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公开(公告)号：US12193806B2
公开(公告)日：2025-01-14
申请号：US18013839
申请日：2021-07-08
Applicant: ENDOMAGNETICS LTD
Inventor： Quentin John Harmer , Kevin Lorimer , Matthew James Stephens
Abstract: A method for detecting a marker in a body, comprising receiving an input signal from a probe, where the input signal is generated by a probe in response to detecting a marker signal from the marker; determining a marker proximity value based on the input signal, the marker proximity value corresponds to a distance between the probe and the marker; generating a feedback signal for output by a user interface device based on the marker proximity value, and outputting feedback signal, wherein range of the marker proximity value is divided into predetermined distance bands; and wherein at least one parameter of the feedback signal, or a rate of change of the at least one parameter of the feedback signal in relation to marker proximity value, is varied discontinuously at a boundary between at least two adjacent bands. The feedback signal may be an audio signal and/or a haptic signal.
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公开(公告)号：US20240310462A1
公开(公告)日：2024-09-19
申请号：US18575610
申请日：2022-11-03
Applicant: ENDOMAGNETICS LTD.
Inventor： Robinson Udale , Gabriel Vallar
CPC classification number: G01R33/16 , A61B2017/00676 , A61B2034/2046 , A61B2090/3958
Abstract: An implantable susceptometry marker (1001) for use in surgical guidance comprising one or more ferromagnetic elements (1004a, 1004b, 1004c); and at least one diamagnetic element (1003); wherein the one or more ferromagnetic elements are formed of at least one ferromagnetic material having an initial relative permeability of at least about 10,000 and a saturation induction Bs of less than about 1.5 T, and the at least one diamagnetic element is formed of at least one diamagnetic material having a bulk susceptibility of at least about −0.16×10−4; and wherein the total volume of diamagnetic material in the marker is about 100-10,000 times greater than the total volume of ferromagnetic material.
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公开(公告)号：US11592501B2
公开(公告)日：2023-02-28
申请号：US16859355
申请日：2020-04-27
Applicant: Endomagnetics Ltd.
Inventor： Simon Richard Hattersley
Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.
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公开(公告)号：US20200256935A1
公开(公告)日：2020-08-13
申请号：US16859355
申请日：2020-04-27
Applicant: Endomagnetics Ltd.
Inventor： Simon Richard Hattersley
Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.
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Patent Agency Ranking
公开(公告)号：US10595957B2
公开(公告)日：2020-03-24
申请号：US15172187
申请日：2016-06-03
Applicant: ENDOMAGNETICS LTD
Inventor： Eric Mayes , Quentin John Harmer , Kevin Lorimer , Quentin Andrew Pankhurst
Abstract: A magnetic marker for marking a site in tissue in the body. In one embodiment, the marker comprises a magnetic metallic glass. In another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 9. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 6. In yet another embodiment, the marker is in a non-spherical configuration having an anisotropy ratio less than 3.
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公开(公告)号：US20180028692A1
公开(公告)日：2018-02-01
申请号：US15727690
申请日：2017-10-09
Applicant: Endomagnetics Ltd.
Inventor： Andrew P. Shawcross , John Gonzalez-Carvajal , Marc Brown , Rob Turner
CPC classification number: A61K49/1806 , A61K41/0052 , A61K49/1863 , A61N2/002
Abstract: Provided are compositions for rapid detection of lymph nodes. The compositions include magnetic particles, such as iron oxide, and a solute present in an amount that results in a hypoosomotic solution. Methods for detecting lymph nodes also are provided.
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公开(公告)号：US09239314B2
公开(公告)日：2016-01-19
申请号：US13799480
申请日：2013-03-13
Applicant: Endomagnetics Ltd. , University of Houston
CPC classification number: G01N27/745 , A61B5/05 , G01R33/0213 , G01R33/10
Abstract: A probe and method for detecting magnetic particles. In one embodiment, the probe includes a probe core having a first end and a second end, the probe core defining two regions for containing coils of wire, one of the regions being adjacent the first end of the cylindrical probe core; two sense coils, one each of the sense coils being located in a respective one of the regions; and two drive coils, one each of the drive coils being located in a respective one of the regions, wherein the regions are separated by a distance equal to or greater than the diameter of one of the coils and a source of a secondary magnetic drive field. In another embodiment, the frequency of the drive signal of the secondary magnetic drive field is less than the frequency of the drive signal of the primary drive coils.
Abstract translation: 用于检测磁性颗粒的探针和方法。 在一个实施例中，探针包括具有第一端和第二端的探针芯，探针芯限定用于容纳线圈的两个区域，其中一个区域与圆柱形探针芯的第一端相邻; 两个感测线圈，每个感测线圈位于相应的一个区域中; 和两个驱动线圈，每个驱动线圈位于相应的一个区域中，其中区域被分开等于或大于一个线圈的直径和次级磁驱动场的源的距离 。 在另一个实施例中，次级磁驱动场的驱动信号的频率小于主驱动线圈的驱动信号的频率。
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公开(公告)号：US20140314679A1
公开(公告)日：2014-10-23
申请号：US14202178
申请日：2014-03-10
Applicant: ENDOMAGNETICS LTD.
Inventor： Andrew P. Shawcross , John Gonzalez-Carvajal , Marc Brown , Rob Turner
CPC classification number: A61K49/1806 , A61K41/0052 , A61K49/1863 , A61N2/002
Abstract: Provided are compositions for rapid detection of lymph nodes. The compositions include magnetic particles, such as iron oxide, and a solute present in an amount that results in a hypoosomotic solution. Methods for detecting lymph nodes also are provided.
Abstract translation: 提供了用于快速检测淋巴结的组合物。 组合物包括磁性颗粒，例如氧化铁和以导致低体液溶液的量存在的溶质。 还提供了检测淋巴结的方法。
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公开(公告)号：US20250025260A1
公开(公告)日：2025-01-23
申请号：US18707092
申请日：2022-11-03
Applicant: ENDOMAGNETICS LTD.
Inventor： Robinson Udale , Gabriel Villar
Abstract: There is provided an implantable marker for use in surgical guidance. The implantable marker comprises one or more ferromagnetic elements formed of at least one ferromagnetic material and at least one diamagnetic element formed of at least one diamagnetic material. The at least one diamagnetic material comprises graphite having a substantially isotropic grain structure and the one or more ferromagnetic elements are juxtaposed the at least one diamagnetic element.
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