-
公开(公告)号：US20050170501A1
公开(公告)日：2005-08-04
申请号：US10511433
申请日：2003-04-24
申请人： Francois Auger , Francois Bergeron , Lucie Germain
发明人： Francois Auger , Francois Bergeron , Lucie Germain
CPC分类号： C12N5/0691 , C12N5/0697 , C12N2502/1323 , C12N2502/28
摘要： The present invention relates to a method of assembling a single living tissue sheet formed of different cell populations. According to this invention at least two cell populations composing at least two living tissue sheets can be assembled into a single continuous tissue construct. The cells of this construct can also be autologous or heterologous depending on the needs and the type of implant to be transferred in a recipient patient.
摘要翻译： 本发明涉及组装由不同细胞群形成的单个活组织片的方法。 根据本发明，构成至少两个活组织片的至少两个细胞群可以组装成单个连续的组织构建体。 这种构建体的细胞也可以是自体的或异源的，这取决于在受体患者中要转移的植入物的需要和类型。
-
公开(公告)号：US5610007A
公开(公告)日：1997-03-11
申请号：US7318
申请日：1993-01-21
CPC分类号： A61L27/3813 , A61L27/60 , C12N5/0629 , A61K35/12 , C12N2500/16 , C12N2501/11 , Y10S623/915
摘要： A process for culturing and generating a chimeric cell culture, in particular chimeric epithelium, is disclosed. The chimeric epithelium can be used to treat skin trauma such as burn victims. Autologous epithelial grafts have been used on burn patients although this requires that the patient's cells are cultured and expanded in vitro which generally takes four to five weeks. The chimeric epithelium of the present invention is composed of cells that are both autologous and allogeneic to the host. Therefore, the allogeneic cells can be maintained in a cell bank and co-cultured with autologous host cells when needed. This significantly reduces the time required (by up to 50%) for autologous cell expansion and culture prior to grafting. Furthermore, it has been demonstrated that the allogeneic cells are passively eliminated from the graft without rejection of the total graft.
摘要翻译： 公开了一种培养和产生嵌合细胞培养物，特别是嵌合上皮的方法。 嵌合上皮可用于治疗皮肤损伤，如烧伤受害者。 自体上皮移植物已经用于烧伤患者，尽管这要求患者的细胞在体外培养和扩增，通常需要四至五周。 本发明的嵌合上皮由对宿主自体和同种异体的细胞组成。 因此，当需要时，同种异体细胞可以保持在细胞库中并与自体宿主细胞共培养。 这显着减少了移植前自体细胞扩增和培养所需的时间（高达50％）。 此外，已经证明，同种异体细胞被从移植物被动消除而不排斥总移植物。
-
公开(公告)号：US20070111307A1
公开(公告)日：2007-05-17
申请号：US11603865
申请日：2006-11-24
申请人： Francois Auger , Francois Bergeron , Lucie Germain
发明人： Francois Auger , Francois Bergeron , Lucie Germain
CPC分类号： C12N5/0691 , C12N5/0697 , C12N2502/1323 , C12N2502/28
摘要： The present invention relates to a method of assembling a single living tissue sheet formed of different cell populations. According to this invention at least two cell populations composing at least two living tissue sheets can be assembled into a single continuous tissue construct The cells of this construct can also be autologous or heterologous depending on the needs and the type of implant to be transferred in a recipient patient.
摘要翻译： 本发明涉及组装由不同细胞群形成的单个活组织片的方法。 根据本发明，构成至少两个活组织片的至少两个细胞群可以组装成单个连续组织构建体。该构建体的细胞也可以是自体的或异源的，这取决于待转移的植入物的需要和类型 受试者。
-
公开(公告)号：US20070005138A9
公开(公告)日：2007-01-04
申请号：US09990320
申请日：2001-11-23
申请人： Francine Goulet , Denis Rancourt , Rejean Cloutier , Julie Tremblay , Francois Auger , Albert Normand , Lucie Germain , Jean Lamontagne , Marc Bouchard , Eve Langelier , Daniel Dupuis , Stephane Bouchard , Nazrul Islam , Louis-Mathieu Stevens , Sheila Laverty , Bertrand Lussier , Anne-Marie Belzil , Pierrot Tremblay
发明人： Francine Goulet , Denis Rancourt , Rejean Cloutier , Julie Tremblay , Francois Auger , Albert Normand , Lucie Germain , Jean Lamontagne , Marc Bouchard , Eve Langelier , Daniel Dupuis , Stephane Bouchard , Nazrul Islam , Louis-Mathieu Stevens , Sheila Laverty , Bertrand Lussier , Anne-Marie Belzil , Pierrot Tremblay
IPC分类号： A61F2/08
CPC分类号： A61L27/3886 , A61F2/08 , A61F2/0811 , A61L27/24 , A61L27/3608 , A61L27/3641 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3843 , A61L27/386 , C12N5/066 , C12N2533/54
摘要： The present invention relates to connective tissue substitute implant and method of preparation thereof. The implant is essentially composed of two bone anchors joined at the proximal ends by matrix layers and/or filaments coated by supplementary biocompatible matrix coating layer which can contain living stem cells isolated from injured connective tissue.
摘要翻译： 本发明涉及结缔组织替代植入物及其制备方法。 植入物基本上由两个骨锚固件组成，其中基质层和/或由附加的生物相容性基质涂层所覆盖的细丝在近端连接，所述辅助生物相容性基质涂层可包含从损伤的结缔组织分离的活的干细胞。
-
公开(公告)号：US20060199263A1
公开(公告)日：2006-09-07
申请号：US11314153
申请日：2005-12-21
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , C12N5/0629 , C12N5/0652 , C12N5/069 , C12N5/0691 , C12N2509/00
摘要： The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterised and utilised in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are used to form a tissue replacement or engineered living composition. Also, the isolated umbilical cells of the invention may have the potential of progenitor cells.
摘要翻译： 本发明涉及一种从单一脐带中分离四种细胞类型的纯化方法。 这些细胞系（上皮细胞，成纤维细胞，平滑肌细胞和内皮细胞）可用于实验模型和治疗目的。 特别地，本文分离的脐带细胞用于形成组织替代或工程生物组合物。 此外，本发明的分离的脐带细胞可能具有祖细胞的潜力。
-
公开(公告)号：US20060128010A1
公开(公告)日：2006-06-15
申请号：US10522010
申请日：2002-07-16
CPC分类号： C12N5/0062
摘要： A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is applied in direction normal to the surface of the tissue. A multi-layer tissue produced by the method decribed above can also possess at least two different types of sheets and/or consist essentially of between two and twelve sheets of living tissue. The method can also be used to prepare a planar tissue that can further be incorporated in a multi-layer tissue construct. The methods and tissues described herein are useful for the preparation of engineered tissues.
摘要翻译： 一种通过向生物体组织堆叠施加压缩力来制备人或动物组织的方法，从而导致相邻层彼此熔合或粘附。 力沿垂直于组织表面的方向施加。 通过上述方法生产的多层组织也可以具有至少两种不同类型的片材和/或基本上由两片和12片生物组织组成。 该方法也可用于制备可以进一步掺入多层组织结构中的平面组织。 本文所述的方法和组织可用于制备工程组织。
-
公开(公告)号：US20050079604A1
公开(公告)日：2005-04-14
申请号：US10495748
申请日：2002-11-27
申请人： Lucie Germain , Francois Auger , Guillaume Grenier , Danielle Larouche , Murielle Remy-Zolghadri , Francois Bergeron
发明人： Lucie Germain , Francois Auger , Guillaume Grenier , Danielle Larouche , Murielle Remy-Zolghadri , Francois Bergeron
CPC分类号： A61L27/3691 , A61L27/18 , A61L27/3604 , A61L27/60 , C12N5/0691 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C08L69/00
摘要： The present invention relates two new methods of improving the functionality of human or animal tissues by physically or biochemically treating the tissue prior to submitting it to different tests or before grafting it to a recipientpatient. Such a treated tissue is therefore rendered having a greater capability to resist to mechanical stress or shows a higher contractility.
摘要翻译： 本发明涉及通过在将其提交给不同的测试之前或在将其接枝到受体患者之前通过物理或生物化学处理组织来改善人或动物组织的功能的两种新方法。 因此，这样处理的组织具有更大的抵抗机械应力的能力或显示较高的收缩性。
-
公开(公告)号：US5618718A
公开(公告)日：1997-04-08
申请号：US368205
申请日：1994-12-30
CPC分类号： C12N5/0691 , C12N2503/00
摘要： A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that have been cultured in vitro under conditions to allow the formation of a sheet of smooth muscle cells and (ii) an endogenous fibrous matrix formed by the smooth muscle cells, wherein the smooth muscle cell construct retains the ability to contract in response to vasoactive agonists. The smooth muscle cell construct may be prepared in planar or tubular form and can be used to study or evaluate the contractile responses of smooth muscle cells.
摘要翻译： 描述了收缩性平滑肌细胞构建体和制备平滑肌细胞构建体的方法。 平滑肌细胞构建体包括（i）已经在允许形成平滑肌细胞片的条件下体外培养的平滑肌细胞和（ii）由平滑肌细胞形成的内源性纤维基质，其中 平滑肌细胞构建物保留响应于血管活性激动剂而收缩的能力。 平滑肌细胞构建体可以以平面或管状形式制备，并且可用于研究或评估平滑肌细胞的收缩反应。
-
公开(公告)号：US07939323B2
公开(公告)日：2011-05-10
申请号：US11924661
申请日：2007-10-26
CPC分类号： C12N5/0605 , C12N5/0629 , C12N5/0652 , C12N5/069 , C12N5/0691 , C12N2509/00
摘要： The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterized and utilized in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are used to form a tissue replacement or engineered living composition. Also, the isolated umbilical cells of the invention may have the potential of progenitor cells.
摘要翻译： 本发明涉及一种从单一脐带中分离四种细胞类型的纯化方法。 这些细胞系（上皮细胞，成纤维细胞，平滑肌细胞和内皮细胞）可用于实验模型和治疗目的。 特别地，本文分离的脐带细胞用于形成组织替代或工程生物组合物。 此外，本发明的分离的脐带细胞可能具有祖细胞的潜力。
-
公开(公告)号：US07521231B2
公开(公告)日：2009-04-21
申请号：US10522010
申请日：2003-07-16
CPC分类号： C12N5/0062
摘要： A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is applied in direction normal to the surface of the tissue. A multi-layer tissue produced by the method described above can also possess at least two different types of sheets and/or consist essentially of between two and twelve sheets of living tissue. The method can also be used to prepare a planar tissue that can further be incorporated in a multi-layer tissue construct. The methods and tissues described herein are useful for the preparation of engineered tissues.
摘要翻译： 一种通过向生物体组织堆叠施加压缩力来制备人或动物组织的方法，从而导致相邻层彼此熔合或粘附。 力沿垂直于组织表面的方向施加。 通过上述方法生产的多层织物还可以具有至少两种不同类型的片材和/或基本上由两片和12片生物组织组成。 该方法也可用于制备可以进一步掺入多层组织结构中的平面组织。 本文所述的方法和组织可用于制备工程组织。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.016 秒)
