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1.发明申请4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION 有权4-BIS（4-甲氧基苯基）咪唑化合物诱导将神经细胞分解成神经细胞或肌肉纤维，包括化合物的药物组合物，诱导神经细胞分化的方法和用于鉴定用于诱导神经细胞的附加化合物的筛选方法 差异化公开(公告)号：US20100184097A1
公开(公告)日：2010-07-22
申请号：US12749922
申请日：2010-03-30
Applicant: In-Jae Shin , Myung-Ryul Lee , Darren Williams
Inventor： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC: G01N33/567 , C07D233/54 , C12N5/071
CPC classification number: C07D405/04 , C07D233/64
Abstract: The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.
Abstract translation: 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法 可用于诱导神经细胞分化。 更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体 ，盐，水合物，溶剂化物和前药，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法和用于鉴定用于诱导神经元细胞分化的另外的化合物的筛选方法。
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2.发明授权Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses 失效含金属螯合基团的二烷基羟基苯甲酸衍生物及其治疗用途公开(公告)号：US07511034B2
公开(公告)日：2009-03-31
申请号：US11329926
申请日：2006-01-11
Applicant: Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
Inventor： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis W. Choi , Laura L. Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
IPC: A61K31/54 , A61K31/35 , C07D279/00 , C07D277/04 , C07D207/46
CPC classification number: C07D213/40 , C07D207/34 , C07D213/26 , C07D213/38 , C07D213/75 , C07D215/38 , C07D231/40 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D261/14 , C07D263/48 , C07D263/58 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
Abstract: Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
Abstract translation: 公开了含有金属螯合基团的新型二烷基羟基苯甲酸衍生物。 新化合物用作治疗和/或预防由活性氧和/或过量的Zn离子，特别是中风，帕金森氏病，阿尔茨海默病引起的各种医学功能障碍和疾病的治疗剂。 该化合物不仅具有低毒性，而且对参考物具有相似或优异的LPO抑制活性。 它们还有效地抑制了由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。
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3.发明申请Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation 有权诱导成肌细胞或肌纤维分化成神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法公开(公告)号：US20070123576A1
公开(公告)日：2007-05-31
申请号：US11337145
申请日：2006-01-20
Applicant: In-Jae Shin , Myung-Ryul Lee , Darren Williams
Inventor： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC: A61K31/4178 , A61K31/4164 , C07D405/04 , C07D233/58
CPC classification number: C07D405/04 , C07D233/64
Abstract: The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.
Abstract translation: 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的化合物，包括所述化合物的药物组合物，诱导神经元分化的方法和用于鉴定用于诱导神经元分化的其它化合物的筛选方法。 更具体地说，本发明涉及从成肌细胞或肌肉纤维诱导神经元分化的化合物，其所有药学上可接受的异构体，盐，水合物，溶剂合物和前药，通过治疗成肌细胞和肌纤维诱导成肌细胞或肌纤维分化成神经细胞的方法 与本发明的化合物，由此成肌细胞和肌肉纤维分化成神经元细胞，以及用于鉴定用于诱导神经元分化的其它化合物的筛选方法，其中成肌细胞和肌肉纤维与本发明的化合物一起孵育并检测。
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公开(公告)号：US08163791B2
公开(公告)日：2012-04-24
申请号：US12528680
申请日：2007-02-26
Applicant: In-Jae Shin , Myung-ryul Lee , Darren Williams
Inventor： In-Jae Shin , Myung-ryul Lee , Darren Williams
IPC: A61K31/415 , C07D233/64
CPC classification number: C07D233/64
Abstract: The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
Abstract translation: 本发明涉及包含用于诱导凋亡的化合物的药物组合物，诱导癌细胞凋亡的方法，抑制淋巴细胞活化的方法，改善错误折叠的突变体的细胞内运输的方法以及鉴定用于诱导的另外的化合物的筛选方法 细胞凋亡，更具体地说，涉及包含咪唑衍生物作为诱导凋亡的活性梯度以治疗各种疾病（包括癌症和免疫相关疾病）的药物组合物，通过用药物组合物治疗癌细胞诱导凋亡的方法， 通过用药物组合物治疗淋巴细胞来灭活人淋巴细胞，通过用药物组合物处理含有突变体的细胞来改善错误折叠的突变体的细胞内运输的方法，以及鉴定用于诱导的另外的化合物的筛选方法 g细胞凋亡，其中将细胞与所述药物组合物孵育并检测。
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公开(公告)号：US20080149645A1
公开(公告)日：2008-06-26
申请号：US11949683
申请日：2007-12-03
Applicant: IN JAE SHIN
Inventor： IN JAE SHIN
CPC classification number: F25D25/00 , F25D13/06 , F25D2400/12
Abstract: A portable temperature controlled container having a body including an internal chamber with an opening into the internal chamber; and a temperature control unit coupled to the body and displaced to be thermally coupled with a first portion of the internal chamber, the temperature control unit configured to selectively alter the temperature in the internal chamber by releasing a thermally controlled material into the internal chamber.
Abstract translation: 一种便携式温度控制容器，其具有主体，该主体包括具有通向所述内部室的开口的内部室; 以及温度控制单元，其耦合到所述主体并移位以与所述内部室的第一部分热耦合，所述温度控制单元被配置为通过将热控制的材料释放到所述内部室中来选择性地改变所述内部室中的温度。
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Patent Agency Ranking
公开(公告)号：US08348173B2
公开(公告)日：2013-01-08
申请号：US13009714
申请日：2011-01-19
Applicant: In Jae Shin
Inventor： In Jae Shin
CPC classification number: F25D25/00 , F25D13/06 , F25D2400/12
Abstract: A portable temperature controlled container having a body including an internal chamber with an opening into the internal chamber; and a temperature control unit coupled to the body and displaced to be thermally coupled with a first portion of the internal chamber, the temperature control unit configured to selectively alter the temperature in the internal chamber by releasing a thermally controlled material into the internal chamber.
Abstract translation: 一种便携式温度控制容器，其具有主体，该主体包括具有通向所述内部室的开口的内部室; 以及温度控制单元，其耦合到所述主体并移位以与所述内部室的第一部分热耦合，所述温度控制单元被配置为通过将热控制的材料释放到所述内部室中来选择性地改变所述内部室中的温度。
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![2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole and methods for inducing differentiation of myoblasts or muscle fibers into neuron cells](/abs-image/US/2011/02/15/US07888118B2/abs.jpg.150x150.jpg)
7.发明授权2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole and methods for inducing differentiation of myoblasts or muscle fibers into neuron cells 有权2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑和诱导成肌细胞或肌纤维分化成神经元细胞的方法公开(公告)号：US07888118B2
公开(公告)日：2011-02-15
申请号：US12749922
申请日：2010-03-30
Applicant: In-Jae Shin , Myung-Ryul Lee , Darren Williams
Inventor： In-Jae Shin , Myung-Ryul Lee , Darren Williams
IPC: C12N5/00
CPC classification number: C07D405/04 , C07D233/64
Abstract: The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.
Abstract translation: 本发明涉及诱导成肌细胞或肌纤维分化为神经元细胞的4,5-双（4-甲氧基苯基）咪唑化合物，包含所述化合物的药物组合物，诱导神经元细胞分化的方法和鉴定另外的化合物的筛选方法 可用于诱导神经细胞分化。 更具体地说，它涉及诱导成肌细胞或肌纤维分化成神经细胞的2- {2- [5-（3-氯苯基）]呋喃基} -4,5-双（4-甲氧基苯基）咪唑，所有药学上可接受的异构体 盐，以及包含所述化合物的药物组合物，诱导神经元细胞分化的方法以及鉴定用于诱导神经元细胞分化的其它化合物的筛选方法。
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公开(公告)号：US20100105726A1
公开(公告)日：2010-04-29
申请号：US12528680
申请日：2007-02-26
Applicant: In-Jae Shin , Myung-ryul Lee , Darren Williams
Inventor： In-Jae Shin , Myung-ryul Lee , Darren Williams
IPC: A61K31/4178 , C12Q1/06 , C40B30/06 , A61K31/4725 , C07D401/04 , C07D405/06 , C07D403/06 , C07D233/61 , A61P35/00
CPC classification number: C07D233/64
Abstract: The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the said pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the said pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the said pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
Abstract translation: 本发明涉及包含用于诱导凋亡的化合物的药物组合物，诱导癌细胞凋亡的方法，抑制淋巴细胞活化的方法，改善错误折叠的突变体的细胞内运输的方法以及鉴定用于诱导的另外的化合物的筛选方法 更具体地，涉及包含咪唑衍生物作为用于诱导凋亡以用于治疗各种疾病（包括癌症和免疫相关疾病）的活性梯度的药物组合物，通过用所述药物组合物治疗癌细胞诱导凋亡的方法，该方法 通过用所述药物组合物处理淋巴细胞来灭活人淋巴细胞，通过用所述药物组合物处理含有突变体的细胞来改善错误折叠突变体的细胞内运输的方法，以及用于鉴定另外的化合物用途的筛选方法 用于诱导细胞凋亡，其中细胞与所述药物组合物一起孵育并检测。
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9.发明申请公开(公告)号：US20060116377A1
公开(公告)日：2006-06-01
申请号：US11329926
申请日：2006-01-11
Applicant: Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis Choi , Laura Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
Inventor： Eu-Gene Oh , Sung-Bo Ko , Kyung-Hwa Kim , In-Kyu Chang , Dennis Choi , Laura Dugan , Jae-Young Koh , In-Jae Shin , Moo-Ho Won
IPC: A61K31/53 , A61K31/50 , A61K31/4965 , A61K31/505 , A61K31/4706 , A61K31/44 , A61K31/433 , A61K31/426 , A61K31/425 , A61K31/421 , A61K31/42
CPC classification number: C07D213/40 , C07D207/34 , C07D213/26 , C07D213/38 , C07D213/75 , C07D215/38 , C07D231/40 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D261/14 , C07D263/48 , C07D263/58 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36
Abstract: Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
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公开(公告)号：US20060006199A1
公开(公告)日：2006-01-12
申请号：US10526790
申请日：2003-04-25
Applicant: In Jae Shin
Inventor： In Jae Shin
Abstract: According to the distribution device, portable ice cream distribution device never shown on earlier technique is provided and due to this soft ice cream can be stored so that with out any power supply storing, carrying and selling of soft ice cream in outdoor such as park and stadiums. And since it has simple composition and does not need high technology, the production cost is cheap and can be minimized and so it maximizes selling.
Abstract translation: 根据分配装置，提供了从未在早期技术中显示的便携式冰淇淋分配装置，并且由于可以存储该软冰淇淋，以便在室外的任何电源存储，携带和销售软冰淇淋，例如公园和 体育场馆 而且由于组成简单，不需要高技术，生产成本便宜，可以最小化，从而最大限度地发挥销售。
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