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11.发明申请公开(公告)号：US20110206715A1
公开(公告)日：2011-08-25
申请号：US12753330
申请日：2010-04-02
申请人： MARCEL BEHR , PETER SMALL , GARY SCHOOLNIK , MICHAEL A. WILSON
发明人： MARCEL BEHR , PETER SMALL , GARY SCHOOLNIK , MICHAEL A. WILSON
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb. isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be reintroduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并用作特异性M.tb的标记物。 分离株 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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12.发明申请公开(公告)号：US20080254052A1
公开(公告)日：2008-10-16
申请号：US12049063
申请日：2008-03-14
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tubercuosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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公开(公告)号：US06254575B1
公开(公告)日：2001-07-03
申请号：US09434036
申请日：1999-11-04
申请人： Gale H. Thorne, Jr. , Mark Nelson , F. Mark Ferguson , Kendall P. Thorne , Michael L. Thorne , David L. Thorne , Gale H. Thorne , Michael A. Wilson
发明人： Gale H. Thorne, Jr. , Mark Nelson , F. Mark Ferguson , Kendall P. Thorne , Michael L. Thorne , David L. Thorne , Gale H. Thorne , Michael A. Wilson
IPC分类号： A61M532
CPC分类号： A61M5/1782 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/3275 , Y10S128/919
摘要： A retractable and extendable medical needle protective shield which provides opportunity for accessing and reaccessing a medical needle and associated sharpened needle tip and recovering the needle and tip for safety between accesses. The shield includes a needle guide which assures the needle tip is untouched by any part of the shield as the shield is displaced to cover and uncover the needle. A releasible latch is provided to guard against inadvertent removal of the protective shield between accesses. An unreleasible latch is also provided to secure the shield relative to the latch preparatory to final disposal. In combination with the protective shield, a plurality of adapters are disclosed which provide examples of passively operated, protected access to membrane pierceable fluid sources such as a “Y” connection site of an IV set line, a drug vial, a vacuum sample tube, an umbilical cord holder and a hypodermic site.
摘要翻译： 可伸缩和可延伸的医用针头保护罩，提供进入和重新使用医疗针头和相关联的尖锐针尖的机会，并在接近之间安全地恢复针头和尖端。 护罩包括针导向器，当护罩移位以覆盖并露出针时，针引导件确保针尖不被罩的任何部分所接触。 提供可释放的闩锁以防止在通路之间无意中去除保护屏蔽。 还提供了不可释放的闩锁以固定屏蔽件相对于闩锁的准备以最终处置。 与保护屏蔽结合，公开了多个适配器，其提供被动操作的受保护的进入膜可刺穿流体源的实例，诸如IV设定线的“Y”连接部位，药物小瓶，真空样品管， 脐带架和皮下注射部位。
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公开(公告)号：US6149629A
公开(公告)日：2000-11-21
申请号：US312317
申请日：1999-05-14
申请人： Michael A. Wilson , Gale H. Thorne
发明人： Michael A. Wilson , Gale H. Thorne
IPC分类号： A61M5/32
CPC分类号： A61M5/3271 , A61M5/3202
摘要： An invention which provides for making low cost apparatus and one-hand activation methods for shielding a syringe needle as a safety precaution after each needle use. A shield, which may be used as a protective cover for the needle during initial transport to site of use, is linearly actuated to three distinct stops by action of a single hand, thereby leaving the second hand of a user free for patient care. The shield is releasible from two of the three stops to make possible uncovering of the needle preparatory to use and temporary needle protection between needle uses. The shield has an elongated hollow barrel shape which is sized to fit snugly about, yet slide smoothly over a body of a syringe associated with the needle. The barrel shape of the shield is longitudinally interrupted by a scissure in which an arm which is hingeably affixed to the shield resides. The arm is selectively bent to provide operative surfaces which permit the shield to be released from two of the three stops and further displaced to selected stops by inward depression of the arm. The invention utilizes a collet with a slot and a pawl which interacts with at least one set of ratchet teeth on the arm to provide one of the releasible stops. Generally release from stops is actuated by inward pressure on a predetermined portion of the arm.
摘要翻译： 本发明提供了在每次使用针头之后制造低成本的装置和用于屏蔽注射器针头的单手激活方法作为安全预防措施。 在初始运送到使用地点期间可用作针的保护罩的护罩通过单手的动作被线性致动到三个不同的止挡部，从而使用户的二手免于病人护理。 防护罩可以从三个挡块中的两个位置脱离，以使针头可以准备使用，也可以在针头之间临时保护针头。 护罩具有细长的中空筒状，其尺寸适于紧贴地配合，但平滑地滑过与针相关联的注射器的主体。 屏蔽件的桶形状由其中可铰接地固定在屏蔽件上的臂的切口纵向间断。 臂被选择性地弯曲以提供操作表面，其允许屏蔽件从三个挡块中的两个挡块释放，并通过臂的向内按压而进一步移位到选定的挡块。 本发明利用具有槽和棘爪的夹头，其与臂上的至少一组棘轮齿相互作用以提供可释放止挡件之一。 通常从止动件释放通过在臂的预定部分上的向内的压力来致动。
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公开(公告)号：US5966927A
公开(公告)日：1999-10-19
申请号：US829217
申请日：1997-03-31
申请人： Michael A. Wilson
发明人： Michael A. Wilson
摘要： An efficiency enhanced turbine engine and method are disclosed for a turbine engine having a rotor and a fluid flow path that extends through compression, combustion, and expansion or turbine stages with fluid flowing through the fluid flow path driving the rotor. The turbine engine has one or more stator-rotor-stator assemblies, and use of a flat rotor disk with turbine blades provides simplicity in fabrication and operation. Increases in pressure during combustion above the pressure at the compression stage are prevented from flowing back to the compression stage and/or capturing of fluid during combustion enables elevation of the temperature and pressure while maintaining the fluid at near constant volume during combustion, both of which enhance the efficiency of the turbine engine. Fluid flow is preferably in a circumferential direction and the fluid is caused to reenter the rotor a plurality of times to provide cyclic exposure of the moving parts of the turbine engine to different portions of the engine cycle for reducing the average temperature of the moving parts and thereby allow higher compression ratios and combustion temperatures to also yield higher efficiency.
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公开(公告)号：US5641938A
公开(公告)日：1997-06-24
申请号：US582079
申请日：1996-02-08
摘要： There is provided a gas generating composition consisting essentially of a mixture of nitroguanidine, phase stabilized ammonium nitrate and an elastomeric binder. When the ammonium nitrate is phase stabilized with from about 7% to about 20%, by weight, of a potassium salt, the mixture is structurally and volumetrically stable over typical automotive operating temperatures and has a melting temperature in excess of 100.degree. C. The mixture generates large volumes of nitrogen and carbon dioxide when ignited with minimal generation of solids or toxic gases and is particularly useful as an inflating medium for automobile airbags.
摘要翻译： 提供了一种主要由硝基胍，相稳定的硝酸铵和弹性体粘合剂的混合物组成的气体发生组合物。 当硝酸铵以约7％至约20％重量的钾盐进行相稳定时，该混合物在典型的汽车操作温度下在结构和体积上是稳定的并且具有超过100℃的熔融温度。 当以最小量的固体或有毒气体点燃时，混合物产生大量的氮和二氧化碳，并且特别用作汽车安全气囊的充气介质。
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公开(公告)号：US5466096A
公开(公告)日：1995-11-14
申请号：US146320
申请日：1993-11-01
IPC分类号： B65G51/03
CPC分类号： B65G51/03 , B65G2201/0244
摘要： An air conveyor is provided with a plenum chamber with a perforated deck plate, side walls, and a holddown with holes of an area density sufficiently low to pressurize an enclosed article transport zone. The side walls include brackets for mounting doors openable to remove damaged articles. The deck plate is mounted to support bars by countersunk rivets.
摘要翻译： 空气输送机设置有具有穿孔甲板板，侧壁和具有足够低的区域密度的孔的压力室，以对封闭物品输送区域加压。 侧壁包括用于安装可拆卸损坏物品的门的支架。 甲板通过埋头铆钉安装到支撑杆上。
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公开(公告)号：US4028686A
公开(公告)日：1977-06-07
申请号：US684564
申请日：1976-05-10
申请人： Michael A. Wilson , Gordon E. Gee
发明人： Michael A. Wilson , Gordon E. Gee
摘要： A detector for a dynamic phenomenon with a cyclically varying condition, as motion of a rotating part. At least three digital sensors are separated in phase with respect to the cyclic condition. The instantaneous outputs of the sensors have a plurality of repeating sequential states so long as the dynamic phenomenon exists. The instantaneous outputs of the sensors have at least one state which does not occur during existence of the dynamic phenomenon but which does occur in the absence thereof. Logic circuits respond to the digital sensor outputs and detect information about the dynamic phenomenon. Detection of the repetition rate of an instantaneous output state of the sensors provides a measure of speed. An absence of rotation is indicated by the occurrence of another output state. In another disclosed embodiment, the detector monitors a three phase power system and detects a phase outage by the occurrence of an abnormal sensor output state.
摘要翻译： 具有周期性变化的动态现象的检测器，作为旋转部件的运动。 至少三个数字传感器相对于循环状态分相。 只要存在动态现象，传感器的瞬时输出具有多个重复的顺序状态。 传感器的瞬时输出具有在动态现象存在期间不发生但在不存在的情况下发生的至少一种状态。 逻辑电路响应数字传感器输出并检测有关动态现象的信息。 检测传感器瞬时输出状态的重复率提供了一个速度的测量。 不存在旋转由另一输出状态的发生指示。 在另一公开的实施例中，检测器监视三相电力系统，并通过发生异常传感器输出状态来检测相停机。
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公开(公告)号：US5984591A
公开(公告)日：1999-11-16
申请号：US129970
申请日：1998-08-06
CPC分类号： B65G51/03 , B65G51/035 , B65G2201/0247
摘要： An air conveyor includes guides for stabilizing articles during conveyance and a plenum with apertures for providing pressurized air. In the preferred embodiment, the air conveyor also includes opposed spacers defining passages having a closed end and an open end. The passages are in fluid communication with the apertures of the plenum for directing streams of pressurized air through the open ends at the articles in a downstream direction to propel the articles. In another embodiment, channels defined in support structure for the guides form part of passageways for directing streams of pressurized air at an inclined and downstream angle to propel the articles. The guides are removable to allow the conveyor to be adapted to different sized and shaped articles. The air conveyor may also include an additional plenum and additional opposed spacers associated with the plenum for propelling the articles downstream. The angle of the slots can be larger for creating an article-to-article separation or smaller for creating a contiguous article flow.
摘要翻译： 空气输送机包括用于在输送期间稳定物品的引导件和具有用于提供加压空气的孔的增压室。 在优选实施例中，空气输送机还包括限定具有封闭端和开口端的通道的相对间隔件。 通道与增压室的孔流体连通，用于在下游方向引导加压空气流通过物品处的开口端，以推进物品。 在另一个实施例中，限定在用于引导件的支撑结构中的通道形成用于以倾斜和下游角度引导加压空气流的通道的一部分，以推进物品。 引导件是可拆卸的，以允许输送机适应不同尺寸和成形的物品。 空气输送机还可以包括附加的增压室和与增压室相关联的附加的相对间隔件，用于将物品推进下游。 狭缝的角度可以更大，用于创建物品到物品的分离或更小以创建连续的物品流。
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20.发明授权System and method for regulating power in tank circuits having a bridge configuration 失效具有桥式结构的油箱回路调节功率的系统和方法
公开(公告)号：US5872703A
公开(公告)日：1999-02-16
申请号：US918242
申请日：1997-08-25
CPC分类号： H02M3/3376
摘要： A system for regulating an alternating current voltage source has a pair of P-channel MOSFETs and a pair of N-channel MOSFETs in a bridge configuration with an inductor-capacitor tank there between. A processor in conjunction with a feedback circuit regulates the energy transferred to the tank by modulating the pulse width of signals that are output from the processor and which are used as inputs to the gates of the MOSFETs. By increasing or decreasing the pulse widths transmitted to the various gates of the MOSFETs, the processor increases or decreases the energy transferred to the tank. The feedback circuit is connected between the tank and the processor so that the processor can compare the feedback voltage from the tank to a threshold level in the processor and modify the pulse widths at the output of the processor accordingly.
摘要翻译： 用于调节交流电压源的系统具有一对P沟道MOSFET和一对桥式配置的N沟道MOSFET，其间具有电感器 - 电容器箱。 与反馈电路结合的处理器通过调制从处理器输出的信号的脉冲宽度并且将其用作MOSFET的栅极的输入来调节传输到储存器的能量。 通过增加或减少传输到MOSFET的各种栅极的脉冲宽度，处理器增加或减少传输到罐的能量。 反馈电路连接在储罐和处理器之间，使得处理器可以将来自储罐的反馈电压与处理器中的阈值水平进行比较，并相应地修改处理器输出端的脉冲宽度。
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