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公开(公告)号：US20150010922A1
公开(公告)日：2015-01-08
申请号：US14375195
申请日：2013-01-29
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
IPC: G01N33/52
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
Abstract translation: 公开了从混合细胞群中选择视网膜色素上皮（RPE）细胞的方法。 该方法包括：（a）分析混合细胞群体的细胞中至少一个以下参数：（i）自发荧光高于预定阈值的细胞; （ii）表达CD81高于预定阈值的细胞; 和（iii）将垂直于激光束的光散射到预定阈值以上的单元; 和（b）选择对至少一个参数是阳性的细胞，从而从混合的细胞群中分选RPE细胞。
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公开(公告)号：US11891622B2
公开(公告)日：2024-02-06
申请号：US15539473
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20230051803A1
公开(公告)日：2023-02-16
申请号：US17883263
申请日：2022-08-08
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
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公开(公告)号：US20220154141A1
公开(公告)日：2022-05-19
申请号：US17546013
申请日：2021-12-08
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20220095608A1
公开(公告)日：2022-03-31
申请号：US17548450
申请日：2021-12-10
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Nir NETZER , Ofer WISER , Bat SHAHAF , Orit GAMBURG , Lior ROSENBERG BELMAKER , Dana HAYOUN NEEMAN , Osnat BOHANA KASHTAN
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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Patent Agency Ranking
公开(公告)号：US20180228846A1
公开(公告)日：2018-08-16
申请号：US15750049
申请日：2016-08-04
Applicant: CELL CURE NEUROSCIENCES LTD
Inventor： Osnat BOHANA-KASHTAN
IPC: A61K35/30 , C12N5/079 , A01N1/02 , C12N5/0793
CPC classification number: A61K35/30 , A01N1/0221 , C12N5/062 , C12N5/0621 , C12N2500/02 , C12N2500/38 , C12N2501/15 , C12N2501/16 , C12N2506/02
Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.
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公开(公告)号：US20180016553A1
公开(公告)日：2018-01-18
申请号：US15539473
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20180011092A1
公开(公告)日：2018-01-11
申请号：US15539514
申请日：2015-12-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
IPC: G01N33/569 , A61K35/30 , C12N5/079
CPC classification number: G01N33/56966 , A61K35/30 , A61K35/545 , C12N5/0621 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2501/999 , C12N2502/1323 , C12N2506/02 , C12N2509/00 , C12N2533/54 , G01N33/57407 , G01N2333/47 , G01N2333/4703 , G01N2500/10
Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
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公开(公告)号：US20170199190A1
公开(公告)日：2017-07-13
申请号：US15470926
申请日：2017-03-28
Inventor： Benjamin Eithan REUBINOFF , Nurit YACHIMOVICH-COHEN , Limor MATZRAFI
IPC: G01N33/569 , C12N5/079 , G01N33/58
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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公开(公告)号：US20240301351A1
公开(公告)日：2024-09-12
申请号：US18662758
申请日：2024-05-13
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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