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公开(公告)号：US20230028321A1
公开(公告)日：2023-01-26
申请号：US17688752
申请日：2022-03-07
Inventor： Jingyue Ju , Xin Chen , Xiaoxu Li , Zengmin Li , Min-Kang Hsieh , Minchen Chien , Shundi Shi , Jianyi Ren , Cheng Guo , Shiv Kumar , James Russo , Chuanjuan Tao , Steffen Jockusch , Sergey Kalachikov
IPC: A61K31/7052 , C07H21/04
Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
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公开(公告)号：US11384391B2
公开(公告)日：2022-07-12
申请号：US16091442
申请日：2017-04-04
Inventor： Jingyue Ju , Shiv Kumar , James J. Russo , Steffen Jockusch , Zengmin Li , Xiaoxu Li , Sergey M. Kalachikov , Irina Morozova
IPC: C12Q1/68 , C07H19/10 , C07H19/20 , C12Q1/6869
Abstract: This invention provides nucleotide analogues each of which comprises a tag comprising one or more Forster resonance energy transfer (FRET) acceptor fluorophores, a nucleotide polymerase having one or more FRET donor fluorophores, and methods for sequencing single-stranded.
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公开(公告)号：US20230417750A1
公开(公告)日：2023-12-28
申请号：US18339717
申请日：2023-06-22
Inventor： Jingyue Ju , Shiv Kumar , James J. Russo , Chuanjuan Tao , Steffen Jockusch , Xiaoxu Li
IPC: G01N33/569 , G01N33/537
CPC classification number: G01N33/56983 , G01N33/537 , G01N2333/165 , G01N2469/20 , G01N2469/10
Abstract: This invention provides methods for detecting viruses, viral antigens, viral antibodies, and other antigens and antibodies using single molecule electronic nanopores and polymer tags.
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公开(公告)号：US20230028388A1
公开(公告)日：2023-01-26
申请号：US17816555
申请日：2022-08-01
Inventor： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC: C12Q1/6869 , C07H19/10 , C07H19/20 , C07H19/14
Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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公开(公告)号：US20250066848A1
公开(公告)日：2025-02-27
申请号：US18944861
申请日：2024-11-12
Inventor： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
IPC: C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/487
Abstract: This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230160000A1
公开(公告)日：2023-05-25
申请号：US17818705
申请日：2022-08-09
Inventor： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC: C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
CPC classification number: C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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公开(公告)号：US11266673B2
公开(公告)日：2022-03-08
申请号：US16303715
申请日：2017-05-23
Inventor： Jingyue Ju , Xin Chen , Xiaoxu Li , Zengmin Li , Min-Kang Hsieh , Minchen Chien , Shundi Shi , Jianyi Ren , Cheng Guo , Shiv Kumar , James J. Russo , Chuanjuan Tao , Steffen Jockusch , Sergey Kalachikov
IPC: C12Q1/68 , A61K31/7052 , C07H21/04 , C07H19/20 , C12Q1/6869
Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
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公开(公告)号：US11225687B2
公开(公告)日：2022-01-18
申请号：US16091435
申请日：2017-04-04
Inventor： Jingyue Ju , Shiv Kumar , James J. Russo , Steffen Jockusch , Zengmin Li , Xiaoxu Li , Sergey Kalachikov , Irina Morozova
IPC: C12Q1/68 , C12Q1/6869 , C12N9/12 , B82Y5/00 , B82Y30/00 , C12Q1/6825 , G01N21/65
Abstract: This invention provides nucleoside polyphosphate analogues each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs. This invention also provides nucleotide polymerases with one or more attached and/or conjugated noble metal nanoparticles, wherein the noble metal nanoparticles are surface-enhanced Raman spectroscopy (SERS) substrates thereby creating a region of enhanced sensitivity for surface enhanced Raman spectroscopy (SERS) within or adjacent to the polymerase. This invention also provides a surface with regions of enhanced sensitivity for surface enhanced Raman spectroscopy comprising interspersed rough or nanostructured noble metal surface. This invention also provides methods for determining the sequence of a single stranded DNA or RNA polynucleotide using one or more of nucleoside polyphosphate analogues, polymerase with noble metal nanoparticles, and surface with noble metal.
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公开(公告)号：US20210139976A1
公开(公告)日：2021-05-13
申请号：US16980708
申请日：2019-03-14
Inventor： Jingyue Ju , Xiaoxu Li , Shiv Kumar , Xin Chen , James J. Russo , Minchen Chien , Steffen Jockusch , Chuanjuan Tao , Xuanting Wang , Sergey Kalachikov , Irina Morozova , Shundi Shi
IPC: C12Q1/6874 , C12Q1/6876 , C07H21/04 , C07H19/00
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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公开(公告)号：US20200283833A1
公开(公告)日：2020-09-10
申请号：US16882353
申请日：2020-05-22
Inventor： Jingyue Ju , Youngjin Cho , Shiv Kumar , Sergey Kalachikov , Chuanjuan Tao , Minchen Chien , James J. Russo
IPC: C12Q1/6827 , G01N33/487 , C12Q1/6869
Abstract: This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer-conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.
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