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公开(公告)号：US20080102522A1
公开(公告)日：2008-05-01
申请号：US11924661
申请日：2007-10-26
CPC分类号： C12N5/0605 , C12N5/0629 , C12N5/0652 , C12N5/069 , C12N5/0691 , C12N2509/00
摘要： The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterised and utilised in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are used to form a tissue replacement or engineered living composition. Also, the isolated umbilical cells of the invention may have the potential of progenitor cells.
摘要翻译： 本发明涉及一种从单一脐带中分离四种细胞类型的纯化方法。 这些细胞系（上皮细胞，成纤维细胞，平滑肌细胞和内皮细胞）可用于实验模型和治疗目的。 特别地，本文分离的脐带细胞用于形成组织替代或工程生物组合物。 此外，本发明的分离的脐带细胞可能具有祖细胞的潜力。
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公开(公告)号：US07347872B2
公开(公告)日：2008-03-25
申请号：US10678167
申请日：2003-10-06
申请人： Francine Goulet , Denis Rancourt , Rejean Cloutier , Julie Tremblay , Francois A. Auger , Constance Guillemette, legal representative , Lucie Germain , Jean Lamontagne , Marc Bouchard , Eve Langelier , Daniel Dupuis , Stephanie Bouchard , Nazrul Islam , Louis-Mathieu Stevens , Sheila Laverty , Bertrand Lussier , Anne-Marie Belzil , Pierrot Tremblay
发明人： Albert Normand
IPC分类号： A61F2/08
CPC分类号： A61L27/3886 , A61F2/08 , A61F2/0811 , A61L27/24 , A61L27/3608 , A61L27/3641 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3843 , A61L27/386 , C12N5/066 , C12N2533/54
摘要： The present invention relates to connective tissue substitute implant and method of preparation thereof. The implant is essentially composed of two bone anchors joined at the proximal ends by matrix layers and/or filaments coated by supplementary biocompatible matrix coating layer which can contain living stem cells isolated from injured connective tissue.
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13.发明授权Method and apparatus for inducing controlled mechanical constraints in a tissue construct 失效用于在组织构建体中诱导受控机械约束的方法和装置公开(公告)号：US07906322B2
公开(公告)日：2011-03-15
申请号：US10866708
申请日：2004-06-15
申请人： François Bergeron , Lucie Germain , François Auger
发明人： François Bergeron , Lucie Germain , François Auger
摘要： A method and a device (10) for reorganizing the fibers of a matrix in a living tissue sheet (S) by inducing controlled mechanical constraints in the living tissue (S) sheet thus causing the fibers of the matrix to be aligned parallel to the strain orientation. The sheet (S) is held in a stretched state until the fibers set in place.
摘要翻译： 一种方法和装置（10），用于通过在活组织（S）片中引起受控的机械约束来重新组织活组织片（S）中的基质的纤维，从而使基质的纤维平行于菌株 方向。 片材（S）保持在拉伸状态，直到纤维固定就位。
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公开(公告)号：US20090169642A1
公开(公告)日：2009-07-02
申请号：US12089590
申请日：2006-10-13
申请人： Julie Fradette , Lucie Germain , Francois A. Auger
发明人： Julie Fradette , Lucie Germain , Francois A. Auger
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/35 , A61K48/00 , A61L27/3804 , A61L27/3839 , A61L27/60 , C12N5/0698 , C12N2500/38 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2501/395 , C12N2502/094 , C12N2502/1305 , C12N2502/1323
摘要： The present invention relates to tissues and tissue sheets assembled from adipose-derived stromal cells. Particularly, it relates to reconstructed adipose tissues which comprise adipocytes as well as reconstructed conjunctive tissues which comprise adipose-derived stromal cells. The reconstructed tissues and sheets can be used, for example, in cosmetic applications for the replacement or addition of soft tissues, in pharmacological and toxicological applications for the in vitro testing of small molecules or cosmetic products as well as in therapeutic applications for the delivery of agents.
摘要翻译： 本发明涉及由脂肪来源的基质细胞组装的组织和组织片。 特别地，其涉及包含脂肪细胞的重建脂肪组织以及包含脂肪来源的基质细胞的重建的结合组织。 重建的组织和片材可用于例如用于替换或添加软组织的化妆品应用，用于药物和毒理学应用中用于小分子或化妆品的体外测试以及用于递送 代理商
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15.发明申请Method and apparatus for inducing controlled mechanical constraints in a tissue construct 失效用于在组织构建体中诱导受控机械约束的方法和装置公开(公告)号：US20050019897A1
公开(公告)日：2005-01-27
申请号：US10866708
申请日：2004-06-15
申请人： Francois Bergeron , Lucie Germain , Francois Auger
发明人： Francois Bergeron , Lucie Germain , Francois Auger
IPC分类号： C12M3/00
摘要： A method and a device (10) for reorganizing the fibers of a matrix in a living tissue sheet (S) by inducing controlled mechanical constraints in the living tissue (S) sheet thus causing the fibers of the matrix to be aligned parallel to the strain orientation. The sheet (S) is held in a stretched state until the fibers set in place.
摘要翻译： 一种方法和装置（10），用于通过在活组织（S）片中引起受控的机械约束来重新组织活组织片（S）中的基质的纤维，从而使基质的纤维平行于菌株 方向。 片材（S）保持在拉伸状态，直到纤维固定就位。
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