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公开(公告)号：US08475779B2
公开(公告)日：2013-07-02
申请号：US12637723
申请日：2009-12-14
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC classification number: A61K38/02 , A61K38/16 , A61K2300/00
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
Abstract translation: 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20080194462A1
公开(公告)日：2008-08-14
申请号：US10591315
申请日：2005-09-15
Applicant: Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
Inventor： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
IPC: A61K38/28 , A61K38/16 , G01N33/566 , A61P3/10 , A61P37/00
CPC classification number: A61K38/02
Abstract: The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.
Abstract translation: 本发明提供用于治疗自身免疫性疾病和其他不需要的免疫反应的方法和组合物，其包括施用与一种或多种HLA-DQ分子结合并调节DQ限制性T细胞应答的共聚物。 共聚物是氨基酸的无规共聚物和包含锚定残基的共聚物，以便于结合DQ结合袋。
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公开(公告)号：US20060252496A1
公开(公告)日：2006-11-09
申请号：US11412741
申请日：2006-04-27
Applicant: James Rasmussen
Inventor： James Rasmussen
IPC: A63F13/00
CPC classification number: G07F17/3216 , G07F17/3211
Abstract: A slot machine comprises a housing, a plurality of physical symbol-bearing reels mounted in the housing, and a display arrangement positioned in front of the reels and interchangeable in the same housing between at least two of the following: (i) a display panel without an interior cavity, (ii) a light-guiding panel having an illuminated interior, and (iii) a transmissive video display.
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公开(公告)号：US20060194725A1
公开(公告)日：2006-08-31
申请号：US11283405
申请日：2005-11-17
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC: A61K38/17
CPC classification number: C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
Abstract translation: 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
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公开(公告)号：US20060189527A1
公开(公告)日：2006-08-24
申请号：US11283406
申请日：2005-11-17
Applicant: James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
Inventor： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
IPC: A61K38/16
CPC classification number: A61K38/02 , A61K38/16 , A61K2300/00
Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
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Patent Agency Ranking
公开(公告)号：US20060189387A1
公开(公告)日：2006-08-24
申请号：US11359738
申请日：2006-02-22
Applicant: Gene Rigsby , James Rasmussen
Inventor： Gene Rigsby , James Rasmussen
IPC: A63F13/00
CPC classification number: G07F17/32 , G07F17/3209 , G07F17/323 , Y10T74/2014 , Y10T74/20244
Abstract: According to one aspect of the invention, a gaming machine for conducting a wagering game, comprising a physically configurable button panel and at least one mechanical button removably disposed in the button panel. The gaming machine also comprises an input panel disposed adjacent to the button to produce an output signal in response to a predetermined movement of the button and a controller for initiating a function in response to the output signal.
Abstract translation: 根据本发明的一个方面，一种用于进行投注游戏的游戏机，包括物理上可配置的按钮面板和可移除地设置在按钮面板中的至少一个机械按钮。 游戏机还包括与按钮相邻设置的输入面板，以响应于按钮的预定移动产生输出信号，以及用于响应于输出信号启动功能的控制器。
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公开(公告)号：US20050026249A1
公开(公告)日：2005-02-03
申请号：US10861041
申请日：2004-06-04
Applicant: James Rasmussen , Gary Barsomian , Michel Bergh
Inventor： James Rasmussen , Gary Barsomian , Michel Bergh
CPC classification number: C12N15/86 , A01K2217/05 , C12N9/2402 , C12N15/85 , C12N2710/14143 , C12N2830/00 , C12N2830/60 , C12N2840/20 , C12N2840/44 , C12Y302/01045
Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.
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公开(公告)号：US06609742B1
公开(公告)日：2003-08-26
申请号：US09848488
申请日：2001-05-03
Applicant: William C. Macom , Joseph H. Landry , William R. Gregor , James Rasmussen
Inventor： William C. Macom , Joseph H. Landry , William R. Gregor , James Rasmussen
IPC: B66C128
Abstract: A lifting apparatus for manipulating manhole castings and the like having at least one pinch clamp with an inner leg and an outer leg opposing one another wherein the inner leg and the outer leg are engageable with the manhole casting. A foot of the pinch clamp is connected to at least one of the inner leg and the outer leg wherein the foot is wider than the width of the inner leg and the outer leg and is engageable with the manhole casting. A flexible support is pivotally connected to the pinch clamp and is connectable to a lifting device wherein the foot and the legs of the pinch clamp are engageable with the manhole casting when the flexible support is pulled taut. Preferably, the inner and outer legs are separate structures pivotally connected thereto. Alternatively, the inner and outer leg may be integrally fabricated from a one-piece structure. The flexible supports are connected to a connector which is connectable to a lifting device.
Abstract translation: 一种用于操纵人孔铸件等的提升装置，其具有至少一个夹紧夹具，其具有彼此相对的内腿和外腿，其中内腿和外腿可与人孔铸件接合。 夹紧夹的脚连接到内腿和外腿中的至少一个，其中脚比内腿和外腿的宽度宽，并且可与人孔铸件接合。 柔性支撑件枢转地连接到夹紧夹具并且可连接到提升装置，其中当柔性支撑件被拉紧时，夹紧夹的脚部和腿部可与井眼铸造接合。 优选地，内腿和外腿是与其枢转连接的分离结构。 或者，内腿和外腿可以由一体式结构整体制造。 柔性支撑件连接到可连接到提升装置的连接器。
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公开(公告)号：US5236838A
公开(公告)日：1993-08-17
申请号：US748283
申请日：1991-08-21
Applicant: James Rasmussen , Gary Barsomian , Michel Bergh
Inventor： James Rasmussen , Gary Barsomian , Michel Bergh
IPC: C12N9/24 , C12N15/56 , C12N15/85 , C12N15/866
CPC classification number: C12N15/86 , C12N15/85 , C12N9/2402 , C12Y302/01045 , C12N2710/14143 , C12N2840/20 , C12N2840/44
Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.
Abstract translation: 重组酶活性葡糖脑苷脂酶由真核细胞产生。 此外，细胞包括编码酶活性葡糖脑苷脂酶的核酸; 真核生物也含有这样的细胞。 此外，生产酶活性葡糖脑苷脂酶的方法包括将葡糖脑苷脂酶编码核酸引入真核细胞，使细胞表达葡糖脑苷脂酶，并从细胞纯化葡糖脑苷脂酶的步骤。
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公开(公告)号：US4844872A
公开(公告)日：1989-07-04
申请号：US74921
申请日：1987-07-17
Applicant: Theodore S. Geiselman , James Rasmussen
Inventor： Theodore S. Geiselman , James Rasmussen
CPC classification number: G01N35/085
Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.
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