公开(公告)号：US07109209B2

公开(公告)日：2006-09-19

申请号：US11245972

申请日：2005-10-07

Applicant: Michael John Alberti ,  Stanley D. Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Anthony Harris ,  Brian A. Johns ,  David Kendall Jung ,  Michael Robert Peel ,  Jennifer Badiang Stanford

Inventor： Michael John Alberti ,  Stanley D. Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Anthony Harris ,  Brian A. Johns ,  David Kendall Jung ,  Michael Robert Peel ,  Jennifer Badiang Stanford

IPC: C07D471/04 ,  A61K31/4162

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US07105530B2

公开(公告)日：2006-09-12

申请号：US10451305

申请日：2001-12-19

Applicant: Amogh Boloor ,  Mui Cheung ,  Ronda Davis ,  Philip Anthony Harris ,  Kevin Hinkle ,  Robert Anthony Mook, Jr. ,  Jeffery Alan Stafford ,  James Marvin Veal

Inventor： Amogh Boloor ,  Mui Cheung ,  Ronda Davis ,  Philip Anthony Harris ,  Kevin Hinkle ,  Robert Anthony Mook, Jr. ,  Jeffery Alan Stafford ,  James Marvin Veal

IPC: C07D239/48 ,  A61K31/506 ,  A61P27/02

CPC classification number: C07D239/30 ,  C07D231/56 ,  C07D235/08 ,  C07D403/12 ,  C07D413/14

Abstract: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。

公开(公告)号：US20060074119A1

公开(公告)日：2006-04-06

申请号：US10522958

申请日：2003-08-04

Applicant: Clarence Andrews ,  Mui Cheung ,  Ronda Davis-Ward ,  David Drewry ,  Kyle Emmitte ,  Robert Hubbard ,  Kevin Kuntz ,  James Linn ,  Robert Mook ,  Gary Smith ,  James Veal

Inventor： Clarence Andrews ,  Mui Cheung ,  Ronda Davis-Ward ,  David Drewry ,  Kyle Emmitte ,  Robert Hubbard ,  Kevin Kuntz ,  James Linn ,  Robert Mook ,  Gary Smith ,  James Veal

IPC: A61K31/4184 ,  C07D409/14

CPC classification number: C07D491/04 ,  C07D409/04 ,  C07D409/14

Abstract: The present invention provides compounds of formula (1): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（1）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US20050234083A1

公开(公告)日：2005-10-20

申请号：US10506447

申请日：2003-02-28

Applicant: Stanley Chamberlain ,  Mui Cheung ,  Holly Emerson ,  Neil Johnson ,  Kristen Nailor ,  Douglas Sammond ,  Marcus Semones

Inventor： Stanley Chamberlain ,  Mui Cheung ,  Holly Emerson ,  Neil Johnson ,  Kristen Nailor ,  Douglas Sammond ,  Marcus Semones

IPC: A61K31/506 ,  A61K31/5377 ,  A61K45/00 ,  A61P9/10 ,  A61P9/14 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D43/02

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

公开(公告)号：US20140113916A1

公开(公告)日：2014-04-24

申请号：US14125370

申请日：2012-06-15

Applicant: Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

Inventor： Carl Brooks ,  Mui Cheung ,  Hilary Schenck Eidam ,  Krista B. Goodman ,  Marlys Hammond ,  Mark A. Hilfiker ,  Jaclyn R. Patterson ,  Patrick Stoy ,  Guosen Ye

IPC: C07D413/14 ,  C07D413/06

CPC classification number: C07D413/14 ,  C07D263/52 ,  C07D413/06 ,  C07D413/08

Abstract: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

公开(公告)号：US08658636B2

公开(公告)日：2014-02-25

申请号：US13635952

申请日：2011-03-23

Applicant: Carl A. Brooks ,  Mui Cheung ,  Hilary S. Eidam ,  Ryan M. Fox ,  Mark A. Hilfiker ,  Eric S. Manas ,  Guosen Ye

Inventor： Carl A. Brooks ,  Mui Cheung ,  Hilary S. Eidam ,  Ryan M. Fox ,  Mark A. Hilfiker ,  Eric S. Manas ,  Guosen Ye

IPC: C07D401/14 ,  A61K31/4453 ,  C07D413/14 ,  A61K31/5355 ,  C07D223/02 ,  A61K31/55 ,  C07D215/14 ,  A61P9/00 ,  A61P11/00 ,  A61P13/00

CPC classification number: C07D401/06 ,  C07D401/14

Abstract: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract translation: 本发明涉及喹啉类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。

公开(公告)号：US07786127B2

公开(公告)日：2010-08-31

申请号：US12065668

申请日：2006-08-28

Applicant: Mui Cheung ,  Kyle Allen Emmitte ,  James Michael Salovich

Inventor： Mui Cheung ,  Kyle Allen Emmitte ,  James Michael Salovich

IPC: A61K31/4184 ,  C07D409/04 ,  A61P35/00

CPC classification number: C07D409/04 ,  C07D409/14

Abstract: The present invention provides benzimidazole thiophene compounds, pharmaceutical compositions containing the same, and their use as pharmaceutical agents.

Abstract translation: 本发明提供苯并咪唑噻吩化合物，含有它们的药物组合物及其作为药剂的用途。

公开(公告)号：US20100216779A1

公开(公告)日：2010-08-26

申请号：US12602289

申请日：2008-05-28

Applicant: Eric W. Baum ,  Kyle Allen Emmitte ,  Kevin Wayne Kuntz ,  Robert Anthony Mook, JR. ,  Kristen Elizabeth Nailor ,  James Michael Salovich ,  John Brad Shotwell ,  Stephon Cornell Smith ,  Kirk Lawrence Stevens ,  David Edward Uehling ,  Alex Gregory Waterson ,  Mui Cheung ,  Ganesh S. Moorthy ,  Brian John Wilson

Inventor： Eric W. Baum ,  Kyle Allen Emmitte ,  Kevin Wayne Kuntz ,  Robert Anthony Mook, JR. ,  Kristen Elizabeth Nailor ,  James Michael Salovich ,  John Brad Shotwell ,  Stephon Cornell Smith ,  Kirk Lawrence Stevens ,  David Edward Uehling ,  Alex Gregory Waterson ,  Mui Cheung ,  Ganesh S. Moorthy ,  Brian John Wilson

IPC: A61K31/506 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/551 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract translation: 本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

公开(公告)号：US20080300247A1

公开(公告)日：2008-12-04

申请号：US11754653

申请日：2007-05-29

Applicant: Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

Inventor： Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

IPC: A61K31/5377 ,  A61K31/454 ,  A61K31/4545 ,  A61P35/00 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D403/14 ,  A61P7/00 ,  A61K31/496 ,  A61K31/513

CPC classification number: C07D409/04 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供了苯并咪唑噻吩化合物含有它们的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US07459455B2

公开(公告)日：2008-12-02

申请号：US10503874

申请日：2003-02-07

Applicant: Mui Cheung ,  Kristen Elizabeth Nailor ,  Douglas McCord Sammond ,  James Marvin Veal

Inventor： Mui Cheung ,  Kristen Elizabeth Nailor ,  Douglas McCord Sammond ,  James Marvin Veal

IPC: C07D239/48 ,  A61K31/505

CPC classification number: C07D239/48

Abstract: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。