公开(公告)号：US08114874B2

公开(公告)日：2012-02-14

申请号：US11644849

申请日：2006-12-22

Applicant: Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antionette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

Inventor： Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antionette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

IPC: A61K31/495

CPC classification number: C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.

Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。 特别地，化合物包括其中环T是咪唑并[1,2-b]哒嗪环体系的实施方案，环A和B各自为芳基且L 1为-C（O）NR 1 - 或-NR 1 C（O） - 。 用于化合物和含有它们的组合物的用途包括治疗由蛋白激酶介导的癌症和其它疾病。

公开(公告)号：US20110288078A1

公开(公告)日：2011-11-24

申请号：US12998634

申请日：2009-11-12

Applicant: Wei-Sheng Huang ,  R. Mathew Thomas

Inventor： Wei-Sheng Huang ,  R. Mathew Thomas

IPC: C07D487/04 ,  A61P35/04 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/541 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/2018 ,  A61K9/2866 ,  A61K9/4858 ,  A61K47/10 ,  C07D471/04

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。

公开(公告)号：US20110124585A1

公开(公告)日：2011-05-26

申请号：US13022033

申请日：2011-02-07

Applicant: Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

Inventor： Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

IPC: A61K38/05 ,  C07D403/14 ,  C07D413/14 ,  A61P35/00 ,  A61P29/00

CPC classification number: C07D413/14 ,  A61K31/41 ,  A61K31/422 ,  C07D207/08 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D409/10 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/04 ,  C07K5/06026 ,  C07K5/06034

Abstract: Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

Abstract translation: 使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。 靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。 接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

公开(公告)号：US20090123177A1

公开(公告)日：2009-05-14

申请号：US11939740

申请日：2007-11-14

Applicant: Jedediah Taylor Dawson ,  Mathew Thomas Kerley

Inventor： Jedediah Taylor Dawson ,  Mathew Thomas Kerley

IPC: G03G15/04

CPC classification number: G03G21/1676 ,  G03G15/0855 ,  G03G15/0865 ,  G03G15/0875 ,  G03G15/0886 ,  G03G21/1647 ,  G03G2215/068 ,  G03G2221/163

Abstract: The present application is directed to retainers and methods of retaining a developer unit within an image forming device. One embodiment may include positioning a retainer attached to a frame at a first position with a second end of the retainer positioned away from the developer unit. A toner cartridge may be inserted into the image forming device in a vertical direction and contact against retainer. The toner cartridge may laterally move the retainer relative to the frame from the first position to a second position with the second end positioned to prevent removal of the developer unit from the frame. Another embodiment features a system to retain a developer unit in an image forming device. The system may include a frame configured to receive the developer unit and the toner cartridge. A retainer may be movably attached to the frame and include a first end with a ramped surface, and a second end spaced away from the first end. The retainer may be movable between a first position prior to insertion of the toner cartridge with the second end positioned away from the developer unit, and a second position after insertion of the toner cartridge with the second end positioned to prevent removal of the developer unit from the frame.

Abstract translation: 本申请涉及将显影剂单元保持在图像形成装置内的保持器和方法。 一个实施例可以包括将保持器附接到框架定位在第一位置处，其中保持器的第二端定位成远离显影单元。 墨粉盒可以在垂直方向上插入图像形成装置中并与保持器接触。 调色剂盒可以将保持器相对于框架从第一位置侧向移动到第二位置，其中第二端被定位成防止显影剂单元从框架移除。 另一个实施例的特征在于将显影剂单元保持在图像形成装置中的系统。 该系统可以包括被配置为接收显影剂单元和调色剂盒的框架。 保持器可以可移动地附接到框架并且包括具有斜面的第一端和与第一端间隔开的第二端。 保持器可以在插入调色剂盒与位于远离显影剂单元的第二端之间的第一位置之间移动，以及在插入调色剂盒之后的第二位置，其中第二端被定位成防止从显影剂单元移除 框架。

公开(公告)号：US20060223565A1

公开(公告)日：2006-10-05

申请号：US11094608

申请日：2005-03-30

Applicant: Asif Gandhi ,  Mathew Thomas

Inventor： Asif Gandhi ,  Mathew Thomas

IPC: H04B7/00 ,  H04Q7/20

CPC classification number: H04W52/42 ,  H04W52/12 ,  H04W52/221 ,  H04W52/225 ,  H04W52/367 ,  H04W72/08

Abstract: A method for optimizing the capacity of a forward link in a cellular telecommunications network involves dynamically setting the minimum gain level on the forward link for each mobile station, based each mobile station's individual performance. The cellular network has one or more base stations and a mixed population of single-diversity mobile stations and dual-diversity mobile stations. In communicating with a particular mobile station, the gain level of the transmission over the forward link is monitored at the base station. The base station also monitors the reverse link for a power measurement report message (“PMRM”) sent by the mobile station. If the gain level stays at or close to a minimum gain level for a certain time period, and if no PMRM″s are received during that time period, then the base station reduces the minimum gain level by a set amount. The reduction in the minimum gain level can be triggered based on other factors, such as the forward link frame error rate.

Abstract translation: 一种用于优化蜂窝电信网络中的前向链路的容量的方法包括基于每个移动台的单独性能来动态地为每个移动台在前向链路上设置最小增益级别。 蜂窝网络具有一个或多个基站和单分集移动站和双分集移动台的混合群。 在与特定移动站进行通信时，在基站处监视前向链路上的传输的增益级别。 基站还监视由移动台发送的功率测量报告消息（“PMRM”）的反向链路。 如果增益电平在某一时间段内保持在或接近最小增益电平，并且如果在该时间段期间没有接收到PMRM'，则基站将最小增益电平降低设定量。 可以基于诸如前向链路帧错误率的其他因素来触发最小增益级别的减小。

公开(公告)号：US06968201B1

公开(公告)日：2005-11-22

申请号：US09413036

申请日：1999-10-06

Applicant: Asif D. Gandhi ,  Lei Song ,  Mathew Thomas ,  Stanley Vitebsky

Inventor： Asif D. Gandhi ,  Lei Song ,  Mathew Thomas ,  Stanley Vitebsky

IPC: H04B7/005 ,  H04B7/26 ,  H04Q7/20

CPC classification number: H04W52/146 ,  H04W52/24

Abstract: A system and a method for reverse link power control in a wireless communications network generates power adjust commands for mobiles being served by a network base station in a centralized manner by considering overall system performance when an increased interference condition is detected. In one implementation, a base station power control processor adopts a modified reverse inner loop power control (RILPC) and/or a reverse outer loop power control (ROLPC) algorithm when an increased interference condition is detected. According to the modified RILPC algorithm, a percentage of power-up adjust commands which would normally be generated when Eb/No measurements for served mobiles do not meet target Eb/No levels are converted to power down-adjust commands, thereby forcing some mobiles to reduce transmit power, at least temporarily, to constrain interference. When the increased interference condition persists, the percentage of power-up adjust commands which are converted to power-down commands may be changed. According to the modified ROLPC algorithm, the power control processor adjusts target Eb/No levels in a centralized manner based on an overall system state so that only a limited number of target Eb/No levels are allowed to increase when frame erasures occur. By preventing a percentage of target Eb/No level increases, at least temporarily, when frame erasures occur, a percentage of power up-adjust commands are avoided. Therefore, a similar effect to that achieved by the modified RILPC is achieved. In accordance with still a further implementation of the present invention, the modified RILPC algorithm may be used in combination with the modified ROLPC algorithm to provide greater resistance to increased interference conditions.

公开(公告)号：US20050201332A1

公开(公告)日：2005-09-15

申请号：US10799727

申请日：2004-03-15

Applicant: Rakesh Bakshi ,  Asif Gandhi ,  Charles Sanders ,  Susan Sanders ,  Mathew Thomas

Inventor： Rakesh Bakshi ,  Asif Gandhi ,  Charles Sanders ,  Susan Sanders ,  Mathew Thomas

IPC: H04W36/00 ,  H04W36/18 ,  H04W52/40 ,  H04Q7/00

CPC classification number: H04W36/18 ,  H04W36/0055 ,  H04W52/40

Abstract: A method for link quality control in a wireless communications network includes determining whether an indicator of link imbalance exists among a plurality of base stations associated with a mobile unit, and implementing a control action to help prevent at least one of fading or signal cutoff between the mobile unit and at least one of the base stations, if the indicator indicates that link imbalance exists.

Abstract translation: 一种用于无线通信网络中的链路质量控制的方法包括：确定在与移动单元相关联的多个基站中是否存在链路不平衡的指示符，以及实现控制动作，以帮助防止在所述移动单元之间的衰落或信号截断中的至少一个 移动单元和至少一个基站，如果指示符指示链路不平衡存在。

公开(公告)号：US06829468B2

公开(公告)日：2004-12-07

申请号：US09797708

申请日：2001-03-05

Applicant: Asif Dawoodi Gandhi ,  Marc Benedict Ibanez ,  Lei Song ,  Mathew Thomas ,  Stanley Vitebsky

Inventor： Asif Dawoodi Gandhi ,  Marc Benedict Ibanez ,  Lei Song ,  Mathew Thomas ,  Stanley Vitebsky

IPC: H04B100

CPC classification number: H04W52/367 ,  H04W52/228

Abstract: In a method for minimizing reverse link power control overshoot in a wireless communications system, the output power of a mobile station is detected to determine whether it falls outside a dynamic range of the mobile station. If outside the dynamic range, a new output power falling within the dynamic range is calculated and set, and the mobile station is instructed to transmit at the new output power.

Abstract translation: 在无线通信系统中用于最小化反向链路功率控制过冲的方法中，检测移动站的输出功率以确定其是否落在移动台的动态范围之外。 如果在动态范围之外，则计算并设置落在动态范围内的新的输出功率，并指示移动台以新的输出功率进行发送。

公开(公告)号：US06618598B1

公开(公告)日：2003-09-09

申请号：US09676179

申请日：2000-09-29

Applicant: Asif D Gandhi ,  Raafat E Kamel ,  Andrew R Kostic ,  Alexandro Salvarani ,  Mathew Thomas ,  Stanley Vitebsky ,  Carl Francis Weaver

Inventor： Asif D Gandhi ,  Raafat E Kamel ,  Andrew R Kostic ,  Alexandro Salvarani ,  Mathew Thomas ,  Stanley Vitebsky ,  Carl Francis Weaver

IPC: H04B700

CPC classification number: H04W52/50 ,  H04W52/16 ,  H04W52/26

Abstract: A method for determining the initial power to be allocated to a secondary channel having a desired data rate. An SNR setpoint is first calculated where such setpoint is based on the SNR setpoint of the associated primary channel and system offset values. The initial power is then calculated based on the calculated setpoint.

Abstract translation: 一种用于确定要分配给具有期望数据速率的辅助信道的初始功率的方法。 首先计算SNR设定点，其中该设定点基于相关联的主通道和系统偏移值的SNR设定点。 然后根据计算的设定值计算初始功率。

公开(公告)号：US20160102470A1

公开(公告)日：2016-04-14

申请号：US14512521

申请日：2014-10-13

Applicant: Harold Albert Brooks ,  Ronal Peter Crowley, JR. ,  Mathew Thomas Geyman ,  Corey Joseph Akstull

Inventor： Harold Albert Brooks ,  Ronal Peter Crowley, JR. ,  Mathew Thomas Geyman ,  Corey Joseph Akstull

IPC: E04H4/14 ,  B32B37/06 ,  B32B37/10

CPC classification number: E04H4/14 ,  B29C65/103 ,  B29C65/20 ,  B29C65/22 ,  B29C65/38 ,  B29C65/4815 ,  B29C65/5042 ,  B29C66/1122 ,  B29C66/1142 ,  B29C66/305 ,  B29C66/32 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73921 ,  B29C66/8122 ,  B29C66/8362 ,  B29C66/86523 ,  B29C66/919 ,  B29L2031/3017 ,  E04H2004/146 ,  B29K2827/18 ,  B29K2075/00 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2027/06

Abstract: A method of making a pool liner, said pool liner having a floor section, a wall section and substantially invisible seams, said method comprising the steps of: providing a plurality of floor sheets wherein each sheet of said plurality of floor sheets has an edge; arranging said floor sheets in a pre-determined direction such that at least one edge of one sheet of said first plurality of floor sheets overlaps an adjacent edge of one sheet of said first plurality of floor sheets thereby creating a floor sheet to floor sheet intersection; heat welding said overlapping floor sheets at said floor sheet to floor sheet intersection; providing at least one wall sheet where said at least one wall sheet has an edge; placing said at least one wall sheet generally perpendicularly relative to said plurality of floor sheets; overlapping said at least one wall sheet with said floor sheets thereby creating a floor sheet to wall sheet intersection; and heat welding said at least one wall sheet with overlapping floor sheets at said floor to wall intersection.

Abstract translation: 一种制造泳池衬垫的方法，所述池衬套具有底板部分，壁部分和基本上不可见的接缝，所述方法包括以下步骤：提供多个地板片，其中所述多个地板片中的每个片材具有边缘; 将所述地板布置在预定方向上，使得所述第一多个地板片中的一张片材的至少一个边缘与一张所述第一多个地板片材的相邻边缘重叠，从而形成地板片与地板片材交集; 将所述地板上的重叠地板热焊接到地板交叉路口; 提供至少一个壁板，其中所述至少一个壁板具有边缘; 将所述至少一个壁板相对于所述多个地板片大致垂直放置; 将所述至少一个壁板与所述地板重叠，从而形成地板到墙板交叉; 以及将所述至少一个壁板与所述地板上的重叠地板片材热焊接到墙壁交叉。