公开(公告)号：US20080319198A2

公开(公告)日：2008-12-25

申请号：US12029501

申请日：2008-02-12

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: C07D405/02 ,  C07D311/00

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 4，R 41至R 46，A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常 。

公开(公告)号：US07351821B2

公开(公告)日：2008-04-01

申请号：US11640417

申请日：2006-12-18

Applicant: Annika Björe ,  Magnus Björsne ,  David Cladingboel ,  Kurt-Jürgen Hoffmann ,  John Pavey ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Colin Thomson ,  Michael Wilsterman

Inventor： Annika Björe ,  Magnus Björsne ,  David Cladingboel ,  Kurt-Jürgen Hoffmann ,  John Pavey ,  Fritiof Pontén ,  Gert Strandlund ,  Peder Svensson ,  Colin Thomson ,  Michael Wilsterman

IPC: C07D265/36 ,  C07D498/02

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 3，R 4，R 4，R 4， A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常 。

公开(公告)号：US20070259864A1

公开(公告)日：2007-11-08

申请号：US11570439

申请日：2005-06-13

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: A61K31/5375 ,  A61P9/00 ,  C07D498/08

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 4，R 41与R A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

公开(公告)号：US20070048215A1

公开(公告)日：2007-03-01

申请号：US10575523

申请日：2004-10-18

Applicant: Brian Springthorpe ,  Gert Strandlund

Inventor： Brian Springthorpe ,  Gert Strandlund

IPC: A61K51/00 ,  C07D471/04 ,  A61K31/4745

CPC classification number: C07D471/08

Abstract: The present invention relates to a labelled ligand compound that is useful in a method of identifying, testing and/or screening of compounds modulating ion channels, in particular myocardial I?Kr# 191 channels such as those encoded by ERG, including hERG. The ligand compound is therefore of use to evaluate the affinity of preclinical compounds at the ERG potassium channel. The or salts, hydrates or solvates thereof and comprising at least one radiolabel: Formula (I).

Abstract translation: 本发明涉及标记的配体化合物，其可用于鉴定，测试和/或筛选调节离子通道的化合物，特别是心肌IκKr＃191通道（例如由ERG编码的那些，包括hERG）的化合物。 因此，配体化合物可用于评估临床前化合物在ERG钾通道的亲和力。 其盐或其盐，水合物或溶剂合物并且包含至少一种放射性标记：式（I）。

公开(公告)号：US20060166979A1

公开(公告)日：2006-07-27

申请号：US11385833

申请日：2006-03-22

Applicant: Annika Bjore ,  Magnus Bjorsne ,  Kurt-Jurgen Hoffmann ,  Fritiof Ponten ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilsterman

Inventor： Annika Bjore ,  Magnus Bjorsne ,  Kurt-Jurgen Hoffmann ,  Fritiof Ponten ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilsterman

IPC: A61K31/538 ,  C07D491/04

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 3，R 4，R 4，R 4， A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常 。

公开(公告)号：US07928225B2

公开(公告)日：2011-04-19

申请号：US11917195

申请日：2006-06-12

Applicant: Annika Björe ,  David Cladingboel ,  Gareth Ensor ,  Adam Herring ,  Johan Kajanus ,  Robert Lundqvist ,  Christina Olsson ,  Carl-Gustav Sigfridsson ,  Gert Strandlund

Inventor： Annika Björe ,  David Cladingboel ,  Gareth Ensor ,  Adam Herring ,  Johan Kajanus ,  Robert Lundqvist ,  Christina Olsson ,  Carl-Gustav Sigfridsson ,  Gert Strandlund

IPC: C07D265/36 ,  C07D498/02 ,  A61K31/535

CPC classification number: C07D498/08 ,  C07C255/54 ,  C07C309/73

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 3，R 41至R 46，X，Y和Z具有描述中给出的含义，哪些化合物可用于预防和治疗心律失常，特别是心房和心室 心律失常

公开(公告)号：US20100298392A1

公开(公告)日：2010-11-25

申请号：US12373065

申请日：2007-07-12

Applicant: Annika Bjore ,  Jonas Bostrom ,  Ojvind Davidsson ,  Hans Emtenas ,  Ulrik Gran ,  Tommy Iliefski ,  Johan Kajanus ,  Roine Olsson ,  Lars Sandberg ,  Gert Strandlund ,  Johan Sundell ,  Zhong-Qing Yuan

Inventor： Annika Bjore ,  Jonas Bostrom ,  Ojvind Davidsson ,  Hans Emtenas ,  Ulrik Gran ,  Tommy Iliefski ,  Johan Kajanus ,  Roine Olsson ,  Lars Sandberg ,  Gert Strandlund ,  Johan Sundell ,  Zhong-Qing Yuan

IPC: A61K31/4035 ,  C07D413/12 ,  C07D209/46 ,  C07D405/12 ,  A61K31/422 ,  A61P9/06

CPC classification number: C07D209/46 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1至R 7具有在描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

公开(公告)号：US07772229B2

公开(公告)日：2010-08-10

申请号：US11385833

申请日：2006-03-22

Applicant: Annika Björe ,  Magnus Björsne ,  Kurt-Jürgen Hoffmann ,  Fritiof Pontėn ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilsterman

Inventor： Annika Björe ,  Magnus Björsne ,  Kurt-Jürgen Hoffmann ,  Fritiof Pontėn ,  Gert Strandlund ,  Peder Svensson ,  Michael Wilsterman

IPC: A61K31/535 ,  C07D265/36

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 3，R 4，R 41至R 46，A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和 室性心律失常。

公开(公告)号：US20090054422A1

公开(公告)日：2009-02-26

申请号：US11917195

申请日：2006-06-12

Applicant: Annika Bjore ,  David Cladingboel ,  Gareth Ensor ,  Adam Herring ,  Johan Kajanus ,  Robert Lundqvist ,  Christina Olsson ,  Carl-Gustav Sigfridsson ,  Gert Strandlund

Inventor： Annika Bjore ,  David Cladingboel ,  Gareth Ensor ,  Adam Herring ,  Johan Kajanus ,  Robert Lundqvist ,  Christina Olsson ,  Carl-Gustav Sigfridsson ,  Gert Strandlund

IPC: A61K31/5386 ,  C07D498/08 ,  C07C43/29 ,  C07C309/68 ,  C07D317/12

CPC classification number: C07D498/08 ,  C07C255/54 ,  C07C309/73

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Abstract translation: 提供式I化合物，其中R 1，R 2，R 3，R 41至R 46，X，Y和Z具有描述中给出的含义，哪些化合物可用于预防和治疗心律失常，特别是心房和心室 心律失常

公开(公告)号：US20080146812A1

公开(公告)日：2008-06-19

申请号：US12029501

申请日：2008-02-12

Applicant: Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

Inventor： Annika Bjore ,  Ulrik Gran ,  Gert Strandlund

IPC: C07D405/02 ,  C07D311/00

CPC classification number: C07D498/08

Abstract: There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.