公开(公告)号：US08436180B2

公开(公告)日：2013-05-07

申请号：US12526951

申请日：2008-02-19

Applicant: Lars Bärfacker ,  Peter Kolkhof ,  Karl-Heinz Schlemmer ,  Rolf Grosser ,  Adam Nitsche ,  Martina Klein ,  Klaus Münter ,  Barbara Albrecht-Küpper ,  Elke Hartmann

Inventor： Lars Bärfacker ,  Peter Kolkhof ,  Karl-Heinz Schlemmer ,  Rolf Grosser ,  Adam Nitsche ,  Martina Klein ,  Klaus Münter ,  Barbara Albrecht-Küpper ,  Elke Hartmann

IPC: C07D471/02 ,  A61K31/44

CPC classification number: C07D471/04

Abstract: The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

Abstract translation: 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。

公开(公告)号：US08389520B2

公开(公告)日：2013-03-05

申请号：US12447192

申请日：2007-10-12

Applicant: Kai Thede ,  Ingo Flamme ,  Felix Oehme ,  Jens-Kerim Ergüden ,  Friederike Stoll ,  Joachim Schuhmacher ,  Hanno Wild ,  Peter Kolkhof ,  Hartmut Beck ,  Jörg Keldenich ,  Metin Akbaba ,  Mario Jeske

Inventor： Kai Thede ,  Ingo Flamme ,  Felix Oehme ,  Jens-Kerim Ergüden ,  Friederike Stoll ,  Joachim Schuhmacher ,  Hanno Wild ,  Peter Kolkhof ,  Hartmut Beck ,  Jörg Keldenich ,  Metin Akbaba ,  Mario Jeske

IPC: A61K31/5377 ,  C07D413/14

CPC classification number: C07D487/04 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

公开(公告)号：US20120264704A1

公开(公告)日：2012-10-18

申请号：US12447201

申请日：2007-10-26

Applicant: Kai Thede ,  Ingo Flamme ,  Felix Oehme ,  Jens-Kerim Ergüden ,  Friederike Stoll ,  Joachim Schuhmacher ,  Hanno Wild ,  Peter Kolkhof ,  Hartmut Beck ,  Metin Akbaba ,  Mario Jeske

Inventor： Kai Thede ,  Ingo Flamme ,  Felix Oehme ,  Jens-Kerim Ergüden ,  Friederike Stoll ,  Joachim Schuhmacher ,  Hanno Wild ,  Peter Kolkhof ,  Hartmut Beck ,  Metin Akbaba ,  Mario Jeske

IPC: A61K31/506 ,  C07D417/14 ,  A61K31/4439 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/517 ,  A61K31/501 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/55 ,  A61P7/10 ,  A61K31/616 ,  A61P31/04 ,  A61P35/00 ,  A61K31/7048 ,  A61P9/00 ,  A61P7/06 ,  A61P13/12 ,  C07D471/04 ,  A61K31/498 ,  A61K31/714 ,  C07D401/14

CPC classification number: C07D417/14 ,  C07D401/14

Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

Abstract translation: 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。

公开(公告)号：US20120172448A1

公开(公告)日：2012-07-05

申请号：US13312320

申请日：2011-12-06

Applicant: Thomas LAMPE ,  Michael G. HAHN ,  Johannes-Peter STASCH ,  Karl-Heinz SCHLEMMER ,  Frank WUNDER ,  Sherif EL SHEIKH ,  Volkhart Min-Jian LI ,  Eva-Maria BECKER ,  Friederike STOLL ,  Andreas KNORR ,  Peter KOLKHOF ,  Elisabeth WOLTERING

Inventor： Thomas LAMPE ,  Michael G. HAHN ,  Johannes-Peter STASCH ,  Karl-Heinz SCHLEMMER ,  Frank WUNDER ,  Sherif EL SHEIKH ,  Volkhart Min-Jian LI ,  Eva-Maria BECKER ,  Friederike STOLL ,  Andreas KNORR ,  Peter KOLKHOF ,  Elisabeth WOLTERING

IPC: A61K31/196 ,  C07C231/14 ,  A61P9/04 ,  A61P13/12 ,  A61P9/12 ,  A61P9/00 ,  A61P7/02 ,  C07C233/55 ,  A61P9/10

CPC classification number: C07C231/02 ,  A61K31/196 ,  C07C233/24 ,  C07C233/55

Abstract: The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract translation: 本申请涉及新的取代的1-苄基环烷基羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 用于治疗和/或预防心血管疾病。

公开(公告)号：US08084481B2

公开(公告)日：2011-12-27

申请号：US12301616

申请日：2007-05-21

Applicant: Heinrich Meier ,  Eckhard Bender ,  Ulf Brüggemeier ,  Ingo Flamme ,  Dagmar Karthaus ,  Peter Kolkhof ,  Daniel Meibom ,  Dirk Schneider ,  Verena Voehringer ,  Chantal Fürstner ,  Jörg Keldenich ,  Dieter Lang ,  Elisabeth Pook ,  Carsten Schmeck

Inventor： Heinrich Meier ,  Eckhard Bender ,  Ulf Brüggemeier ,  Ingo Flamme ,  Dagmar Karthaus ,  Peter Kolkhof ,  Daniel Meibom ,  Dirk Schneider ,  Verena Voehringer ,  Chantal Fürstner ,  Jörg Keldenich ,  Dieter Lang ,  Elisabeth Pook ,  Carsten Schmeck

IPC: A61K31/41 ,  A61K31/415 ,  C07D249/00 ,  C07D233/00

CPC classification number: C07D249/12 ,  C07D233/70 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D409/14

Abstract: The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Abstract translation: 本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20100261771A1

公开(公告)日：2010-10-14

申请号：US12727044

申请日：2010-03-18

Applicant: Ulf Brüggemeier ,  Chantal Fürstner ,  Volker Geiss ,  Joerg Keldenich ,  Armin Kern ,  Martina Delbeck ,  Peter Kolkhof ,  Axel Kretschmer ,  Elisabeth Pook ,  Carsten Schmeck ,  Hubert Trübel

Inventor： Ulf Brüggemeier ,  Chantal Fürstner ,  Volker Geiss ,  Joerg Keldenich ,  Armin Kern ,  Martina Delbeck ,  Peter Kolkhof ,  Axel Kretschmer ,  Elisabeth Pook ,  Carsten Schmeck ,  Hubert Trübel

IPC: A61K31/422 ,  C07D249/12 ,  A61K31/4196 ,  C07D413/12 ,  A61P1/16 ,  A61P7/10 ,  A61P9/00

CPC classification number: C07D233/70 ,  A61K9/0095 ,  A61K9/2054 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/422 ,  A61K45/06 ,  C07D249/12 ,  C07D409/04 ,  C07D413/12 ,  A61K2300/00

Abstract: The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.

Abstract translation: 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。

公开(公告)号：US20100099681A1

公开(公告)日：2010-04-22

申请号：US12540657

申请日：2009-08-13

Applicant: Lars Bärfacker ,  Raimund Kast ,  Nils Griebenow ,  Heinrich Meier ,  Peter Kolkhof ,  Barbara Albrecht-Küpper ,  Adam Nitsche ,  Nicole Teusch ,  Johannes-Peter Stasch ,  Dirk Schneider

Inventor： Lars Bärfacker ,  Raimund Kast ,  Nils Griebenow ,  Heinrich Meier ,  Peter Kolkhof ,  Barbara Albrecht-Küpper ,  Adam Nitsche ,  Nicole Teusch ,  Johannes-Peter Stasch ,  Dirk Schneider

IPC: A61K31/498 ,  A61K31/517 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/415 ,  C07D403/10 ,  C07D231/38 ,  A61P9/00

CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D471/04

Abstract: The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

Abstract translation: 本申请涉及新型取代的5-氨基吡唑，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途。

公开(公告)号：US20090215743A1

公开(公告)日：2009-08-27

申请号：US10586023

申请日：2004-12-31

Applicant: Elisabeth Woltering ,  Michael Härter ,  Timo Flessner ,  Mario Jeske ,  Nils Griebenow ,  Frank Süssmeier ,  Hilmar Bischoff ,  Martin Raabe ,  Anja Buchmüller ,  Peter Kolkhof ,  Peter Ellinghaus ,  Olaf Weber

Inventor： Elisabeth Woltering ,  Michael Härter ,  Timo Flessner ,  Mario Jeske ,  Nils Griebenow ,  Frank Süssmeier ,  Hilmar Bischoff ,  Martin Raabe ,  Anja Buchmüller ,  Peter Kolkhof ,  Peter Ellinghaus ,  Olaf Weber

IPC: A61K31/5383 ,  C07D498/04

CPC classification number: C07D498/04

Abstract: The present application relates to novel tricyclic benzazepine derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.

Abstract translation: 本申请涉及新型三环苯并氮杂衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或 预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和局部缺血。

公开(公告)号：US20090214477A1

公开(公告)日：2009-08-27

申请号：US11911528

申请日：2006-04-08

Applicant: Ulrich Betz ,  Donatella D'Urso ,  Peter Kolkhof ,  Michael Seewald ,  Jochen Strayle ,  Anne Plötner ,  Michael Hannus

Inventor： Ulrich Betz ,  Donatella D'Urso ,  Peter Kolkhof ,  Michael Seewald ,  Jochen Strayle ,  Anne Plötner ,  Michael Hannus

IPC: A61K48/00 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/66 ,  A61K31/7105 ,  C12N15/63 ,  C12Q1/68

CPC classification number: G01N33/6893 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2800/32 ,  G01N2800/323

Abstract: The invention relates to novel targets in the screening for compounds useful in the treatment and/or prophylaxis of a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention relates to novel compounds for use as a medicament for diseases or conditions involving a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis. The invention especially relates to antagonists and expression-inhibitory compounds that target G-protein coupled receptors (GPCRs), kinases and proteases, and to methods for identifying such compounds. The invention further relates to methods for identifying these antagonists and expression-inhibitory compounds, and methods for diagnosing a disease selected from the group comprising cardiovascular diseases, disorders of lipid metabolism or atherosclerosis or a susceptibility to such a condition.

Abstract translation: 本发明涉及筛选用于治疗和/或预防选自包括心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病的疾病的化合物的新靶标。 本发明涉及用作涉及选自包含心血管疾病，脂质代谢紊乱或动脉粥样硬化的疾病的疾病或病症的药物的新化合物。 本发明特别涉及靶向G蛋白偶联受体（GPCR），激酶和蛋白酶的拮抗剂和表达抑制性化合物，以及用于鉴定这些化合物的方法。 本发明还涉及用于鉴定这些拮抗剂和表达抑制化合物的方法，以及用于诊断选自包含心血管疾病，脂质代谢紊乱或动脉粥样硬化或对这种病症的易感性的疾病的方法。

公开(公告)号：US20070287698A1

公开(公告)日：2007-12-13

申请号：US10588862

申请日：2005-02-01

Applicant: Nils Griebenow ,  Timo Flessner ,  Michael Harter ,  Martin Raabe ,  Anja Buchmuller ,  Hilmar Bischoff ,  Peter Ellinghaus ,  Peter Kolkhof

Inventor： Nils Griebenow ,  Timo Flessner ,  Michael Harter ,  Martin Raabe ,  Anja Buchmuller ,  Hilmar Bischoff ,  Peter Ellinghaus ,  Peter Kolkhof

IPC: A61K31/55 ,  A61P9/00 ,  C07D223/16

CPC classification number: C07D223/16 ,  C07D401/06

Abstract: The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.

Abstract translation: 本申请涉及新的四氢苯并[d]吖庚因-2-酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和缺血性疾病。