公开(公告)号：US20060211017A1

公开(公告)日：2006-09-21

申请号：US11343797

申请日：2006-01-31

Applicant: Arul Chinnaiyan ,  Mark Rubin ,  Arun Sreekumar

Inventor： Arul Chinnaiyan ,  Mark Rubin ,  Arun Sreekumar

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: G01N33/57434 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S436/811 ,  Y10S436/813

Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.

公开(公告)号：US20050136493A1

公开(公告)日：2005-06-23

申请号：US10909035

申请日：2004-07-30

Applicant: Mark Rubin ,  Arul Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

Inventor： Mark Rubin ,  Arul Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

IPC: C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  C07K16/40 ,  C12Q1/48

CPC classification number: G01N33/57434 ,  C07K16/3069 ,  C07K16/40 ,  C12Q1/533 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y10S435/96 ,  Y10S436/813

Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the use of α-methylacyl-CoA racemase (AMACR) as a marker for prostate cancer detection and prognosis.

Abstract translation: 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 本发明还提供了可用于诊断，表征和治疗前列腺癌的新型标志物。 特别地，本发明提供了使用α-甲酰基-CoA消旋酶（AMACR）作为前列腺癌检测和预后的标记物的方法和组合物。

公开(公告)号：US08620935B2

公开(公告)日：2013-12-31

申请号：US13531337

申请日：2012-06-22

Applicant: Mark Rubin ,  Brian Hein

Inventor： Mark Rubin ,  Brian Hein

IPC: G06F7/00 ,  G06F17/30

CPC classification number: G06F17/30867 ,  G06F17/3053 ,  G06F17/30699 ,  G06Q30/02 ,  G06Q30/0277 ,  G06Q50/01 ,  H04L67/306

Abstract: An Internet or other online service is personalized or customized based on data collected for a user of a computing device. In one embodiment, a method includes: storing a plurality of person profiles for persons associated with communications received by a user of a computing device; receiving data associated with an online service; and filtering, using at least one processor, the data based on the plurality of person profiles, wherein the filtered data is for display to the user on the computing device.

Abstract translation: 基于针对计算设备的用户收集的数据来个人化或定制因特网或其他在线服务。 在一个实施例中，一种方法包括：存储与计算设备的用户接收到的通信相关联的人员的多个人简档; 接收与在线服务相关联的数据; 以及使用至少一个处理器来过滤基于所述多个人简档的数据，其中所述经过滤数据用于在所述计算设备上向所述用户显示。

公开(公告)号：US20120330394A1

公开(公告)日：2012-12-27

申请号：US13169553

申请日：2011-06-27

Applicant: Amit Dar ,  Mark Rubin ,  Shmuel Springer ,  Amir Cohen

Inventor： Amit Dar ,  Mark Rubin ,  Shmuel Springer ,  Amir Cohen

IPC: A61N1/04

CPC classification number: A61N1/0452 ,  A61F5/0102 ,  A61N1/0456 ,  A61N1/0484

Abstract: Devices and methods of treating a targeted body tissue by stimulating the body tissue with an electric current. In one embodiment, an apparatus includes an electrode carrier configured to be removably coupled to an interior surface of an orthosis. The electrode carrier includes a recess configured to matingly receive a portion of an electrode. The electrode carrier is electrically coupled to the electrode when the portion of the electrode is disposed within the recess. A connection member is electrically coupled to the electrode carrier and is configured to be releasably coupled to a surface of the orthosis. The electrode carrier is electrically coupled to the orthosis when the connection member is coupled to the orthosis. In some embodiments, the electrode carrier is configured to be removably coupled to the interior surface of the orthosis. In some embodiments, at least a portion of the electrode is constructed of an absorptive material.

Abstract translation: 通过用电流刺激身体组织来治疗靶向的身体组织的装置和方法。 在一个实施例中，一种装置包括构造成可移除地耦合到矫形器内表面的电极载体。 电极载体包括配置成配合地接收电极的一部分的凹部。 当电极的部分设置在凹部内时，电极载体电耦合到电极。 连接构件电耦合到电极载体并且构造成可释放地耦合到矫形器的表面。 当连接构件连接到矫形器时，电极载体电耦合到矫形器。 在一些实施例中，电极载体被配置为可移除地联接到矫形器的内表面。 在一些实施例中，电极的至少一部分由吸收材料构成。

公开(公告)号：US20110020517A1

公开(公告)日：2011-01-27

申请号：US12933470

申请日：2009-03-23

Applicant: Mark Rubin

Inventor： Mark Rubin

IPC: A23L1/226

CPC classification number: A23L27/2054

Abstract: The present invention relates to the use of an alkylpyridine of formula (I) wherein R represents a cyclic alkyl or alkenyl group as taste-conferring or enhancing ingredient to impart or reinforce the kokumi or umami taste in flavored compositions or flavored foods.

Abstract translation: 本发明涉及式（I）的烷基吡啶的用途，其中R表示环状烷基或链烯基作为赋形剂或增强成分，以赋予或加强调味组合物或风味食品中的香味或鲜味。

公开(公告)号：US20100095371A1

公开(公告)日：2010-04-15

申请号：US12287770

申请日：2008-10-14

Applicant: Mark Rubin

Inventor： Mark Rubin

IPC: H04L9/32 ,  G06F7/04

CPC classification number: H04L9/32 ,  G06F21/36

Abstract: Methods for authenticating a user including presenting a series of images that are solely identifiable by the user, and that are not otherwise capable of being represented or expressed by the user, apart from the recognition thereof. Additionally, methods are provided that include the use of a gradient of morphed images created from a related set of initial images, including facial photos of various emotions that have been morphed into discernable images that are uniquely identifiable by a single user for use in authenticating the identification of that user by a secure system.

Abstract translation: 用于认证用户的方法，包括呈现用户唯一可识别的，并且不能由用户表示或表达的一系列图像，除了其识别之外。 此外，提供了包括使用由相关的初始图像集合创建的变形图像的梯度的方法，包括已经变形为可辨别的图像的各种情绪的面部照片，可辨别的图像可由单个用户唯一地标识以用于认证 通过安全系统识别该用户。

公开(公告)号：US20070212702A1

公开(公告)日：2007-09-13

申请号：US11519397

申请日：2006-09-12

Applicant: Scott Tomlins ,  Daniel Rhodes ,  Arul Chinnaiyan ,  Rohit Mehra ,  Xiao-Wei Sun ,  Sven Perner ,  Lee Charles ,  Mark Rubin

Inventor： Scott Tomlins ,  Daniel Rhodes ,  Arul Chinnaiyan ,  Rohit Mehra ,  Xiao-Wei Sun ,  Sven Perner ,  Lee Charles ,  Mark Rubin

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/6424 ,  C12N9/6445 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57434 ,  Y10S435/81

Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

Abstract translation: 描述了前列腺癌中雄激素调节基因和ETS家族成员基因的复发基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。

公开(公告)号：US09951388B2

公开(公告)日：2018-04-24

申请号：US14115327

申请日：2012-05-07

Applicant: Francesca Demichelis ,  Karl Garsha ,  Phillip C. Miller ,  Ray B. Nagle ,  Michael Otter ,  Gary Anthony Pestano ,  Mark Rubin

Inventor： Francesca Demichelis ,  Karl Garsha ,  Phillip C. Miller ,  Ray B. Nagle ,  Michael Otter ,  Gary Anthony Pestano ,  Mark Rubin

IPC: C12Q1/68 ,  H01H35/14 ,  H01M2/34 ,  G06F19/18

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/156 ,  G01N33/57407 ,  G06F19/18 ,  H01H35/146 ,  H01M2/34 ,  H01M2/345 ,  H01M2/347 ,  H01M2/348 ,  H01M2220/20

Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.

公开(公告)号：US20150197811A9

公开(公告)日：2015-07-16

申请号：US14115327

申请日：2013-04-23

Applicant: Francesca Demichelis ,  Karl Garsha ,  Phillip C. Miller ,  Ray B. Nagle ,  Michael Otter ,  Gary Anthony Pestano ,  Mark Rubin

Inventor： Francesca Demichelis ,  Karl Garsha ,  Phillip C. Miller ,  Ray B. Nagle ,  Michael Otter ,  Gary Anthony Pestano ,  Mark Rubin

IPC: C12Q1/68 ,  G06F19/18

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/156 ,  G01N33/57407 ,  G06F19/18 ,  H01H35/146 ,  H01M2/34 ,  H01M2/345 ,  H01M2/347 ,  H01M2/348 ,  H01M2220/20

Abstract: In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.

Abstract translation: 一般来说，目前公开的技术涉及癌症亚型的鉴定。 更具体地，该技术涉及使用多变量图像数据确定癌症和/或进展的分子驱动因素的方法，以及怀疑患有b癌症的生物样品的相同细胞中的原位分子标记物和形态特征的统计分析。 这种分析是在单次采集后并行获得分子和解剖形态数据进行的。 该分析将特定的形态学和分子标记与展示癌症的特定遗传驱动因子的已知样品进行比较。 该方法提供统计信息，可以增加对癌症特异性分子驱动因子的识别的信心。

公开(公告)号：US08868217B2

公开(公告)日：2014-10-21

申请号：US13169553

申请日：2011-06-27

Applicant: Amit Dar ,  Mark Rubin ,  Shmuel Springer ,  Amir Cohen

Inventor： Amit Dar ,  Mark Rubin ,  Shmuel Springer ,  Amir Cohen

IPC: A61N1/04 ,  A61F5/01

CPC classification number: A61N1/0452 ,  A61F5/0102 ,  A61N1/0456 ,  A61N1/0484

Abstract: Devices and methods of treating a targeted body tissue by stimulating the body tissue with an electric current. In one embodiment, an apparatus includes an electrode carrier configured to be removably coupled to an interior surface of an orthosis. The electrode carrier includes a recess configured to matingly receive a portion of an electrode. The electrode carrier is electrically coupled to the electrode when the portion of the electrode is disposed within the recess. A connection member is electrically coupled to the electrode carrier and is configured to be releasably coupled to a surface of the orthosis. The electrode carrier is electrically coupled to the orthosis when the connection member is coupled to the orthosis. In some embodiments, the electrode carrier is configured to be removably coupled to the interior surface of the orthosis. In some embodiments, at least a portion of the electrode is constructed of an absorptive material.

Abstract translation: 通过用电流刺激身体组织来治疗靶向的身体组织的装置和方法。 在一个实施例中，一种装置包括构造成可移除地耦合到矫形器内表面的电极载体。 电极载体包括配置成配合地接收电极的一部分的凹部。 当电极的部分设置在凹部内时，电极载体电耦合到电极。 连接构件电耦合到电极载体并且构造成可释放地耦合到矫形器的表面。 当连接构件连接到矫形器时，电极载体电耦合到矫形器。 在一些实施例中，电极载体被配置为可移除地联接到矫形器的内表面。 在一些实施例中，电极的至少一部分由吸收材料构成。