公开(公告)号：US09855400B2

公开(公告)日：2018-01-02

申请号：US12477695

申请日：2009-06-03

Applicant: Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White

Inventor： Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White

IPC: A61M29/00 ,  A61M25/00 ,  A61L29/08 ,  A61M25/10

CPC classification number: A61M25/0045 ,  A61L29/085 ,  A61M25/0009 ,  A61M25/104 ,  C08L77/12 ,  C08L75/04 ,  C08L79/08

Abstract: A catheter having an multilayered shaft section with a first layer formed of a polyimide first material and a second layer formed of a second material. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. However, in alternative embodiments, a thermoplastic polyimide is used. The thermoset polyimide has a very high glass transition temperature (Tg) of approximately 400° C. (as measured by differential scanning calorimetry), and excellent dimensional stability at the processing temperature of polyamides commonly used in catheter components. As a result, during formation and assembly of the catheter, production of a thin polyimide layer with controlled dimensions is facilitated. The polyimide has a high modulus and provides a thin walled yet highly pushable shaft section, while the second layer provides kink resistance. In one embodiment, the second material is selected from the group consisting of a polyamide material and a polyurethane material.

公开(公告)号：US08221444B2

公开(公告)日：2012-07-17

申请号：US12271726

申请日：2008-11-14

Applicant: Edwin Wang ,  Roseminda J. White ,  Jeong S. Lee ,  Tim Kitchen

Inventor： Edwin Wang ,  Roseminda J. White ,  Jeong S. Lee ,  Tim Kitchen

IPC: A61M29/00

CPC classification number: A61M25/0069 ,  A61M25/001 ,  A61M25/10 ,  A61M2025/1093

Abstract: An elongated balloon catheter having a distal tip member on the distal end of the catheter and having a sleeve surrounding and secured at least to the proximal end of the distal tip member.

Abstract translation: 一种细长的气囊导管，其具有在导管的远端上的远侧末端构件，并且具有围绕并固定至远侧末端构件的近端的套筒。

公开(公告)号：US07175607B2

公开(公告)日：2007-02-13

申请号：US10382965

申请日：2003-03-06

Applicant: Florencia Lim ,  Edwin Wang

Inventor： Florencia Lim ,  Edwin Wang

IPC: A61M29/00

CPC classification number: A61M25/1029 ,  A61M25/1034 ,  A61M2025/1075

Abstract: A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by providing a tubular member to serve as a non porous liner for cooperation with a polymeric tube, and enlarging radially a central or working section of the tubular member such that a first end of the tubular member is smaller in the radial direction with respect to the working section. The tubular member may also have a thickness at the working section that is less than a thickness of the first and second end portions. The first end section of the tubular member is bonded to a catheter shaft having a first outer diameter to form at least a portion of a skirt section of the balloon, and the second end section is bonded to the catheter shaft having a second outer diameter to form a portion of a skirt section, where the skirt sections have an improved high rupture pressure.

公开(公告)号：US07172575B2

公开(公告)日：2007-02-06

申请号：US10382330

申请日：2003-03-05

Applicant: Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

Inventor： Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

IPC: A61M29/00 ,  A61M31/00 ,  B32B3/26 ,  B32B3/06 ,  B32B9/00

CPC classification number: A61M25/104 ,  A61F2/958 ,  A61M2025/1075 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249972 ,  Y10T428/249987 ,  Y10T428/3154

Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.

公开(公告)号：US20060136032A1

公开(公告)日：2006-06-22

申请号：US11015716

申请日：2004-12-16

Applicant: Nora Legarda ,  Edwin Wang ,  Avegel Hernando

Inventor： Nora Legarda ,  Edwin Wang ,  Avegel Hernando

IPC: A61F2/06

CPC classification number: A61M25/1006 ,  A61F2/958 ,  A61M2025/1075

Abstract: formed of at least two sublayers of the porous polymeric material which have a different porosity. Additionally, in one embodiment, the sublayers of porous polymeric material have other characteristics which vary, such as tensile strength and orientation. As a result, the balloon of the invention has an improved combination of characteristics such as a low profile with a desired compliance and rupture pressure.

Abstract translation: 由具有不同孔隙率的多孔聚合物材料的至少两个子层形成。 此外，在一个实施方案中，多孔聚合物材料的亚层具有变化的其它特性，例如拉伸强度和取向。 结果，本发明的球囊具有改进的特性组合，例如具有所需顺应性和破裂压力的低轮廓。

公开(公告)号：US06979342B2

公开(公告)日：2005-12-27

申请号：US09957593

申请日：2001-09-19

Applicant: Jeong S. Lee ,  Edwin Wang

Inventor： Jeong S. Lee ,  Edwin Wang

IPC: A61F2/958 ,  A61M25/00 ,  A61M29/00

CPC classification number: A61M25/10 ,  A61L29/085 ,  A61L2420/08 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0069 ,  A61M2025/1093 ,  C08L79/08 ,  C08L77/00 ,  C08L77/12 ,  C08L75/04

Abstract: A catheter having an elongated shaft which has a multilayered distal tip with a first layer formed of a polyimide first material and a second layer formed of a polymeric second material. In one embodiment the multilayered distal tip is a separate member, distal to the distal end of a proximal portion of the shaft. In another embodiment, the shaft has an outer tubular member, and a multilayered inner tubular member with a distal end which forms the multilayered distal tip of the shaft. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. In one embodiment, the polymeric second material is a polyamide material.

Abstract translation: 一种具有细长轴的导管，该细长轴具有由聚酰亚胺第一材料形成的第一层和由聚合物第二材料形成的第二层的多层远端。 在一个实施例中，多层远侧末端是远离轴的近端部分的远端的分离的构件。 在另一个实施例中，轴具有外部管状构件和多层内部管状构件，其具有形成轴的多层远侧末端的远端。 在目前优选的实施方案中，聚酰亚胺材料是热固性聚酰亚胺。 在一个实施方案中，聚合物第二材料是聚酰胺材料。

公开(公告)号：US06939321B2

公开(公告)日：2005-09-06

申请号：US10255487

申请日：2002-09-26

Applicant: Edwin Wang ,  Florencia Lim ,  Huong Chung ,  Chi Le Long ,  Nadine Ding

Inventor： Edwin Wang ,  Florencia Lim ,  Huong Chung ,  Chi Le Long ,  Nadine Ding

IPC: A61F2/958 ,  A61M25/00 ,  A61M31/00 ,  A61F2/06 ,  A61M29/00 ,  A61M37/00

CPC classification number: A61M25/1034 ,  A61M25/10 ,  A61M25/1006 ,  A61M2025/1075 ,  Y10T428/1334

Abstract: A balloon catheter and a method of making the balloon catheter, having a balloon which is bonded to an elongated shaft, and which has a first layer and a second layer and an improved strong bond between the balloon and the shaft. One aspect of the invention is directed to a balloon in which the balloon first layer has at least a section with a gas plasma-etched or chemical solution-etched surface for improved bondability. Another aspect of the invention is directed to a balloon in which the balloon first layer has a proximal end section bonded to an outer surface of the shaft and the balloon second layer has a proximal end section bonded to an inner surface of the shaft, and, in one embodiment, at least a section of the balloon first layer has a gas plasma-etched or chemical solution-etched surface.

Abstract translation: 气囊导管和制造气囊导管的方法，具有结合到细长轴的气球，并且具有第一层和第二层以及在球囊和轴之间改善的强结合。 本发明的一个方面涉及一种球囊，其中球囊第一层具有至少一个具有气体等离子体蚀刻或化学溶液蚀刻表面的部分，以提高粘合性。 本发明的另一方面涉及一种球囊，其中球囊第一层具有接合到轴的外表面的近端部分，球囊第二层具有接合到轴的内表面的近端部分， 在一个实施例中，气囊第一层的至少一部分具有气体等离子体蚀刻或化学溶液蚀刻表面。

公开(公告)号：US06911017B2

公开(公告)日：2005-06-28

申请号：US09957354

申请日：2001-09-19

Applicant: Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White ,  Jose A. Romero

Inventor： Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White ,  Jose A. Romero

IPC: A61B19/00 ,  A61F2/958 ,  A61L29/10 ,  A61L29/12 ,  A61L29/18 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61F2/95 ,  A61B2090/3954 ,  A61L29/106 ,  A61L29/126 ,  A61L29/18 ,  A61M25/10 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1079

Abstract: Medical devices or components thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, which are formed at least in part of a polymeric material and a ferromagnetic or paramagnetic material, so that the medical device or component thereof is visible on magnetic resonance imaging (MRI) scans. In one embodiment, the medical device is a balloon catheter having an MRI visible balloon. In a presently preferred embodiment, there is an insufficient amount of the ferromagnetic or paramagnetic material within a wall of the balloon or coated onto a wall of the balloon to make the balloon radiopaque.

Abstract translation: 医疗器械或其组件，特别是用于治疗或诊断用途的体内器件，其至少部分地由聚合物材料和铁磁性或顺磁性材料形成，使得医疗器械或其组件在磁共振成像（MRI） ）扫描。 在一个实施例中，医疗装置是具有MRI可见气囊的气囊导管。 在目前优选的实施方案中，在球囊的壁内存在不足量的铁磁性或顺磁性材料，或涂覆在气球的壁上，以使气球不透射线。

公开(公告)号：US5061276A

公开(公告)日：1991-10-29

申请号：US286440

申请日：1988-12-19

Applicant: Roger Tu ,  Edwin Wang

Inventor： Roger Tu ,  Edwin Wang

IPC: A61F2/00 ,  A61F2/06 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  B29C55/00

CPC classification number: A61L27/507 ,  A61F2/06 ,  A61L27/16 ,  A61L27/26 ,  B29C55/005 ,  A61F2/0077 ,  A61F2250/0023 ,  B29K2027/18 ,  B29K2105/04

Abstract: A vascular graft having a composite structure prepared by wrapping about the external surface of a tube having one or more layers of polytetrafluoroethylene or a polytetrafluoroethylene-elastomeric polymer blend, either alone or in combination, an elastic fiber, while maintaining the fiber under tension. The elastic fibers can be wound about the entire length of the tube while being maintained under the same of different degrees of tension. Furthermore, the elastic fibers may be wound about the tube under a higher degree of tension along locations adjacent the opposite ends the tubing.

Abstract translation: 具有复合结构的血管移植物，其通过围绕具有一层或多层聚四氟乙烯或聚四氟乙烯 - 弹性体聚合物共混物的管的外表面单独或组合缠绕弹性纤维而制备，同时保持纤维处于张力下。 弹性纤维可以围绕管的整个长度缠绕，同时保持在不同程度的张力下。 此外，弹性纤维可以在更靠近相邻端部的管道的位置处以更高的张力缠绕在管上。

公开(公告)号：US20140011701A1

公开(公告)日：2014-01-09

申请号：US14004507

申请日：2012-02-16

Applicant: Edwin Wang ,  Jie Li ,  Maureen O'Connor-McCourt

Inventor： Edwin Wang ,  Jie Li ,  Maureen O'Connor-McCourt

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2800/52 ,  G01N2800/60

Abstract: Prostate cancer marker sets consisting of particular genes differentially expressed in prostate tumours provide improved accuracy of prostate cancer prognosis. The prostate cancer marker sets of the present invention, one of which consists of 30 genes related to apoptosis, one of which consists of 22 genes related to cell cycle and one of which consists of 30 genes related to response to external stimulus, may be used in a clinical setting to provide information about the likelihood of a prostate cancer patient to survive without treatment (i.e. whether the prostate tumour is “good” or “bad”).

Abstract translation: 由前列腺肿瘤差异表达的特定基因组成的前列腺癌标志物组提供前列腺癌预后的准确性。 本发明的前列腺癌标志物组，其中之一由与细胞凋亡相关的30个基因组成，其中之一由22个与细胞周期相关的基因组成，其中一个由与外部刺激反应有关的30个基因组成 在临床环境中提供关于前列腺癌患者在没有治疗的情况下生存的可能性的信息（即前列腺肿瘤是否“良好”或“坏”）。