公开(公告)号：US06949654B2

公开(公告)日：2005-09-27

申请号：US10456024

申请日：2003-06-05

Applicant: Eu-Gene Oh ,  Sung-Bo Ko ,  Won-Yeob Kim ,  Kyung-Hwa Kim ,  Dennis W. Choi ,  Laura L. Dugan ,  Tae-Cheon Kang ,  Jae-Young Koh ,  Kyung-Mi Kim ,  In-Jae Shin

Inventor： Eu-Gene Oh ,  Sung-Bo Ko ,  Won-Yeob Kim ,  Kyung-Hwa Kim ,  Dennis W. Choi ,  Laura L. Dugan ,  Tae-Cheon Kang ,  Jae-Young Koh ,  Kyung-Mi Kim ,  In-Jae Shin

IPC: C07C239/18 ,  C07D213/75 ,  C07D215/38 ,  C07D231/42 ,  C07D233/88 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D249/14 ,  C07D251/42 ,  C07D257/06 ,  C07D263/48 ,  C07D277/46 ,  C07D277/48 ,  C07D307/66 ,  C07D333/36 ,  C07D277/44 ,  A61K31/425 ,  A61K31/44

CPC classification number: C07D213/75 ,  C07C239/18 ,  C07D215/38 ,  C07D231/42 ,  C07D233/88 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D249/14 ,  C07D251/42 ,  C07D257/06 ,  C07D263/48 ,  C07D277/46 ,  C07D307/66 ,  C07D333/36

Abstract: The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and/or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.

Abstract translation: 本发明提供了含有金属螯合基团的新型N-烷基-N-苯基羟胺衍生物及其制备方法，该新化合物用作治疗和/或预防各种医学功能障碍和由活性氧产生的疾病的用途（ ROS）和/或过量的Zn离子，特别是中风，帕金森病和阿尔茨海默病。 本发明的化合物对Trolox和依布硒林的参考化合物具有相似或优异的LPO抑制活性。 虽然毒性较低，但也有效地抑制由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。

公开(公告)号：US20110226444A1

公开(公告)日：2011-09-22

申请号：US13009714

申请日：2011-01-19

Applicant: IN JAE SHIN

Inventor： IN JAE SHIN

IPC: F25B29/00

CPC classification number: F25D25/00 ,  F25D13/06 ,  F25D2400/12

Abstract: A portable temperature controlled container having a body including an internal chamber with an opening into the internal chamber; and a temperature control unit coupled to the body arid displaced to be thermally coupled with a first portion of the internal chamber, the temperature control unit configured to selectively alter the temperature in the internal chamber by releasing a thermally controlled material into the internal chamber.

Abstract translation: 一种便携式温度控制容器，其具有主体，该主体包括具有通向所述内部室的开口的内部室; 以及温度控制单元，其耦合到所述主体并被移位以与所述内部室的第一部分热耦合，所述温度控制单元被配置为通过将热控制的材料释放到所述内部室中来选择性地改变所述内部室中的温度。

公开(公告)号：US07718685B2

公开(公告)日：2010-05-18

申请号：US11337145

申请日：2006-01-20

Applicant: In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

Inventor： In-Jae Shin ,  Myung-Ryul Lee ,  Darren Williams

IPC: A01N43/50

CPC classification number: C07D405/04 ,  C07D233/64

Abstract: The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells and a pharmaceutical composition including said compound. More specifically, it relates to 2-(2-fluorenyl)-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound.

Abstract translation: 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物和包含所述化合物的药物组合物。 更具体地说，本发明涉及诱导成肌细胞或肌纤维分化的2-（2-芴基）-4,5-双（4-甲氧基苯基）咪唑，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，以及 包含所述化合物的药物组合物。

公开(公告)号：US07229988B2

公开(公告)日：2007-06-12

申请号：US10456399

申请日：2003-06-05

Applicant: Eu-Gene Oh ,  Sung-Bo Ko ,  Kyung-Hwa Kim ,  In-Kyu Chang ,  Dennis W. Choi ,  Laura L. Dugan ,  Jae-Young Koh ,  In-Jae Shin ,  Moo-Ho Won

Inventor： Eu-Gene Oh ,  Sung-Bo Ko ,  Kyung-Hwa Kim ,  In-Kyu Chang ,  Dennis W. Choi ,  Laura L. Dugan ,  Jae-Young Koh ,  In-Jae Shin ,  Moo-Ho Won

IPC: A61K31/54

CPC classification number: C07D213/40 ,  C07D207/34 ,  C07D213/26 ,  C07D213/38 ,  C07D213/75 ,  C07D215/38 ,  C07D231/40 ,  C07D233/88 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D249/14 ,  C07D251/42 ,  C07D257/06 ,  C07D261/14 ,  C07D263/48 ,  C07D263/58 ,  C07D271/10 ,  C07D271/113 ,  C07D275/02 ,  C07D275/03 ,  C07D277/46 ,  C07D277/56 ,  C07D285/12 ,  C07D285/135 ,  C07D307/66 ,  C07D333/36

Abstract: The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds of the invention have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.

Abstract translation: 本发明提供了含有金属螯合基团的新型二烷基羟基苯甲酸衍生物以及该新化合物作为治疗剂用于治疗和/或预防各种医学功能障碍和由活性氧和/或过量的Zn离子，特别是中风，帕金森病引起的疾病 ， 阿尔茨海默氏病。 本发明的化合物不仅具有低毒性，而且具有与参考物相似或优异的LPO抑制活性。 它们还有效地抑制了由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。