公开(公告)号：US09080155B2

公开(公告)日：2015-07-14

申请号：US13997054

申请日：2011-12-21

Applicant: So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  Sung Kwang Son ,  In Kyung Heo ,  Han Jin Lee ,  Ju Eun Kim ,  Hyun Ah Kim ,  Jee Yeon Bae ,  Kwang Ho Na

Inventor： So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  Sung Kwang Son ,  In Kyung Heo ,  Han Jin Lee ,  Ju Eun Kim ,  Hyun Ah Kim ,  Jee Yeon Bae ,  Kwang Ho Na

IPC: C12N9/10 ,  C12P7/54 ,  C12P13/12

CPC classification number: C12N9/1085 ,  C12P7/54 ,  C12P13/12 ,  C12Y205/01049

Abstract: The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield.

Abstract translation: 本发明涉及具有O-乙酰高丝氨酸二硫氢化酶活性的新蛋白质，其突变蛋白质，编码该多核苷酸的多核苷酸，包含多核苷酸的重组载体，用重组载体转化的微生物，以及产生甲硫氨酸或乙酸的方法 使用蛋白质。 本发明的制备方法具有通过与现有方法相比具有更高的转化率和降低的反应时间来成本有效地生产L-甲硫氨酸和乙酸的优点，并且可以使使用突变体时添加的酶匀浆的量最小化 蛋白质，从而容易以高产率生产L-甲硫氨酸和乙酸。

公开(公告)号：US09005952B2

公开(公告)日：2015-04-14

申请号：US12062835

申请日：2008-04-04

Applicant: Chul Ha Kim ,  So Young Kim ,  Young Uk Shin ,  Hye Won Um ,  Jin Sook Chang ,  Young Wook Cho ,  Han Jin Lee ,  In Kyung Heo ,  Chang Il Seo ,  Kwang Ho Na

Inventor： Chul Ha Kim ,  So Young Kim ,  Young Uk Shin ,  Hye Won Um ,  Jin Sook Chang ,  Young Wook Cho ,  Han Jin Lee ,  In Kyung Heo ,  Chang Il Seo ,  Kwang Ho Na

IPC: C12P13/12 ,  C12N1/00 ,  C12N15/00 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/12 ,  C12P13/06 ,  C12R1/19

CPC classification number: C12N1/20 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1217 ,  C12P13/06 ,  C12P13/12 ,  C12R1/19

Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.

Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物O-乙酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法。

公开(公告)号：US20130273615A1

公开(公告)日：2013-10-17

申请号：US13996990

申请日：2011-12-21

Applicant: So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  In Kyung Heo ,  Ju Eun Kim ,  Hyun Ah Kim ,  Han Jin Lee ,  Kwang Ho Na ,  Sung Kwang Son

Inventor： So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  In Kyung Heo ,  Ju Eun Kim ,  Hyun Ah Kim ,  Han Jin Lee ,  Kwang Ho Na ,  Sung Kwang Son

IPC: C12N9/10

CPC classification number: C12N9/1029 ,  C12N1/00 ,  C12N15/70 ,  C12N15/74 ,  C12P13/06 ,  C12Y203/01031

Abstract: The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.

Abstract translation: 本发明涉及被修饰为具有高丝氨酸O-乙酰转移酶活性的多肽，特别是本发明提供具有高丝氨酸O-乙酰转移酶活性的修饰多肽，其中具有高丝氨酸琥珀酰转移酶的多肽的111位氨基酸 活性被其他氨基酸取代。

公开(公告)号：US20130273614A1

公开(公告)日：2013-10-17

申请号：US13997054

申请日：2011-12-21

Applicant: So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  Sung Kwang Son ,  In Kyung Heo ,  Han Jin Lee ,  Ju Eun Kim ,  Hyun Ah Kim ,  Jee Yeon Bae ,  Kwang Ho Na

Inventor： So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  Sung Kwang Son ,  In Kyung Heo ,  Han Jin Lee ,  Ju Eun Kim ,  Hyun Ah Kim ,  Jee Yeon Bae ,  Kwang Ho Na

IPC: C12N9/10

CPC classification number: C12N9/1085 ,  C12P7/54 ,  C12P13/12 ,  C12Y205/01049

Abstract: The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield.

Abstract translation: 本发明涉及具有O-乙酰高丝氨酸二硫氢化酶活性的新蛋白质，其突变蛋白质，编码该多核苷酸的多核苷酸，包含多核苷酸的重组载体，用重组载体转化的微生物，以及产生甲硫氨酸或乙酸的方法 使用蛋白质。 本发明的制备方法具有通过与现有方法相比具有更高的转化率和降低的反应时间来成本有效地生产L-甲硫氨酸和乙酸的优点，并且可以使使用突变体时添加的酶匀浆的量最小化 蛋白质，从而容易以高产率生产L-甲硫氨酸和乙酸。

公开(公告)号：US08224332B2

公开(公告)日：2012-07-17

申请号：US12380708

申请日：2009-03-03

Applicant: Chan-Ho Min ,  Young-Hyun Jeon ,  Jong-Hyung Kwun ,  Hyun-Soo Yoon ,  Han-Jin Lee ,  Dong-Wook Kim ,  Seung-Woo Jeon ,  Sawhney Mrinalini

Inventor： Chan-Ho Min ,  Young-Hyun Jeon ,  Jong-Hyung Kwun ,  Hyun-Soo Yoon ,  Han-Jin Lee ,  Dong-Wook Kim ,  Seung-Woo Jeon ,  Sawhney Mrinalini

IPC: H04W36/00

CPC classification number: H04W84/005 ,  H04B7/15507 ,  H04W64/006 ,  H04W88/005

Abstract: A method for forming a moving network group by a mobile relay station (MRS) in a mobile multi-hop relay (MMR) system is provided. The MRS determines whether a transportation means mounted with the mobile relay station is at a predetermined location derived from travel information. When a velocity information of the transportation means at the predetermined location is zero (0), the MRS determines whether to include a mobile station (MS) to the moving network group based at least partly upon a signal that the mobile station receives from the mobile relay station.

Abstract translation: 提供了一种在移动多跳中继（MMR）系统中由移动中继站（MRS）形成移动网络组的方法。 MRS确定安装有移动中继站的传送装置是否位于从旅行信息导出的预定位置。 当预定位置处的运送装置的速度信息为零（0）时，MRS至少部分地基于移动台从移动台接收到的信号来确定是否将移动台（MS）包括在移动网络组中 中继站。

公开(公告)号：US09127257B2

公开(公告)日：2015-09-08

申请号：US13996990

申请日：2011-12-21

Applicant: So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  In Kyung Heo ,  Ju Eun Kim ,  Hyun Ah Kim ,  Han Jin Lee ,  Kwang Ho Na ,  Sung Kwang Son

Inventor： So Young Kim ,  Yong Uk Shin ,  Chang Il Seo ,  In Kyung Heo ,  Ju Eun Kim ,  Hyun Ah Kim ,  Han Jin Lee ,  Kwang Ho Na ,  Sung Kwang Son

IPC: C12N9/10 ,  C12N15/70 ,  C12N15/74 ,  C12N1/00 ,  C12P13/06

CPC classification number: C12N9/1029 ,  C12N1/00 ,  C12N15/70 ,  C12N15/74 ,  C12P13/06 ,  C12Y203/01031

Abstract: The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.

Abstract translation: 本发明涉及被修饰为具有高丝氨酸O-乙酰转移酶活性的多肽，特别是本发明提供具有高丝氨酸O-乙酰转移酶活性的修饰多肽，其中具有高丝氨酸琥珀酰转移酶的多肽的111位氨基酸 活性被其他氨基酸取代。

公开(公告)号：US09024063B2

公开(公告)日：2015-05-05

申请号：US13203521

申请日：2010-02-26

Applicant: So Young Kim ,  Yong Uk Shin ,  In Kyung Heo ,  Hyun Ah Kim ,  Ju Eun Kim ,  Chang Il Seo ,  Sung Kwang Son ,  Sang Mok Lee ,  Sung Hoo Jhon ,  Han Jin Lee ,  Kwang Ho Na ,  Il Chul Kim

Inventor： So Young Kim ,  Yong Uk Shin ,  In Kyung Heo ,  Hyun Ah Kim ,  Ju Eun Kim ,  Chang Il Seo ,  Sung Kwang Son ,  Sang Mok Lee ,  Sung Hoo Jhon ,  Han Jin Lee ,  Kwang Ho Na ,  Il Chul Kim

IPC: C12P13/12 ,  C07C323/58

CPC classification number: C12P13/12

Abstract: The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.

Abstract translation: 本发明涉及提高L-甲硫氨酸生产率和有机酸生产率的方法。 更具体地，本发明涉及一种方法，其包括以适当的比例向O-乙酰高丝氨酸或O-琥珀酰高丝氨酸加入含有甲硫醇和二甲硫醚的混合物和具有将甲硫氨酸前体转化为L-甲硫氨酸的活性的酶 进行酶反应，从而提高L-甲硫氨酸前体的L-甲硫氨酸和有机酸的转化率，从而与常规方法相比增加L-甲硫氨酸的产率。

公开(公告)号：US08465952B2

公开(公告)日：2013-06-18

申请号：US12983788

申请日：2011-01-03

Applicant: Chul Ha Kim ,  So Young Kim ,  Young Uk Shin ,  Hye Won Um ,  Jin Sook Chang ,  Young Wook Cho ,  Han Jin Lee ,  In Kyung Heo ,  Chang II Seo ,  Kwang Ho Na

Inventor： Chul Ha Kim ,  So Young Kim ,  Young Uk Shin ,  Hye Won Um ,  Jin Sook Chang ,  Young Wook Cho ,  Han Jin Lee ,  In Kyung Heo ,  Chang II Seo ,  Kwang Ho Na

IPC: C12P13/12 ,  C12N1/00 ,  C12N15/00 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12N1/20 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1217 ,  C12P13/06 ,  C12P13/12 ,  C12R1/19

Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.

公开(公告)号：US08283152B2

公开(公告)日：2012-10-09

申请号：US12550121

申请日：2009-08-28

Applicant: So Young Kim ,  Yong Uk Shin ,  In Kyung Heo ,  Hyun Ah Kim ,  Chang Il Seo ,  Ju Eun Kim ,  Sung Kwang Son ,  Sang Mok Lee ,  Sung Hoo Jhon ,  Han Jin Lee ,  Kwang Ho Na

Inventor： So Young Kim ,  Yong Uk Shin ,  In Kyung Heo ,  Hyun Ah Kim ,  Chang Il Seo ,  Ju Eun Kim ,  Sung Kwang Son ,  Sang Mok Lee ,  Sung Hoo Jhon ,  Han Jin Lee ,  Kwang Ho Na

IPC: C12N1/21 ,  C12P21/06

CPC classification number: C12N9/1217 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/88 ,  C12P13/06

Abstract: Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.

Abstract translation: 公开了一种能够以高产率生产O-乙酰高丝氨酸的大肠杆菌菌株，其中引入和增强了高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶的活性; 和选自由磷酸烯醇丙酮酸羧化酶，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组中的至少一种酶。 此外，提供了使用该菌株生产O-乙酰高丝氨酸的方法。

公开(公告)号：US08019345B2

公开(公告)日：2011-09-13

申请号：US11985514

申请日：2007-11-15

Applicant: Jong-Hyung Kwun ,  Young-Hyun Jeon ,  Hyun-Soo Yoon ,  Han-Jin Lee ,  Dong-Wook Kim

Inventor： Jong-Hyung Kwun ,  Young-Hyun Jeon ,  Hyun-Soo Yoon ,  Han-Jin Lee ,  Dong-Wook Kim

IPC: H04W88/02

CPC classification number: H04W36/0083 ,  H04W36/38

Abstract: An apparatus and method for performing a handover in a broadband wireless communication system is provided. In the broadband wireless communication system, a base station includes: a grouping unit for grouping mobile stations by using information on a movement path of each mobile station and information on a received signal strength of a neighboring base station, thereby constituting at least one group; a controller for modifying hystereses of remaining mobile stations among the mobile stations belonging to the same group, if a predetermined number of mobile stations perform handovers; and a transmitter for transmitting a message including modified hysteresis information to the remaining mobile stations belonging to the group.

Abstract translation: 提供了一种用于在宽带无线通信系统中执行切换的装置和方法。 在宽带无线通信系统中，基站包括：分组单元，用于通过使用关于每个移动站的移动路径的信息和关于相邻基站的接收信号强度的信息来分组移动站，从而构成至少一个组; 如果预定数量的移动台执行切换，则控制器用于修改属于同一组的移动站中剩余移动台的滞后; 以及发射机，用于向属于该组的剩余移动台发送包括修改的滞后信息的消息。