公开(公告)号：US20220125333A1

公开(公告)日：2022-04-28

申请号：US17511487

申请日：2021-10-26

Applicant: INNOVAPREP LLC

Inventor： David S. Alburty ,  Andew E. Page ,  John D. Birkenholz ,  Kathleen Ruegsegger ,  Ann K. Packingham ,  Zachary A. Packingham ,  Alec D. Adolphson ,  Pamela S. Murowchick ,  Hugh Olsen ,  Bryan C. Long ,  Steven D. Graham

IPC: A61B5/097 ,  A61B5/00

Abstract: Devices and methods are described for using normal human breath to separately capture particles from inhaled and exhaled breath for analysis. This device can be constructed as a wearable device worn as a mask with separately removable filters on the inside and the outside of an efficient collection material.

公开(公告)号：US20210148797A1

公开(公告)日：2021-05-20

申请号：US17103900

申请日：2020-11-24

Applicant: InnovaPrep LLC

Inventor： Zachary Allen Packingham ,  Andrew Edward Page ,  David Scott Alburty ,  Steven Dale Graham ,  Alec Douglas Adolphson

IPC: G01N1/40 ,  B01D61/20 ,  B01D61/22 ,  B01D63/08

Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

公开(公告)号：US10953350B2

公开(公告)日：2021-03-23

申请号：US15960483

申请日：2018-04-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: A47G19/22 ,  B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  C12H1/18 ,  A23L5/20 ,  G01N33/14

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US09593359B2

公开(公告)日：2017-03-14

申请号：US14084385

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: C12Q1/24 ,  G01N1/40

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。

公开(公告)号：US20140231256A1

公开(公告)日：2014-08-21

申请号：US14058193

申请日：2013-10-18

Applicant: InnovaPrep LLC

Inventor： Zachary Allen Packingham ,  Andrew Edward Page ,  David Scott Alburty ,  Steven Dale Graham ,  Alec Douglas Adolphson

IPC: G01N1/40

CPC classification number: G01N1/405 ,  B01D61/20 ,  B01D61/22 ,  B01D63/082 ,  B01D63/088 ,  B01D2315/08 ,  B01D2319/06 ,  B01D2321/02 ,  G01N1/40 ,  G01N1/4055 ,  G01N1/4077 ,  G01N2001/4016 ,  G01N2001/4038 ,  G01N2001/4088

Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

Abstract translation: 本公开提供了用于从流体样品分级和浓缩颗粒的装置，系统和方法。 这包括一个包含分级过滤器的筒，该过滤器具有一系列减小孔径的多孔表面，用于从流体样品捕获颗粒; 以及与所述盒流体连通的渗透压力源; 其中所述颗粒从所述多孔表面洗脱并以减少的流体体积分配。

公开(公告)号：US20250130145A1

公开(公告)日：2025-04-24

申请号：US18926159

申请日：2024-10-24

Applicant: INNOVAPREP LLC

Inventor： Andrew E. Page ,  John D. Birkenholz ,  Alec D. Adolphson ,  David Goad

IPC: G01N1/40 ,  B01D69/06 ,  B01D69/08

Abstract: The subject disclosure relates generally to the field of sample preparation. More particularly, the subject disclosure relates to devices, systems and methods for processing large liquid volumes through a concentrating pipette tip whereby targeted particles or large molecules are captured onto an internal membrane filter. The concentrating pipette tip is then packaged for transport to a facility or laboratory for subsequent elution into a small volume of buffer for analysis. The disclosed system simplifies sample transport while also enhancing the sensitivity of subsequent analysis methods.

公开(公告)号：US20250025834A1

公开(公告)日：2025-01-23

申请号：US18778834

申请日：2024-07-19

Applicant: INNOVAPREP LLC

Inventor： Andrew E. Page ,  David Goad ,  David S. Alburty

IPC: B01D61/14

Abstract: Highly efficient and rapid filtration-based methods for isolation and concentration of exosomes and extracellular vesicles from biological fluids, including urine, which utilize pretreatment, prefiltration, wash steps and isolation and concentration using the concentrating pipette are disclosed.

公开(公告)号：US20220397494A1

公开(公告)日：2022-12-15

申请号：US17841563

申请日：2022-06-15

Applicant: Boehringer Ingelheim Vetmedica GmbH ,  INNOVAPREP LLC

Inventor： Zachary A. Packingham ,  Steven D. Graham ,  Sidney J. Spry ,  Dale D. Polson

IPC: G01N1/22 ,  G01N1/24

Abstract: The present subject disclosure discloses devices, systems, and methods related to collection and recovery of Aerosols and Bioaerosols for analysis. The system includes an omni-directional inlet assembly that is easily removed for decontamination and can be replaced with an already clean inlet assembly or with directional inlets or other tools for collection from animal breathing zones, air ducts, air nearing moving vehicles and other sampling scenarios. Further, the system includes other features that enable the device to be lower in cost than other similar systems while providing improved usability and performance.

公开(公告)号：US10955316B2

公开(公告)日：2021-03-23

申请号：US15431655

申请日：2017-02-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/10 ,  G01N1/34 ,  G01N1/40 ,  G01N1/14

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

公开(公告)号：US20210077080A1

公开(公告)日：2021-03-18

申请号：US17103912

申请日：2020-11-24

Applicant: InnovaPrep LLC

Inventor： Alec D. Adolphson ,  Ann K. Packingham ,  Andrew E. Page ,  David S. Alburty ,  Zachary A. Packingham ,  John D. Birkenholz ,  Michael F. Fischer

IPC: A61B10/02 ,  A61B10/00

Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.