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    SYSTEMS, METHODS, AND MEDIA FOR ESTABLISHING AUTHENTICITY OF IMAGE CONTENT
    12.
    发明申请
    SYSTEMS, METHODS, AND MEDIA FOR ESTABLISHING AUTHENTICITY OF IMAGE CONTENT 有权

    公开(公告)号：US20250070987A1

    公开(公告)日：2025-02-27

    申请号：US18811230

    申请日：2024-08-21

    Applicant: The Trustees of Columbia University in the City of New York

    Inventor： Mohit Gupta ,  Suman Jana ,  Vishal Misra

    IPC: H04L9/32 ,  H04L9/00

    Abstract: Mechanisms, including systems, methods, and media for establishing authenticity of image content are provided, the methods including: capturing an image using a camera; digitally signing the image using the camera to create a digital signature; and storing a first copy of the image in remote storage with the digital signature. In some embodiments, the image and the digital signature are stored in a blockchain. In some embodiments, the methods further comprise: retrieving a second copy of the image; and determining whether the second copy of the image is authentic based on the digital signature. In some embodiments, the methods further comprise generating an indicator that indicates to a person whether the second copy of the image is authentic. In some embodiments, the methods further comprise storing an indicator of edits made in the edited copy in the blockchain.

    TREATMENT AND METHOD FOR INHIBITING LATE NA CURRENT
    16.
    发明申请
    TREATMENT AND METHOD FOR INHIBITING LATE NA CURRENT 有权

    公开(公告)号：US20250049953A1

    公开(公告)日：2025-02-13

    申请号：US18801053

    申请日：2024-08-12

    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

    Inventor： Nourdine CHAKOURI ,  Manu BEN JOHNY ,  Steven O. MARX

    IPC: A61K48/00 ,  A61K38/18 ,  A61P9/06 ,  C12N15/86

    Abstract: Treatments and methods for inhibiting late Na current use fibroblast growth factor homologous factor (FHF), an endogenous channel modulator, to inhibit late Na current with high potency. A minimal effector domain is engineered within FHF (the “FHF-inhibiting-X-region” (FixR)) as a peptide inhibitor of late Na current that may be delivered intracellularly, for example as a cell-penetrating peptide, or via viral or plasmid delivery. As a non-limiting example, human adenovirus type 5 may be genetically modified with the sequence 5′-ATGGCTGCGGCGATAGCCAGCTCCTTGATCCGGCAGAAGCGGCAGGCGAGGGAG TCCAACAGCGACCGAGTGTCGGCCTCCAAGCGCCGCTCCAGCCCCAGCAAAGAC GGGCGCTCC-3′ (SEQ ID NO: 1). As pathophysiological impact of late Na current extends beyond cardiac myocytes to other physiological settings, including neurons of the central and peripheral nervous system and skeletal muscle, these treatments and methods provide potential therapeutic avenues for a range of human ailments, including cardiac conditions, neurological/neuropsychiatric disorders, and skeletal muscle conditions. Neurological/neuropsychiatric disorders include, for example, epilepsy and autism spectrum disorders, pain-related diseases, and myotonia.

    INCREASING DEVELOPMENTAL POTENTIAL OF HUMAN PREIMPLANTATION EMBRYOS BY REDUCING GENETIC INSTABILITY, ANEUPLOIDIES AND CHROMOSOMAL MOSAICISM
    17.
    发明申请
    INCREASING DEVELOPMENTAL POTENTIAL OF HUMAN PREIMPLANTATION EMBRYOS BY REDUCING GENETIC INSTABILITY, ANEUPLOIDIES AND CHROMOSOMAL MOSAICISM 有权

    公开(公告)号：US20250034520A1

    公开(公告)日：2025-01-30

    申请号：US18909710

    申请日：2024-10-08

    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

    Inventor： Dietrich EGLI

    IPC: C12N5/073 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

    Abstract: Disclosed herein are agents, compositions and methods for increasing the developmental potential of human preimplantation embryos.
    Disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo by activating kinases and/or their signaling pathway in an oocyte including but not limited to ATR, WEE1, and CHK1.
    Also disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo using polynucleotides, polypeptides and/or agents which increase efficiency of the “fork reversion and repair” pathway and/or decrease detrimental outcomes such as fork collapse, translesion synthesis and/or gap formation.
    Lastly disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo using one or more polynucleotides or polypeptides including but not limited to CHEK1, WEE1, ETAA1, ATRX, BLM, BRCA2, CHD4, DNA2 (DNA2L), EXO1, FANCC, FANCG, FBH1 (FBX018), HLTF (SMARCA3), MCM9, MSH6, POLD3, POLK, RAD51, RAD52, RAD54L, RB1, RECQL, REV3L, RIF1, RNF8, SETD1A, SHPRH, SMARCAL1, TDRD3, TOPBP1, TP53BP1, WRNIP1, XRCC2, WRN, BRCAI, ZRANB3, CDC6, CDT1, POLH, POLI, FANCD2, INO80, FANCB, ASH2L, FAM35A, XRCC3, BRIP1, and RNF168.

    Detecting Multiple Fluorophores Using Swept, Confocally-Aligned Planar Excitation (SCAPE) Microscopy
    18.
    发明申请
    Detecting Multiple Fluorophores Using Swept, Confocally-Aligned Planar Excitation (SCAPE) Microscopy 有权

    公开(公告)号：US20250012723A1

    公开(公告)日：2025-01-09

    申请号：US18888927

    申请日：2024-09-18

    Applicant: The Trustees of Columbia University in the City of New York

    Inventor： Elizabeth M.C. HILLMAN

    IPC: G01N21/64

    Abstract: Multiple fluorophores within a sample can be imaged by merging a plurality of beams from different wavelength light sources of excitation light into a single path, directing the excitation light into the sample, and detecting light emitted by the fluorophores within the sample on two different arrays of pixels (e.g., two regions within a single camera sensor chip). The light sources are activated during respective timeslots, and captured image data is processed. For at least one of the timeslots, the processing of the image data comprises using the image data captured using the first array of pixels to detect a presence of a given fluorophore, and using the image data captured using the second array of pixels to detect a presence of a different fluorophore. This arrangement enables a system that includes only N light sources to image more than N fluorophores.

    Circuits and methods for multi-phase clock generators and phase interpolators
    19.
    发明授权
    Circuits and methods for multi-phase clock generators and phase interpolators 有权

    公开(公告)号：US12189413B2

    公开(公告)日：2025-01-07

    申请号：US17665401

    申请日：2022-02-04

    Applicant: The Trustees of Columbia University in the City of New York

    Inventor： Zhaowen Wang ,  Yudong Zhang ,  Peter Kinget

    IPC: G06F1/06 ,  H03B27/00 ,  H03K3/03 ,  H03K5/133

    Abstract: Circuits and methods for multi-phase clock generators and phase interpolators are provided. The multi-phase clock generators include a delay line and multi-phase injection locked oscillator. At each stage of the multi-phase injection locked oscillator, injection currents are provided from a corresponding stage of the delay line. Outputs of the multi-phase injection locked oscillator and provided to mixers which produce inputs to an operational transconductance amplifier which provides feedback to the delay line and the multi-phase injection locked oscillator. The phase interpolator uses a technique of flipping certain input clock signals to reduce the number of components required while still being able to interpolate phase over 360 degrees and to reduce noise.

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