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公开(公告)号:US07785792B2
公开(公告)日:2010-08-31
申请号:US12217953
申请日:2008-07-10
申请人: Alan P. Wolffe , Elizabeth J. Wolffe, legal representative , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号: C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
摘要翻译: 提供了在细胞染色质感兴趣的区域内靶向修饰染色质结构的方法和组合物。 这些方法和组合物可用于促进需要外源分子进入染色体DNA序列的过程,例如转录和重组。
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公开(公告)号:US20090322487A1
公开(公告)日:2009-12-31
申请号:US12112894
申请日:2008-04-30
CPC分类号: H04Q9/00 , H04Q2209/47
摘要: In a communication network or system, cables that interconnect systems or subsystems are provided with RFID tags embedded or affixed at least at one endpoint of each cable. An installed or portable RFID reader in the proximity of an RFID tag of a given cable enables a unique cable endpoint identifier contained in the RFID tag to be read. The identifier is combined with a unique port identifier of the port to which the cable endpoint is attached at the message is sent to a far-end system or subsystem connected to the other end of the cable. That system reads the message and the information contained therein along with a unique port identifier of its own port connected to the given cable, enables positive confirmation of the communicative connection between the two ports and also the cable providing the connection. It also enables communication of the physical routing information to an operations support system for cable management.
摘要翻译: 在通信网络或系统中,互连系统或子系统的电缆设置有嵌入或固定在每个电缆的至少一个端点处的RFID标签。 在给定电缆的RFID标签附近的安装或便携式RFID读取器能够读取包含在RFID标签中的独特的电缆端点标识符。 该标识符与电缆端点附接的端口的唯一端口标识符相结合,该消息被发送到连接到电缆另一端的远端系统或子系统。 该系统读取消息和其中包含的信息以及连接到给定电缆的其自身端口的唯一端口标识符,能够正确地确认两个端口之间的通信连接以及提供连接的电缆。 它还能够将物理路由信息传送到用于电缆管理的操作支持系统。
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公开(公告)号:US20090153321A1
公开(公告)日:2009-06-18
申请号:US12000823
申请日:2007-12-18
IPC分类号: G08B1/08
CPC分类号: G01V15/00
摘要: In a communication network or networked system, cables that interconnect systems or parts of a system are provided with RFID tags embedded at periodic intervals along their lengths. A network of GPS-enabled RFID readers with triangulation capabilities enables the determination of the physical routing of cables within an area of interest. It also enables communication of the physical routing information to an operations support system for cable management.
摘要翻译: 在通信网络或网络系统中,将系统或系统部件互连的电缆提供有沿其长度以周期性间隔嵌入的RFID标签。 具有三角测量能力的具有GPS功能的RFID读取器网络能够确定感兴趣区域内的电缆的物理布线。 它还能够将物理路由信息传送到用于电缆管理的操作支持系统。
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公开(公告)号:US07220719B2
公开(公告)日:2007-05-22
申请号:US10845384
申请日:2004-05-13
申请人: Casey C. Case , Elizabeth Wolffe, legal representative , Fyodor Urnov , Albert Lai , Andrew Snowden , Siyuan Tan , Philip Gregory
CPC分类号: A01K67/0275 , A01K2217/05 , A61K48/00 , A61K48/005 , C07K14/47 , C07K14/52 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/85 , C12N2830/002 , C12N2830/005 , C12N2830/008 , C12N2830/85 , C12Q1/66 , C12Q1/6897 , G01N33/5091
摘要: Disclosed herein are methods and compositions for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
摘要翻译: 本文公开了使用重组锌指蛋白调节内源细胞基因表达的方法和组合物。
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公开(公告)号:US08071370B2
公开(公告)日:2011-12-06
申请号:US12803927
申请日:2010-07-09
申请人: Alan P. Wolffe , Elizabeth J. Wolffe, legal representative , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号: C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
摘要翻译: 提供了在细胞染色质感兴趣的区域内靶向修饰染色质结构的方法和组合物。 这些方法和组合物可用于促进需要外源分子进入染色体DNA序列的过程,例如转录和重组。
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公开(公告)号:US20110269233A1
公开(公告)日:2011-11-03
申请号:US13063912
申请日:2009-09-15
申请人: Laetitia Malphettes , Andrew Snowden , Inn H. Yuk
发明人: Laetitia Malphettes , Andrew Snowden , Inn H. Yuk
CPC分类号: C12N15/67 , C12N15/63 , C12N2830/002
摘要: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
摘要翻译: 本发明提供用于调节细胞中的细胞内渗透压的组合物和方法,例如在培养的细胞中,包括在生物反应器中的培养细胞中。 本发明提供包含至少一种渗透应答转录调控元件(OR-TRE)的核酸,以及含有渗透应答转录调节元件(OR-TRE)的细胞,载体,制造产物,人造器官或植入物等, 。
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公开(公告)号:US20100323424A1
公开(公告)日:2010-12-23
申请号:US12803927
申请日:2010-07-09
申请人: Alan P. Wolffe , Elizabeth J. Wolffe , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
发明人: Alan P. Wolffe , Elizabeth J. Wolffe , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号: C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
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