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公开(公告)号：US20130263292A1
公开(公告)日：2013-10-03
申请号：US13434361
申请日：2012-03-29
申请人： Qi Liang , Allan Bradley , E-Chiang Lee , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人： Qi Liang , Allan Bradley , E-Chiang Lee , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号： A01K67/027 , C12N15/85 , C12N5/10
CPC分类号： C07K16/461 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07H21/04 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/63 , C12N15/8509 , C12N2015/8518 , C12N2800/30 , C12N2800/80
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译： 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链，如此产生的抗体和抗体链的方法及其衍生物，包括完全人源化抗体; 包含适合用于所述方法的所述抗体，抗体链和衍生物的组合物，以及细胞，非人哺乳动物和载体。
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公开(公告)号：US20130042331A2
公开(公告)日：2013-02-14
申请号：US13416684
申请日：2012-03-09
申请人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号： A01K67/027 , C12N5/10 , C12N15/85 , C12N15/13 , C07K16/00
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US20120204278A1
公开(公告)日：2012-08-09
申请号：US13310431
申请日：2011-12-02
申请人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号： A01K67/027 , C07H21/04 , C07K16/00 , C12N15/63 , C12N5/10
CPC分类号： A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译： 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链，如此产生的抗体和抗体链的方法及其衍生物，包括完全人源化抗体; 包含适合用于所述方法的所述抗体，抗体链和衍生物的组合物，以及细胞，非人哺乳动物和载体。
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公开(公告)号：US20110008359A1
公开(公告)日：2011-01-13
申请号：US12631598
申请日：2009-12-04
申请人： E-Chiang LEE , Gregory M. LANDES , Kyu CHUNG , Ling CHEN , Urvi DESAI , David Reed POWELL , Seokjoo HONG
发明人： E-Chiang LEE , Gregory M. LANDES , Kyu CHUNG , Ling CHEN , Urvi DESAI , David Reed POWELL , Seokjoo HONG
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译： 提供特异性结合ANGPTL4的单克隆抗体。 提供中和至少一种ANGPTL4活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号：US20120171217A1
公开(公告)日：2012-07-05
申请号：US13315027
申请日：2011-12-08
申请人： E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
发明人： E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译： 提供特异性结合ANGPTL4的单克隆抗体。 提供中和至少一种ANGPTL4活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号：US08092796B2
公开(公告)日：2012-01-10
申请号：US12631598
申请日：2009-12-04
申请人： E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
发明人： E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译： 提供特异性结合ANGPTL4的单克隆抗体。 提供中和至少一种ANGPTL4活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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17.发明申请ENHANCED HOMOLOGOUS RECOMBINATION MEDIATED BY LAMBDA RECOMBINATION PROTEINS 审中-公开由LAMBDA重组蛋白介导的增强的同源重组公开(公告)号：US20100267093A1
公开(公告)日：2010-10-21
申请号：US12760461
申请日：2010-04-14
申请人： Donald L. Court , Daiguan Yu , E-Chiang Lee , Hilary M. Ellis , Nancy A. Jenkins , Pentao Liu , Neal G. Copeland
发明人： Donald L. Court , Daiguan Yu , E-Chiang Lee , Hilary M. Ellis , Nancy A. Jenkins , Pentao Liu , Neal G. Copeland
IPC分类号： C12N15/87
CPC分类号： A01K67/0275 , A01K2217/05 , C12N15/66 , C12N15/8213 , C12N15/902 , C12N2800/204 , C12N2800/30 , C12N2830/002 , C12N2830/55 , C12N2830/60 , C12N2840/203
摘要： Disclosed herein are methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency homologous recombination in bacterial cells, and in eukaryotic cells such as mammalian cells. The methods are useful for cloning, the generation of transgenic and knockout animals, and gene replacement. The methods are also useful for subcloning large DNA fragments without the need for restriction enzymes. The methods are also useful for repairing single or multiple base mutations to wild type or creating specific mutations in the genome. Also disclosed are bacterial strains and vectors which are useful for high-efficiency homologous recombination.
摘要翻译： 本文公开了使用由重组酶和类似蛋白质介导的同源重组在细胞中产生重组DNA分子的方法。 这些方法促进细菌细胞和真核细胞如哺乳动物细胞中的高效同源重组。 该方法可用于克隆，转基因和敲除动物的产生以及基因替换。 该方法也可用于亚克隆大的DNA片段而不需要限制酶。 该方法对修复单基因或多基因突变至野生型或在基因组中产生特异性突变也是有用的。 还公开了可用于高效同源重组的细菌菌株和载体。
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公开(公告)号：US07144734B2
公开(公告)日：2006-12-05
申请号：US10366044
申请日：2003-02-12
申请人： Donald L. Court , Daiguan Yu , E-Chiang Lee , Hilary M. Ellis , Nancy A. Jenkins , Neal G. Copeland
发明人： Donald L. Court , Daiguan Yu , E-Chiang Lee , Hilary M. Ellis , Nancy A. Jenkins , Neal G. Copeland
CPC分类号： A01K67/0275 , A01K2217/05 , C12N15/66 , C12N15/8213 , C12N15/902 , C12N2800/204 , C12N2800/30 , C12N2830/002 , C12N2830/55 , C12N2830/60 , C12N2840/203
摘要： Disclosed herein are methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency homologous recombination in bacterial cells, and in eukaryotic cells such as mammalian cells. The methods are useful for cloning, the generation of transgenic and knockout animals, and gene replacement. The methods are also useful for subcloning large DNA fragments without the need for restriction enzymes. The methods are also useful for repairing single or multiple base mutations to wild type or creating specific mutations in the genome. Also disclosed are bacterial strains and vectors which are useful for high-efficiency homologous recombination.
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公开(公告)号：US20130263293A1
公开(公告)日：2013-10-03
申请号：US13433084
申请日：2012-03-28
申请人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人： Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号： C07K16/46 , C12N15/85 , A01K67/027
CPC分类号： C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要： The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号：US07935796B2
公开(公告)日：2011-05-03
申请号：US12001012
申请日：2007-12-06
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译： 提供特异性结合ANGPTL3的单克隆抗体。 提供中和至少一种ANGPTL3活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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