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公开(公告)号：US20090181982A1
公开(公告)日：2009-07-16
申请号：US12401764
申请日：2009-03-11
Applicant: Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
Inventor： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC: A61K31/437 , C07D471/04 , A61K31/497 , A61K31/506
CPC classification number: C07D471/04
Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US20090176806A1
公开(公告)日：2009-07-09
申请号：US12401777
申请日：2009-03-11
Applicant: Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
Inventor： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC: A61K31/497 , C07D403/14 , A61K31/437 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/506
CPC classification number: C07D471/04
Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
Abstract translation: 本发明涉及用作激酶抑制剂的新型取代的吡咯啉化合物和用于治疗或改善激酶介导的病症的方法。
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公开(公告)号：US20080176912A1
公开(公告)日：2008-07-24
申请号：US11939039
申请日：2007-11-13
Applicant: Gee-Hong Kuo , Fengbin Song , Joseph Gunnet , Keith Demarest
Inventor： Gee-Hong Kuo , Fengbin Song , Joseph Gunnet , Keith Demarest
IPC: A61K31/426 , A61K31/421 , A61K31/34 , A61K31/381 , A61K31/192 , C07D333/24 , C07D277/22 , C07D263/30
CPC classification number: C07D333/24 , C07C59/64 , C07C59/72
Abstract: The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.
Abstract translation: 本发明涉及用作GPR40激动剂的式（I）化合物。 使用本发明化合物治疗一种或多种病症的药物组合物和方法，包括但不限于胰岛素抵抗，高血糖症，肥胖症，糖尿病如NIDDM，以及与脂质代谢相关的其它障碍，能量稳态及其并发症， 也描述。
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公开(公告)号：US20080076754A1
公开(公告)日：2008-03-27
申请号：US11857954
申请日：2007-09-19
Applicant: Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
Inventor： Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
IPC: A61K31/55 , A61P25/00 , A61P9/00 , C07D471/10 , C07D487/10
CPC classification number: C07D487/10
Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
Abstract translation: 本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。 包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾衰竭，糖尿病性肾病，脑水肿，脑缺血， 中风，血栓形成或保水性也被公开。
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公开(公告)号：US20070213387A1
公开(公告)日：2007-09-13
申请号：US11800912
申请日：2007-05-08
Applicant: Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
Inventor： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
IPC: A61K31/415 , A61K31/40
CPC classification number: C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
Abstract translation: 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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Patent Agency Ranking
公开(公告)号：US06828327B2
公开(公告)日：2004-12-07
申请号：US10008982
申请日：2001-12-06
Applicant: Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
Inventor： Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
IPC: A61K3144
CPC classification number: C07D471/22 , C07D487/22 , C07D498/22 , C07D515/22
Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
Abstract translation: 本发明涉及可用作激酶或双重激酶抑制剂的大量杂环化合物，用于制备此类化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US20090318332A1
公开(公告)日：2009-12-24
申请号：US12549426
申请日：2009-08-28
Applicant: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
Inventor： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
CPC classification number: C07C59/68 , C07C323/20
Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
Abstract translation: 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号：US20070197590A1
公开(公告)日：2007-08-23
申请号：US11669284
申请日：2007-01-31
Applicant: Duane DeMong , Mingde Xia , Scott Pollack , Xiaoping Zheng , James Brackley , Michael Wachter , Druie Cavender , Keith Demarest
Inventor： Duane DeMong , Mingde Xia , Scott Pollack , Xiaoping Zheng , James Brackley , Michael Wachter , Druie Cavender , Keith Demarest
IPC: A61K31/4545 , C07D401/14
CPC classification number: C07D401/14 , C07D211/26 , C07D211/48 , C07D405/14 , C07D471/04
Abstract: Substituted dipiperidine compounds of Formula (I) or a form thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
Abstract translation: 式（I）的取代二哌啶化合物或其形式，其是CCR2拮抗剂，并且可用于预防，治疗或改善有需要的受试者中CCR2介导的炎性综合征，病症或疾病。
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公开(公告)号：US20060094786A1
公开(公告)日：2006-05-04
申请号：US11145358
申请日：2005-06-03
Applicant: Xiaoli Chen , Keith Demarest , Jung Lee , Jay Matthews , Philip Rybczynski
Inventor： Xiaoli Chen , Keith Demarest , Jung Lee , Jay Matthews , Philip Rybczynski
IPC: A61K31/195 , C07C317/22
CPC classification number: C07C275/34 , C07C323/52 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10
Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
Abstract translation: 本发明具有四氢化萘和二氢化茚化合物，含有它们的组合物，以及使用它们作为PPARα调节剂来治疗或抑制例如糖尿病进展的方法。
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公开(公告)号：US20060058382A1
公开(公告)日：2006-03-16
申请号：US11226645
申请日：2005-09-14
Applicant: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
Inventor： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC: A61K31/277 , A61K31/192 , A61K31/195 , C07C255/40 , C07C59/64
CPC classification number: C07C59/68 , C07C323/20
Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
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