公开(公告)号：US20050107445A1

公开(公告)日：2005-05-19

申请号：US10811332

申请日：2004-03-29

申请人： Clare Watkins ,  Maria Rosario Romero-Martin ,  Kathryn Moore ,  James Ritchie ,  Paul Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Vija Gailite ,  Maxim Vorona ,  Irina Piskunova ,  Igor Starchenkov ,  Victor Andrianov ,  C. Harris ,  James Duffy

发明人： Clare Watkins ,  Maria Rosario Romero-Martin ,  Kathryn Moore ,  James Ritchie ,  Paul Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Vija Gailite ,  Maxim Vorona ,  Irina Piskunova ,  Igor Starchenkov ,  Victor Andrianov ,  C. Harris ,  James Duffy

IPC分类号： A61K31/341 ,  A61K31/403 ,  A61K31/4406 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00 ,  C07C311/06 ,  C07C311/08 ,  C07C311/10 ,  C07C311/13 ,  C07C311/16 ,  C07C311/17 ,  C07C311/19 ,  C07C311/20 ,  C07C311/21 ,  C07C311/29 ,  C07D209/82 ,  C07D209/88 ,  C07D213/40 ,  C07D213/42 ,  C07D213/65 ,  C07D213/71 ,  C07D307/52 ,  C07D317/58 ,  A61K31/44 ,  A61K31/19 ,  A61K31/4015 ,  C07C311/35

CPC分类号： C07D213/40 ,  C07C311/06 ,  C07C311/13 ,  C07C311/16 ,  C07C311/19 ,  C07C311/20 ,  C07C311/21 ,  C07C311/29 ,  C07C2602/08 ,  C07D209/88 ,  C07D213/42 ,  C07D213/65 ,  C07D213/71 ,  C07D307/52 ,  C07D317/58

摘要： This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(═O)2NR1— and —NR1S(═O)2—; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is —S(═O)2NR1—, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.

公开(公告)号：US06888027B2

公开(公告)日：2005-05-03

申请号：US10381790

申请日：2001-09-27

申请人： Clare J Watkins ,  Maria Rosario Romero-Martin ,  Kathryn G Moore ,  James Ritchie ,  Paul W Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Vija Gailite ,  Maxim Vorona ,  Irina Piskunova ,  Igor Starchenkov ,  Victor Andrianov ,  C. John Harris ,  James E. S. Duffy

发明人： Clare J Watkins ,  Maria Rosario Romero-Martin ,  Kathryn G Moore ,  James Ritchie ,  Paul W Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Vija Gailite ,  Maxim Vorona ,  Irina Piskunova ,  Igor Starchenkov ,  Victor Andrianov ,  C. John Harris ,  James E. S. Duffy

IPC分类号： A61K31/341 ,  A61K31/403 ,  A61K31/4406 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00 ,  C07C311/06 ,  C07C311/08 ,  C07C311/10 ,  C07C311/13 ,  C07C311/16 ,  C07C311/17 ,  C07C311/19 ,  C07C311/20 ,  C07C311/21 ,  C07C311/29 ,  C07D209/82 ,  C07D209/88 ,  C07D213/40 ,  C07D213/42 ,  C07D213/65 ,  C07D213/71 ,  C07D307/52 ,  C07D317/58 ,  A01N37/28

CPC分类号： C07D213/40 ,  C07C311/06 ,  C07C311/13 ,  C07C311/16 ,  C07C311/19 ,  C07C311/20 ,  C07C311/21 ,  C07C311/29 ,  C07C2602/08 ,  C07D209/88 ,  C07D213/42 ,  C07D213/65 ,  C07D213/71 ,  C07D307/52 ,  C07D317/58

摘要： This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(═O)2NR1— and —NR1S(═O)2—; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is —S(═O)2NR1—, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.

摘要翻译： 本发明涉及抑制HDAC活性的一些活性氨基甲酸化合物，其具有下式：（I）A为芳基; Q 1是共价键或芳基前导基团; J是选自以下的磺酰胺键：-S（-O）2 NR 1 - 和-NR 1 S（-O） > 2 - ; R1是亚磺酰氨基取代基; 而Q 2是酸性引导基团; 条件是如果J是-S（-O）2 NR 1 - ，则Q 1是芳基前导基团; 和其药学上可接受的盐，溶剂合物，酰胺，酯，醚，化学保护形式及其前药。 本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制HDAC，并且例如抑制增殖性疾病如癌症和牛皮癣。

公开(公告)号：US12011342B2

公开(公告)日：2024-06-18

申请号：US17703055

申请日：2022-03-24

申请人： William James Ritchie ,  Walter James Ferguson

发明人： William James Ritchie ,  Walter James Ferguson

IPC分类号： A61F13/02 ,  A61F13/00 ,  A61F13/0246

CPC分类号： A61F13/0289 ,  A61F13/0253 ,  A61F2013/00182

摘要： Dressing or bandage for protecting a wound accidentally incurred, surgical incision deliberately made in the skin, epidermal delivery of medication, or musculotherapy of a human being or animal, said bandage/dressing having the primary characteristic of being significantly atraumatic upon removal of same by virtue of a novel stringlike member that is intentionally incorporated into or debossed into the construction of said parent bandage/dressing in a multi-spiral geometry, said stringlike member firstly being pulled gently and progressively in multiple turns around the wound site or epidermal treatment area to in effect significantly reduce the area of remaining/undisturbed adhesive between the bandage/dressing and patient's skin before the bandage/dressing is peeled away from the skin in conventional manner and thus affording the patient a significantly less traumatic experience.

公开(公告)号：US09889365B2

公开(公告)日：2018-02-13

申请号：US14795047

申请日：2015-07-09

申请人： James H. Gravel ,  James Ritchie, Jr.

发明人： James H. Gravel ,  James Ritchie, Jr.

IPC分类号： A63B71/00 ,  A63B63/00 ,  A63B71/02

CPC分类号： A63B71/0036 ,  A63B63/004 ,  A63B2071/025 ,  A63B2071/026

摘要： An auxiliary weighted roller assembly attachable to a sports goal ground crossbar to stabilize the goal and to facilitate temporary or long term relocation for field maintenance, alternative field use, or storage consisting of a framework attachable to the crossbar and a pair of weighted rollers attached to the framework one each disposed on the front and rear of the crossbar and of sufficient diameter to raise the crossbar above the ground.

公开(公告)号：US20170209757A1

公开(公告)日：2017-07-27

申请号：US15405842

申请日：2017-01-13

申请人： James H. Gravel ,  James Ritchie, JR.

发明人： James H. Gravel ,  James Ritchie, JR.

IPC分类号： A63B63/00

CPC分类号： A63B63/004 ,  A63B71/0036 ,  A63B2071/025 ,  A63B2071/026

摘要： An improved auxiliary weighted roller assembly attachable to a sports goal ground crossbar to stabilize the goal and to facilitate temporary or long term relocation for field maintenance, alternative field use, or storage consisting of a framework attachable to the crossbar and a pair of weighted rollers attached to the framework one each disposed on the front and rear of the crossbar of sufficient diameter to raise the crossbar above the ground, the improvement comprising devices to increase the strength of the clamping mechanism employed to attach the roller assembly and the goal ground crossbar.

公开(公告)号：US20080298970A1

公开(公告)日：2008-12-04

申请号：US12045895

申请日：2008-03-11

申请人： Joergen Ferber ,  James Ritchie ,  Slawomir Slowik

发明人： Joergen Ferber ,  James Ritchie ,  Slawomir Slowik

IPC分类号： F01D5/22

CPC分类号： F01D5/225 ,  F05B2240/33 ,  F05D2230/60 ,  F05D2260/30 ,  Y02T50/671 ,  Y02T50/673

摘要： A turbo machine (1, 101), in particular turbine or compressor, includes a rotor (2, 102) which has at least one moving blade row (4, 104) with a plurality of moving blades (5, 105), and a stator (3) which has at least one guide vane row (6, 106) with a plurality of guide vanes (7, 107), at least one moving blade row (4, 104) having a shroud (8, 108). The shroud (8, 108) is designed to be self-supporting in such a way that it can at least partially absorb the centrifugal forces arising during operation and discharge them in the circumferential direction.

摘要翻译： 特别是涡轮机或压缩机的涡轮机（1,101）包括具有至少一个具有多个活动叶片（5,105）的活动叶片排（4,104）的转子（2,102），以及 定子（3）具有至少一个具有多个导向叶片（7,107）的导向叶片排（6,106），至少一个具有护罩（8,108）的活动叶片排（4,104）。 护罩（8,108）被设计成自支撑，使得其可以至少部分地吸收在操作过程中产生的离心力并在圆周方向上排出它们。

公开(公告)号：US20080269237A1

公开(公告)日：2008-10-30

申请号：US12165686

申请日：2008-07-01

申请人： Clare J. WATKINS ,  Maria-Rosario Romero-Martin ,  James Ritchie ,  Paul W. Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Igor Starchenkov ,  Daina Lolya ,  Vija Gailite

发明人： Clare J. WATKINS ,  Maria-Rosario Romero-Martin ,  James Ritchie ,  Paul W. Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klara Dikovska ,  Igor Starchenkov ,  Daina Lolya ,  Vija Gailite

IPC分类号： A61K31/506 ,  A61K31/495 ,  A61P35/00 ,  C12N9/99 ,  A61P25/28 ,  A61P25/16

CPC分类号： C07D213/74 ,  C07D239/42 ,  C07D295/185 ,  C07D295/192 ,  C07D295/26 ,  C07D317/58 ,  C07D333/60

摘要： This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.

摘要翻译： 本发明涉及抑制下式的HDAC（组蛋白脱乙酰酶）活性的某些氨基甲酸化合物：本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途 抑制HDAC，以及治疗由HDAC，癌症，增殖性病症，牛皮癣等介导的病症。

公开(公告)号：US20070231143A1

公开(公告)日：2007-10-04

申请号：US11682624

申请日：2007-03-06

申请人： Andreas Boegli ,  James Ritchie

发明人： Andreas Boegli ,  James Ritchie

IPC分类号： F01D5/22

CPC分类号： F01D5/225

摘要： A blade for a turbo machine has a blade section and a shroud element terminating the blade section in the blade section longitudinal direction. The blade section has a suction face and a pressure face. The shroud element extends essentially at right angles to the blade section longitudinal direction and has a first platform section projecting beyond the blade section and a second platform section projecting beyond the blade section. The platform sections are asymmetric with respect to one another. At least the first platform section of the shroud element is arranged at an additional inclination angle with respect to a normal alignment of the first platform section, with the additional inclination angle being in the opposite direction to the bending torque which acts on the first platform section during operation.

摘要翻译： 用于涡轮机的叶片具有叶片部分和在叶片部分纵向方向上终止叶片部分的护罩元件。 叶片部分具有吸力面和压力面。 护罩元件基本上与叶片部分纵向方向成直角地延伸，并且具有突出超过叶片部分的第一平台部分和突出超过叶片部分的第二平台部分。 平台部分相对于彼此是不对称的。 护罩元件的至少第一平台部分相对于第一平台部分的正常对准以额外的倾斜角度布置，附加倾斜角度与作用在第一平台部分上的弯曲扭矩相反的方向 在运行期间。

公开(公告)号：US20060105464A1

公开(公告)日：2006-05-18

申请号：US10988069

申请日：2004-11-12

申请人： Jorg Friedrich Weber ,  John Rizzo ,  James Ritchie ,  Alan Berry ,  Allen Godwin

发明人： Jorg Friedrich Weber ,  John Rizzo ,  James Ritchie ,  Alan Berry ,  Allen Godwin

IPC分类号： G01N33/00

CPC分类号： G01N31/22 ,  C07C29/16 ,  Y10T436/200833

摘要： The invention relates to an analytical technique for the quantitative determination of an analyte and a reagent solution useful in said quantitative determination. The analytical technique is conveniently adapted for quantitative determination of carbonyl and even more particularly adapted for finishing an alcohol produced in the Oxo Process.

摘要翻译： 本发明涉及用于定量测定所述定量测定中所用分析物和试剂溶液的分析技术。 分析技术方便地适用于羰基的定量测定，甚至更特别适用于在Oxo方法中生产的醇。

公开(公告)号：US20050143385A1

公开(公告)日：2005-06-30

申请号：US10509732

申请日：2003-04-03

申请人： Clare Watkins ,  Maria-Rosario Romero-Martin ,  James Ritchie ,  Paul Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klar Dikovska ,  Igor Starchenkov ,  Daina Lolya ,  Vija Gailite

发明人： Clare Watkins ,  Maria-Rosario Romero-Martin ,  James Ritchie ,  Paul Finn ,  Ivars Kalvinsh ,  Einars Loza ,  Klar Dikovska ,  Igor Starchenkov ,  Daina Lolya ,  Vija Gailite

IPC分类号： C07D295/16 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/42 ,  C07D213/36 ,  C07D213/74 ,  C07D239/42 ,  C07D241/04 ,  C07D295/18 ,  C07D295/185 ,  C07D295/192 ,  C07D295/22 ,  C07D295/26 ,  C07D317/58 ,  C07D333/60 ,  C07D43/02

CPC分类号： C07D213/74 ,  C07D239/42 ,  C07D295/185 ,  C07D295/192 ,  C07D295/26 ,  C07D317/58 ,  C07D333/60

摘要： This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: wherein: Cy is independently a cyclyl group; Q1 is independently a covalent bond or cyclyl leader group; the piperazin-1,4-diyl group is optionally substituted; J1 is independently a covalent bond or —C(═;O)—; J2 is independently —C(═O)— or —S(═O)2—; Q2 is independently an acid leader group; wherein: Cy is independently: C3-20carbocyclyl, C3-20heterocyclyl, or C5-20aryl; and is optionally substituted; Q1 is independently: a covalent bond; C1-7alkylene; or C1-7alkylene-X—C1-7alkylene, —X—C1-7alkylene, or C1-7alkylene-X—, wherein X is —O— or —S—; and is optionally substituted; Q2 is independently: C4-8alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or: Q2 is independently: C5-20arylene; C5-20arylene-C1-7alkylene; C1-7alkylene-C5-20arylene; or, C1-7alkylene-C5-20arylene-C1-7alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.