公开(公告)号：US06659966B2

公开(公告)日：2003-12-09

申请号：US10002325

申请日：2001-11-15

申请人： Matthias Essenpreis

发明人： Matthias Essenpreis

IPC分类号： A61B500

CPC分类号： A61B18/20 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2017/00508 ,  A61B2018/00636

摘要： A fluid sampling apparatus is provided that in accordance with the present invention. The apparatus includes a housing defining a chamber, a lancet positioned in the chamber and including an end formed to create a fluid collection incision, and a light source positioned in the chamber. The light source is formed to emit a light beam of a pre-determined wavelength and for a time sufficient to seal the incision.

公开(公告)号：US10299737B2

公开(公告)日：2019-05-28

申请号：US12786993

申请日：2010-05-25

申请人： Matthias Essenpreis ,  Michael Schoemaker ,  Sebastiaan La Bastide ,  Derek Brandt ,  Theodor Koschinsky ,  Sascha Heckermann

发明人： Matthias Essenpreis ,  Michael Schoemaker ,  Sebastiaan La Bastide ,  Derek Brandt ,  Theodor Koschinsky ,  Sascha Heckermann

IPC分类号： A61B5/00 ,  G06F19/00 ,  A61B5/145

摘要： A method for diabetes care, the method (which also may be referred to as, involve or incorporate at least one of a tool, device or program) allowing for the characterization of the relevance of errors of parameters affecting glucose concentration on a postprandial glucose concentration outcome for a person with diabetes mellitusm, wherein the method involves at least one of sensing, determining, calculating, predicting, describing and communicating the effects of potential errors of parameters affecting glucose concentration on postprandial glucose concentration values within a clinically relevant glucose range.

公开(公告)号：US20130211849A1

公开(公告)日：2013-08-15

申请号：US13586409

申请日：2012-08-15

申请人： Matthias Essenpreis ,  Dirk Voelkel ,  Stefan Weinert

发明人： Matthias Essenpreis ,  Dirk Voelkel ,  Stefan Weinert

IPC分类号： G06F19/00

CPC分类号： G16H40/20 ,  G16H40/63

摘要： A device and method are disclosed for supporting a patient with a disease, comprising a display facility, a user interface, a processor, and a user interface, and with an application module comprising program instructions, which are configured, on executing by the processor to bring about the following: providing medical protocols for diagnostic and/or therapeutic purposes, collecting time information concerning a future event which is a trigger for at least one medical protocol, selecting one of the medical protocols which indicates a group of cohesive protocol events which are spaced apart chronologically over a protocol period in accordance with a protocol regime, monitoring a chronological interval between a current date and the future event, and issuing a user start notice concerning the beginning of the medical protocol at a time which from a chronological point of view lies at least by the protocol period before the future event.

摘要翻译： 公开了一种用于支持具有疾病的患者的装置和方法，包括显示设施，用户界面，处理器和用户界面，以及包括程序指令的应用模块，所述应用模块被配置为在由处理器执行时 提供以下内容：提供用于诊断和/或治疗目的的医疗协议，收集关于未来事件的时间信息，该事件是至少一个医疗协议的触发器，选择指示一组内聚协议事件的医疗协议之一 按照协议制度在协议周期上按时间顺序隔开，监视当前日期与未来事件之间的时间间隔，并且从按时间顺序的时间点发出关于医疗协议开始的用户启动通知 至少在未来事件发生前的协议期限内。

公开(公告)号：US20110251472A1

公开(公告)日：2011-10-13

申请号：US13165510

申请日：2011-06-21

申请人： Stefan Weinert ,  Nicole Bernini ,  Derek Brandt ,  Matthias Essenpreis ,  Kelly Heaton ,  Joel Jeckelmann ,  Sebastiaan LaBastide ,  Gunnar Meyer-Olden ,  Michael Schoemaker ,  Robin Wagner

发明人： Stefan Weinert ,  Nicole Bernini ,  Derek Brandt ,  Matthias Essenpreis ,  Kelly Heaton ,  Joel Jeckelmann ,  Sebastiaan LaBastide ,  Gunnar Meyer-Olden ,  Michael Schoemaker ,  Robin Wagner

IPC分类号： A61B5/145

CPC分类号： G06F19/3456 ,  G06F19/3418 ,  G06F19/3475 ,  G16H10/20 ,  G16H10/60 ,  G16H40/63 ,  G16H50/20

摘要： A system is provided for collecting patient information from which diabetes therapy may be determined. The system may comprise a patient interface device, a patient notification device, an input device for entering patient information, and an information collecting unit. The information collecting unit may include a processor electrically coupled to a memory having stored therein at least one algorithm executable by the processor to activate the patient notification device followed by presenting instructions to the patient via the patient interface device for collecting specified information from the patient via the input device.

摘要翻译： 提供了用于收集可以从其确定糖尿病治疗的患者信息的系统。 该系统可以包括患者接口设备，患者通知设备，用于输入患者信息的输入设备和信息收集单元。 信息收集单元可以包括处理器，电耦合到存储器，其中存储有至少一个算法，其可由处理器执行以激活患者通知装置，随后经由患者接口装置向患者呈现指令，用于从患者经由 输入设备。

公开(公告)号：US20050271546A1

公开(公告)日：2005-12-08

申请号：US11115889

申请日：2005-04-27

申请人： Martin Gerber ,  Matthias Essenpreis ,  Wolfgang Petrich

发明人： Martin Gerber ,  Matthias Essenpreis ,  Wolfgang Petrich

IPC分类号： G01N21/01 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  G01N21/41 ,  G01N21/00

CPC分类号： A61B5/1459 ,  A61B5/14532

摘要： Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is impermeable to background species in the biological matrix. A refractive element is positioned in the cavity. A light source transmits light of a first intensity onto the refractive element, and a light detector receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.

公开(公告)号：US06405066B1

公开(公告)日：2002-06-11

申请号：US09528277

申请日：2000-03-17

申请人： Matthias Essenpreis ,  Tejal A. Desai ,  Mauro Ferrari ,  Derek J. Hansford

发明人： Matthias Essenpreis ,  Tejal A. Desai ,  Mauro Ferrari ,  Derek J. Hansford

IPC分类号： A61B505

CPC分类号： A61B5/14865 ,  C12Q1/006

摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.

摘要翻译： 可植入分析物传感器包括基底，基底上的电极和电极上的膜。 膜可以包含元素硅，并且在330分钟内具有至少1mg / dl的葡萄糖扩散测试结果，并且在420分钟内白蛋白扩散测试结果为至多0.1g / dl。

公开(公告)号：US5710630A

公开(公告)日：1998-01-20

申请号：US530241

申请日：1995-10-10

申请人： Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

发明人： Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/45 ,  G01N21/49 ,  G01N33/487 ,  G01B9/02

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/45 ,  G01N21/49

摘要： A method for the analytical determination of the glucose concentration in a biological sample. In a detection step, light is irradiated into the sample and the light emerging therefrom after interaction with the sample emerges therefrom is detected in order to measure a physical light property affected by said interaction. The glucose concentration is determined from this measurement in an evaluation step. To provide a method for determining glucose in reagent-free and non-invasive manner, the invention proposes that a portion of the light emitted by the light source be guided along a reference light path of defined optical path length to the photodetector, that the total measuring light path also has a defined optical length and that the measuring light path after it has traversed the sample is so combined with the reference light path that the measuring light and the reference light interfere with each other. The photodetector measures an interference signal used in the evaluation step to determine the glucose concentration.

摘要翻译： PCT No.PCT / DE95 / 00573 Sec。 371 1995年10月10日第 102（e）1995年10月10日日期PCT提交1995年4月26日PCT公布。 WO95 / 30368 PCT出版物 日期：1995年11月16日一种用于分析生物样品中葡萄糖浓度的方法。 在检测步骤中，将光照射到样品中，并且检测出与样品相互作用后从其出来的光从其中出来的光，以测量受所述相互作用影响的物理光特性。 在评价步骤中由该测定确定葡萄糖浓度。 为了提供一种以无试剂和非侵入性方式测定葡萄糖的方法，本发明提出将由光源发射的光的一部分沿着限定的光路长度的参考光路引导到光电检测器，总共 测量光路还具有限定的光学长度，并且其经过样本之后的测量光路与参考光路组合，使得测量光和参考光彼此干涉。 光电检测器测量在评估步骤中使用的干扰信号以确定葡萄糖浓度。

公开(公告)号：US06952603B2

公开(公告)日：2005-10-04

申请号：US09810635

申请日：2001-03-16

申请人： Martin Gerber ,  Matthias Essenpreis ,  Wolfgang Petrich

发明人： Martin Gerber ,  Matthias Essenpreis ,  Wolfgang Petrich

IPC分类号： G01N21/01 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  G01N21/41 ,  G01B9/02

CPC分类号： A61B5/1459 ,  A61B5/14532

摘要： Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is impermeable to background species in the biological matrix. A refractive element is positioned in the cavity. A light source transmits light of a first intensity onto the refractive element, and a light detector receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.

摘要翻译： 用于测量生物基质中分析物浓度的装配和方法。 组件包括可植入的光学感测元件，其包括主体和以使得膜和主体限定空腔的方式安装在主体上的膜。 膜对分析物是可渗透的，但对于生物基质中的背景物质是不可渗透的。 折射元件位于空腔中。 光源将第一强度的光透射到折射元件上，并且光检测器接收从腔体反射的第二强度的光。 光耦合到检测器的控制器设备比较第一和第二光强度，并将强度与分析物浓度相关联。

公开(公告)号：US20050211572A1

公开(公告)日：2005-09-29

申请号：US11038970

申请日：2005-01-19

申请人： Harvey Buck ,  Matthias Essenpreis

发明人： Harvey Buck ,  Matthias Essenpreis

IPC分类号： A61B5/00 ,  C12Q1/00 ,  G01N27/26

CPC分类号： C12Q1/006 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/001 ,  C12Q1/004

摘要： Sensors and a method for detecting an analyte are described. Sensors each have a volume of a hydrophilic medium that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes and a redox enzyme in contact with medium, and an electron transfer mediator. The fluid contacts sensors and at initially predetermined intervals intermittently applies a potential to electrode sufficient to oxidize the mediator and sensing current through electrode as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode. The current flow is correlated with the current flow for known concentrations of the analyte in medium.

摘要翻译： 描述了传感器和检测分析物的方法。 传感器各自具有一定量的亲水介质，其保留与生物流体，电极和与介质接触的氧化还原酶的分析物浓度成比例的分析物和电子转移介体。 液体接触传感器并且以最初预定间隔间歇地将电位施加到足以氧化介体并将感应通过电极的电流作为施加电位的持续时间的函数。 所施加的介体氧化施加电位保持足够长的时间以确定电流随时​​间的变化通过电极的速率。 目前的流量与已知浓度的分析物在介质中的电流相关。

公开(公告)号：US06418339B1

公开(公告)日：2002-07-09

申请号：US09424086

申请日：1999-11-16

申请人： Matthias Essenpreis ,  Stephen Nickell ,  Dirk Bocker

发明人： Matthias Essenpreis ,  Stephen Nickell ,  Dirk Bocker

IPC分类号： A61B600

CPC分类号： A61B5/441 ,  A61B5/0059 ,  A61B5/0073 ,  A61B5/14552 ,  G01N21/4795

摘要： The invention relates to a method and a device for in vivo detection of the direction of Langer's lines in the skin. Light is irradiated into the skin as primary light at one defined site (7) identified through the epidermis (6) in such a way that it is transported in the skin (5) by scattering or absorption, while part of said irradiated light emerges from the skin as secondary light in the region surrounding the irradiated site. An amplitude-dependent property of secondary light emerging from the skin (5) around the irradiated site is measured in order to determine the preferential direction of the diffuse light transport in the skin (5) and, consequently, determine the orientation of Langer's lines thereof.

摘要翻译： 本发明涉及用于体内检测皮肤中兰格氏线方向的方法和装置。 光通过表皮（6）以一定的位置（7）照射到皮肤中，使其通过散射或吸收在皮肤（5）中运输，同时所述照射的光的一部分从 皮肤作为照射部位周围区域的二次光。 测量从照射部位周围的皮肤（5）出射的二次光的振幅依赖性，以确定在皮肤（5）中漫射光传输的优先方向，并因此确定兰格线的取向 。