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    Method and compositions for reducing neurotoxic injury
    2.
    发明授权
    Method and compositions for reducing neurotoxic injury 失效
    用于减少神经毒性损伤的方法和组合物

    公开(公告)号：US4806543A

    公开(公告)日：1989-02-21

    申请号：US934733

    申请日：1986-11-25

    申请人： Dennis W. Choi

    发明人： Dennis W. Choi

    IPC分类号： C07D489/02 ,  A61K31/485 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61K31/36

    CPC分类号： A61K31/485

    摘要： A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound which is an enantiomer of an analgesic opioid agonist or antagonist, preferably an opiate agonist having a ring system of the following stereochemistry, which shows only carbon and nitrogen atoms in the rings: ##STR1## The dextrorotatory opiates, dextrorphan and dextromethorphan, are particularly suitable for use in the method of the invention.

    摘要翻译： 一种用于减少神经毒性损伤的不良影响的方法，其包括向具有神经毒性损伤的患者施用足以减少损伤的有效量的化合物，其为镇痛阿片样物质激动剂或拮抗剂的对映异构体，优选为具有 以下立体化学的环体系仅在环中仅显示碳原子和氮原子：右旋阿片剂，右美沙芬和右美沙芬特别适用于本发明的方法。

    Neuroprotection by indolactam V and derivatives thereof
    6.
    发明授权
    Neuroprotection by indolactam V and derivatives thereof 失效
    吲哚内酰胺V及其衍生物的神经保护作用

    公开(公告)号：US5292765A

    公开(公告)日：1994-03-08

    申请号：US800148

    申请日：1991-11-27

    申请人： Dennis W. Choi ,  Dean M. Hartley

    发明人： Dennis W. Choi ,  Dean M. Hartley

    IPC分类号： A61K31/40 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  C07D487/06 ,  A01N43/90 ,  C07D487/02

    CPC分类号： A61K31/40

    摘要： A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound having an indolactam V ring system. Particularly preferred are compounds having ring stereochemistry as indicated in the following formula: ##STR1## The indicated substituents show preferred locations of substituents; preferred substituents are defined in the specification.

    摘要翻译： 一种减少神经毒性损伤的不良反应的方法，其包括给患有神经毒性损伤的患者施用足以减少损伤的有吲哚美胺V环系的化合物的有效量。 特别优选的是具有如下式所示的环立体化学的化合物：（*化学结构*）指定的取代基显示取代基的优选位置; 优选的取代基在说明书中定义。

    Neuroprotection by indolactam V and derivatives thereof
    7.
    发明授权
    Neuroprotection by indolactam V and derivatives thereof 失效
    由吲哚咪胺V及其衍生物进行神经保护

    公开(公告)号：US5089517A

    公开(公告)日：1992-02-18

    申请号：US562680

    申请日：1990-08-03

    申请人： Dennis W. Choi ,  Dean M. Hartley

    发明人： Dennis W. Choi ,  Dean M. Hartley

    IPC分类号： A61K31/40 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  C07D487/06

    CPC分类号： A61K31/40

    摘要： A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound having an indolactam V ring system. Particularly preferred are compounds having ring stereochemistry as indicated in the following formula: ##STR1## The indicated substituents show preferred locations of substituents; preferred substituents are defined in the specification.

    摘要翻译： 一种减少神经毒性损伤的不良反应的方法，其包括给患有神经毒性损伤的患者施用足以减少损伤的有吲哚美胺V环系的化合物的有效量。 特别优选的是具有如下式所示的环立体化学的化合物：所示取代基显示取代基的优选位置; 优选的取代基在说明书中定义。