公开(公告)号：US20230277736A1

公开(公告)日：2023-09-07

申请号：US18314951

申请日：2023-05-10

Applicant: Alfred Health ,  Monash University

Inventor： Mark FITZGERALD ,  Peter FINNEGAN ,  Wing CHIU ,  Nayeem CHOWDHURY ,  Nabil CHOWDHURY

IPC: A61M1/04 ,  A61B17/34

CPC classification number: A61M1/04 ,  A61B17/3462 ,  A61B17/3496 ,  A61B17/3403 ,  A61B17/3421 ,  A61B2017/00455

Abstract: A surgical system for use in establishing and maintaining an opening to an anatomical space of a body, the system comprising an obturator assembly having a cutting portion at a distal end and a cannula, the cannula being detachably coupled to the cutting portion and deployable into the anatomical space of a patient, the cannula comprises a locking portion, and a lengthwise extendable body; a valve assembly comprising a passage for receiving the cannula, a first end for coupling to a fluid extraction device and a second end for placement external and adjacent the anatomical space; a base comprising a plate for placement on a patient external and adjacent the anatomical space, the plate has an aperture configured for receiving the obturator assembly and coupling means located about the aperture for coupling with the valve assembly; and wherein, in use, the locking portion of the cannula is configured to be retained in the valve assembly with the extendable body extended into the anatomical space to facilitate a path for fluid extraction, and wherein the cannula comprises means for retaining the cannula in its extended state.

公开(公告)号：US20230270859A1

公开(公告)日：2023-08-31

申请号：US17906601

申请日：2021-03-19

Applicant: MONASH UNIVERSITY

Inventor： Joshua OOI ,  Peter EGGENHUIZEN ,  Eric MORAND

IPC: A61K39/00 ,  C07K14/725 ,  C07K16/28 ,  A61P37/06

CPC classification number: A61K39/4632 ,  C07K14/7051 ,  C07K16/2833 ,  A61K39/4611 ,  A61P37/06 ,  C07K2319/00 ,  A61K2239/13

Abstract: The present invention relates to compositions and methods for the treatment of lupus, particularly systemic lupus erythematosus. The present invention involves, amongst other things, a binding protein comprising a T cell receptor (TCR) α-chain variable (Vα or Valpha) domain and a TCR β-chain variable (Vβ or Vbeta) domain, wherein the binding protein is capable of binding to a complex of a fragment of a Smith protein and an HLA-DR15 or HLA-DR3 molecule.

公开(公告)号：US20230227580A1

公开(公告)日：2023-07-20

申请号：US18000557

申请日：2021-06-25

Applicant: MONASH UNIVERSITY ,  BAKER HEART AND DIABETES INSTITUTE

Inventor： Christoph HAGEMEYER ,  Erik WESTEIN ,  Thomas HOEFER ,  Robert ANDREWS ,  Elizabeth GARDINER

IPC: C07K16/36 ,  A61P7/02

CPC classification number: C07K16/36 ,  A61P7/02 ,  C07K2317/76 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622

Abstract: The invention also relates to antigen binding proteins and related fragments thereof for binding Von Willebrand factor (VWF) and uses thereof. In one aspect, the present invention provides an antigen binding protein comprising an antigen binding domain that binds to or specifically binds to Von Willebrand factor (VWF) under shear gradient conditions. Preferably, the antigen binding protein comprises an antigen binding domain that does not bind to VWF under constant shear conditions.

公开(公告)号：US20230220112A1

公开(公告)日：2023-07-13

申请号：US17772090

申请日：2020-10-28

Applicant: MONASH UNIVERSITY

Inventor： James Whisstock ,  Ruby Law ,  Adam Quek ,  Paul Conroy ,  Guojie Wu

IPC: C07K16/40 ,  A61P7/00

CPC classification number: C07K16/40 ,  A61P7/00 ,  C07K2317/92 ,  C07K2317/567 ,  C07K2317/565

Abstract: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.

公开(公告)号：US11557788B2

公开(公告)日：2023-01-17

申请号：US15930711

申请日：2020-05-13

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  Monash University

Inventor： Rana Mohtadi ,  Oscar Tutusaus ,  Douglas R. MacFarlane ,  Mega Kar

IPC: H01M10/05 ,  H01M10/056 ,  C07F5/02 ,  C07C217/08 ,  H01M10/0568 ,  H01M10/054 ,  H01M10/0525

Abstract: Electrolytes and electrochemical cells include a novel ionic liquid having a quaternary cation and a boron cluster anion. In some versions, the boron cluster anion will be a functionalized or unfunctionalized icosahedral boranyl or carboranyl anion. Electrochemical cells have an electrolyte including the ionic liquid. In some versions, the ionic liquid is used as a solvent to dissolve an ionic shuttle salt for transport of active material, with an optional co-solvent. Methods to synthesize the ionic liquid include contacting a boron cluster salt with a quaternary salt to form the ionic liquid by a metathesis reaction.

公开(公告)号：US20220403343A1

公开(公告)日：2022-12-22

申请号：US17779275

申请日：2019-11-26

Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA ,  MONASH UNIVERSITY

Inventor： Ryan LISTER ,  Sam BUCKBERRY ,  Jose POLO ,  Xiaodong LIU

IPC: C12N5/074

Abstract: The present invention relates to methods for producing an induced pluripotent stem (iPSC), the method comprising the following steps in order: culturing a somatic cell in a first culture condition adapted to promote the reprogramming of the cell towards a pluripotent state; culturing the cell in a second culture condition adapted to promote a hypomethylated DNA state in the cell; and culturing the cell in a third culture condition adapted to promote a primed pluripotent state, thereby producing an iPSC from a somatic cell. The invention also relates to cells and compositions resulting from those methods.

公开(公告)号：US20220389376A1

公开(公告)日：2022-12-08

申请号：US17776506

申请日：2020-11-13

Applicant: Monash University ,  National University of Singapore ,  Nantes Université

Inventor： Jose Polo ,  Xiaodong Liu ,  Kathryn Davidson ,  Owen Rackham ,  John F. Ouyang ,  Laurent David ,  Gael Castel

IPC: C12N5/073

Abstract: The present invention provides a method for reprogramming a human somatic cell to a cell exhibiting at least one characteristic of a trophoblast stem cell (TSC), the method comprising the following steps in order: a) increasing the protein expression of one or more factors in the somatic cell, wherein the factors are for reprogramming the somatic cell towards a pluripotent state; b) culturing the cell for a sufficient time and under conditions to allow the reprogramming of the cell towards a pluripotent state; c) contacting the cell with a culture medium suitable for sustaining trophoblast stem cells (TSC); and d) culturing the cell in the TSC medium for a sufficient time and under conditions to allow the cell to exhibit at least one characteristic of a TSC, thereby reprogramming the somatic cell to a cell exhibiting at least one characteristic of a TSC.

公开(公告)号：US20220372491A1

公开(公告)日：2022-11-24

申请号：US17772107

申请日：2020-10-28

Applicant: MONASH UNIVERSITY

Inventor： Denny COTTLE ,  Ian SMYTH ,  Ming Shen THAM

IPC: C12N15/113 ,  A61P13/12 ,  C12Q1/6883

Abstract: The present invention relates to compositions, methods, uses and kits for the treatment of renal cystogenesis. In particular, the compositions, methods, uses and kits are particularly useful, but not limited to, the treatment or prevention of Polycystic Kidney Disease. In one aspect, the prevent invention provides a method of minimising or delaying renal cystogenesis in a subject in need thereof, the method comprising inhibiting AKT in the subject, or reducing the level of Aurora kinase in the subject, thereby minimising or delaying renal cystogenesis.

公开(公告)号：US11441148B2

公开(公告)日：2022-09-13

申请号：US17411932

申请日：2021-08-25

Applicant: MONASH UNIVERSITY ,  MURDOCH UNIVERSITY

Inventor： Stephen Wilton ,  Merlin Christopher Thomas ,  Carlos Rosado ,  Raelene Jane Pickering

IPC: C12N15/113 ,  C12Q1/68

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

公开(公告)号：US20220270731A1

公开(公告)日：2022-08-25

申请号：US17399128

申请日：2021-08-11

Applicant: Florida Institute for Human and Machine Cognition, Inc. ,  Monash University Malaysia SON BHD

Inventor： Nik Nailah Abdullah ,  Anil K. Raj ,  Sergey V. Drakunov ,  William J. Clancey ,  David Steinhaus

IPC: G16H20/10 ,  G16H40/63

Abstract: An individualized machine learning model embedded on a mobile health application, coupled to autonomous workflow agents systems to operate as a small artificial intelligence program. The machine learning algorithm learns from small datasets—making it possible to compute real-time data even on a low-grade smartphone device. It predicts early worsening outcomes by extracting patterns (features) that correlate with the individual baseline changes in heart failure status. The workflow agents support dynamic machine learning model deployment to different devices and configurations for real-time prediction and intervention. The different device configurations include patients who own only a smartphone device, patients who own a smartphone and wearable/biosensors, and patients who own a smartphone and who have an implanted cardiac device.