公开(公告)号：US20140329834A1

公开(公告)日：2014-11-06

申请号：US14237625

申请日：2012-07-13

申请人： James Cunningham ,  Kyungae Lee ,  Tao Ren ,  Kartik Chandran

发明人： James Cunningham ,  Kyungae Lee ,  Tao Ren ,  Kartik Chandran

IPC分类号： C07D295/185

CPC分类号： C07D295/185

摘要： The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.

摘要翻译： 本发明涉及用于治疗包膜病毒如埃博拉和拉萨热病毒感染的组合物和方法。

公开(公告)号：US20140018338A1

公开(公告)日：2014-01-16

申请号：US13979179

申请日：2012-01-24

申请人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

发明人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

IPC分类号： G01N33/50 ,  A61K31/55 ,  A61K31/566 ,  C12Q1/70 ,  G01N33/569

CPC分类号： G01N33/5035 ,  A61K31/55 ,  A61K31/566 ,  A61K31/5685 ,  C12N2760/14034 ,  C12N2760/14111 ,  C12N2760/14211 ,  C12N2760/20243 ,  C12Q1/70 ,  G01N33/56983

摘要： Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.

摘要翻译： 使用抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4的药物治疗患有病毒感染的受试者的方法和测定法。 用于筛选治疗和/或预防患有病毒感染受试者的药剂的方法，其中所述方法包括确定该药物是否抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39中的一种或多种 ，VPS41。 BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4，其中抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4中的一种或多种的药剂是 治疗和/或预防感染病毒，并且其中不抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A的药剂。 VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4不是用于治疗和/或预防感染病毒的候选物。

公开(公告)号：US20130231332A1

公开(公告)日：2013-09-05

申请号：US13818790

申请日：2011-09-01

申请人： James Cunningham ,  Kyungae Lee ,  Tao Ren ,  Kartik Chandran

发明人： James Cunningham ,  Kyungae Lee ,  Tao Ren ,  Kartik Chandran

IPC分类号： C07D401/04 ,  C07D211/58 ,  C07D207/08 ,  C07C311/29 ,  C07D243/08 ,  C07D207/14

CPC分类号： C07D417/04 ,  C07C311/29 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D211/58 ,  C07D243/08 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04

摘要： The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.

摘要翻译： 本发明涉及用于治疗包膜病毒如埃博拉和拉萨热病毒感染的组合物和方法。

公开(公告)号：US20100233777A1

公开(公告)日：2010-09-16

申请号：US12681123

申请日：2008-10-06

申请人： Kartik Chandran ,  Ran Yu ,  Joon Ho Ahn

发明人： Kartik Chandran ,  Ran Yu ,  Joon Ho Ahn

IPC分类号： C12P3/00 ,  C12M1/34

CPC分类号： C02F3/006 ,  C02F3/02 ,  C02F2101/16 ,  C02F2103/001 ,  C02F2103/06 ,  C02F2103/20 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/22 ,  C02F2209/44 ,  C02F2303/00 ,  Y02W10/15

摘要： Methods of controlling a nitrification reaction in a biological nitrogen removal reactor to favor partial nitrification of ammonia to nitrite instead of complete oxidation of ammonia to nitrate are disclosed. In some embodiments, the methods include the following: maintaining a pH in the reactor within a range that promotes growth of ammonia oxidizing bacteria; maintaining a concentration of dissolved oxygen in the reactor within a range that limits the ammonia oxidizing bacteria from completing nitrification; selecting an operational solids retention time within a range suitable for maintaining increasing concentrations of the ammonia oxidizing bacteria in the reactor while reducing concentrations of nitrite oxidizing bacteria in the reactor; and increasing a concentration of free ammonia in the reactor thereby inhibiting growth of the nitrite oxidizing bacteria in the reactor.

摘要翻译： 公开了在生物除氮反应器中控制硝化反应以有利于将氨部分硝化成亚硝酸盐而不是氨完全氧化成硝酸盐的方法。 在一些实施方案中，所述方法包括以下步骤：将反应器中的pH保持在促进氨氧化细菌生长的范围内; 在限制氨氧化细菌完成硝化的范围内保持反应器中溶解氧的浓度; 选择在适于维持反应器中氨氧化细菌浓度增加的范围内的操作固体停留时间，同时减少反应器中亚硝酸盐氧化细菌的浓度; 并增加反应器中游离氨的浓度，从而抑制反应器中亚硝酸盐氧化细菌的生长。

公开(公告)号：US20060120369A1

公开(公告)日：2006-06-08

申请号：US11327006

申请日：2006-01-06

申请人： Kartik Chandran ,  Prashant Gandhi

发明人： Kartik Chandran ,  Prashant Gandhi

IPC分类号： H04L12/56

CPC分类号： H04L12/18

摘要： A method and apparatus for providing quality of service parameters for transmissions of multicast streams on a cable network is provided. A cable network headend connects an external network to a hybrid fiber coax or cable network. The cable network headend maintains a table of cable modems with entries associating each cable modem with one or more quality of service parameters. Virtual cable modem entries are created for multicast streams when indications of quality of service for multicast streams are received by the cable network headend. Multicast packets arriving at the cable network headend are processed using the stored quality of service parameters for the corresponding multicast stream. The multicast packets may then be transmitted, queued, or dropped depending on the specified parameters and traffic shaping or policing algorithms.

公开(公告)号：US20110015082A1

公开(公告)日：2011-01-20

申请号：US12679582

申请日：2008-10-06

申请人： Kartik Chandran ,  Ran Yu

发明人： Kartik Chandran ,  Ran Yu

IPC分类号： C40B30/00 ,  C40B60/12

CPC分类号： C02F3/006 ,  C02F3/302 ,  C02F2209/005

摘要： Systems and methods for evaluating the operating conditions in a biological nitrogen removal reactor using gene expression and abundance tracking are disclosed. In some embodiments, the systems and methods include the following: obtaining a sample from the reactor during continuous reactor operation; expressing predetermined nitrification, denitrification, and structural genes for ammonia oxidizing bacteria contained in the sample to develop a sample genetic profile of the ammonia oxidizing bacteria; obtaining a genetic profile of a second bacteria substantially similar to the ammonia oxidizing bacteria, wherein the second bacteria was grown in a reactor having substantially optimum operating conditions; and comparing the sample genetic profile to the genetic profile of the second bacteria.

摘要翻译： 公开了使用基因表达和丰度跟踪来评估生物除氮反应器中的操作条件的系统和方法。 在一些实施例中，系统和方法包括以下：在连续反应器操作期间从反应器获得样品; 表达样品中所含的氨氧化细菌的预定硝化，反硝化和结构基因，以形成氨氧化细菌的样品遗传图谱; 获得与氨氧化细菌基本相似的第二细菌的遗传图谱，其中第二细菌在具有基本上最佳操作条件的反应器中生长; 并将样品遗传图谱与第二细菌的遗传图谱进行比较。

公开(公告)号：US20100040916A1

公开(公告)日：2010-02-18

申请号：US12301056

申请日：2007-05-31

申请人： Marco J. Castaldi ,  Kartik Chandran

发明人： Marco J. Castaldi ,  Kartik Chandran

IPC分类号： H01M8/04 ,  H01M8/18 ,  C01B3/06 ,  B01J19/00

CPC分类号： C12P3/00 ,  Y02P20/128

摘要： Methods and systems for producing hydrogen from a biomass are disclosed. In some embodiments, the method includes decomposing a biomass to produce an aqueous effluent including nitrogen species, generating ammonia from the nitrogen species, combusting the ammonia in the presence of catalysts to decompose the ammonia to hydrogen and nitrogen, and combusting a portion of the hydrogen and the nitrogen to provide heat for combusting the ammonia. In some embodiments, the system includes a bioreactor for decomposing a biomass to produce an aqueous effluent including nitrogen species, a mechanism for generating ammonia gas from the nitrogen species, a catalytic reforming reactor for converting the ammonia gas to hydrogen gas and nitrogen gas, a combustor for combusting a portion of the hydrogen gas and the nitrogen gas to provide heat for converting the ammonia gas, and a separator for isolating the hydrogen gas.

摘要翻译： 公开了从生物质生产氢的方法和系统。 在一些实施方案中，该方法包括分解生物质以产生包含氮物质的含水流出物，从氮物种产生氨，在催化剂存在下燃烧氨以将氨分解成氢和氮，并将一部分氢 和氮气以提供用于燃烧氨的热量。 在一些实施方案中，该系统包括用于分解生物质以产生包含氮物质的含水流出物的生物反应器，用于从氮物质产生氨气的机理，用于将氨气转化为氢气和氮气的催化重整反应器， 用于燃烧一部分氢气和氮气以提供用于转化氨气的热量的燃烧器和用于分离氢气的隔板。

公开(公告)号：US07620055B1

公开(公告)日：2009-11-17

申请号：US11484382

申请日：2006-07-10

申请人： Kartik Chandran ,  Chrisanto Leano ,  Sunil Khaunte ,  Jerry D. Goodrich ,  Kelly Schaefer

发明人： Kartik Chandran ,  Chrisanto Leano ,  Sunil Khaunte ,  Jerry D. Goodrich ,  Kelly Schaefer

IPC分类号： H04L12/28 ,  H04L12/56 ,  H04J3/12 ,  H04N7/173

CPC分类号： H04L12/2801 ,  H04L45/50 ,  H04L47/10 ,  H04L47/2441

摘要： A method of using DOCSIS 1.1 features to allow the addition of ISPs and QOS levels to a single cable modem without having to modify the CMTS is described in the various figures. Instead of using the SID of a data packet to determine the VPN tag of a data packet (DOCSIS 1.0), a service flow is used to identify the appropriate tag. This is done using the DOCSIS 1.1 configuration file. By doing so, the need for creating additional sub-interfaces in the cable modem interface does not arise. Instead, the configuration is modified at the provisioning server, i.e., the DHCP/TFTP server.

摘要翻译： 在各图中描述了使用DOCSIS 1.1特征来允许在单个电缆调制解调器上添加ISP和QOS电平而不必修改CMTS的方法。 代替使用数据包的SID来确定数据包（DOCSIS 1.0）的VPN标签，使用服务流来标识适当的标签。 这是使用DOCSIS 1.1配置文件完成的。 通过这样做，不需要在有线调制解调器接口中创建附加的子接口。 而是在配置服务器，即DHCP / TFTP服务器上修改配置。

公开(公告)号：US20090053263A1

公开(公告)日：2009-02-26

申请号：US11884901

申请日：2006-02-23

申请人： James Cunningham ,  Kartik Chandran

发明人： James Cunningham ,  Kartik Chandran

IPC分类号： A61K38/16 ,  A61K39/12 ,  A61K31/7105 ,  A61P31/12

CPC分类号： A61K35/55 ,  C07K14/8139

摘要： The present invention relates to treatment of infection by enveloped viruses through the use of papain-like cysteine protease inhibitors and kits thereof. Specifically, methods for treatment of filoviruses as well as other enveloped viruses such as Nipah, in particular using cathepsin inhibitors are described.

摘要翻译： 本发明涉及通过使用木瓜蛋白酶半胱氨酸蛋白酶抑制剂及其试剂盒来治疗包膜病毒的感染。 具体地，描述了用于治疗丝状病毒以及其它包膜病毒如Nipah的方法，特别是使用组织蛋白酶抑制剂的方法。

公开(公告)号：US20140339157A1

公开(公告)日：2014-11-20

申请号：US14083549

申请日：2013-11-19

申请人： Kartik Chandran ,  Ran Yu ,  Joon Ho Ahn

发明人： Kartik Chandran ,  Ran Yu ,  Joon Ho Ahn

IPC分类号： C02F3/00 ,  C02F3/02

CPC分类号： C02F3/006 ,  C02F3/02 ,  C02F2101/16 ,  C02F2103/001 ,  C02F2103/06 ,  C02F2103/20 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/22 ,  C02F2209/44 ,  C02F2303/00 ,  Y02W10/15

摘要： Methods of controlling a nitrification reaction in a biological nitrogen removal reactor to favor partial nitrification of ammonia to nitrite instead of complete oxidation of ammonia to nitrate are disclosed. In some embodiments, the methods include the following: maintaining a pH in the reactor within a range that promotes growth of ammonia oxidizing bacteria; maintaining a concentration of dissolved oxygen in the reactor within a range that limits the ammonia oxidizing bacteria from completing nitrification; selecting an operational solids retention time within a range suitable for maintaining increasing concentrations of the ammonia oxidizing bacteria in the reactor while reducing concentrations of nitrite oxidizing bacteria in the reactor; and increasing a concentration of free ammonia in the reactor thereby inhibiting growth of the nitrite oxidizing bacteria in the reactor.

摘要翻译： 公开了在生物除氮反应器中控制硝化反应以有利于将氨部分硝化成亚硝酸盐而不是氨完全氧化成硝酸盐的方法。 在一些实施方案中，所述方法包括以下步骤：将反应器中的pH保持在促进氨氧化细菌生长的范围内; 在限制氨氧化细菌完成硝化的范围内保持反应器中溶解氧的浓度; 选择在适于维持反应器中氨氧化细菌浓度增加的范围内的操作固体停留时间，同时减少反应器中亚硝酸盐氧化细菌的浓度; 并增加反应器中游离氨的浓度，从而抑制反应器中亚硝酸盐氧化细菌的生长。