公开(公告)号：US20170360897A1

公开(公告)日：2017-12-21

申请号：US15328355

申请日：2015-07-01

Applicant: National Center for Nanoscience and Technology, China ,  Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

Inventor： Chen Wang ,  Hongyang Duan ,  Yanlian Yang ,  Haiyan Xu ,  Xiaojin Li ,  Hua Guo ,  Hanyi Xie ,  Yue Yu

IPC: A61K38/38 ,  A61K38/08 ,  A61K47/42 ,  A61K47/64 ,  C07K14/00 ,  A61K45/06 ,  C07K7/06

CPC classification number: A61K38/385 ,  A61K38/08 ,  A61K38/16 ,  A61K45/06 ,  A61K47/42 ,  A61K47/643 ,  C07K7/06 ,  C07K14/00

Abstract: The present invention provides a group of polypeptides and a complex formed by the polypeptides and human serum albumin, a method for improving the solubility of the group of polypeptides in a salt solution by combining the polypeptides with human serum albumin, a method for preparing the complex formed by the group of polypeptides and human serum albumin, and an application of the group of polypeptides and the complex formed by the polypeptides and human serum albumin in the preparation of drugs for suppressing tumor metastasis and treating leukemia.

公开(公告)号：US20250012717A1

公开(公告)日：2025-01-09

申请号：US18277094

申请日：2022-07-05

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY

Inventor： Qing DAI ,  Chenchen WU ,  Xiaoxia YANG ,  Xiangdong GUO

IPC: G01N21/3577 ,  G01N21/85

Abstract: The invention provides a plasmon enhanced infrared spectrum sensor for detecting a protein secondary structure in an aqueous solution and a preparation method of the plasmon enhanced infrared spectrum sensor, and belongs to the technical field of infrared optical sensing. The sensor includes a graphene plasmon chip and a micro-fluidic system compatible with infrared transmission testing. Under excitation of incident infrared light, a locally enhanced electromagnetic field (surface plasmon) is formed on the surface of the graphene layer due to collective oscillation of charges, and molecules to be detected in an aqueous solution are enriched in a surface plasmon region due to Van der Waals interaction of the graphene layer. The infrared response of to-be-detected molecules gathered in the plasmon region is enhanced under the driving of an electromagnetic field of graphene plasmon; meanwhile, water molecules are excluded out of a plasmon region, molecular signals out of the plasmon region can be completely eliminated by using an in-situ electrical background deduction method, and direct and in-situ monitoring of trace solution components by infrared spectroscopy is realized.

公开(公告)号：US20230250183A1

公开(公告)日：2023-08-10

申请号：US18012040

申请日：2021-06-22

Applicant: Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ,  National Center for Nanoscience and Technology

Inventor： Haiyan XU ,  Chen WANG ,  Shilin XU ,  Yanlian YANG ,  Jie MENG ,  Jian LIU ,  Tao WEN

IPC: C07K16/28 ,  A61P35/02 ,  A61K31/475 ,  A61K31/704 ,  A61K31/4745 ,  A61K31/675

CPC classification number: C07K16/2896 ,  A61P35/02 ,  A61K31/475 ,  A61K31/704 ,  A61K31/4745 ,  A61K31/675

Abstract: The invention discloses a polypeptide that specifically binding to CD123 protein, a polypeptide complex and a co-delivery system, and preparation methods and use thereof. The general formula of amino acid arrangement in the polypeptide is X1-DYDTR-X2-QGTD-X3-G-X4-DFRRISD-X5; it can bind to CD123-positive cells and inhibit the progression of leukemia; the polypeptide complex can increase the binding quantity of the polypeptide to CD123-positive cells, and drug can inhibit the progression of leukemia alone and prolong the survival of leukemia mice; the co-delivery system can load chemotherapy drugs for tumor treatment and reduce the toxicity of chemotherapy drugs to normal cells.

公开(公告)号：US20220276419A1

公开(公告)日：2022-09-01

申请号：US17631470

申请日：2019-08-28

Applicant: National Center for Nanoscience and Technology, China

Inventor： Xiaojun LI

IPC: G02B5/18 ,  G03F7/00 ,  B29C33/38

Abstract: Some embodiments of the present disclosure relate to a manufacturing method using nano-imprint lithography for a diffraction grating waveguide of a near-eye display. The manufacturing method includes: manufacturing an imprint lithography template with a diffraction grating waveguide pattern; transferring the diffraction grating waveguide pattern of the imprint lithography template to a transferring template by nano-imprint lithography, so as to obtain a transferring template with a reverse pattern of the diffraction grating waveguide pattern; and transferring the reverse pattern of the diffraction grating waveguide pattern of the transferring template to a waveguide substrate by nano-imprint lithography, so as to obtain the diffraction grating waveguide of the near-eye display.

公开(公告)号：US20190313933A1

公开(公告)日：2019-10-17

申请号：US16471545

申请日：2017-02-06

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

Inventor： Ying FANG ,  Jinfen WANG ,  Shouliang GUAN ,  Mingde DU ,  Liang ZOU

IPC: A61B5/0478 ,  H05K1/02 ,  H05K1/11 ,  H05K1/09 ,  H05K3/14 ,  H05K3/00 ,  H05K3/28 ,  A61B5/04

Abstract: Disclosed are an implantable flexible neural microelectrode comb, and a preparation method and implantation method therefor. The flexible neural microelectrode comb is mainly composed of a flexible substrate layer (1), a flexible insulation layer (2), and a metal connection wire layer (3) arranged between the flexible substrate layer (1) and the flexible insulation layer (2); the flexible neural microelectrode comb comprises a filament structure (4), a mesh structure (5), a plane structure (6) and a bonding pad area (7) connected in sequence; electrode sites (8) are arranged on the filament structure (4); bonding pads are arranged on the bonding pad area (7); the metal connection wire layer (3) is composed of metal connection wires connecting the electrode sites (8) and the bonding pads; and the flexible insulation layer (2) is not arranged on the surfaces of the electrode sites (8) and the bonding pads. The prepared flexible neural microelectrode comb has a structure gradually changing from a filament to a mesh to a plane structure, thus improving mechanical stability during a deformation process. The mechanical properties of the implantable flexible neural microelectrode comb match brain tissue, the implantation footprint is small, an inflammatory response of the brain is avoided, and electrophysiological signals in the brain can be stably tracked and measured in a multi-site manner for a long time.

公开(公告)号：US20190107556A1

公开(公告)日：2019-04-11

申请号：US16086821

申请日：2016-03-29

Applicant: (NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY)

Inventor： Jianxun Xu ,  Yuliang Zhao

IPC: G01R1/067 ,  G01R3/00 ,  G01Q70/12 ,  G01Q30/02

Abstract: Provided is a conical nano-carbon material functionalized needle tip, formed by assembling a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the conical nano-carbon material functionalized needle tip. The conical nano-material functionalized needle tip has an outstanding interface formed by metal-carbide covalent bonds, and the orientation of the conical nano-material is matched with the axial direction of the metal needle tip (illustrated in FIG. 6). The proposed preparation method affords a robust interface and avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or platinum or the like, in other preparation methods.

公开(公告)号：US20190074156A1

公开(公告)日：2019-03-07

申请号：US15834152

申请日：2017-12-07

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

Inventor： Xixue HU ,  Hongbo GUO ,  Dongliang WANG ,  Yaling GAN ,  Xiaohui XU

IPC: H01J37/067 ,  G06T7/73

Abstract: Disclosed are a filament positioning system and a filament positioning method. The filament positioning system includes a bottom plate, a first positioning regulating mechanism and a second positioning regulating mechanism, wherein the first positioning regulating mechanism is configured to conduct positioning regulation of a position of a filament seat on the bottom plate, so that filament seats of different models can be fixed to the bottom plate, and the second positioning regulating mechanism is configured to conduct positioning regulation on the filament; and a detection module configured to collect and display position information of a filament tip and the filament seat, wherein the first positioning regulating mechanism and the second positioning regulating mechanism correspondingly regulate positions of the filament seat and the filament tip according to the position information.

公开(公告)号：US20250038753A1

公开(公告)日：2025-01-30

申请号：US18761358

申请日：2024-07-02

Applicant: The University of Hong Kong ,  National Center for Nanoscience and Technology

Inventor： Shuang ZHANG ,  Fuxin GUAN ,  Kebo ZENG ,  Qing DAI ,  Xiangdong GUO

IPC: H03L7/16

Abstract: A method for enhancing characteristic signals by synthesizing multiple frequency waves is provided, which includes: obtaining real frequency responses based on the measurement results of spectral signals; selecting complex frequencies to at least partially compensate for spectral line broadening caused by losses; and obtaining complex frequency responses based on multiple real frequency responses and the selected complex frequencies to enhance the characteristic signals.

公开(公告)号：US12174403B2

公开(公告)日：2024-12-24

申请号：US17631470

申请日：2019-08-28

Applicant: National Center for Nanoscience and Technology, China

Inventor： Xiaojun Li

IPC: G02B5/18 ,  B29C33/38 ,  G03F7/00

Abstract: Some embodiments of the present disclosure relate to a manufacturing method using nano-imprint lithography for a diffraction grating waveguide of a near-eye display. The manufacturing method includes: manufacturing an imprint lithography template with a diffraction grating waveguide pattern; transferring the diffraction grating waveguide pattern of the imprint lithography template to a transferring template by nano-imprint lithography, so as to obtain a transferring template with a reverse pattern of the diffraction grating waveguide pattern; and transferring the reverse pattern of the diffraction grating waveguide pattern of the transferring template to a waveguide substrate by nano-imprint lithography, so as to obtain the diffraction grating waveguide of the near-eye display.

公开(公告)号：US20220308087A1

公开(公告)日：2022-09-29

申请号：US17444017

申请日：2021-07-29

Applicant: National center for nanoscience and technology

Inventor： Jianxun XU ,  Yuliang ZHAO ,  Yifei GE

IPC: G01R1/067

Abstract: A carbon nanomaterial functionalized needle tip is modified with a low work function material. The needle tip is formed by combining a carbon nanomaterial with a material of a needle tip through a covalent bond. The interior or outer surface of the carbon nanomaterial is modified with a low work function material. The material of the needle tip is a metal which can be any of tungsten, iron, cobalt, nickel, and titanium. The carbon nanomaterial can be carbon nanocone or carbon nanotube. The tip of the carbon nanomaterial has the same orientation as the metal needle tip. The low work function material can be selected from metals, metal carbides, metal oxides, borides, nitrides, and endohedral metallofullerene. The carbon nanomaterial functionalized needle tip has a lower electron emission barrier, and can effectively reduce the electric field intensity required for electron emission, and improve the emission current and emission efficiency.