公开(公告)号：US6144449A

公开(公告)日：2000-11-07

申请号：US875351

申请日：1997-07-28

Applicant: Alexander Knuettel ,  Dirk Boecker

Inventor： Alexander Knuettel ,  Dirk Boecker

IPC: G01B9/02 ,  G01J9/02 ,  G01N21/47 ,  G02B6/12

CPC classification number: G01N21/4795 ,  G01B9/02027 ,  G01B9/02051 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/0209 ,  G02B6/12004 ,  G01J2009/023 ,  G02B2006/12104

Abstract: Low coherence interferometer apparatus for investigation of a sample (15), in particular for multidimensional imaging, having an interferometer configuration (2) comprising a low coherence light source, a probe head (9) having a light exit opening (16) for irradiating light into the sample, an optical coupler, a reference reflector and a detector (13). The optical paths between the elements of the interferometer configuration (2) form interferometer arms. The optical coupler and the reference arm of the interferometer configuration (2) are integrated into a common optical chip (28). In addition to the reference reflector (11), the reference arm comprises a deflection reflector (33) formed on an end surface (35) of the optical chip (28) in such a manner that the reference light is cross-coupled between a first light guide (10a) forming a first portion of the reference arm (10) and a second light guide (10b) forming a second portion of the reference arm (10).

Abstract translation: PCT No.PCT / DE97 / 00167 Sec。 371日期1997年7月28日第 102（e）1997年7月28日PCT PCT 1997年1月23日PCT公布。 出版物WO97 / 27468 日期1997年7月31日用于研究样品（15）的低相干干涉仪装置，特别是用于多维成像，具有包括低相干光源的干涉仪配置（2），具有光出射开口的探头（9） 16），用于将光照射到样品中，光耦合器，参考反射器和检测器（13）。 干涉仪配置（2）的元件之间的光路形成干涉仪臂。 干涉仪配置（2）的光耦合器和参考臂被集成到公共光学芯片（28）中。 除了参考反射器（11）之外，参考臂包括形成在光学芯片（28）的端面（35）上的偏转反射器（33），使得参考光交替耦合在第一 形成参考臂（10）的第一部分的光导（10a）和形成参考臂（10）的第二部分的第二光导（10b）。

公开(公告)号：US5710630A

公开(公告)日：1998-01-20

申请号：US530241

申请日：1995-10-10

Applicant: Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

Inventor： Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/45 ,  G01N21/49 ,  G01N33/487 ,  G01B9/02

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/45 ,  G01N21/49

Abstract: A method for the analytical determination of the glucose concentration in a biological sample. In a detection step, light is irradiated into the sample and the light emerging therefrom after interaction with the sample emerges therefrom is detected in order to measure a physical light property affected by said interaction. The glucose concentration is determined from this measurement in an evaluation step. To provide a method for determining glucose in reagent-free and non-invasive manner, the invention proposes that a portion of the light emitted by the light source be guided along a reference light path of defined optical path length to the photodetector, that the total measuring light path also has a defined optical length and that the measuring light path after it has traversed the sample is so combined with the reference light path that the measuring light and the reference light interfere with each other. The photodetector measures an interference signal used in the evaluation step to determine the glucose concentration.

Abstract translation: PCT No.PCT / DE95 / 00573 Sec。 371 1995年10月10日第 102（e）1995年10月10日日期PCT提交1995年4月26日PCT公布。 WO95 / 30368 PCT出版物 日期：1995年11月16日一种用于分析生物样品中葡萄糖浓度的方法。 在检测步骤中，将光照射到样品中，并且检测出与样品相互作用后从其出来的光从其中出来的光，以测量受所述相互作用影响的物理光特性。 在评价步骤中由该测定确定葡萄糖浓度。 为了提供一种以无试剂和非侵入性方式测定葡萄糖的方法，本发明提出将由光源发射的光的一部分沿着限定的光路长度的参考光路引导到光电检测器，总共 测量光路还具有限定的光学长度，并且其经过样本之后的测量光路与参考光路组合，使得测量光和参考光彼此干涉。 光电检测器测量在评估步骤中使用的干扰信号以确定葡萄糖浓度。

公开(公告)号：US5962852A

公开(公告)日：1999-10-05

申请号：US875349

申请日：1997-07-28

Applicant: Alexander Knuettel ,  Dirk Boecker ,  Matthias Essenpreis

Inventor： Alexander Knuettel ,  Dirk Boecker ,  Matthias Essenpreis

IPC: A61B5/00 ,  G01N21/49

CPC classification number: A61B5/1455 ,  A61B5/0066 ,  A61B5/14532 ,  G01N21/49

Abstract: Method for determining an analyte in a scattering matrix. In a detection step detection measurements are made in which light is irradiated into the matrix as primary light and light leaving the scattering matrix is detected as secondary light, in order to determine as a measurement quantity a measurable physical property of the light which is variable due to the interaction of the light with the matrix. Information on the presence of the analyte in the matrix is determined in an evaluation step. The determination of optically weakly absorbing analytes against a strongly absorbing interference background is improved by the use of two selection methods for the depth selective detection of the secondary light in combination with one another. Primary light is focused by means of a primary light optically focussing element onto a region of focus lying in the matrix at a predetermined measuring depth and the region of focus is imaged by means of a secondary light optically focusing element onto a light entry aperture arranged in the light path of the secondary light to the detector. In addition to this first depth selection by a confocal arrangement, a second depth selection device is used to detect light reflected from a defined measuring depth as secondary light, with the measuring depth coinciding with the depth of focus.

Abstract translation: PCT No.PCT / DE97 / 00168 Sec。 371日期1997年7月28日第 102（e）1997年7月28日PCT PCT 1997年1月23日PCT公布。 公开号WO97 / 27469 日期1997年7月31日确定散射矩阵中的分析物的方法。 在检测步骤中，进行检测测量，其中将光作为初级光照射到基质中，并且离开散射矩阵的光被检测为次级光，以便将测量量确定为可变的光的可测量的物理性质 对光与基质的相互作用。 在评估步骤中确定基质中分析物存在的信息。 通过使用两种选择方法来对二次光的深度选择性检测相结​​合，可以改善光吸收弱吸收分析物的强吸收干涉背景的测定。 初级光通过初级光光聚焦元件聚焦在位于矩阵中的预定测量深度的焦点区域上，并且聚焦的区域通过次光光学聚焦元件成像到布置在 次级光到检测器的光路。 除了通过共焦排列的第一深度选择之外，使用第二深度选择装置来检测从限定的测量深度反射的光作为次级光，其测量深度与焦深一致。

公开(公告)号：US06330063B1

公开(公告)日：2001-12-11

申请号：US09613748

申请日：2000-07-11

Applicant: Alexander Knuettel ,  Dirk Boecker

Inventor： Alexander Knuettel ,  Dirk Boecker

IPC: G01B902

CPC classification number: G01N21/4795 ,  G01B9/02027 ,  G01B9/02051 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/0209 ,  G01J2009/023 ,  G02B6/12004 ,  G02B2006/12104

Abstract: Low coherence interferometer apparatus for investigation of a sample (15), in particular for multi-dimensional imaging, having an interferometer configuration (2) comprising a low coherence light source, a probe head (9) having a light exit opening (16) for irradiating light into the sample, an optical coupler, a reference reflector and a detector (13). The optical paths between the elements of the interferometer configuration (2) form interferometer arms. The optical coupler and the reference arm of the interferometer configuration (2) are integrated into a common optical chip (28). In addition to the reference reflector (11), the reference arm comprises a deflection reflector (33) formed on an end surface (35) of the optical chip (28) in such a manner that the reference light is cross-coupled between a first light guide (10a) forming a first portion of the reference arm (10) and a second light guide (10b) forming a second portion of the reference arm (10).

Abstract translation: 用于研究样品（15）的低相干干涉仪装置，特别是用于具有包括低相干光源的干涉仪配置（2）的多维成像的探针头（9），具有光出射开口（16）的探针头（9） 将光照射到样品中，光耦合器，参考反射器和检测器（13）。 干涉仪配置（2）的元件之间的光路形成干涉仪臂。 干涉仪配置（2）的光耦合器和参考臂被集成到公共光学芯片（28）中。 除了参考反射器（11）之外，参考臂包括形成在光学芯片（28）的端面（35）上的偏转反射器（33），使得参考光交替耦合在第一 形成参考臂（10）的第一部分的光导（10a）和形成参考臂（10）的第二部分的第二光导（10b）。

公开(公告)号：US5713352A

公开(公告)日：1998-02-03

申请号：US572641

申请日：1995-12-14

Applicant: Matthias Essenpreis ,  Hans-Peter Haar ,  Dirk Boecker ,  Alexander Knuettel

Inventor： Matthias Essenpreis ,  Hans-Peter Haar ,  Dirk Boecker ,  Alexander Knuettel

IPC: G01N33/483 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/41 ,  G01N21/49 ,  A61B5/00

CPC classification number: G01N21/49

Abstract: The invention concerns a method for investigating a scattering medium, especially a biological matrix, with intensity-modulated light. In order, in such a frequency-domain measuring procedure, to reduce the expenditure on electronics without restricting accuracy of measurement, a method is proposed, in which, in order to investigate a scattering medium, especially a biological matrix, with intensity-modulated light, a high-frequency modulation signal is generated by a frequency generator (18), the intensity of a light emitter (10) is modulated with a modulation signal and the light from the light emitter (10) is radiated into the medium, the modulation signal includes frequency chirps during which the modulation frequency is tuned from an initial frequency to a final frequency, the modulation signal is delivered from the frequency generator (18) via at least two different signal paths (23A, 24) to a signal mixer (31), so that during a frequency chirp the input signals of the signal mixer (31) differ by a differential frequency whose magnitude is a function of the difference between the signal transit times over the at least two signal paths (23A, 24) and of the rate of change of the modulation frequency, wherein at least one of the signal paths includes a light path section (20A) passing through the medium as a measurement signal path (23A), and the output signal of the signal mixer (31) is further processed to produce information relating to the scattering medium (FIG. 2).

Abstract translation: 本发明涉及用强度调制光来研究散射介质，特别是生物基质的方法。 为了在这样的频域测量过程中，为了减少电子设备的开销而不限制测量精度，提出了一种方法，其中为了研究具有强度调制光的散射介质，特别是生物矩阵 ，由频率发生器（18）产生高频调制信号，用调制信号调制发光体（10）的强度，将来自发光体（10）的光照射到介质中，调制 信号包括调制频率从初始频率调谐到最终频率的频率啁啾，调制信号经由至少两个不同的信号路径（23A，24）从频率发生器（18）传送到信号混合器（31 ），使得在频率啁啾期间，信号混合器（31）的输入信号相差一个差分频率，其幅度是在at信号传输时间之间的差值的函数 至少两个信号路径（23A，24）和调制频率的变化率，其中信号路径中的至少一个包括通过介质作为测量信号路径（23A）的光路部分（20A），以及 信号混合器（31）的输出信号被进一步处理以产生与散射介质有关的信息（图3）。 2）。