additional signals to aid in the triggering of the pulse-oximeter or in analyzing the data received by the pulse oximeter. This includes detecting when the patient moves and analyzing the pulse-oximetry data in light of the detected movement.
摘要翻译： 需要一种在病人附属的关键监护仪器中补偿或消除运动诱发的人为产生的技术。 因此，本发明旨在通过引入额外的信号来辅助脉冲血氧计的触发或分析由脉搏血氧计接收的数据来改善脉搏血氧饱和度。 这包括根据检测到的运动来检测患者什么时候移动并分析脉搏血氧饱和度数据。
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14.发明授权
公开(公告)号：US6159536A
公开(公告)日：2000-12-12
申请号：US538318
申请日：2000-03-30
IPC分类号： A61B5/00 , C08F2/04 , C08F2/48 , C08F2/50 , C08F220/54 , C08F220/58 , G01N21/64 , G01N21/77 , B05D5/06 , B05D1/38
CPC分类号： A61B5/14539 , A61B5/1459 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , G01N2021/7786
摘要： A method for making a fiber optic sensor includes the steps of applying an adhesive composition to the distal end of an optical fiber, and applying a solution containing a copolymer of (a) a cellulose acrylamide, (b) an acrylamide, and (c) a copolymerizable monomeric fluorescent indicator species thereto to form a sensing layer.
摘要翻译： 制造光纤传感器的方法包括以下步骤：将粘合剂组合物施加到光纤的远端，并施加含有（a）纤维素丙烯酰胺，（b）丙烯酰胺和（c） 可共聚的单体荧光指示剂来形成感测层。
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15.发明授权Device for maintaining the partial pressure of a dissolved gas in a fluid and related methods of use 失效用于将溶解气体的分压维持在流体中的装置和相关的使用方法
公开(公告)号：US5690215A
公开(公告)日：1997-11-25
申请号：US676945
申请日：1996-07-08
CPC分类号： A61J1/10 , A61J1/16 , B65D75/38 , B65D81/2084
摘要： A device is provided for maintaining a volume of gas dissolved in a fluid at a predetermined partial pressure. The device includes a first sealable, gas-tight pouch containing the fluid and a second sealable, gas-tight pouch encasing the first pouch and providing a space between the first and second pouches. The space may be charged with an atmosphere containing a volume of the gas dissolved in the fluid that is greater than the volume of dissolved gas, at a partial pressure that is substantially the same as the partial pressure of the dissolved gas. A method is also provided for using the device to maintain a volume of a gas dissolved in a fluid at a predetermined partial pressure.
摘要翻译： 提供了一种用于在预定分压下保持溶解在流体中的气体体积的装置。 该装置包括容纳流体的第一可密封的气密袋和封装第一袋的第二可密封的气密袋，并且在第一和第二袋之间提供空间。 该空间可以以与溶解气体的分压基本相同的分压，装入溶解在流体中的体积大于溶解气体的体积的气体。 还提供了一种使用该装置以在预定分压保持溶解在流体中的气体体积的方法。
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公开(公告)号：US5656241A
公开(公告)日：1997-08-12
申请号：US524592
申请日：1995-09-07
CPC分类号： G01N21/7703 , G01N2021/772 , G01N2021/7759 , G01N2021/7786
摘要： A method is provided-for manufacturing a fiber optic sensor for detecting or measuring a parameter of interest in a sample fluid, including pH, concentration of dissolved gases such as O.sub.2 or CO.sub.2, and the like. The sensing chemistry is affixed to the distal end of an elongated optical fiber by way of an adhesive layer typically comprised of an acrylic adhesive composition. Novel optical sensors, fabricated using the aforementioned method, are provided as well.
摘要翻译： 提供了一种用于制造用于检测或测量样品流体中感兴趣的参数的光纤传感器的方法，包括pH，溶解气体如O 2或CO 2的浓度等。 感测化学品通过通常由丙烯酸粘合剂组合物组成的粘合剂层固定在细长光纤的远端。 还提供了使用上述方法制造的新型光学传感器。
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17.发明授权Indicator containing perfluorinated polyurethane membranes for use in optical oxygen sensors 失效含有用于光学氧传感器的全氟化聚氨酯膜的指示剂
公开(公告)号：US5632958A
公开(公告)日：1997-05-27
申请号：US449356
申请日：1995-05-24
申请人： James Kane , Roy Martin , Anne Schilling
发明人： James Kane , Roy Martin , Anne Schilling
CPC分类号： G01N21/643 , G01N21/7703 , G01N2021/6484 , G01N2021/772 , G01N2021/7786 , Y10T436/207497 , Y10T436/209163
摘要： A ratiometric method for using optical sensors is provided to measure dissolved oxygen in a fluid sample. The sensor is formulated so as to contain an oxygen permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein, an oxygen-sensitive indicator component and a reference dye component. The emission spectrum from the indicator component is calibrated by comparison with that of the reference dye, which is substantially less sensitive to oxygen-quenching and which has a photodecomposition rate similar to the indicator component. Methods for making and using the membrane and sensor are provided as well.
摘要翻译： 提供了使用光学传感器的比例计方法来测量流体样品中的溶解氧。 该传感器被配制成包含固化的全氟化氨基甲酸酯聚合物的透氧膜，并且其中并入有氧敏指示剂组分和参考染料组分。 通过与参考染料的比较来校准来自指示剂组分的发射光谱，其对氧气淬灭基本上较不敏感，并且具有与指示剂组分相似的光分解速率。 还提供了制造和使用膜和传感器的方法。
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18.发明授权Membranes and optical sensors made therewith having improved barrier properties 失效由此制成的膜和光学传感器具有改进的阻挡性能
公开(公告)号：US6139799A
公开(公告)日：2000-10-31
申请号：US991395
申请日：1997-12-16
IPC分类号： A61B5/00 , C08F2/04 , C08F2/48 , C08F2/50 , C08F220/54 , C08F220/58 , G01N21/64 , G01N21/77
CPC分类号： A61B5/14539 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , A61B5/1459 , G01N2021/7786
摘要： The present invention discloses novel polymer compositions comprising cellulose acrylamide, acrylamide and/or a fluorescent indicator species, and membranes made with these compositions. Optical pH sensors for monitoring the pH in a fluid sample, and methods for making such pH sensors are also disclosed. The pH sensors have reduced sensitivity to sample components that can interfere with pH measurements.
摘要翻译： 本发明公开了包含纤维素丙烯酰胺，丙烯酰胺和/或荧光指示剂物质的新型聚合物组合物，以及用这些组合物制成的膜。 还公开了用于监测流体样品中的pH的光学pH传感器以及用于制备这种pH传感器的方法。 pH传感器对可能干扰pH测量的样品成分的敏感性降低。
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19.发明授权Optical sensor for the measurement of pH in a fluid, and related sensing compositions and methods 失效用于测量流体中pH值的光学传感器，以及相关的感测组合物和方法
公开(公告)号：US5607644A
公开(公告)日：1997-03-04
申请号：US74749
申请日：1993-06-10
申请人： Alan Olstein , William Fowler , Jo Pritchard
发明人： Alan Olstein , William Fowler , Jo Pritchard
IPC分类号： G01N21/80 , C08F290/00 , C08F290/06 , C08L75/14 , G01N21/64 , G01N21/77
CPC分类号： G01N21/7703 , G01N21/6428 , G01N33/84 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N21/80
摘要： An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer species, wherein the ratio of precursor and fluorescent monomer species is such that a predetermined apparent pKa is provided. The sensor is prepared by coating the distal end of an optical waveguide with the fluorescent polymer composition, and curing the copolymer contained in the composition, e.g., by exposure to radiation of a suitable wavelength.
摘要翻译： 提供了用于测量流体样品的pH的光学传感器。 使用包含可水分散性聚醚的聚氨酯烯烃前体和荧光单体种类的共聚物的荧光聚合物组合物来配制传感器，其中前体和荧光单体种类的比例使得提供预定的表观pKa。 通过用荧光聚合物组合物涂覆光波导的远端并且例如通过暴露于合适波长的辐射来固化包含在组合物中的共聚物来制备传感器。
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20.发明授权
公开(公告)号：US5480723A
公开(公告)日：1996-01-02
申请号：US243961
申请日：1994-05-17
CPC分类号： C09K11/06 , G01N21/6428 , G01N21/7703 , G01N33/552 , G01N2021/6432 , G01N2021/6484 , G01N2021/772 , G01N21/81 , Y10T428/31645 , Y10T428/31855
摘要： A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chromophores and lumophores, the photoactive moieties spaced apart so as to minimize chemical or physical interaction therebetween while optimizing the density of photoactive moieties. In one embodiment, a polymer chain is covalently bound to photoactive moieties through functional groups such as esters, amides, or the like. In a second embodiment, a polymer chain is inherently fluorescent and is formed from at least one monomeric unit. These devices are particularly useful as pH and oxygen sensors.
摘要翻译： 提供了一种用于测量体液或组织的化学或生理参数的光纤感测装置。 纤维的一端连接聚合物，该聚合物包括选自发色团和间隙基团的多个光活性部分，间隔开的光活性部分，以使其间的化学或物理相互作用最小化，同时优化光活性部分的密度。 在一个实施方案中，聚合物链通过官能团如酯，酰胺等与光活性部分共价结合。 在第二个实施方案中，聚合物链固有地是荧光的并且由至少一个单体单元形成。 这些装置特别适用于pH和氧传感器。
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