公开(公告)号：US06780443B1

公开(公告)日：2004-08-24

申请号：US09498592

申请日：2000-02-04

申请人： Tetsuo Nakatsu ,  Peter J. Mazeiko ,  Andrew T. Lupo, Jr. ,  Carter B. Green ,  Charles H. Manley ,  David J. Spence ,  Hideaki Ohta

发明人： Tetsuo Nakatsu ,  Peter J. Mazeiko ,  Andrew T. Lupo, Jr. ,  Carter B. Green ,  Charles H. Manley ,  David J. Spence ,  Hideaki Ohta

IPC分类号： A61K716

CPC分类号： A61Q13/00 ,  A23G3/36 ,  A23G4/06 ,  A23L27/204 ,  A61K8/42 ,  A61K8/922 ,  A61K2800/244 ,  A61Q11/00 ,  C07C43/196 ,  C07C2601/14

摘要： The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.

摘要翻译： 本发明涉及包含至少一种冷却感，加温感和刺痛感的敏感组合物。 刺痛的感觉是至少一种Jambu Oleoresin和Spilanthol。 本发明还涉及在食品，药物或个人护理产品中使用感觉组合物的方法。

公开(公告)号：US06506756B2

公开(公告)日：2003-01-14

申请号：US09954867

申请日：2001-09-18

申请人： Neng-Yang Shih ,  Daniel M. Solomon ,  John J. Piwinski ,  Andrew T. Lupo, Jr. ,  Michael J. Green

发明人： Neng-Yang Shih ,  Daniel M. Solomon ,  John J. Piwinski ,  Andrew T. Lupo, Jr. ,  Michael J. Green

IPC分类号： C07D40112

CPC分类号： C07D401/12 ,  C07D401/14

摘要： The present invention discloses novel substituted imidazole compounds which have dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.

公开(公告)号：US06200254B1

公开(公告)日：2001-03-13

申请号：US09316722

申请日：1999-05-21

申请人： Andrew T. Lupo, Jr. ,  Tetsuo Nakatsu ,  John Caldwell ,  Michael E. Lankin ,  Carter B. Green ,  Takashi Aida

发明人： Andrew T. Lupo, Jr. ,  Tetsuo Nakatsu ,  John Caldwell ,  Michael E. Lankin ,  Carter B. Green ,  Takashi Aida

IPC分类号： A61K746

CPC分类号： C11B9/0038 ,  C07C45/30 ,  C07C45/45 ,  C07C45/62 ,  C07C45/65 ,  C07C45/676 ,  C07C49/385 ,  C07C49/587 ,  C07C47/12 ,  C07C49/703

摘要： Novel macrocyclic diene ketone compounds useful as fragrance materials are described having the following general formula (I): where R1, R2, R3 and R4 are each either a hydrogen atom or a C1 to C4 alkyl, a is the integer 1 or 2 and b is an integer in a range from 1 to 6. Novel pathways are described for synthesizing these macrocyclic diene ketones, as well as saturated and mono-unsaturated macrocyclic ketones having the following general formula (IV): where R1, R2, R3 and R4 are each independently a hydrogen atom or a C1 to C4 alkyl, a is the integer 1 or 2 and b is an integer in a range from 1 to 6.

摘要翻译： 描述了用作香料的新型大环二烯酮化合物，其具有以下通式（I）：其中R 1，R 2，R 3和R 4各自为氢原子或C 1至C 4烷基，a为整数1或2，b为 描述了用于合成这些大环二烯酮的新途径，以及具有以下通式（IV）的饱和和单不饱和的大环酮：其中R1，R2，R3和R4是 各自独立地为氢原子或C1至C4烷基，a为整数1或2，b为1至6的整数。

公开(公告)号：US06110888A

公开(公告)日：2000-08-29

申请号：US309251

申请日：1999-05-10

申请人： Andrew T. Lupo, Jr. ,  Tetsuo Nakatsu ,  John Caldwell ,  Raphael K. L. Kang ,  Alba T. Cilia ,  Augustinus G. Van Loveren ,  Lolita Villamaria

发明人： Andrew T. Lupo, Jr. ,  Tetsuo Nakatsu ,  John Caldwell ,  Raphael K. L. Kang ,  Alba T. Cilia ,  Augustinus G. Van Loveren ,  Lolita Villamaria

IPC分类号： A61K8/30 ,  A01N31/08 ,  A61K8/00 ,  A61K8/33 ,  A61K31/05 ,  A61P31/04 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/04 ,  C07C39/06 ,  C07C39/19 ,  C11B9/00 ,  C11D3/48 ,  C11D3/50 ,  A61K7/46 ,  A61K7/00 ,  A61K7/06 ,  A61K7/16 ,  A61K7/32

CPC分类号： A61Q13/00 ,  A61K8/347 ,  A61Q11/00 ,  A61K2800/77

摘要： A fragrance and/or flavor compound of the general formula (I): ##STR1## wherein R.sub.1 is one of propyl or a 2-propenyl group and R.sub.2 is a C.sub.1 -C.sub.5 alkyl group, said compound having exactly one R.sub.1 and from one to four R.sub.2. The compounds possess antimicrobial activity as well as flavor or odor characteristics acceptable for use in flavors and fragrances, respectively. The compounds are useful in forming flavor and/or fragrance compositions having antimicrobial activity. Product formulations, such as detergents, are useful for imparting both acceptable fragrance and antimicrobial properties. Other product formulations, such as mouthwashes, are useful for imparting both acceptable flavor and antimicrobial properties.

摘要翻译： 通式（I）的芳香剂和/或风味化合物：其中R 1是丙基或2-丙烯基中的一种，R 2是C 1 -C 5烷基，所述化合物具有正好一个R 1和一个至四个R 2。 这些化合物分别具有抗菌活性以及可以分别用于香料和香料中的风味或气味特征。 该化合物可用于形成具有抗微生物活性的风味和/或香料组合物。 产品制剂，例如洗涤剂，可用于赋予可接受的香料和抗微生物性质。 其他产品制剂，例如漱口水，可用于赋予可接受的风味和抗微生物性质。