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1.发明授权Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 有权生产O-乙酰高丝氨酸的微生物和使用该微生物生产O-乙酰高丝氨酸的方法公开(公告)号：US08609396B2
公开(公告)日：2013-12-17
申请号：US12550099
申请日：2009-08-28
申请人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
发明人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coaA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
摘要翻译： 本文公开了能够以高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株和使用其的O-乙酰高丝氨酸的生产方法。 微生物菌株是大肠杆菌属的菌株。 其中引入并表达了编码由CoA反馈抑制难治的泛酸激酶基因的乙酰辅酶A合酶基因（acs）和/或泛酸激酶基因（coaA）。
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2.发明申请L-Methionine Producting Microorganism And Method Of Producing L-Methionine Using The Microorganism 有权L-甲硫氨酸生产微生物和使用微生物生产L-甲硫氨酸的方法公开(公告)号：US20080194030A1
公开(公告)日：2008-08-14
申请号：US11631024
申请日：2005-06-16
申请人： Young Hoon Park , Kwang Myung Cho , Yong-Uk Shin
发明人： Young Hoon Park , Kwang Myung Cho , Yong-Uk Shin
CPC分类号： C12P13/12 , C12N9/0044 , C12N9/1014 , C12N9/88
摘要： Disclosed herein are a method of preparing an L-methionine production strain by overexpressing proteins involved in L-methionine biosynthesis in an L-threonine production strain, a strain prepared by the method, and a method of producing L-methionine using the strain.
摘要翻译： 本文公开了通过在L-苏氨酸生产菌株中过表达涉及L-甲硫氨酸生物合成的蛋白质的方法和通过该方法制备的菌株以及使用该菌株生产L-甲硫氨酸的方法来制备L-甲硫氨酸生产菌株的方法。
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3.发明授权Modified polypeptide having homoserine acetyltransferase activity and microorganism expressing the same 有权具有高丝氨酸乙酰转移酶活性的修饰多肽和表达其的微生物公开(公告)号：US09127257B2
公开(公告)日：2015-09-08
申请号：US13996990
申请日：2011-12-21
申请人： So Young Kim , Yong Uk Shin , Chang Il Seo , In Kyung Heo , Ju Eun Kim , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Sung Kwang Son
发明人： So Young Kim , Yong Uk Shin , Chang Il Seo , In Kyung Heo , Ju Eun Kim , Hyun Ah Kim , Han Jin Lee , Kwang Ho Na , Sung Kwang Son
CPC分类号： C12N9/1029 , C12N1/00 , C12N15/70 , C12N15/74 , C12P13/06 , C12Y203/01031
摘要： The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.
摘要翻译： 本发明涉及被修饰为具有高丝氨酸O-乙酰转移酶活性的多肽，特别是本发明提供具有高丝氨酸O-乙酰转移酶活性的修饰多肽，其中具有高丝氨酸琥珀酰转移酶的多肽的111位氨基酸 活性被其他氨基酸取代。
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4.发明授权Method for increasing methionine productivity using a mixture of methyl mercaptan and dimethyl sulfide 有权使用甲硫醇和二甲硫醚的混合物提高甲硫氨酸生产率的方法公开(公告)号：US09024063B2
公开(公告)日：2015-05-05
申请号：US13203521
申请日：2010-02-26
申请人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang Il Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , Il Chul Kim
发明人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Ju Eun Kim , Chang Il Seo , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na , Il Chul Kim
IPC分类号： C12P13/12 , C07C323/58
CPC分类号： C12P13/12
摘要： The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.
摘要翻译： 本发明涉及提高L-甲硫氨酸生产率和有机酸生产率的方法。 更具体地，本发明涉及一种方法，其包括以适当的比例向O-乙酰高丝氨酸或O-琥珀酰高丝氨酸加入含有甲硫醇和二甲硫醚的混合物和具有将甲硫氨酸前体转化为L-甲硫氨酸的活性的酶 进行酶反应，从而提高L-甲硫氨酸前体的L-甲硫氨酸和有机酸的转化率，从而与常规方法相比增加L-甲硫氨酸的产率。
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5.发明授权Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism 有权生产O-乙酰高丝氨酸的微生物和使用该微生物生产O-乙酰高丝氨酸的方法公开(公告)号：US08283152B2
公开(公告)日：2012-10-09
申请号：US12550121
申请日：2009-08-28
申请人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
发明人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
CPC分类号： C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
摘要： Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.
摘要翻译： 公开了一种能够以高产率生产O-乙酰高丝氨酸的大肠杆菌菌株，其中引入和增强了高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶的活性; 和选自由磷酸烯醇丙酮酸羧化酶，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组中的至少一种酶。 此外，提供了使用该菌株生产O-乙酰高丝氨酸的方法。
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6.发明申请MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 有权生产O-乙酰羟基苯甲酸的微生物和使用微生物生产O-乙酰羟基苯甲酸的方法公开(公告)号：US20110053252A1
公开(公告)日：2011-03-03
申请号：US12550099
申请日：2009-08-28
申请人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
发明人： So Young Kim , Yong Uk Shin , In Kyung Heo , Hyun Ah Kim , Chang Il Seo , Ju Eun Kim , Sung Kwang Son , Sang Mok Lee , Sung Hoo Jhon , Han Jin Lee , Kwang Ho Na
IPC分类号： C12N1/21
CPC分类号： C12N9/1205 , C12N9/93 , C12P13/06 , C12Y207/01033 , C12Y602/01001
摘要： Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.
摘要翻译： 本文公开了能够以高产率生产L-甲硫氨酸前体O-乙酰高丝氨酸的微生物菌株和使用其的O-乙酰高丝氨酸的生产方法。 微生物菌株是大肠杆菌属的菌株。 其中引入并表达了编码可由CoA反馈抑制难治的泛酸激酶基因的乙酰辅酶A合成酶基因（acs）和/或泛酸激酶基因（coA）。
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7.发明申请POLYPEPTIDE BEING CAPABLE OF INCREASING THE PRODUCTION OF L-METHIONINE, A MICROORGANISM THAT OVEREXPRESSES SAID POLYPEPTIDE AND A PROCESS OF PREPARING L-METHIONINE IN HIGH YIELD USING SAME 审中-公开可以增加L-甲硫氨酸的生产的多肽，超过表达多肽的微生物和使用它们在高产量中制备L-甲硫氨酸的方法公开(公告)号：US20100062498A1
公开(公告)日：2010-03-11
申请号：US12521541
申请日：2007-12-28
申请人： Young Hoon Park , Kwang Myung Cho , So Young Kim , Yong Uk Shin , Hye Won Um
发明人： Young Hoon Park , Kwang Myung Cho , So Young Kim , Yong Uk Shin , Hye Won Um
CPC分类号： C12P13/12 , C07K14/245
摘要： The present invention relates to a polypeptide capable of increasing the production of L-methionine in a microorganism. In particular, the present invention relates to an YgaZ and YgaH polypeptide or a complex thereof, referred to herein as YgaZH polypeptide, which are novel putative L-methionine exporters, polynucleotides encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing L-methionine and/or S-adenosyl-methionine, comprising the steps of culturing the transformed microorganism to produce L-methionine and/or S-adenosyl-methionine, and isolating L-methionine and/or S-adenosyl-methionine. The transformed microorganism of the present invention produces L-methionine in a high yield, thereby being used for medicinal and pharmaceutical industries and feed industry, in particular, animal feeds
摘要翻译： 本发明涉及能够增加微生物中L-甲硫氨酸生产的多肽。 特别地，本发明涉及本文称为YgaZH多肽的YgaZ和YgaH多肽或其复合物，其为新型推定的L-甲硫氨酸出口商，其编码该多核苷酸的多核苷酸，包含该多核苷酸的重组载体， 重组载体和L-甲硫氨酸和/或S-腺苷 - 甲硫氨酸的制备方法，包括培养转化的微生物以产生L-甲硫氨酸和/或S-腺苷 - 甲硫氨酸并分离L-甲硫氨酸和/ 或S-腺苷 - 甲硫氨酸。 本发明的转化微生物以高产率生产L-甲硫氨酸，从而用于药用和制药工业和饲料工业，特别是动物饲料
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公开(公告)号：US20090325243A1
公开(公告)日：2009-12-31
申请号：US12308810
申请日：2007-06-26
申请人： Young Hoon Park , Kwang Myung Cho , Yong Uk Shin , Hyun Ae Bae , Jin Sook Chang , Jae Yeong Ju
发明人： Young Hoon Park , Kwang Myung Cho , Yong Uk Shin , Hyun Ae Bae , Jin Sook Chang , Jae Yeong Ju
CPC分类号： C12P13/08 , C07K14/245 , C12N1/32 , C12P13/04 , C12P13/12
摘要： The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel production, glycerol, thereby substituting a cheaper material for the conventional fermentation materials such as glucose.
摘要翻译： 本发明涉及能够同时利用甘油作为碳源的氨基酸生产微生物，微生物的制备方法和使用该微生物的氨基酸的制造方法。 根据本发明，可以使用生物柴油生产的副产物甘油有效地生产氨基酸，从而用较便宜的原料代替常规发酵材料如葡萄糖。
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9.发明授权Microorganism producing L-threonine having inactivated tyrR gene, method of producing the same and method of producing L-threonine using the microorganism 有权生产具有灭活tyrR基因的L-苏氨酸的微生物，其生产方法和使用该微生物产生L-苏氨酸的方法公开(公告)号：US07256018B2
公开(公告)日：2007-08-14
申请号：US11049844
申请日：2005-02-04
CPC分类号： C12P13/08
摘要： Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield.
摘要翻译： 提供能够产生L-苏氨酸并具有失活的tyrR基因的微生物，其制备方法和使用该微生物生产L-苏氨酸的方法。 该微生物可用于以高产率生产L-苏氨酸。
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10.发明授权Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism 有权生产具有失活的galR基因的L-苏氨酸的微生物，其生产方法和使用该微生物产生L-苏氨酸的方法公开(公告)号：US07229794B2
公开(公告)日：2007-06-12
申请号：US11049845
申请日：2005-02-04
申请人： Young Hoon Park , Byoung Choon Lee , Kwang Myung Cho , Dae Cheol Kim , Yong Uk Shin , Jin Ho Lee
发明人： Young Hoon Park , Byoung Choon Lee , Kwang Myung Cho , Dae Cheol Kim , Yong Uk Shin , Jin Ho Lee
CPC分类号： C12P13/08 , C07K14/245
摘要： Provided are a microorganism capable of producing L-threonine and having an inactivated galR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield.
摘要翻译： 提供能够产生L-苏氨酸并具有失活的galR基因的微生物，其生产方法和使用该微生物生产L-苏氨酸的方法。 该微生物可用于以高产率生产L-苏氨酸。
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