Patent search ap:"Longcheng Wang" Page 2

11.

发明授权
Protein kinase modulators and methods of use 失效
Title translation: 蛋白激酶调节剂和使用方法

公开(公告)号：US07704995B2

公开(公告)日：2010-04-27

申请号：US10513081

申请日：2003-05-02

Applicant: Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller

Inventor： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller

IPC: C07D279/16 , C07D279/12 , C07D417/12 , C07D265/36 , C07D413/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D419/12 , C07D241/18 , C07D241/20 , A61K31/55 , A61K31/497 , A61K31/5355 , A61K31/541 , C07D305/12 , C07D307/79 , A61K31/44 , A61P35/00

CPC classification number: C07D241/26 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12

Abstract: This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

Abstract translation: 本发明涉及用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物，以及含有这些化合物的药物组合物。更具体地，本发明涉及抑制，调节和/或调节激酶，特别是检查点激酶，甚至更特别是检查点激酶1或Chk1的化合物。治疗或预防性地使用化合物和组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面，并且包括通过以下方法治疗癌症以及与不期望的血管生成和/或细胞增殖相关的其它疾病状态，施用有效量的这些化合物。

12.

发明申请
Pyridopyrimidinone inhibitors of pi3kalpha 失效
Title translation: pi3kalpha的吡啶并嘧啶酮抑制剂

公开(公告)号：US20090062274A1

公开(公告)日：2009-03-05

申请号：US11988859

申请日：2006-10-09

Applicant: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung

Inventor： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K.S. Yeung

IPC: A61K31/5377 , C07D471/04 , A61K31/519

CPC classification number: C07D471/04

Abstract: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

13.

发明申请
INHIBITORS OF BRUTON'S TYROSINE KINASE 有权
Title translation: BRUTON的酪氨酸激酶抑制剂

公开(公告)号：US20160002225A1

公开(公告)日：2016-01-07

申请号：US14790978

申请日：2015-07-02

Applicant: Wei CHEN , Longcheng WANG , Shunqi YAN , David J. LOURY , Zhaozhong J. JIA , Leah Lynn FRYE , Jeremy Robert GREENWOOD , Mee Yoo SHELLEY , Gordana Babic ATALLAH , Riccardo ZANALETTI , Maria Pia CATALANI , Luca Francesco RAVEGLIA

Inventor： Wei CHEN , Longcheng WANG , Shunqi YAN , David J. LOURY , Zhaozhong J. JIA , Leah Lynn FRYE , Jeremy Robert GREENWOOD , Mee Yoo SHELLEY , Gordana Babic ATALLAH , Riccardo ZANALETTI , Maria Pia CATALANI , Luca Francesco RAVEGLIA

IPC: C07D471/04 , C07D519/00 , C07D471/06 , C07D487/04

CPC classification number: C07D471/04 , C07D471/06 , C07D487/04 , C07D519/00

Abstract: Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract translation: 本文公开了抑制Bruton酪氨酸激酶（Btk）的化合物。还描述了Btk的不可逆抑制剂。此外，还描述了Btk的可逆抑制剂。还公开了包含化合物的药物组合物。公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

14.

发明申请
Pyridopyrimidinone Inhibitors of PI3Kalpha 审中-公开
Title translation: 吡啶并嘧啶酮PI3Kα的抑制剂

公开(公告)号：US20110237608A1

公开(公告)日：2011-09-29

申请号：US13152045

申请日：2011-06-02

Applicant: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

Inventor： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Morrison Mac , John M. Nuss , Longcheng Wang , Yong Wang , Bryan K.S. Yeung

IPC: A61K31/519 , C07D471/04 , A61P35/00 , A61P35/02

CPC classification number: C07D471/04 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/4858

Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

15.

发明授权
Formation of p-n homogeneous junctions 有权
Title translation: 形成p-n均质结

公开(公告)号：US07768003B2

公开(公告)日：2010-08-03

申请号：US11855568

申请日：2007-09-14

Applicant: Meng Tao , Longcheng Wang

Inventor： Meng Tao , Longcheng Wang

IPC: H01L29/10

CPC classification number: H01L31/068 , H01L31/032 , H01L31/0445 , H01L31/18 , Y02E10/547

Abstract: Methods, structures and devices are described, in which structures and devices have one or more p-n homo-junctions fabricated in solution. The junctions are formed by a sequential deposition of an oxide of copper from solution. Conduction type of the oxide of copper is controlled by pH of the solution.

Abstract translation: 描述了方法，结构和装置，其中结构和装置在溶液中制造了一个或多个p-n均聚点。通过从溶液中顺次沉积铜的氧化物形成结。铜的氧化物的传导类型由溶液的pH控制。

16.

发明申请
INHIBITORS OF BRUTON'S TYROSINE KINASE 有权

公开(公告)号：US20130018032A1

公开(公告)日：2013-01-17

申请号：US13549267

申请日：2012-07-13

Applicant: Wei CHEN , David J. Loury , Tarak D. Mody , Longcheng Wang

Inventor： Wei CHEN , David J. Loury , Tarak D. Mody , Longcheng Wang

IPC: A61K31/519 , A61P29/00 , A61P35/00 , A61P37/00 , C07D487/04 , A61K31/553

CPC classification number: C07D487/04 , A61K31/52 , C07D473/34

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

17.

发明授权
Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer 失效
Title translation: 用于治疗癌症的PI3Kα吡啶并嘧啶酮抑制剂

公开(公告)号：US08247408B2

公开(公告)日：2012-08-21

申请号：US11988859

申请日：2006-10-09

Applicant: Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung

Inventor： Tae-Gon Baik , Chris A. Buhr , Katherine Lara , Sunghoon Ma , Longcheng Wang , Bryan K. S. Yeung

IPC: C07D471/04 , C07D471/14 , C07D413/14 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P29/00 , A61P3/10

CPC classification number: C07D471/04

Abstract: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。