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11.发明申请MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 有权生产O-乙酰羟基苯甲酸的微生物和使用微生物生产O-乙酰羟基苯甲酸的方法公开(公告)号：US20110053252A1
公开(公告)日：2011-03-03
申请号：US12550099
申请日：2009-08-28
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
IPC: C12N1/21
CPC classification number: C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
Abstract: Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
Abstract translation: 本文公开了能够以高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株和使用其的O-乙酰高丝氨酸的生产方法。 微生物菌株是大肠杆菌属的菌株。 其中引入并表达了编码可由CoA反馈抑制难治的泛酸激酶基因的乙酰辅酶A合成酶基因（acs）和/或泛酸激酶基因（coA）。
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12.发明申请MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM 有权生产L-甲磺酸前体的微生物和使用微生物生产L-甲磺酸前体的方法公开(公告)号：US20090253187A1
公开(公告)日：2009-10-08
申请号：US12062927
申请日：2008-04-04
Applicant: Young Uk SHIN , So Young KIM , Jin Sook CHANG , Young Wook CHO , Han Jin LEE , In Kyung HEO , Kwang Ho NA , Chang Il SEO , Chul Ha KIM , Hye Won UM
Inventor： Young Uk SHIN , So Young KIM , Jin Sook CHANG , Young Wook CHO , Han Jin LEE , In Kyung HEO , Kwang Ho NA , Chang Il SEO , Chul Ha KIM , Hye Won UM
CPC classification number: C12P13/06 , C12N9/1029
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism,
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物，O-琥珀酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法，
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公开(公告)号：US09297030B2
公开(公告)日：2016-03-29
申请号：US13979673
申请日：2012-01-16
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Chang Il Seo , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Jee Yeon Bae
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Chang Il Seo , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Jee Yeon Bae
IPC: C12P17/12 , C07D213/80
CPC classification number: C12P17/12 , C07D213/80
Abstract: A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
Abstract translation: 一种制备烟酸的方法，其包括通过温育具有生产喹啉酸的能力的微生物获得含有喹啉酸的培养液的步骤，以及向培养液中加入酸和进行脱羧反应的步骤。
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公开(公告)号：US20140315263A1
公开(公告)日：2014-10-23
申请号：US13979673
申请日：2012-01-16
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Chang II Seo , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Jee Yeon Bae
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Chang II Seo , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Jee Yeon Bae
IPC: C12P17/12
CPC classification number: C12P17/12 , C07D213/80
Abstract: A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
Abstract translation: 一种制备烟酸的方法，其包括通过温育具有生产喹啉酸的能力的微生物获得含有喹啉酸的培养液的步骤，以及向培养液中加入酸和进行脱羧反应的步骤。
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15.发明申请Method For Increasing The Solubility Of Methionine By Mineral Addition And Acid Treatment 审中-公开通过矿物添加和酸处理提高甲硫氨酸的溶解度的方法公开(公告)号：US20120136058A1
公开(公告)日：2012-05-31
申请号：US13203539
申请日：2010-02-26
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang II Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , II Chul Kim
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang II Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , II Chul Kim
IPC: A61K31/198 , A61P3/02
CPC classification number: C12P13/12 , A23L33/175 , A23V2002/00 , A61K9/08 , A61K31/20 , A61K47/02 , C07C319/26 , C07C323/52
Abstract: The present invention relates to a method for enhancing the solubility of methionine. More particularly, the present invention relates to a method for increasing the solubility of methionine, in which mineral and sulfuric acid are added at an appropriate ratio to enhance the methionine solubility, thereby overcoming the problem of low solubility of methionine in water.
Abstract translation: 本发明涉及提高甲硫氨酸溶解度的方法。 更具体地说，本发明涉及增加甲硫氨酸的溶解度的方法，其中以适当的比例加入矿物和硫酸以提高甲硫氨酸的溶解度，从而克服了蛋氨酸在水中溶解度低的问题。
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Patent Agency Ranking
16.发明申请Method for Increasing Methionine Productivity Using a Mixture of Methyl Mercaptan and Dimethyl Sulfide 有权使用甲硫醇和二甲基硫醚混合物提高甲硫氨酸生产力的方法公开(公告)号：US20120123158A1
公开(公告)日：2012-05-17
申请号：US13203521
申请日：2010-02-26
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang Il Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , Il Chul Kim
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang Il Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , Il Chul Kim
IPC: C12P13/12 , C07C323/58
CPC classification number: C12P13/12
Abstract: The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.
Abstract translation: 本发明涉及提高L-甲硫氨酸生产率和有机酸生产率的方法。 更具体地，本发明涉及一种方法，其包括以适当的比例向O-乙酰高丝氨酸或O-琥珀酰高丝氨酸加入含有甲硫醇和二甲硫醚的混合物和具有将甲硫氨酸前体转化为L-甲硫氨酸的活性的酶 进行酶反应，从而提高L-甲硫氨酸前体的L-甲硫氨酸和有机酸的转化率，从而与常规方法相比增加L-甲硫氨酸的产率。
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17.发明申请MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 有权生产O-乙酰羟基苯甲酸的微生物和使用微生物生产O-乙酰羟基苯甲酸的方法公开(公告)号：US20110053253A1
公开(公告)日：2011-03-03
申请号：US12550121
申请日：2009-08-28
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
IPC: C12N1/21
CPC classification number: C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
Abstract: Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.
Abstract translation: 公开了一种能够以高产率生产O-乙酰高丝氨酸的大肠杆菌菌株，其中引入和增强了高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶的活性; 和选自由磷酸烯醇丙酮酸羧化酶，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组中的至少一种酶。 此外，提供了使用该菌株生产O-乙酰高丝氨酸的方法。
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18.发明授权Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism 有权生产L-甲硫氨酸前体的微生物和使用该微生物生产L-甲硫氨酸前体的方法公开(公告)号：US07851180B2
公开(公告)日：2010-12-14
申请号：US12062927
申请日：2008-04-04
Applicant: Young Uk Shin , So Young Kim , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Kwang Ho Na , Chang Il Seo , Chul Ha Kim , Hye Won Um
Inventor： Young Uk Shin , So Young Kim , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Kwang Ho Na , Chang Il Seo , Chul Ha Kim , Hye Won Um
CPC classification number: C12P13/06 , C12N9/1029
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism,
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物，O-琥珀酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法，
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19.发明授权Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 有权生产O-乙酰高丝氨酸的微生物和使用该微生物生产O-乙酰高丝氨酸的方法公开(公告)号：US08609396B2
公开(公告)日：2013-12-17
申请号：US12550099
申请日：2009-08-28
Applicant: So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
Inventor： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
CPC classification number: C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
Abstract: Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coaA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
Abstract translation: 本文公开了能够以高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株和使用其的O-乙酰高丝氨酸的生产方法。 微生物菌株是大肠杆菌属的菌株。 其中引入并表达了编码由CoA反馈抑制难治的泛酸激酶基因的乙酰辅酶A合酶基因（acs）和/或泛酸激酶基因（coaA）。
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20.发明申请MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM 有权生产L-甲磺酸前体的微生物和使用微生物生产L-甲磺酸前体的方法公开(公告)号：US20110207184A1
公开(公告)日：2011-08-25
申请号：US12983788
申请日：2011-01-03
Applicant: Chul Ha Kim , So Young Kim , Young Uk Shin , Hye Won Um , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Chang II Seo , Kwang Ho Na
Inventor： Chul Ha Kim , So Young Kim , Young Uk Shin , Hye Won Um , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Chang II Seo , Kwang Ho Na
IPC: C12P13/12
CPC classification number: C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12P13/06 , C12P13/12 , C12R1/19
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物O-乙酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法。
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