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11.发明申请SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES 有权用于治疗心血管和血液病的替代二氢吡咯烷酮公开(公告)号：US20120121727A1
公开(公告)日：2012-05-17
申请号：US13356256
申请日：2012-01-23
申请人： Kai THEDE , Ingo FLAMME , Felix OEHME , Jens-Kerim ERGÜDEN , Friederike STOLL , Joachim SCHUHMACHER , Hanno WILD , Peter KOLKHOF , Hartmut BECK , Jörg KELDENICH , Metin AKBABA , Mario JESKE
发明人： Kai THEDE , Ingo FLAMME , Felix OEHME , Jens-Kerim ERGÜDEN , Friederike STOLL , Joachim SCHUHMACHER , Hanno WILD , Peter KOLKHOF , Hartmut BECK , Jörg KELDENICH , Metin AKBABA , Mario JESKE
IPC分类号： A61K33/26 , A61K31/4439 , C07D417/14 , A61K31/5377 , A61K31/506 , C07D403/14 , A61K31/497 , A61K31/427 , C07D413/14 , A61K31/541 , C07D471/04 , C07D487/08 , A61K31/55 , A61K31/551 , C07D487/04 , A61K31/616 , A61K31/714 , A61K31/519 , A61K31/7048 , A61P9/00 , A61P7/06 , A61P13/12 , C07D401/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US20120035151A1
公开(公告)日：2012-02-09
申请号：US13271957
申请日：2011-10-12
申请人： Mario Jeske , Ingo Flamme , Friederike Stoll , Hartmut Beck , Metin Akbaba
发明人： Mario Jeske , Ingo Flamme , Friederike Stoll , Hartmut Beck , Metin Akbaba
IPC分类号： A61K31/506 , A61K31/5355 , A61P9/10 , A61P35/00 , A61P13/12 , A61K31/553 , A61P9/00
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是心血管和血液病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US08067407B2
公开(公告)日：2011-11-29
申请号：US12427749
申请日：2009-04-22
申请人： Mario Jeske , Ingo Flamme , Friederike Stoll , Hartmut Beck , Metin Akbaba
发明人： Mario Jeske , Ingo Flamme , Friederike Stoll , Hartmut Beck , Metin Akbaba
IPC分类号： C07D401/14 , C07D403/14 , A61K31/435 , A61K31/495
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是心血管和血液病和肾脏的药物的用途 疾病和促进伤口愈合。
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14.发明申请公开(公告)号：US20110124665A1
公开(公告)日：2011-05-26
申请号：US12086784
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A61K31/519 , C07D491/048 , A61P9/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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15.发明申请SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES 有权用于治疗心血管和血液病的替代二氢吡咯烷酮公开(公告)号：US20100305085A1
公开(公告)日：2010-12-02
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/4545 , C07D403/14 , A61K31/506 , A61P9/00 , A61P13/12
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.
摘要翻译： 本发明涉及式（I）的二氢吡唑酮衍生物，其生产方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管和血液学 疾病，肾脏疾病和促进伤口愈合。
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公开(公告)号：US20100273789A1
公开(公告)日：2010-10-28
申请号：US12668619
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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17.发明申请公开(公告)号：US20100041646A1
公开(公告)日：2010-02-18
申请号：US12084267
申请日：2006-10-20
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C07D413/14 , A61K31/5355 , A61P7/02 , C12N5/00
CPC分类号： C07D413/14
摘要： The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本申请涉及新的1,4-亚苯基 - 双恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是血栓栓塞性疾病。
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18.发明申请公开(公告)号：US20090318475A1
公开(公告)日：2009-12-24
申请号：US12086783
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A61K31/519 , C07D491/048
CPC分类号： C07D491/04
摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US20080214533A1
公开(公告)日：2008-09-04
申请号：US11792108
申请日：2005-11-22
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号： A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译： 本发明涉及式（I）的新型环状亚氨基化物，其中R 1，R 2，R 3，A，Z和n 具有本说明书中所述的含义，其制备方法，含有这些材料的药物组合物，以及使用它们治疗和/或预防血栓栓塞性疾病的方法。
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公开(公告)号：US20060287315A1
公开(公告)日：2006-12-21
申请号：US11299342
申请日：2005-12-08
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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