公开(公告)号：US08309586B2

公开(公告)日：2012-11-13

申请号：US13329831

申请日：2011-12-19

Applicant: Soon Ha Kim ,  Sung Bae Lee ,  Seung Hyun Yoon ,  Mi Kyoung Cho ,  Kyoung Hee Kim ,  Heui Sul Park ,  Hyoung Jin Kim

Inventor： Soon Ha Kim ,  Sung Bae Lee ,  Seung Hyun Yoon ,  Mi Kyoung Cho ,  Kyoung Hee Kim ,  Heui Sul Park ,  Hyoung Jin Kim

IPC: A61K31/427 ,  C07D417/04

CPC classification number: C07D417/14 ,  C07D417/04 ,  C07D487/04

Abstract: Disclosed are new compounds of formula (1) exhibiting excellent activity for glucokinase, pharmaceutical compositions having the same as an active ingredient, and a method of using the same as an active ingredient for lowering blood glucose level: in which the substituents are as defined herein.

Abstract translation: 公开了对葡糖激酶具有优异活性的新的式（1）化合物，与活性成分相同的药物组合物及其用作降低血糖水平的活性成分的方法：其中取代基如本文所定义 。

公开(公告)号：US20120252798A1

公开(公告)日：2012-10-04

申请号：US13493045

申请日：2012-06-11

Applicant: Soon Ha KIM ,  Hyoung Jin Kim ,  Sun Young Koo ,  Sung Bae Lee ,  Heui Sul Park ,  Seung Hyun Yoon ,  Seung Yup Paek ,  Hyo Shin Kwak ,  Dong Ook Seo ,  Eok Park

Inventor： Soon Ha KIM ,  Hyoung Jin Kim ,  Sun Young Koo ,  Sung Bae Lee ,  Heui Sul Park ,  Seung Hyun Yoon ,  Seung Yup Paek ,  Hyo Shin Kwak ,  Dong Ook Seo ,  Eok Park

IPC: A61K31/427 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61K31/4985 ,  A61P1/16 ,  A61P25/28 ,  A61P9/10 ,  A61P3/10 ,  A61P1/18 ,  A61P31/04 ,  A61P31/12 ,  A61P37/00 ,  A61P19/02 ,  A61P13/12 ,  A61P35/02 ,  A61P35/00 ,  A61P25/00 ,  A61P17/06 ,  A61P29/00 ,  A61P13/00 ,  A61P17/02 ,  A61P17/16 ,  A61P25/16 ,  A61P31/00 ,  A61P3/04 ,  A61P7/02 ,  A61P9/12 ,  A61P3/00 ,  A61P37/06 ,  A61K31/454

CPC classification number: C07D417/06 ,  A61K31/404 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/65586

Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

Abstract translation: 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。

公开(公告)号：US07027638B2

公开(公告)日：2006-04-11

申请号：US09949111

申请日：2001-09-07

Applicant: Chung-sam Jun ,  Sang-mun Chon ,  Hyoung-jin Kim ,  Dong-chun Lee ,  Sang-bong Choi ,  Sung-gon Ryu

Inventor： Chung-sam Jun ,  Sang-mun Chon ,  Hyoung-jin Kim ,  Dong-chun Lee ,  Sang-bong Choi ,  Sung-gon Ryu

IPC: G06K9/00

CPC classification number: G06T5/008 ,  G06T7/90 ,  G06T2207/20021 ,  G06T2207/30148

Abstract: A method for correcting color variations on the surface of a wafer, a method for selectively detecting a defect from different patterns, and computer readable recording media for the same are provided. Color variations in images of different parts of a wafer can be corrected using the mean and standard deviation of grey level values for the pixels forming each of the different parts of the wafer. In addition, different threshold values are applied to metal interconnect patterns and spaces of the wafer so that a defect can be selectively detected from the different patterns. Thus, a bridge known as a fatal, or killing defect to a semiconductor device can be detected without also falsely detecting grains as fatal defects. Due to increased defect screening capacity of the methods, the defect detecting method can be further efficiently managed.

公开(公告)号：US08349885B2

公开(公告)日：2013-01-08

申请号：US13534682

申请日：2012-06-27

Applicant: Soon Ha Kim ,  Hyoung Jin Kim ,  Chul Woong Chung ,  Heui Sul Park ,  Hyo Shin Kwak ,  Sung Ho Kim ,  Jin Gu Park

Inventor： Soon Ha Kim ,  Hyoung Jin Kim ,  Chul Woong Chung ,  Heui Sul Park ,  Hyo Shin Kwak ,  Sung Ho Kim ,  Jin Gu Park

IPC: A61K31/416 ,  A61K31/404 ,  C07D231/56 ,  C07D209/10

CPC classification number: C07D417/04 ,  C07D209/08 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

Abstract translation: 本发明涉及一种用于保存细胞，组织和器官的组合物，其包含作为活性成分的式（1）的吲哚和吲唑化合物或其药学上可接受的盐或异构体，其可有效预防器官损伤，分离的细胞 由冷藏，移植手术或移植后再灌注引起的系统或组织; 保存方法; 和组合物的制备方法。

公开(公告)号：US20120100169A1

公开(公告)日：2012-04-26

申请号：US13379212

申请日：2009-10-20

Applicant: Hong-Jin Kim ,  Na Gyong Lee ,  Yang-Je Cho ,  Jin-Wook Jang ,  Hyoung Jin Kim ,  Kwang Sung Kim

Inventor： Hong-Jin Kim ,  Na Gyong Lee ,  Yang-Je Cho ,  Jin-Wook Jang ,  Hyoung Jin Kim ,  Kwang Sung Kim

IPC: A61K39/12 ,  A61P35/00 ,  C12N1/19 ,  A61P37/04 ,  C12P21/02 ,  C12N15/37

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/70 ,  C12N2710/20023 ,  C12N2710/20034

Abstract: The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1 VLP of HPV type 18, or a combination thereof; and (ii) a deacylated non-toxic lipooligosaccharide (LOS); and (b) a pharmaceutically acceptable carrier; and a method for preparing a human papillomavirus (HPV) L1 virus-like particle (VLP). The pharmaceutical vaccine composition of the present invention is in both Th1-type immune response (cellular immunity) and Th2-type immune response (humoral immunity) against HPV more excellent than Cervrix™ and Gardasil™, exhibiting a superior efficacy as a vaccine for a human cervical cancer.

Abstract translation: 本发明涉及用于人宫颈癌的药物疫苗组合物，其包括：（i）（i）16型人乳头状瘤病毒（HPV）的L1病毒样颗粒（VLP），HPV 18型的L1 VLP或 其组合; 和（ii）脱酰无毒低密度寡糖（LOS）; 和（b）药学上可接受的载体; 以及制备人乳头状瘤病毒（HPV）L1病毒样颗粒（VLP）的方法。 本发明的药物疫苗组合物具有比Cervrix TM和Gardasil TM更优异的Th1型免疫应答（细胞免疫）和对HPV的Th2型免疫应答（体液免疫），表现出作为疫苗的优异功效 人宫颈癌。

公开(公告)号：US20120088760A1

公开(公告)日：2012-04-12

申请号：US13329831

申请日：2011-12-19

Applicant: Soon Ha KIM ,  Sung Bae LEE ,  Seung Hyun YOON ,  Mi Kyoung CHO ,  Kyoung Hee KIM ,  Heui Sul PARK ,  Hyoung Jin KIM

Inventor： Soon Ha KIM ,  Sung Bae LEE ,  Seung Hyun YOON ,  Mi Kyoung CHO ,  Kyoung Hee KIM ,  Heui Sul PARK ,  Hyoung Jin KIM

IPC: A61K31/541 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/497 ,  A61K31/506 ,  A61K31/4245 ,  A61P3/10 ,  A61P3/04 ,  A61P25/00 ,  A61P3/06 ,  A61P9/12 ,  A61P13/12 ,  A61P27/02 ,  A61K31/427

CPC classification number: C07D417/14 ,  C07D417/04 ,  C07D487/04

Abstract: Disclosed are new compounds of formula (1) exhibiting excellent activity for glucokinase, pharmaceutical compositions having the same as an active ingredient, and a method of using the same as an active ingredient for lowering blood glucose level: in which the substituents are as defined herein.

Abstract translation: 公开了对葡糖激酶具有优异活性的新的式（1）化合物，与活性成分相同的药物组合物及其用作降低血糖水平的活性成分的方法：其中取代基如本文所定义 。

公开(公告)号：US20090247874A1

公开(公告)日：2009-10-01

申请号：US12413024

申请日：2009-03-27

Applicant: Hyoung Jin KIM

Inventor： Hyoung Jin KIM

IPC: A61B8/14

CPC classification number: A61B8/465 ,  A61B8/00 ,  A61B8/462 ,  G06F19/00 ,  G16H40/63

Abstract: Embodiments of a user interface in an ultrasound system are disclosed. In one embodiment, the ultrasound system comprises a display unit for prompting a user to touch a desired one of hierarchically arranged soft buttons for triggering an execution of the function of the ultrasound system associated with the touched button. The display unit includes a display having a display with touch panel mounted. The display unit is configured to display a touch screen menu together with the ultrasound image on the display.

Abstract translation: 公开了超声系统中的用户界面的实施例。 在一个实施例中，超声系统包括显示单元，用于提示用户触摸所需的分层布置的软按钮，以触发执行与触摸的按钮相关联的超声系统的功能。 显示单元包括具有安装有触摸面板的显示器的显示器。 显示单元被配置为在显示器上显示与超声波图像一起的触摸屏菜单。

公开(公告)号：US07282300B2

公开(公告)日：2007-10-16

申请号：US10478802

申请日：2002-12-02

Applicant: Eun-Young Goh ,  Seung-Tae Hong ,  Hyoung-Jin Kim ,  Hyung-Keun Lee

Inventor： Eun-Young Goh ,  Seung-Tae Hong ,  Hyoung-Jin Kim ,  Hyung-Keun Lee

IPC: H01M4/58 ,  H01M4/50 ,  H01M4/88

CPC classification number: H01M4/525 ,  H01M4/131 ,  H01M4/364 ,  H01M4/505 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/4235 ,  H01M2004/028 ,  H01M2300/0037 ,  Y02E60/122

Abstract: The present invention relates to a lithium secondary battery comprising an overdischarge-preventing agent. Particularly, the present invention provides a lithium secondary battery comprising an overdischarge-preventing agent having superior effects for an overdischarge test and showing 90% or more capacity recovery after the test, by introducing lithium nickel oxide into a cathode for a lithium secondary battery comprising a lithium transition metal oxide capable of occluding and releasing lithium ions as an overdischarge-preventing agent to supply lithium ions such that irreversible capacity of an anode can be compensated or better, thereby lowering voltage of a cathode first to prevent voltage increase of an anode during the overdischarge test.

Abstract translation: 本发明涉及包含防止过放电剂的锂二次电池。 特别地，本发明提供一种锂二次电池，其具有对过放电试验具有优异效果的过放电防止剂，并且在试验后显示出90％以上的容量恢复率，将锂二氧化镍引入锂二次电池用阴极， 能够吸收和释放锂离子的锂过渡金属氧化物作为过放电防止剂以提供锂离子，从而可以补偿或更好地补偿阳极的不可逆容量，从而首先降低阴极的电压以防止阳极的电压升高 过放电试验。

公开(公告)号：US09566323B2

公开(公告)日：2017-02-14

申请号：US13379212

申请日：2009-10-20

Applicant: Hong-Jin Kim ,  Na Gyong Lee ,  Yang-Je Cho ,  Jin-Wook Jang ,  Hyoung Jin Kim ,  Kwang Sung Kim

Inventor： Hong-Jin Kim ,  Na Gyong Lee ,  Yang-Je Cho ,  Jin-Wook Jang ,  Hyoung Jin Kim ,  Kwang Sung Kim

IPC: A61K39/12 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/70 ,  C12N2710/20023 ,  C12N2710/20034

Abstract: The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1 VLP of HPV type 18, or a combination thereof; and (ii) a deacylated non-toxic lipooligosaccharide (LOS); and (b) a pharmaceutically acceptable carrier; and a method for preparing a human papillomavirus (HPV) L1 virus-like particle (VLP). The pharmaceutical vaccine composition of the present invention is in both Th1-type immune response (cellular immunity) and Th2-type immune response (humoral immunity) against HPV more excellent than Cervrix™ and Gardasil™, exhibiting a superior efficacy as a vaccine for a human cervical cancer.

Abstract translation: 本发明涉及用于人宫颈癌的药物疫苗组合物，其包括：（i）（i）16型人乳头状瘤病毒（HPV）的L1病毒样颗粒（VLP），HPV 18型的L1 VLP或 其组合; 和（ii）脱酰无毒低密度寡糖（LOS）; 和（b）药学上可接受的载体; 以及制备人乳头状瘤病毒（HPV）L1病毒样颗粒（VLP）的方法。 本发明的药物疫苗组合物具有比Cervrix TM和Gardasil TM更优异的Th1型免疫应答（细胞免疫）和对HPV的Th2型免疫应答（体液免疫），表现出作为疫苗的优异功效 人宫颈癌。

公开(公告)号：US20130165792A1

公开(公告)日：2013-06-27

申请号：US13619784

申请日：2012-09-14

Applicant: Han Woo Lee ,  Min Woo Kim ,  Deok Gon Kim ,  Hyoung Jin Kim

Inventor： Han Woo Lee ,  Min Woo Kim ,  Deok Gon Kim ,  Hyoung Jin Kim

IPC: A61B8/08

CPC classification number: G01S15/8984 ,  G01S7/52034 ,  G01S7/52085

Abstract: There are provided embodiments for transmitting ultrasound signals to a living body including a moving target object in at least one transmission direction, and receiving ultrasound echo signals from the living body in at least one reception direction to form vector information of the target object. In one embodiment, by way of non-limiting example, an ultrasound system comprises: an ultrasound data acquiring unit configured to transmit ultrasound signals to a living body including a moving target object in at least one transmission direction, and receive ultrasound echo signals from the living body in at least one reception direction to acquire ultrasound data; and a processing unit configured to form vector information of the target object based on ultrasound data corresponding to the at least one reception direction.

Abstract translation: 提供了用于在至少一个发送方向上向包括移动目标对象的生物体发送超声波信号的实施例，并且在至少一个接收方向上从生物体接收超声波回波信号以形成目标对象的矢量信息。 在一个实施例中，作为非限制性示例，超声波系统包括：超声数据获取单元，被配置为在至少一个发送方向上向包括移动目标对象的生物体发送超声波信号，并从 生物体在至少一个接收方向上获取超声数据; 以及处理单元，被配置为基于与所述至少一个接收方向相对应的超声数据来形成所述目标对象的向量信息。