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11.发明授权Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof 失效dl-3,4-反式-2,2-二取代-3,4-二芳基苯并二氢吡喃及其衍生物的1-和d-异构体的制备
公开(公告)号：US4447622A
公开(公告)日：1984-05-08
申请号：US304507
申请日：1981-09-22
申请人： Mohammad Salman , Suprabhat Ray , Ved P. Kamboj , Nitya Anand
发明人： Mohammad Salman , Suprabhat Ray , Ved P. Kamboj , Nitya Anand
IPC分类号： C07D311/58 , C07D405/12 , C07D311/74
CPC分类号： C07D311/58
摘要： The laevo and dextro forms of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and similar derivatives thereof have substantially double the post-coital anti-fertility activity of the known racemic compound. The resolution of such known compound into the l- and d-isomeric forms may be carried out using di-p-toluoyl-l-tartaric acid monohydrate or di-p-toluoyl-d-tartaric acid.
摘要翻译： dl-3,4-反式-2,2-二取代-3,4-二芳基苯并二氢吡喃及其类似衍生物的laevo和右旋形式具有已知外消旋化合物的post-coital抗生育活性的实质上的两倍。 这种已知化合物分解成1-和D-异构体形式可以使用二对甲苯甲酰-1-酒石酸一水合物或二对甲苯酰基-D-酒石酸进行。
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公开(公告)号：US20110190369A1
公开(公告)日：2011-08-04
申请号：US13084390
申请日：2011-04-11
申请人： Mohammad SALMAN , Jitendra SATTIGERI , Yatendra KUMAR , Ram Chander ARYAN , Vikram Krishna RAMANATHAN , Anita CHUGH
发明人： Mohammad SALMAN , Jitendra SATTIGERI , Yatendra KUMAR , Ram Chander ARYAN , Vikram Krishna RAMANATHAN , Anita CHUGH
IPC分类号： A61K31/40 , A61K31/4025 , A61P3/00
CPC分类号： C07D207/34 , A61K31/40 , C07C69/716 , C07C69/738 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/14 , C07D413/04
摘要： The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
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公开(公告)号：US20100113371A9
公开(公告)日：2010-05-06
申请号：US11722573
申请日：2005-12-22
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
IPC分类号： A61K31/7008 , C07H15/04 , A61P29/00 , C07H15/12
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。 本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法 疾病
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14.发明申请公开(公告)号：US20100056602A1
公开(公告)日：2010-03-04
申请号：US10558859
申请日：2004-05-28
申请人： Mohammad Salman , Jitendra Sattigeri , Yatendra Kumar , Ram Chander Aryan , Vikram Krishna Ramanathan , Anita Chugh
发明人： Mohammad Salman , Jitendra Sattigeri , Yatendra Kumar , Ram Chander Aryan , Vikram Krishna Ramanathan , Anita Chugh
IPC分类号： A61K31/40 , C07D207/00 , C07C69/66 , C07D405/02 , A61P9/00
CPC分类号： C07D207/34 , A61K31/40 , C07C69/716 , C07C69/738 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/14 , C07D413/04
摘要： The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
摘要翻译： 本发明涉及可用作3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂的取代吡咯衍生物。 本文公开的化合物可用作胆固醇降低剂，并且可用于治疗胆固醇相关疾病和相关症状。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物，以及治疗胆固醇相关疾病和相关症状的方法。
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公开(公告)号：US20090170790A1
公开(公告)日：2009-07-02
申请号：US11577900
申请日：2005-10-25
申请人： Biswajit Das , Mohammad Salman , Santosh Haribhau Kurhade , Ramadass Venkataramanan , Rajesh Kumar , Gobind Singh Kapkoti , Rita Katoch , Anish Bandyopadhyay , Ashok Rattan
发明人： Biswajit Das , Mohammad Salman , Santosh Haribhau Kurhade , Ramadass Venkataramanan , Rajesh Kumar , Gobind Singh Kapkoti , Rita Katoch , Anish Bandyopadhyay , Ashok Rattan
IPC分类号： A61K31/7028 , C07H17/08 , A61P31/04
CPC分类号： C07H17/00
摘要： The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译： 本发明提供可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属， 支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物和治疗细菌感染的方法。
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公开(公告)号：US20090005325A1
公开(公告)日：2009-01-01
申请号：US12094839
申请日：2006-11-21
申请人： Biswajit Bas , Anjan Chakrabarti , Ramadass Venkataramanan , Atul Kashinath Hajare , Anish Bandyopadhyay , Rita Katoch , Gobind Singh Kapkoti , Yogash Baban Surase , Mohammad Salman , Dilip J. Upadhyay
发明人： Biswajit Bas , Anjan Chakrabarti , Ramadass Venkataramanan , Atul Kashinath Hajare , Anish Bandyopadhyay , Rita Katoch , Gobind Singh Kapkoti , Yogash Baban Surase , Mohammad Salman , Dilip J. Upadhyay
IPC分类号： A61K31/7048 , A61P31/12 , C07H17/08
CPC分类号： C07H17/08
摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译： 本文提供了可用作抗菌剂的酮内酯衍生物。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌属，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。 还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。
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公开(公告)号：US20080319002A1
公开(公告)日：2008-12-25
申请号：US11570749
申请日：2004-06-16
IPC分类号： A61K31/4353 , C07D221/04 , A61P1/00 , A61P13/02 , A61P3/04 , A61P3/10 , A61P9/00
CPC分类号： C07D405/12 , C07D405/14
摘要： This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及作为毒蕈碱受体拮抗剂的黄嘌呤衍生物，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。
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公开(公告)号：US20080287376A1
公开(公告)日：2008-11-20
申请号：US11572619
申请日：2005-07-28
申请人： Biswajit Das , Mohammad Salman , Atul Kashinath Hajare , Ramadass Venkataramanan , Rita Katoch , Rajesh Kumar , Gobind Singh Kapkoti , Anjan Chakrabarti , Anish Bandyopadhyay , Santosh Haribhau Kurhade , Yogesh Baban Surase , Ashok Rattan
发明人： Biswajit Das , Mohammad Salman , Atul Kashinath Hajare , Ramadass Venkataramanan , Rita Katoch , Rajesh Kumar , Gobind Singh Kapkoti , Anjan Chakrabarti , Anish Bandyopadhyay , Santosh Haribhau Kurhade , Yogesh Baban Surase , Ashok Rattan
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/04
CPC分类号： C07H17/00
摘要： The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp. Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebaclerium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译： 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌。 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。
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公开(公告)号：US20080167317A1
公开(公告)日：2008-07-10
申请号：US10593939
申请日：2004-03-23
申请人： Anita Chugh , Mohammad Salman , Atul Tiwari , Gowri R. Shankar , Sandeep Sinha
发明人： Anita Chugh , Mohammad Salman , Atul Tiwari , Gowri R. Shankar , Sandeep Sinha
IPC分类号： A61K31/496 , A61P13/00 , A61K31/18 , A61K31/403 , A61K31/47 , A61K31/235 , A61K31/473
CPC分类号： A61K31/496 , A61K31/216 , A61K2300/00
摘要： This invention relates to combination therapy for the treatment of lower urinary tract symptoms (LUTS) associated with or without benign prostatic hyperplasia (BPH). The combination therapy comprises of tailored 1 adrenoceptor antagonist, which is selective for 1a over 1b subtype but non-selective for 1a over 1d subtype, in combination with muscarinic receptor antagonist, preferably bladder selective antagonist and optionally included 5-reductase inhibitor for relief of LUTS in a mammal with or without BPH.
摘要翻译： 本发明涉及用于治疗与或不伴有良性前列腺增生（BPH）相关的下尿路症状（LUTS）的组合疗法。 联合治疗包括定制的1肾上腺素受体拮抗剂，其对于1a超过1b亚型是选择性的，但对于1a超过1d亚型是非选择性的，与毒蕈碱受体拮抗剂组合，优选膀胱选择性拮抗剂和任选包含的5-还原酶抑制剂以缓解LUTS 在具有或不具有BPH的哺乳动物中。
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20.发明申请公开(公告)号：US20070149605A1
公开(公告)日：2007-06-28
申请号：US10558858
申请日：2004-05-28
IPC分类号： A61K31/4025 , A61K31/401 , C07D405/02
CPC分类号： C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to substituted pyrrole derivatives of Formula (I), wherein (Y), with the proviso that one of R2, R4 and R5 is a heterocycle and with the further provision that if R2 is not a heterocycle then either R4 or R5 alone is not unsubstituted pyridyl, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
摘要翻译： 本发明涉及式（I）的取代吡咯衍生物，其中（Y），条件是R 2，R 4和R 5中的一个 并且进一步的规定是，如果R 2不是杂环，则R 4或R 5独立地是 未被取代的吡啶基，可用作3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂。 本文公开的化合物可用作胆固醇降低剂，并且可用于治疗胆固醇相关疾病和相关症状。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物，以及治疗胆固醇相关疾病和相关症状的方法。
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