公开(公告)号：US07742823B2

公开(公告)日：2010-06-22

申请号：US11746748

申请日：2007-05-10

Applicant: John D. H. King ,  James R. Thacker

Inventor： John D. H. King ,  James R. Thacker

IPC: A61N1/08

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US20080286327A1

公开(公告)日：2008-11-20

申请号：US11949752

申请日：2007-12-03

Applicant: Todd K. Whitehurst ,  Kelly H. McClure ,  James R. Thacker

Inventor： Todd K. Whitehurst ,  Kelly H. McClure ,  James R. Thacker

IPC: A61K9/00 ,  A61K31/727 ,  A61K31/353 ,  A61K31/60 ,  A61K38/48

CPC classification number: A61M5/14276 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/8243 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/30 ,  A61N1/362 ,  A61M2230/005

Abstract: Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.

Abstract translation: 用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个： 心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制 通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

公开(公告)号：US20080103559A1

公开(公告)日：2008-05-01

申请号：US11553447

申请日：2006-10-26

Applicant: James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K.L. Peterson ,  Kerry Bradley

Inventor： James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K.L. Peterson ,  Kerry Bradley

IPC: A61N1/00

CPC classification number: A61N1/37247 ,  A61N1/36071 ,  A61N1/36146 ,  A61N1/36171 ,  A61N1/36175

Abstract: Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.

Abstract translation: 组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。 刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。 在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。 编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

公开(公告)号：US07155284B1

公开(公告)日：2006-12-26

申请号：US10346538

申请日：2003-01-16

Applicant: Todd K Whitehurst ,  Kelly H. McClure ,  James R Thacker ,  James P McGivern

Inventor： Todd K Whitehurst ,  Kelly H. McClure ,  James R Thacker ,  James P McGivern

IPC: A61N1/18

CPC classification number: A61N1/36117 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/3787

Abstract: Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.

Abstract translation: 高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。 刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。 微型激励器也可以/替代地递送电刺激脉冲。 刺激部位包括颈动脉窦和颈动脉体等。 治疗包括用于急性和/或慢性治疗高血压的药物。 在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

公开(公告)号：US07099718B1

公开(公告)日：2006-08-29

申请号：US10155146

申请日：2002-05-24

Applicant: James R. Thacker ,  David K. L. Peterson ,  James P. McGivern ,  Michael S. Colvin

Inventor： James R. Thacker ,  David K. L. Peterson ,  James P. McGivern ,  Michael S. Colvin

IPC: A61N1/05

CPC classification number: A61N1/0558 ,  A61M25/10

Abstract: An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. The pressure of the balloon is monitored or otherwise controlled during the filling process in order to determine at what point the filling process should be discontinued. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

Abstract translation: 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 气球可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 在填充过程中监测或以其他方式控制气囊的压力，以便确定在何时应该停止填充过程。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

公开(公告)号：US5024222A

公开(公告)日：1991-06-18

申请号：US482603

申请日：1990-02-21

Applicant: James R. Thacker

Inventor： James R. Thacker

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC classification number: A61N1/3627 ,  A61N1/36557 ,  A61N1/3682

Abstract: In a rate responsive pacemaker, a physiological sensor is used to sense the physiological needs of the patient's heart and to control both the pacing rate and the A-V interval accordingly. A first adjustment means triggers the timing circuitry to adjust the stimulation rate to a slightly sub-optimal value of cardiac output. A second adjustment means adjusts the A-V interval until hemodynamics are optimized according to the physiological sensor. The improvement in hemodynamics due to the A-V adjustment allows a further decrease in the stimulation rate by the first adjustment means, thereby conserving the limited battery supply.

公开(公告)号：US09687653B2

公开(公告)日：2017-06-27

申请号：US13538022

申请日：2012-06-29

Applicant: Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

Inventor： Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

IPC: A61N1/372 ,  A61N1/36 ,  A61N1/08

CPC classification number: A61N1/36071 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/37241 ,  A61N1/37247

Abstract: A programming system for selecting an electrode configuration for use in a medical electrical stimulator coupled to an electrode array. A programmer is configured for providing a set of electrode configurations for the electrode array, automatically testing a first portion of the set of electrode configurations in a first order, allowing the selection of one or more of the tested electrode configurations, determining whether a suitable number of electrode configurations from among the first portion have been selected within a predefined interval, and automatically testing a second portion of the set of electrode configurations in a second order if the suitable number of electrode configurations from among the first portion are not selected within the predefined interval. The programmer may further allow the selection of the tested electrode configurations, and adjusting parameters during the testing, wherein the adjusting is controllably shared in parallel between a clinician and a patient.

公开(公告)号：US09205263B2

公开(公告)日：2015-12-08

申请号：US12783187

申请日：2010-05-19

Applicant: John D. H. King ,  James R. Thacker

Inventor： John D. H. King ,  James R. Thacker

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/08

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US08989865B2

公开(公告)日：2015-03-24

申请号：US13620235

申请日：2012-09-14

Applicant: Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

Inventor： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

IPC: A61N1/18 ,  A61N1/06 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 100 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

Abstract translation: 公开了用于抑制副作用减轻的疼痛的选择性高频脊髓调节和相关系统和方法。 在特定实施例中，可以将约1.5KHz至约100KHz范围内的高频调制施加到患者的脊髓区域以解决腰背痛而不产生不希望的感觉和/或运动副作用。 在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。

公开(公告)号：US08838248B2

公开(公告)日：2014-09-16

申请号：US12765824

申请日：2010-04-22

Applicant: Andre B. Walker ,  Jon Parker ,  Konstantinos Alataris ,  James R. Thacker

Inventor： Andre B. Walker ,  Jon Parker ,  Konstantinos Alataris ,  James R. Thacker

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/06 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

Abstract: Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

Abstract translation: 公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。 在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。 在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。 在具体实施例中，前述调制疗法的方面可以由具有简化功能的系统和设备来实现。