公开(公告)号：US07282513B2

公开(公告)日：2007-10-16

申请号：US11366866

申请日：2006-03-02

Applicant: Ian James Collins ,  Laura Catherine Cooper ,  Timothy Harrison ,  Linda Elizabeth Keown ,  Andrew Madin ,  Mark Peter Ridgill

Inventor： Ian James Collins ,  Laura Catherine Cooper ,  Timothy Harrison ,  Linda Elizabeth Keown ,  Andrew Madin ,  Mark Peter Ridgill

IPC: A61K31/433 ,  C07D417/02

CPC classification number: C07D285/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04

Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Abstract translation: 公开了式I化合物：其中X是5元杂芳基环，R如本文所定义。 这些化合物是通过γ-分泌酶处理APP的抑制剂，因此可用于治疗或预防阿尔茨海默氏病。

公开(公告)号：US20070119968A1

公开(公告)日：2007-05-31

申请号：US11698438

申请日：2007-01-26

Applicant: James Collins ,  Michael Jobin ,  Alexander Tee

Inventor： James Collins ,  Michael Jobin ,  Alexander Tee

IPC: B05B1/08

CPC classification number: A61M11/005 ,  A61F9/0008 ,  A61M11/041 ,  A61M11/044 ,  A61M11/065 ,  A61M2202/04 ,  A61M2205/18 ,  A61M2205/3386 ,  A61M2205/3653 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/59 ,  A61M2205/8212 ,  A61M2210/0612

Abstract: The present invention provides an ophthalmic fluid delivery device adapted to deliver an ophthalmic fluid in the form of a mist to an ocular region of a patient. The ophthalmic fluid delivery device comprises a nozzle defining an aperture through which the ophthalmic fluid can flow and at least one shutter positioned proximate to the aperture of the nozzle. The shutter is mounted for movement with respect to the aperture of the nozzle between an open position permitting flow of the ophthalmic fluid through the aperture of the nozzle and a closed position at least partially covering the aperture. A shutter actuator is positioned proximate to the shutter. The shutter actuator is mounted for movement with respect to the nozzle, and the shutter actuator is coupled to the shutter such that the movement of the shutter actuator moves the shutter between the open position and the closed position.

Abstract translation: 本发明提供了一种眼用液输送装置，其适于将雾状形式的眼液输送到患者的眼部区域。 眼科流体递送装置包括限定眼睛流体可以流动的孔的喷嘴和至少一个位于喷嘴孔附近的快门。 快门被安装成相对于喷嘴的孔移动，允许眼流体通过喷嘴的孔流动的打开位置和至少部分地覆盖孔的关闭位置。 快门致动器靠近快门定位。 快门致动器安装成相对于喷嘴移动，并且快门致动器联接到快门，使得快门致动器的运动使打开位置和关闭位置之间的快门移动。

公开(公告)号：US20070016390A1

公开(公告)日：2007-01-18

申请号：US11174989

申请日：2005-07-05

Applicant: Diego Bernardo ,  James Collins ,  Timothy Gardner ,  Michael Thompson

Inventor： Diego Bernardo ,  James Collins ,  Timothy Gardner ,  Michael Thompson

IPC: G06G7/48 ,  G06G7/58

CPC classification number: G16B5/00 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract translation: 本发明提供了存储在用于构建生物网络的模型的计算机可读介质上的方法和伴随的基于计算机的系统和计算机可执行代码。 本发明还提供了用于在生物网络上执行灵敏度分析并且用于识别网络和整个网络中物种的主要调节剂的方法。 此外，本发明提供用于鉴定诸如由化合物暴露或环境变化引起的扰动目标的方法。 本发明还提供用于鉴定有助于生物系统表型差异的表型介质的方法。

公开(公告)号：US20060293873A1

公开(公告)日：2006-12-28

申请号：US10506734

申请日：2003-03-05

Applicant: Timothy Gardner ,  James Collins ,  Diego di Bernardo ,  Jesper Tegner ,  Man Yeung

Inventor： Timothy Gardner ,  James Collins ,  Diego di Bernardo ,  Jesper Tegner ,  Man Yeung

IPC: G06G7/48 ,  G06G7/58

CPC classification number: G16B5/00 ,  G16B20/00 ,  G16B40/00

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract translation: 本发明提供了存储在用于构建生物网络的模型的计算机可读介质上的方法和伴随的基于计算机的系统和计算机可执行代码。 本发明还提供了用于在生物网络上执行灵敏度分析并且用于识别网络和整个网络中物种的主要调节剂的方法。 此外，本发明提供用于鉴定诸如由化合物暴露或环境变化引起的扰动目标的方法。 本发明还提供用于鉴定有助于生物系统表型差异的表型介质的方法。

公开(公告)号：US20060144809A1

公开(公告)日：2006-07-06

申请号：US11262856

申请日：2005-10-31

Applicant: James Collins ,  David Wojotowicz ,  Anthony Troyner

Inventor： James Collins ,  David Wojotowicz ,  Anthony Troyner

IPC: A47B57/00

CPC classification number: A47B57/406 ,  A47B47/028

Abstract: A connector is provided for securing two members together. The connector includes an opening formed in one member and a tab extending from the other member. Either the opening or the tab is tapered for frictional engagement with the other when the members are joined.

Abstract translation: 提供连接器用于将两个构件固定在一起。 连接器包括形成在一个构件中的开口和从另一个构件延伸的突出部。 当构件接合时，开口或突片都是锥形的，用于与另一个的摩擦接合。

公开(公告)号：US20060138162A1

公开(公告)日：2006-06-29

申请号：US10561375

申请日：2004-07-09

Applicant: Gregor John Anderson ,  James Collins ,  Ralph Lamble ,  Allen Pearson ,  Tom Snow ,  Paul Turner

Inventor： Gregor John Anderson ,  James Collins ,  Ralph Lamble ,  Allen Pearson ,  Tom Snow ,  Paul Turner

IPC: G07F11/00

CPC classification number: A61J7/0472 ,  A61J1/03 ,  A61J7/0076 ,  A61J7/02 ,  A61J7/0436 ,  B65D83/0409 ,  B65D2583/0409

Abstract: A hand-held dispenser (1) for dispensing a multiplicity of unit products (3) having a storage area (100) for storing the unit products, an outlet opening (311) through which the unit products are dispensable from the dispenser, a dispensing mechanism (350) actuable to dispense the unit products through the outlet opening, and a dispensing indicator (400) for indicating the number of unit products left in, or dispensed from, the dispenser. The dispensing indicator is integrated with the dispenser such that it is automatically updated in response to the dispensing of the unit products therefrom.

Abstract translation: 一种用于分配具有用于存储单元产品的存储区域（100）的多个单元产品（3）的手持式分配器（1），单元产品可通过该出口开口从分配器中分出，分配器 机构（350），其可致动以通过出口开口分配单元产品;以及分配指示器（400），用于指示留在分配器中或从分配器分配的单位产品的数量。 分配指示器与分配器集成，使得其响应于从其分配单元产品而自动更新。

公开(公告)号：US07060409B2

公开(公告)日：2006-06-13

申请号：US10384988

申请日：2003-03-10

Applicant: Ting Tao ,  Jeffrey James Collins ,  Thomas Jordan ,  Scott A. Beckley

Inventor： Ting Tao ,  Jeffrey James Collins ,  Thomas Jordan ,  Scott A. Beckley

IPC: G03F7/021 ,  G03F7/30

CPC classification number: B41M5/368 ,  B41C1/1008 ,  B41C2210/04 ,  B41C2210/06 ,  B41C2210/22 ,  B41C2210/24 ,  B41C2210/262

Abstract: Imageable elements with improved dot stability are disclosed. The imageable elements comprise a layer of an imageable composition over a support. The imageable composition comprises an infrared absorbing compound, an acid generator, an acid activatable crosslinking agent, a polymeric binder, and about 0.01 wt % to 1 wt % of an added onium compound. The elements may be thermally imaged and developed to produce images useful as lithographic printing plates.

Abstract translation: 公开了具有改善的点稳定性的可成像元件。 可成像元件包括在支撑件上的可成像组合物的层。 可成像组合物包含红外吸收化合物，酸产生剂，可酸活化的交联剂，聚合物粘合剂和约0.01重量％至1重量％的加入的鎓化合物。 元件可以被热成像和显影以产生用作平版印刷版的图像。

公开(公告)号：US20050212293A1

公开(公告)日：2005-09-29

申请号：US10811132

申请日：2004-03-26

Applicant: Gunter Matt ,  James Collins ,  Michael Cain ,  Paul Adkins

Inventor： Gunter Matt ,  James Collins ,  Michael Cain ,  Paul Adkins

IPC: F16L21/08 ,  F16L25/00 ,  E21B7/04

CPC classification number: F16L21/08 ,  F16L25/0009

Abstract: A fluid distribution system comprising a hollow pipe section having at least one bore extending longitudinally therethrough. At least one longitudinal boss extends along the pipe section. An end fitting comprises a body configured to be received in the bore and a shoulder extending radially from the body. At least one bolt hole extends through the shoulder and is configured to align with the at least one longitudinal boss. A secondary component is configured for connection to the end fitting. Alternatively, an outlet plate fitting is configured for attaching a secondary component to a fluid pipe section. The fluid pipe section includes opposed flanges that define a receiving groove. The outlet plate fitting comprises a main body and an engagement platform having a planar surface with a seal member. Rotation of the engagement platform within the receiving groove causes the planar surface and seal member into sealing engagement within the receiving groove.

Abstract translation: 一种流体分配系统，包括具有至少一个纵向延伸穿过的孔的中空管段。 至少一个纵向凸台沿管段延伸。 端部配件包括构造成容纳在孔中的主体和从主体径向延伸的肩部。 至少一个螺栓孔延伸穿过所述肩部并且构造成与所述至少一个纵向凸台对准。 辅助部件配置为连接到端部接头。 或者，出口板配件构造成用于将次要部件附接到流体管道部分。 流体管部分包括限定接收槽的相对的凸缘。 出口板配件包括主体和具有带有密封构件的平面的接合平台。 接合平台在接收槽内的旋转导致平面和密封件在接收槽内形成密封接合。

公开(公告)号：US20050211736A1

公开(公告)日：2005-09-29

申请号：US11081108

申请日：2005-03-16

Applicant: Patrick Finlay ,  Kenneth Ritsher ,  James Collins

Inventor： Patrick Finlay ,  Kenneth Ritsher ,  James Collins

IPC: B67D7/08 ,  B67B7/00 ,  B67D1/04

CPC classification number: B67D1/0456 ,  Y10T137/87981 ,  Y10T137/88046

Abstract: A dispenser includes a dispenser body which defines a flow passage, a valve assembly, and an actuator. The valve assembly is disposed in the flow passage and includes a first valve member and a second valve member. An actuator is coupled to the valve assembly. When the actuator is manipulated through a first range of motion, only the first of the two valve members is displaced, and when the actuator is manipulated through a second range of motion, both the first and second valve members are displaced in unison.

Abstract translation: 分配器包括分配器本体，其限定流路，阀组件和致动器。 阀组件设置在流动通道中并且包括第一阀构件和第二阀构件。 致动器联接到阀组件。 当致动器经过第一运动范围操作时，只有两个阀构件中的第一个被移动，并且当致动器被操纵在第二运动范围时，第一和第二阀构件一致地移位。

公开(公告)号：US06730681B2

公开(公告)日：2004-05-04

申请号：US10149851

申请日：2002-06-14

Applicant: Mark Stuart Chambers ,  Ian James Collins ,  Simon Charles Goodacre ,  David James Hallett ,  Philip Jones ,  Linda Elizabeth Keown ,  Robert James Maxey ,  Leslie Joseph Street

Inventor： Mark Stuart Chambers ,  Ian James Collins ,  Simon Charles Goodacre ,  David James Hallett ,  Philip Jones ,  Linda Elizabeth Keown ,  Robert James Maxey ,  Leslie Joseph Street

IPC: A61K31519

CPC classification number: C07D487/04

Abstract: A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Abstract translation: 一类取代或6,7环稠合的[1,2,3]三唑并[1,5-a]嘧啶衍生物，其在3-位上具有任选取代的环烷基，苯基或杂芳基取代基，氨基部分 5位是GABA A受体的选择性配体，特别是对其α2和/或α3亚基具有高亲和力，因此有益于治疗和/或预防中枢神经系统疾病，包括焦虑和 抽搐