中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

41 records (took 0.046 seconds)

    Methods for the production of biliverdin
    13.
    发明授权
    Methods for the production of biliverdin 有权
    生产胆红素的方法

    公开(公告)号：US08344019B2

    公开(公告)日：2013-01-01

    申请号：US13372361

    申请日：2012-02-13

    Applicant: Michael L Pendrak ,  David D Roberts

    Inventor： Michael L Pendrak ,  David D Roberts

    IPC: A61K31/40 ,  A61K31/33 ,  G01N33/53

    CPC classification number: C12P17/165

    Abstract: The present invention relates to compositions and methods for the production of biliverdin and methods of treatment and prevention. In particular, the invention concerns methods for producing biliverdin in yeast, especially Candida albicans, and other microorganisms.

    Abstract translation: 本发明涉及用于生产胆红素的组合物和方法以及治疗和预防方法。 特别地，本发明涉及在酵母中产生胆色素的方法，特别是白色念珠菌和其它微生物。

    Use of Semenogelin in the Diagnosis, Prognosis and Treatment of Cancer
    15.
    发明申请
    Use of Semenogelin in the Diagnosis, Prognosis and Treatment of Cancer 审中-公开
    使用精液蛋白在癌症的诊断，预后和治疗中的应用

    公开(公告)号：US20100112626A1

    公开(公告)日：2010-05-06

    申请号：US12609817

    申请日：2009-10-30

    Applicant: David D. Roberts ,  Henry C. Krutzsch ,  Christine Krutzsch

    Inventor： David D. Roberts ,  Henry C. Krutzsch ,  Christine Krutzsch

    IPC: C12Q1/02 ,  G01N33/48

    CPC classification number: G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/5743 ,  G01N33/57488 ,  G01N2333/47

    Abstract: Method of diagnosing cancer in a mammal comprising assaying a test sample from the mammal for an increased level of semenogelin, wherein the increased level of semenogelin in the test sample is diagnostic for the cancer; methods of prognosticating and assessing the effectiveness of treatment of a cancer in a mammal based on the level of semenogelin in a test sample; a composition comprising (a) an immune-response inducing effective amount of (i) semenogelin or polypeptide fragment thereof or (ii) antibody thereto or (b) a recombinant vector encoding and expressing an immune-response inducing effective amount of (i) or (ii); a method of inducing an immune response to a cancer in a mammal comprising administering to the mammal the foregoing composition.

    Abstract translation: 诊断哺乳动物癌症的方法，包括测定来自哺乳动物的测试样品以增加水平的精液蛋白，其中测试样品中精液蛋白的水平增加是癌症的诊断; 基于测试样品中精液蛋白水平预测和评估哺乳动物癌症治疗有效性的方法; 一种组合物，其包含（a）诱导有效量的（i）精液蛋白或其多肽片段或（ii）抗体的免疫应答或（b）编码和表达免疫应答诱导有效量的（i）或 （ii）; 诱导哺乳动物对癌症的免疫应答的方法，包括向哺乳动物施用前述组合物。

    Planar magnetic ring head for contact recording with a rigid disk
    18.
    发明授权
    Planar magnetic ring head for contact recording with a rigid disk 失效
    平面磁环头，用于与刚性盘接触记录

    公开(公告)号：US06493191B1

    公开(公告)日：2002-12-10

    申请号：US08528890

    申请日：1995-09-15

    Applicant: William C. Cain ,  Richard D. Anderson ,  Michael A. Baldwinson ,  Keith R. Berding ,  Michael E. Devillier ,  Garrett A. Garrettson ,  Randolph S. Gluck ,  Harold J. Hamilton ,  Robert D. Hempstead ,  Darren T. Imai ,  Kwang K. Kim ,  Dimitre A. Latev ,  Alexander P. Payne ,  David D. Roberts

    Inventor： William C. Cain ,  Richard D. Anderson ,  Michael A. Baldwinson ,  Keith R. Berding ,  Michael E. Devillier ,  Garrett A. Garrettson ,  Randolph S. Gluck ,  Harold J. Hamilton ,  Robert D. Hempstead ,  Darren T. Imai ,  Kwang K. Kim ,  Dimitre A. Latev ,  Alexander P. Payne ,  David D. Roberts

    IPC: G11B5187

    CPC classification number: G11B5/3163 ,  G11B5/3106 ,  G11B5/3183

    Abstract: A transducer for a hard disk drive system has a planar magnetic core and a pair of poletips that project transversely from the core for sliding contact with the disk during reading and writing. The transducer is formed entirely of thin films in the shape of a low profile table having three legs that slide on the disk, the poletips being exposed at a bottom of one of the legs for high resolution communication with the disk, the throat height of the poletips affording sufficient tolerance to allow for wear. The legs elevate the transducer from the disk sufficiently to minimize lifting by a thin air layer that moves with the spinning disk which, in combination with the small size of the thin film head allows a low load and a flexible beam and gimbal to hold the transducer to the disk. The transducer includes a loop shaped core of magnetic material that ends at the poletips, the core extending further parallel than perpendicular to the disk surface and preferably being formed of a plurality of slightly spaced ribbons of magnetic material in order to increase high frequency permeance. A high magnetic saturation layer may be formed adjoining the gap in at least the trailing poletip, in order to avoid saturation at the poletips during writing. The dimensions of the yoke adjacent to the poletips are also designed to avoid saturation at the poletips by saturating at a lower flux in the yoke than the poletips. The close relationship between the transducer and the media of the disk affords high density magnetic data storage and retrieval.

    Abstract translation: 用于硬盘驱动系统的换能器具有平面磁芯和一对从芯体横向突出的小纸片，用于在读写期间与盘滑动接触。 传感器完全由薄板形成，其具有在盘上滑动的三条腿的小型表，其中一条腿露出在一条腿的底部，用于与盘的高分辨率通信，喉部的高度 小腿提供足够的耐受性以允许磨损。 这些腿将传感器从盘上提升到足以最小化由旋转盘移动的薄空气层的提升，其与小尺寸的薄膜头允许低负载并且柔性梁和万向节保持换能器 到磁盘。 换能器包括磁性材料的环形磁芯，其在端部终止，芯体比垂直于磁盘表面进一步平行延伸，并且优选地由多个稍微间隔的磁性材料带形成，以便增加高频磁导率。 至少可以在至少尾部poletip中形成邻接间隙的高磁饱和层，以避免写入期间在poletips处的饱和。 靠近小翼片的轭的尺寸也被设计成通过在轭中的低通量饱和而不是poletips饱和。 传感器与磁盘介质之间的紧密关系提供了高密度的磁数据存储和检索。

    Compositions for stimulating TGF-&bgr; activity
    19.
    发明授权
    Compositions for stimulating TGF-&bgr; activity 失效
    用于刺激TGF-β活性的组合物

    公开(公告)号：US06384189B1

    公开(公告)日：2002-05-07

    申请号：US08871561

    申请日：1997-06-10

    Applicant: Joanne E. Murphy-Ullrich ,  Stacey Schultz-Cherry ,  David D. Roberts ,  Henry C. Krutzsch

    Inventor： Joanne E. Murphy-Ullrich ,  Stacey Schultz-Cherry ,  David D. Roberts ,  Henry C. Krutzsch

    IPC: C07K900

    CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K5/1019 ,  C07K5/1021 ,  C07K16/18

    Abstract: The invention provides a method of stimulating TGF-&bgr; activity, comprising contacting latent TGF-&bgr; with an amount of an activating peptide from TSP effective to convert latent TGF-&bgr; to active TGF-&bgr;. Also provided is a method of inhibiting the stimulation of TGF-&bgr; activity, comprising contacting latent TGF-&bgr; with an amount of an inhibiting peptide from TSP effective to inhibit conversion of latent of TGF-&bgr; to active TGF-&bgr;. The invention also provides a method of enhancing wound healing, comprising the step of administering to the wound site an amount of an activating peptide from TSP effective to convert latent TGF-&bgr; to active TGF-&bgr;, the activation of TGF-&bgr; resulting in enhanced wound healing. A method of preventing excessive fibrosis stimulated by TGF-&bgr; in pathology is also provided, comprising administering to a site of potential fibrosis an amount of inhibiting peptide from TSP effective to inhibit conversion of latent TGF-&bgr; to active TGF-&bgr;, resulting in reduced fibrosis. The invention also provides a method of blocking TGF-&bgr;-mediated inhibition of endothelial cell proliferation comprising contacting the endothelial cells with an inhibiting peptide effective to inhibit conversion of latent TGF-&bgr; to active TGF-&bgr;, resulting in proliferation of endothelial cells.

    Abstract translation: 本发明提供了一种刺激TGF-β活性的方法，其包括使潜在的TGF-β与一定量的来自TSP的活化肽有效地将潜伏性TGF-β转化为活性TGF-β。 还提供了抑制TGF-β活性刺激的方法，包括将潜在TGF-β与一定量的来自TSP的抑制肽接触，有效抑制TGF-β潜在转化为活性TGF-β。 本发明还提供了一种增强伤口愈合的方法，包括给伤口部位施用一定量的有效将潜在TGF-β转化为活性TGF-β的TSP的活化肽的步骤，TGF-β的激活导致增强 伤口愈合。 还提供了一种在病理学中预防TGF-β刺激的过度纤维化的方法，包括向潜在纤维化部位施用一定量的来自TSP的抑制性肽，其有效抑制潜伏性TGF-β转化为活性TGF-β，导致减少 纤维化。 本发明还提供了阻断TGF-β介导的内皮细胞增殖抑制的方法，包括使内皮细胞与有效抑制潜伏性TGF-β转化为活性TGF-β的抑制肽接触，导致内皮细胞增殖。

Patent Agency Ranking