公开(公告)号：US20220080037A1

公开(公告)日：2022-03-17

申请号：US17537336

申请日：2021-11-29

Applicant: Hawaii Biotech, Inc.

Inventor： David E. CLEMENTS ,  Michael M. LIEBERMAN ,  Axel T. LEHRER

IPC: A61K39/12 ,  A61P31/14 ,  A61K39/295

Abstract: The data reported herein describe the production and evaluation of a recombinant subunit filovirus vaccine using insect cell expressed surface glycoprotein (GP) and a highly effective adjuvant. The vaccine provides protection in humans against filovirus infection, including Ebola virus and Marburg virus.

公开(公告)号：US09505710B2

公开(公告)日：2016-11-29

申请号：US15099438

申请日：2016-04-14

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D213/56 ,  C07D295/16 ,  C07C259/10 ,  C07D207/337 ,  C07D239/26 ,  C07D239/42 ,  C07D231/12 ,  C07D295/185 ,  C07D295/155 ,  C07D233/64 ,  C07D303/46 ,  C07D211/34

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。

公开(公告)号：US20230312656A1

公开(公告)日：2023-10-05

申请号：US18024538

申请日：2021-09-01

Applicant: Hawaii Biotech, Inc.

Inventor： David E. Clements ,  James T. Senda ,  Jaime S. Horton

IPC: C07K14/005 ,  C12N15/85 ,  A61K39/39 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/005 ,  C12N15/85 ,  A61K39/39 ,  A61K39/215 ,  A61P31/14 ,  C12N2770/20022 ,  C12N2770/20034 ,  A61K2039/55572

Abstract: The present invention is directed to the expression and secretion recombinant SARS-CoV-2 spike protein subunits. Various subunits have been designed and expressed as secreted products into the culture medium of transformed insect cell lines. The design of subunits is focused on the production of products that provide the ability to induce focused immune responses without inducing immune enhancing responses. The expressed and purified products are suitable as vaccine candidates to protect against disease caused by SARS-CoV-2.

公开(公告)号：US11046652B2

公开(公告)日：2021-06-29

申请号：US16911075

申请日：2020-06-24

Applicant: HAWAII BIOTECH, INC.

Inventor： Guan-Sheng Jiao ,  Alan T. Johnson ,  Sean O'Malley ,  Seong Jin Kim

IPC: C07D231/12

Abstract: Compounds of Formula I are provided: R1 is —OR5, m is an integer from 0 to 5, n is an integer from 0 to 2, each R2 is independently selected from hydrogen, halogen, and alkyl, R3 is selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, R5 is an alkyl, each R4 is independently hydrogen or alkyl, and each of R2, R3, R4, and R5 is independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to a botulinum toxin.

公开(公告)号：US20170036996A1

公开(公告)日：2017-02-09

申请号：US15280817

申请日：2016-09-29

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D295/16 ,  C07D207/337 ,  C07C259/10 ,  C07D303/46 ,  C07D239/42 ,  C07D231/12 ,  C07D295/205 ,  C07D295/155 ,  C07D213/56 ,  C07D239/26

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。

公开(公告)号：US20160304443A1

公开(公告)日：2016-10-20

申请号：US15099438

申请日：2016-04-14

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D295/16 ,  C07C259/10 ,  C07D207/337 ,  C07D239/26 ,  C07D211/34 ,  C07D231/12 ,  C07D295/185 ,  C07D295/155 ,  C07D233/64 ,  C07D303/46 ,  C07D213/56 ,  C07D239/42

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。